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Originally published as JCO Early Release 10.1200/JCO.2006.07.5754 on January 16 2007 © 2007 American Society of Clinical Oncology.
Phase II Clinical Trial of Chemotherapy-Naïve Patients
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ABSTRACT |
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 TOP ABSTRACT INTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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70 years who were treated with erlotinib and evaluated to determine the median, 1-year, and 2-year survival. The secondary end points include radiographic response rate, time to progression (TTP), toxicity, and symptom improvement. Patients and Methods Eligible patients with NSCLC were treated with erlotinib 150 mg/d until disease progression or significant toxicity. Tumor response was assessed every 8 weeks by computed tomography scan using Response Evaluation Criteria in Solid Tumors. Tumor samples were analyzed for the presence of somatic mutations in EGFR and KRAS.
Results Eighty eligible patients initiated erlotinib therapy between March 2003 and May 2005. There were eight partial responses (10%), and an additional 33 patients (41%) had stable disease for 2 months or longer. The median TTP was 3.5 months (95% CI, 2.0 to 5.5 months). The median survival time was 10.9 months (95% CI, 7.8 to 14.6 months). The 1- and 2- year survival rates were 46% and 19%, respectively. The most common toxicities were acneiform rash (79%) and diarrhea (69%). Four patients developed interstitial lung disease of grade 3 or higher, with one treatment-related death. EGFR mutations were detected in nine of 43 patients studied. The presence of an EGFR mutation was strongly correlated with disease control, prolonged TTP, and survival.
Conclusion Erlotinib monotherapy is active and relatively well tolerated in chemotherapy-naïve elderly patients with advanced NSCLC. Erlotinib merits consideration for further investigation as a first-line therapeutic option in elderly patients.
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INTRODUCTION |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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3 toxicity when treated with a platinum-based doublet.3 Availability of an effective, less toxic therapy might help extend potentially beneficial treatment to a greater proportion of older patients.
Given the manageable toxicity and demonstrated efficacy of erlotinib in patients experiencing treatment failure with one to two prior regimens,9 we conducted a phase II study of erlotinib in chemotherapy-naïve elderly patients (age 70 years) with stage IIIB or IV non–small-cell lung cancer (NSCLC). As part of the trial, pretreatment tissue was collected for future correlative science analyses. When it was discovered that EGFR mutations were associated with sensitivity to gefitinib and erlotinib10-12 and that KRAS mutations were associated with resistance to these agents,13,14 specimens were then analyzed for these mutations. This allowed investigators to correlate mutation status with clinical outcomes in patients not yet exposed to other chemotherapy regimens.
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PATIENTS AND METHODS |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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70 years of age with histologically or cytologically confirmed stage IIIB/IV NSCLC. Additional inclusion criteria included Eastern Cooperative Oncology Group performance status of 0 to 2; WBC 3,000/µL; hemoglobin 9.0 g/dL; platelet count 100,000/µL; total bilirubin 
1.5 mg/dL; AST 2.0x institutional upper limit of normal; creatinine 1.5 mg/dL; measurable or assessable lesions as defined by Response Evaluation Criteria in Solid Tumors; and life expectancy more than 8 weeks. Patients with stable brain metastases after surgical resection and/or cranial irradiation were eligible. Exclusion criteria included prior chemotherapy or treatment with any ErbB1- or ErbB2-targeted agent; major surgery or radiation therapy within the last 21 days; any malignancy within the last 5 years (excluding nonmelanoma skin cancers or definitively treated cervical cancer); any active gastrointestinal disorder that alters motility or absorption; and severe and unstable medical comorbidities.
Study Procedures and Treatment
The study was approved by the Dana-Farber/Partners Cancer Care institutional review board. All patients gave written, informed consent. Baseline assessment included a history and physical examination, standard laboratory studies, ECG, computed tomography (CT) of the chest and abdomen, head CT or magnetic resonance imaging, and quality-of-life (QOL) assessment using the patient scale of the Lung Cancer Symptom Scale.15 Lung cancer histology was classified using the 1999 WHO classification system.16
Patients were treated with erlotinib 150 mg daily without interruption until disease progression, severe or intolerable toxicity, or withdrawal of consent. Compliance was checked after each 28-day cycle with a treatment diary. At the start of each cycle, patients underwent assessment of performance status, adverse events, and QOL; physical examination; and laboratory studies. Tumor assessment by CT was evaluated after every two cycles of therapy. Toxicity was graded by the National Cancer Institute Common Toxicity Criteria, version 2.0.17 Treatment interruptions up to 14 days were allowed. For toxicities grade 3, patients were restarted on a reduced dose (100 mg/d) if symptoms improved to grade 2 within 14 days. A second dose reduction to 50 mg/d was allowed, if necessary.
