EDITORIALS

Interim Analyses in Clinical Trials: Why Do We Plan Them?

Sophie D. Fosså and Eva Skovlund

JCO Dec 15 2000: 4007–4008. [Full Text] [PDF]

GENITOURINARY CANCER
	Treatment of Patients With Metastatic Renal Carcinoma With a Combination of Subcutaneous Interleukin-2 and Interferon Alfa With or Without Fluorouracil
	Sylvie Négrier, Armelle Caty, Thierry Lesimple, Jean-Yves Douillard, Bernard Escudier, Jean-François Rossi, Patrice Viens, and Frédéric Gomez
	JCO Dec 15 2000: 4009–4015. [Abstract] [Full Text] [PDF]

SARCOMAS
	Long-Term Outcome for Patients With Nonmetastatic Osteosarcoma of the Extremity Treated at the Istituto Ortopedico Rizzoli According to the Istituto Ortopedico Rizzoli/Osteosarcoma-2 Protocol: An Updated Report
	Gaetano Bacci, Stefano Ferrari, Franco Bertoni, Pietro Ruggieri, Piero Picci, Alessandra Longhi, Roberto Casadei, Nicola Fabbri, Cristiana Forni, Michela Versari, and Mario Campanacci
	JCO Dec 15 2000: 4016–4027. [Abstract] [Full Text] [PDF]
	Received Dose and Dose-Intensity of Chemotherapy and Outcome in Nonmetastatic Extremity Osteosarcoma
	Ian J. Lewis, Simon Weeden, David Machin, Dan Stark, and Alan W. Craft
	JCO Dec 15 2000: 4028–4037. [Abstract] [Full Text] [PDF]

GYNECOLOGIC CANCER
	Phase II Feasibility Study of Sequential Couplets of Cisplatin/Topotecan Followed by Paclitaxel/Cisplatin as Primary Treatment for Advanced Epithelial Ovarian Cancer: A National Cancer Institute of Canada Clinical Trials Group Study
	P. Hoskins, E. Eisenhauer, I. Vergote, J. Dubuc-Lissoir, B. Fisher, R. Grimshaw, A. Oza, M. Plante, G. Stuart, and J. Vermorken
	JCO Dec 15 2000: 4038–4044. [Abstract] [Full Text] [PDF]

BREAST CANCER
	Germline BRCA1/2 Mutations and p27Kip1 Protein Levels Independently Predict Outcome After Breast Cancer
	Pierre O. Chappuis, Linda Kapusta, Louis R. Bégin, Nora Wong, Jean-Sébastien Brunet, Steven A. Narod, Joyce Slingerland, and William D. Foulkes
	JCO Dec 15 2000: 4045–4052. [Abstract] [Full Text] [PDF]
	Familial Invasive Breast Cancers: Worse Outcome Related to BRCA1 Mutations
	Dominique Stoppa-Lyonnet, Yan Ansquer, Hélène Dreyfus, Chantal Gautier, Marion Gauthier-Villars, Edwige Bourstyn, Krishna B. Clough, Henri Magdelénat, Pierre Pouillart, Anne Vincent-Salomon, Alain Fourquet, and Bernard Asselain
	JCO Dec 15 2000: 4053–4059. [Abstract] [Full Text] [PDF]

PEDIATRIC ONCOLOGY
	Symptoms of Posttraumatic Stress in Young Adult Survivors of Childhood Cancer
	Wendy L. Hobbie, Margaret Stuber, Kathleen Meeske, Kathryn Wissler, Mary T. Rourke, Kathy Ruccione, Andrea Hinkle, and Anne E. Kazak
	JCO Dec 15 2000: 4060–4066. [Abstract] [Full Text] [PDF]
	Quantitative Tumor Cell Content of Bone Marrow and Blood as a Predictor of Outcome in Stage IV Neuroblastoma: A Children’s Cancer Group Study
	Robert C. Seeger, C. Patrick Reynolds, Richard Gallego, Daniel O. Stram, Robert B. Gerbing, and Katherine K. Matthay
	JCO Dec 15 2000: 4067–4076. [Abstract] [Full Text] [PDF]
	Phase I Study of Chimeric Human/Murine Anti–Ganglioside GD2 Monoclonal Antibody (ch14.18) With Granulocyte-Macrophage Colony-Stimulating Factor in Children With Neuroblastoma Immediately After Hematopoietic Stem-Cell Transplantation: A Children’s Cancer Group Study
	M. Fevzi Ozkaynak, Paul M. Sondel, Mark D. Krailo, Jacek Gan, Brad Javorsky, Ralph A. Reisfeld, Katherine K. Matthay, Gregory H. Reaman, and Robert C. Seeger
	JCO Dec 15 2000: 4077–4085. [Abstract] [Full Text] [PDF]

PHASE I AND CLINICAL PHARMACOLOGY
	Phase I and Pharmacokinetic Study of Irofulven, a Novel Mushroom-Derived Cytotoxin, Administered for Five Consecutive Days Every Four Weeks in Patients With Advanced Solid Malignancies
	S. Gail Eckhardt, Sharyn D. Baker, Carolyn D. Britten, Manuel Hidalgo, Lillian Siu, Lisa A. Hammond, Miguel A. Villalona-Calero, Sally Felton, Ronald Drengler, John G. Kuhn, Gary M. Clark, Sheri L. Smith, John R. MacDonald, Charlotte Smith, Judy Moczygemba, Steve Weitman, Daniel D. Von Hoff, and Eric K. Rowinsky
	JCO Dec 15 2000: 4086–4097. [Abstract] [Full Text] [PDF]
	Phase I Dose-Finding Study of a New Taxane, RPR 109881A, Administered as a One-Hour Intravenous Infusion Days 1 and 8 to Patients With Advanced Solid Tumors
	Karen A. Gelmon, Jean Latreille, Anthony Tolcher, Luc Génier, Bryn Fisher, Dominique Forand, Susan D’Aloisio, Laurent Vernillet, Luc Daigneault, Ann Lebecq, Michele Besenval, and Elizabeth Eisenhauer
	JCO Dec 15 2000: 4098–4108. [Abstract] [Full Text] [PDF]

CORRESPONDENCE

Clarification of Anastrozole/Megestrol Acetate Trial Program Design

Anthony Howell and M. Kaufmann

JCO Dec 15 2000: 4109. [Full Text] [PDF]

SPECIAL DEPARTMENTS

ERRATA

Correction for vol. 18, p. 3339

JCO Dec 15 2000: 4110–4111. [Full Text] [PDF]

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