Statistical Analysis
This single-arm, open-label, phase II study recruited 82 patients in two centers. In this two-stage trial, continuation past the first stage was based on a response rate 10% among the first 29 patients enrolled. The primary end point of the study was median survival. Secondary end points included clinical response rate, time to progression (TTP), toxicity, QOL, and correlation of EGFR and KRAS mutations with clinical outcomes.
Study size was based on a statistical model that estimated that a cohort of 60 erlotinib-treated patients achieving a median survival of 37 weeks would provide sufficient power to warrant a phase III trial comparing erlotinib with vinorelbine.18 After the discovery of activating mutations in tumor EGFR,10,11 the planned study size was expanded to 80 patients to increase the number of tumor samples available for EGFR and KRAS mutation analyses.
Best clinical response to treatment with erlotinib was determined using Response Evaluation Criteria in Solid Tumors.19 TTP and survival were calculated from the date of enrollment to the date of progression or death, respectively. Outcomes were censored if an end point was not reached by the time of last follow-up or if a patient was lost to follow-up. TTP and survival were estimated using the Kaplan-Meier method.20 Univariate analyses of TTP and survival used the log-rank test to examine effects of baseline clinical factors, EGFR mutation status, and treatment-related rash. Proportional hazards models were fitted to TTP and overall survival data to assess the effects of mutational status and clinical characteristics.21 Statistical analyses were performed using SAS, version 9.1 (SAS Institute Inc, Cary, NC).
Symptom Response and Quality-of-Life Analysis
Symptoms and global QOL were assessed using the nine-item, visual analog patient scale of the Lung Cancer Symptom Scale. Results on symptom prevalence, response, and QOL changes will be reported separately.
EGFR and KRAS Mutation Analysis
Written consent for tissue banking and correlative studies was obtained. Tumor specimens (frozen or paraffin embedded) were collected from previous diagnostic or surgical procedures. No specific requirements were prospectively mandated for the type of tumor specimen. The primary correlative science analysis was determination of the presence of EGFR and KRAS mutations.
For patients with sufficient tissue for direct DNA sequencing, tumor cells were isolated by microdissection. Exons 18 through 24 of the EGFR and exons 2 and 3 of KRAS were amplified and sequenced according to previously described methods.10,11,22 For tumor samples deemed inadequate by a molecular pathologist for direct sequencing based on a high percentage of normal cells (< 50% tumor cells), mutation analysis was performed with the WAVE-HS (Transgenomic Inc, Omaha, NE) platform using previously published methods.23 All detected mutations were confirmed by repeat analysis.
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RESULTS |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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grade 3. Thirteen patients required dose reduction to 100 mg/d for treatment-related toxicity (eight patients with rash, two with hand-foot syndrome, one with mucositis, one with eye dryness and irritation, and one with diarrhea). Twelve patients were removed from the protocol because of erlotinib-related toxicity (three patients with interstitial lung disease [ILD], three with dehydration, three with diarrhea, one with hemoptysis, one with rash, and one with anorexia). There were four patients with possible ILD, with one treatment-related death. Of three patients with major bleeding (two with gastrointestinal bleeds and one with hemoptysis), two patients had concomitantly received erlotinib and warfarin and had elevations in their prothrombin time, with international normalized ratios of more than 10. There were several notable events believed to be unrelated to erlotinib. These were primarily vascular (three cerebrovascular accidents and one myocardial infarction) and occurred in patients with pre-existing risk factors for these conditions; two stroke patients had high-grade stenosis of the internal carotid artery on magnetic resonance angiography, and another patient had atrial fibrillation and mitral regurgitation. The myocardial infarction patient had known coronary artery disease, hypertension, and hyperlipidemia. There was also a case of melanoma occurring in a patient with a prior history of suspicious skin lesions and dermatologic care that predated administration of erlotinib.
Response
There were eight partial responses (PR) among the eighty patients treated (response rate, 10%). Thirty-three patients (41%) achieved stable disease (SD), whereas 28 patients (35%) had progressive disease as their best clinical response. The overall disease control rate (PR + SD) was 51%. Eleven patients were removed from study before being evaluated for response; five patients had toxicity (two had diarrhea, one had rash, one had dehydration, and one had hemoptysis), three had exacerbation of pre-existing medical conditions (one had coronary artery disease, one had stroke, and one had chronic obstructive pulmonary disease), two withdrew consent before restaging scans, and one was lost to follow-up.
TTP and Survival
All 80 treated patients were assessable for TTP and survival, with minimum potential follow-up of 7 months and median potential follow-up of 23 months. At the time of analysis, there were 57 deaths, 22 patients confirmed alive, and one patient lost to follow-up. Of the surviving patients, only seven remain progression free on therapy with erlotinib (range, 7.3 to 31.8 months). Median TTP was 3.5 months (95% CI, 2.0 to 5.5 months; Fig 1A). One-year progression-free rate was 20%. Median survival time was 10.9 months (95% CI, 7.8 to 14.6 months; Fig 1B). The 1- and 2-year survival rates were 46% and 19%, respectively.
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Tissue samples from 41 patients were analyzed for KRAS mutations (32 by direct DNA sequencing and nine by WAVE-HS). KRAS mutations were detected in six patients (five by direct sequencing and one by WAVE-HS). All six patients had a history of tobacco use (five former smokers and one current smoker), with an average of 52 pack-years smoked (range, 30 to 78 pack-years). There were no clinical responses in this group (Table 5). Although median time on study was only 2.5 months for this subset, median survival time for these six patients was 15.5 months (95% CI, 4.2 to 16.8 months). No patients had both KRAS and EGFR mutations.
Statistical Modeling
A previously published statistical model estimates the expected probability that a phase II regimen would yield a significant result in a subsequent phase III trial; regimens with an expected power of more than 55% were likely to be good candidates for phase III testing.18 With a 19-week survival difference between erlotinib in the current trial and vinorelbine in the Elderly Lung Cancer Vinorelbine Italian Study1 (47 weeks v 28 weeks, respectively), the statistical model predicts a power of 97%.
Second-Line Chemotherapy
Thirty-five patients received second-line chemotherapy (carboplatin plus paclitaxel, n = 6; carboplatin plus gemcitabine, n = 4; vinorelbine monotherapy, n = 19; pemetrexed monotherapy, n = 3; gefitinib monotherapy, n = 1; or erlotinib rechallenge, n = 2). Altogether, two patients partially responded to second-line vinorelbine, with no responses among patients receiving other regimens. Overall response rate to second-line chemotherapy was 6%.
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DISCUSSION |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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In the present study, erlotinib was administered to 80 unselected, previously untreated NSCLC patients older than age 70 years. A median survival time of 10.9 months (47 weeks) compares favorably with the survival times achieved in elderly patients receiving vinorelbine (6.5 to 8.5 months),1,2 paclitaxel (5.5 months),24 and cisplatin-based combination therapy (8.0 to 8.5 months).3,24
One potential limitation in interpreting survival data from this trial is that 64% of patients had adenocarcinoma (including bronchioloalveolar carcinoma). Earlier studies suggested a higher response rate and higher likelihood of somatic EGFR mutations in patients with adenocarcinoma.9,25,26 Although the protocol did not specifically recruit by tumor histology, a selection bias on the part of treating physicians may partly account for the increased prevalence of adenocarcinoma among enrolled patients in our trial compared with other trials of elderly patients with NSCLC (34% to 36%).1,2 However, in multivariate analysis, tumor histology was not associated with improved survival in this trial.
Conversely, because planned treatment on this trial did not include chemotherapy, patients with better performance status may have chosen or been recommended doublet chemotherapy, which might introduce a negative selection bias. A less fit population might account for adverse events both related and unrelated to erlotinib treatment, as well as for the low number of patients receiving second-line treatment.
Regarding treatment-related adverse effects, there were four patients with suspected ILD (5%), with one death. One of the four patients was of Asian ethnicity, and none had received prior chemotherapy or chest radiotherapy. Although the rate of ILD in this trial was less than the 12% incidence seen in a recent Japanese phase II study,27 it is higher than the rate of less than 1% seen in each arm of the BR.21 trial.9 However, it was unclear in at least one patient whether radiographic findings represented ILD or lymphangitic spread of a tumor that was progressing systemically.
The toxicity of erlotinib in this population compares favorably with other studies performed in patients with NSCLC older than age 70 years. Fifteen patients (19%) in this study developed at least one toxicity of grade 3 compared with more than 25% of elderly patients in studies with vinorelbine,2 73% in studies with paclitaxel,24 and 90% to 95% in studies with platinum-based combination therapy.3,24 The relative tolerability of erlotinib in patients older than age 70 years may represent an important first-line option in this undertreated population.4-8
Given their age and concomitant comorbidities, patients on the current trial were expected to have a higher incidence of adverse effects than younger patients receiving erlotinib. Not surprisingly, 12% of patients in this study required toxicity-related discontinuation compared with 5% of patients in the erlotinib arm of the BR.21 trial, whose median age was only 62 years.9 The percentage of patients requiring dose reduction as a result of treatment-related adverse effects in this trial was similar to that seen in the erlotinib arm of the BR.21 trial (16% v 19%, respectively).9
The 51% disease control rate (PR + SD) in this trial is very similar to the rate found in both the BR.21 trial (45%)9 and a European trial of first-line erlotinib in unselected patients with advanced NSCLC (53%).28 In the current trial, the presence of an EGFR mutation was the only pretreatment factor studied that was independently correlated to disease control, TTP, and survival in multivariate analysis. For a trial that did not mandate the collection of tumor tissue as a criterion for enrollment, it is noteworthy that tumor tissue was obtained and analyzed for EGFR mutations in more than half of the eligible patients (54%).
There are important limitations to EGFR mutation testing as a method to select patients for treatment. First, nearly half of the patients in this trial lacked adequate tissue for such testing; however, these patients did not differ significantly in baseline characteristics (age, sex, performance status, smoking history, tumor histology, or development of a treatment-related rash) from those patients with assessable tissue. Second, response and prolonged SD were found in patients with wild-type EGFR; 12 patients with confirmed wild-type EGFR status were alive for more than 1 year, with two of these patients showing PRs to therapy. Although not studied in this trial, combined analysis of EGFR mutation status, EGFR copy number, and EGFR immunochemistry may provide a more comprehensive means of appropriate patient selection.29,30 Third, it remains unclear whether presence of an EGFR mutation is truly predictive of erlotinib treatment benefit or merely prognostic of prolonged survival. In the TRIBUTE and BR.21 trials, patients with EGFR mutations seemed to do better regardless of treatment regimen.13,31 In contrast, EGFR mutations were a negative prognostic marker in a large series of resected NSCLC patients.32 In either case, the predictive utility of EGFR mutations may ultimately depend on specific genotypes. Two recently published studies showed an association between prolonged survival for patients with exon 19 deletions compared with L858R point mutations.33,34
Treatment-related rash was independently correlated with disease control, prolonged TTP, and survival. The survival of patients according to rash status (14.3 months for patients with rash and 4.2 months for patients without rash) mirrors the difference noted in a recent first-line trial of gefitinib (survival time of 16 months with rash and 5 months without rash).35 It is unknown whether development of treatment-related rash is a reflection of differences in immunocompetence, pharmacokinetics, or some other factor. Also remarkable were the poor outcomes seen in current smokers; median TTP and survival time in the five patients who were still smoking at the time of enrollment were only 1.2 months and 1.5 months, respectively. Nonetheless, although four current smokers survived for less than 5 months, the fifth had prolonged SD and remains on therapy after nearly 17 months.
The lack of clinical response with EGFR tyrosine kinase inhibitors (TKIs) in patients with KRAS mutations has been previously described.13,14 In the current study, patients with a KRAS mutation had no clinical responses and a median TTP of only 2.5 months. Although the negative impact of KRAS mutations may be partly confounded by smoking history (in this study, all six patients with KRAS mutations were current or former smokers, with a mean of 53 pack-years), the collective evidence suggests that patients with KRAS mutations do not benefit from therapy with an EGFR TKI.
In summary, erlotinib represents a first-line treatment option worthy of further consideration for elderly patients with advanced NSCLC. A median survival time of 10.9 months in patients older than age 70 years exceeded our predetermined statistical end point. Erlotinib was generally well tolerated, with fewer high-grade toxicities than seen in other trials of systemic chemotherapy in this population. Vigilance for and treatment of ILD is required in this more vulnerable group. As with any treatment regimen, the preselection of patients who will ultimately benefit requires further investigation. Ongoing prospective trials with EGFR TKIs in clinically and pathologically defined subsets of patients will hopefully add to our understanding of the mechanism of action and appropriate patient selection for erlotinib and related agents.
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Authors' Disclosures of Potential Conflicts of Interest |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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Employment: N/A Leadership: N/A Consultant: Matthew Meyerson, Novartis; Thomas J. Lynch, Genentech; Bruce E. Johnson, Genzyme Stock: N/A Honoraria: David M. Jackman, Roche, Genentech; Panos Fidias, Genentech; Jennifer Temel, Genentech, Eli Lilly; Arthur T. Skarin, Genentech; Thomas J. Lynch, Genentech Research Funds: Jennifer Temel, Amgen; Matthew Meyerson, Genentech, Novartis Testimony: N/A Other: Thomas J. Lynch, Genzyme (patent for EGFR testing); Matthew Meyerson, Genzyme (patent for EGFR testing); Bruce E. Johnson, Genzyme (patent on EGFR testing); Pasi A. Jänne, Genentech (unrestricted funding), Genzyme (patent for EGFR testing)
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Author Contributions |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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Provision of study materials or patients: David M. Jackman, Neal I. Lindeman, Panos Fidias, Michael S. Rabin, Jennifer Temel, Arthur T. Skarin, Thomas J. Lynch, Bruce E. Johnson, Pasi A. Jänne
Collection and assembly of data: David M. Jackman, Patricia A. Ostler, Joan Lucca
Data analysis and interpretation: David M. Jackman, Beow Y. Yeap, Boris Freidlin, Bruce E. Johnson, Pasi A. Jänne
Manuscript writing: David M. Jackman, Bruce E. Johnson, Pasi A. Jänne
Final approval of manuscript: David M. Jackman, Beow Y. Yeap, Neal I. Lindeman, Panos Fidias, Michael S. Rabin, Jennifer Temel, Arthur T. Skarin, Matthew Meyerson, Alison J. Holmes, Ana M. Borras, Boris Freidlin, Patricia A. Ostler, Joan Lucca, Thomas J. Lynch, Bruce E. Johnson, Pasi A. Jänne
Other: Neal I. Lindeman, Matthew Meyerson, Alison J. Holmes, Ana M. Borras
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NOTES |
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Supported by Grants No. 1K12CA87723-01 (P.A.J.) and 1RO1CA114465-01 (B.E.J. and P.A.J.) from the National Institutes of Health, Grant No. P20CA90578-02 (B.E.J. and B.Y.Y) from the National Cancer Institute Specialized Program of Research Excellence in Lung Cancer, and a grant from Genentech Inc, as well as by the Doris and William Krupp Research Fund in Thoracic Oncology.
Authors' disclosures of potential conflicts of interest and author contributions are found at the end of this article.
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REFERENCES |
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TOPABSTRACTINTRODUCTIONPATIENTS AND METHODSRESULTSDISCUSSIONAuthors' Disclosures of...Author ContributionsREFERENCES |
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2. Gridelli C, Perrone F, Gallo C, et al: Chemotherapy for elderly patients with advanced non-small-cell lung cancer: The Multicenter Italian Lung Cancer in the Elderly Study (MILES) phase III randomized trial. J Natl Cancer Inst 95:362-372, 2003
3. Langer CJ, Manola J, Bernardo P, et al: Cisplatin-based therapy for elderly patients with advanced non-small-cell lung cancer: Implications of Eastern Cooperative Oncology Group 5592, a randomized trial. J Natl Cancer Inst 94:173-181, 2002
4. Hillner BE, McDonald MK, Desch CE, et al: A comparison of patterns of care of nonsmall cell lung carcinoma patients in a younger and Medigap commercially insured cohort. Cancer 83:1930-1937, 1998[CrossRef][Medline]
5. de Rijke JM, Schouten LJ, ten Velde GP, et al: Influence of age, comorbidity and performance status on the choice of treatment for patients with non-small cell lung cancer: Results of a population-based study. Lung Cancer 46:233-245, 2004[CrossRef][Medline]
6. Earle CC, Venditti LN, Neumann PJ, et al: Who gets chemotherapy for metastatic lung cancer? Chest 117:1239-1246, 2000[CrossRef][Medline]
7. Hutchins LF, Unger JM, Crowley JJ, et al: Underrepresentation of patients 65 years of age or older in cancer-treatment trials. N Engl J Med 341:2061-2067, 1999
8. Peake MD, Thompson S, Lowe D, et al: Ageism in the management of lung cancer. Age Ageing 32:171-177, 2003
9. Shepherd FA, Rodrigues Pereira J, Ciuleanu T, et al: Erlotinib in previously treated non-small-cell lung cancer. N Engl J Med 353:123-132, 2005
10. Lynch TJ, Bell DW, Sordella R, et al: Activating mutations in the epidermal growth factor receptor underlying responsiveness of non-small-cell lung cancer to gefitinib. N Engl J Med 350:2129-2139, 2004
11. Paez JG, Janne PA, Lee JC, et al: EGFR mutations in lung cancer: Correlation with clinical response to gefitinib therapy. Science 304:1497-1500, 2004
12. Pao W, Miller V, Zakowski M, et al: EGF receptor gene mutations are common in lung cancers from "never smokers" and are associated with sensitivity of tumors to gefitinib and erlotinib. Proc Natl Acad Sci U S A 101:13306-13311, 2004
13. Eberhard DA, Johnson BE, Amler LC, et al: Mutations in the epidermal growth factor receptor and in KRAS are predictive and prognostic indicators in patients with non–small-cell lung cancer treated with chemotherapy alone and in combination with erlotinib. J Clin Oncol 23:5900-5909, 2005
14. Pao W, Wang TY, Riely GJ, et al: KRAS mutations and primary resistance of lung adenocarcinomas to gefitinib or erlotinib. PLoS Med 2:e17, 2005[CrossRef][Medline]
15. Hollen PJ, Gralla RJ, Kris MG, et al: Quality of life assessment in individuals with lung cancer: Testing the Lung Cancer Symptom Scale (LCSS). Eur J Cancer 29A:S51-S58, 1993 (suppl 1)
16. Travis WD, Colby TV, Corrin B, et al: World Health Organization: Histological Typing of Lung and Pleural Tumours (ed 3). Berlin, Germany, Springer-Verlag, 1999
17. National Cancer Institute: Common Toxicity Criteria (CTC) v2.0. http://ctep.cancer.gov/reporting/ctc.html
18. Freidlin B, Breathnach OS, Johnson BE: A model to select regimens for phase III trials for patients with advanced-stage non-small cell lung cancer. Clin Cancer Res 9:917-922, 2003
19. Therasse P, Arbuck SG, Eisenhauer EA, et al: New guidelines to evaluate the response to treatment in solid tumors: European Organization for Research and Treatment of Cancer, National Cancer Institute of the United States, National Cancer Institute of Canada. J Natl Cancer Inst 92:205-216, 2000
20. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Assoc 53:457-481, 1958[CrossRef]
21. Cox DR: Regression models and life tables. J R Stat Soc B 34:187-220, 1972
22. Thatcher N, Chang A, Purvish P, et al: Gefitinib plus best supportive care in previously treated patients with refractory advanced non-small-cell lung cancer: Results from a randomised, placebo-controlled, multicentre study (Iressa Survival Evaluation in Lung Cancer). Lancet 366:1527-1537, 2005[CrossRef][Medline]
23. Janne PA, Borras AM, Kuang Y, et al: A rapid and sensitive enzymatic method for epidermal growth factor receptor mutation screening. Clin Cancer Res 12:751-758, 2006
24. Lilenbaum RC, Herndon JE II, List MA, et al: Single-agent versus combination chemotherapy in advanced non-small-cell lung cancer: The Cancer and Leukemia Group B (study 9730). J Clin Oncol 23:190-196, 2005
25. Fukuoka M, Yano S, Giaccone G, et al: Multi-institutional randomized phase II trial of gefitinib for previously treated patients with advanced non-small-cell lung cancer (The IDEAL 1 Trial). J Clin Oncol 21:2237-2246, 2003
26. Kris MG, Natale RB, Herbst RS, et al: Efficacy of gefitinib, an inhibitor of the epidermal growth factor receptor tyrosine kinase, in symptomatic patients with non-small cell lung cancer: A randomized trial. JAMA 290:2149-2158, 2003
27. Niho S, Kubota K, Goto K, et al: First-line single agent treatment with gefitinib in patients with advanced non-small-cell lung cancer: A phase II study. J Clin Oncol 24:64-69, 2006
28. Giaccone G, Lechevalier T, Thatcher N, et al: A phase II study of erlotinib as first-line treatment of advanced non-small cell lung cancer. J Clin Oncol 23:638s, 2005 (suppl, abstr 7073)
29. Cappuzzo F, Hirsch FR, Rossi E, et al: Epidermal growth factor receptor gene and protein and gefitinib sensitivity in non-small-cell lung cancer. J Natl Cancer Inst 97:643-655, 2005
30. Hirsch FR, Varella-Garcia M, McCoy J, et al: Increased epidermal growth factor receptor gene copy number detected by fluorescence in situ hybridization associates with increased sensitivity to gefitinib in patients with bronchioloalveolar carcinoma subtypes: A Southwest Oncology Group Study. J Clin Oncol 23:6838-6845, 2005
31. Tsao MS, Sakurada A, Cutz JC, et al: Erlotinib in lung cancer: Molecular and clinical predictors of outcome. N Engl J Med 353:133-144, 2005
32. Shigematsu H, Lin L, Takahashi T, et al: Clinical and biological features associated with epidermal growth factor receptor gene mutations in lung cancers. J Natl Cancer Inst 97:339-346, 2005
33. Riely GJ, Pao W, Pham DK, et al: Clinical course of patients with non-small cell lung cancer and epidermal growth factor receptor exon 19 and exon 21 mutations treated with gefitinib or erlotinib. Clin Cancer Res 12:839-844, 2006
34. Jackman DM, Yeap BY, Sequist LV, et al: Exon 19 deletion mutations of epidermal growth factor receptor are associated with prolonged survival in non-small cell lung cancer patients treated with gefitinib or erlotinib. Clin Cancer Res 12:3908-3914, 2006
35. West HL, Franklin WA, McCoy J, et al: Gefitinib therapy in advanced bronchioloalveolar carcinoma: Southwest Oncology Group Study S0126. J Clin Oncol 24:1807-1813, 2006
Submitted June 15, 2006; accepted September 7, 2006.
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A. Broniscer, S. J. Baker, C. F. Stewart, T. E. Merchant, F. H. Laningham, P. Schaiquevich, M. Kocak, E. B. Morris, R. Endersby, D. W. Ellison, et al. Phase I and Pharmacokinetic Studies of Erlotinib Administered Concurrently with Radiotherapy for Children, Adolescents, and Young Adults with High-Grade Glioma Clin. Cancer Res., January 15, 2009; 15(2): 701 - 707. [Abstract] [Full Text] [PDF]
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|
 C. Gridelli, P. Maione, and A. Rossi Chemotherapy and Targeted Therapy for Older Patients with Advanced Non-small Cell Lung Cancer ASCO Educational Book, January 1, 2009; 2009(1): 283 - 287. [Abstract] [Full Text] [PDF]
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M. A. Socinski What Guides Decisions about the Use of Epidermal Growth Factor Receptor Antibody or Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors in Advanced Non-small Cell Lung Cancer? ASCO Educational Book, January 1, 2009; 2009(1): 436 - 443. [Abstract] [Full Text] [PDF]
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 S.-G. Wu, Y.-L. Chang, Y.-C. Hsu, J.-Y. Wu, C.-H. Yang, C.-J. Yu, M.-F. Tsai, J.-Y. Shih, and P.-C. Yang Good Response to Gefitinib in Lung Adenocarcinoma of Complex Epidermal Growth Factor Receptor (EGFR) Mutations with the Classical Mutation Pattern Oncologist, December 1, 2008; 13(12): 1276 - 1284. [Abstract] [Full Text] [PDF]
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 G. J. Riely and M. Ladanyi KRAS Mutations: An Old Oncogene Becomes a New Predictive Biomarker J. Mol. Diagn., November 1, 2008; 10(6): 493 - 495. [Abstract] [Full Text] [PDF]
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K. Yonesaka, K. Zejnullahu, N. Lindeman, A. J. Homes, D. M. Jackman, F. Zhao, A. M. Rogers, B. E. Johnson, and P. A. Janne Autocrine Production of Amphiregulin Predicts Sensitivity to Both Gefitinib and Cetuximab in EGFR Wild-type Cancers Clin. Cancer Res., November 1, 2008; 14(21): 6963 - 6973. [Abstract] [Full Text] [PDF]
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 L. Crino, F. Cappuzzo, P. Zatloukal, M. Reck, M. Pesek, J. C. Thompson, H. E.R. Ford, F. R. Hirsch, M. Varella-Garcia, S. Ghiorghiu, et al. Gefitinib Versus Vinorelbine in Chemotherapy-Naive Elderly Patients With Advanced Non-Small-Cell Lung Cancer (INVITE): A Randomized, Phase II Study J. Clin. Oncol., September 10, 2008; 26(26): 4253 - 4260. [Abstract] [Full Text] [PDF]
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P. Wheatley-Price, K. Ding, L. Seymour, G. M. Clark, and F. A. Shepherd Erlotinib for Advanced Non-Small-Cell Lung Cancer in the Elderly: An Analysis of the National Cancer Institute of Canada Clinical Trials Group Study BR.21 J. Clin. Oncol., May 10, 2008; 26(14): 2350 - 2357. [Abstract] [Full Text] [PDF]
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G. D'Addario, D. Rauch, R. Stupp, M. Pless, R. Stahel, N. Mach, L. Jost, L. Widmer, C. Tapia, M. Bihl, et al. Multicenter phase II trial of gefitinib first-line therapy followed by chemotherapy in advanced non-small-cell lung cancer (NSCLC): SAKK protocol 19/03 Ann. Onc., April 1, 2008; 19(4): 739 - 745. [Abstract] [Full Text] [PDF]
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N. A. Rizvi, G. J. Riely, C. G. Azzoli, V. A. Miller, K. K. Ng, J. Fiore, G. Chia, M. Brower, R. Heelan, M. J. Hawkins, et al. Phase I/II Trial of Weekly Intravenous 130-nm Albumin-Bound Paclitaxel As Initial Chemotherapy in Patients With Stage IV Non-Small-Cell Lung Cancer J. Clin. Oncol., February 1, 2008; 26(4): 639 - 643. [Abstract] [Full Text] [PDF]
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S. S. Ramalingam, S. E. Dahlberg, C. J. Langer, R. Gray, C. P. Belani, J. R. Brahmer, A. B. Sandler, J. H. Schiller, and D. H. Johnson Outcomes for Elderly, Advanced-Stage Non Small-Cell Lung Cancer Patients Treated With Bevacizumab in Combination With Carboplatin and Paclitaxel: Analysis of Eastern Cooperative Oncology Group Trial 4599 J. Clin. Oncol., January 1, 2008; 26(1): 60 - 65. [Abstract] [Full Text] [PDF]
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S. M. Lichtman Pharmacology of Antineoplastic Agents for Older Patients ASCO Educational Book, January 1, 2008; 2008(1): 210 - 214. [Abstract] [Full Text] [PDF]
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B. E. Johnson, D. Jackman, and P. A. Janne Rationale for a Phase I Trial of Erlotinib and the Mammalian Target of Rapamycin Inhibitor Everolimus (RAD001) for Patients with Relapsed Non Small Cell Lung Cancer Clin. Cancer Res., August 1, 2007; 13(15): 4628s - 4631s. [Abstract] [Full Text] [PDF]
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B. Wacker, T. Nagrani, J. Weinberg, K. Witt, G. Clark, and P. J. Cagnoni Correlation between Development of Rash and Efficacy in Patients Treated with the Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitor Erlotinib in Two Large Phase III Studies Clin. Cancer Res., July 1, 2007; 13(13): 3913 - 3921. [Abstract] [Full Text] [PDF]
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C. Gridelli, M. A. Bareschino, C. Schettino, A. Rossi, P. Maione, and F. Ciardiello Erlotinib in Non-Small Cell Lung Cancer Treatment: Current Status and Future Development Oncologist, July 1, 2007; 12(7): 840 - 849. [Abstract] [Full Text] [PDF]
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C. J. Langer Mind Your Elders: Therapeutic Implications of Epidermal Growth Factor Receptor Inhibition in Older Patients With Advanced Non-Small-Cell Lung Cancer J. Clin. Oncol., March 1, 2007; 25(7): 751 - 753. [Full Text] [PDF]
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Copyright © 2007 by the American Society of Clinical Oncology, Online ISSN: 1527-7755. Print ISSN: 0732-183X
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70 Years of Age Treated With Erlotinib for Advanced Non–Small-Cell Lung Cancer
