EDITORIALS

Primary Central Nervous System Lymphoma: A Curable Brain Tumor

Lisa M. DeAngelis

JCO Dec 15 2003: 4471–4473. First published on Nov 3 2003; 10.1200/JCO.2003.08.900. [Full Text] [PDF]

Reversible Ovarian Ablation or Chemotherapy: Are We Ready for Quality of Life to Guide Adjuvant Treatment Decisions in Breast Cancer?

Pamela J. Goodwin

JCO Dec 15 2003: 4474–4475. First published on Nov 10 2003; 10.1200/JCO.2003.07.966. [Full Text] [PDF]

Topical ONYX-015 in the Treatment of Premalignant Oral Dysplasia: Another Role for the Cold Virus?

Ian Ganly and Bhuvanesh Singh

JCO Dec 15 2003: 4476–4478. First published on Nov 3 2003; 10.1200/JCO.2003.08.997. [Full Text] [PDF]

Patterns of Care Studies: Creating "An Environment of Watchful Concern"

Craig C. Earle and Ezekiel J. Emanuel

JCO Dec 15 2003: 4479–4480. First published on Nov 3 2003; 10.1200/JCO.2003.09.979. [Full Text] [PDF]

Preoperative Chemotherapy for Breast Cancer: Lessons Learned and Future Prospects

George W. Sledge, Jr

JCO Dec 15 2003: 4481–4482. First published on Nov 18 2003; 10.1200/JCO.2003.05.980. [Full Text] [PDF]

ORIGINAL REPORTS
Hematologic Malignancies
	High-Dose Methotrexate-Based Chemotherapy Followed by Consolidating Radiotherapy in Non–AIDS-Related Primary Central Nervous System Lymphoma: European Organization for Research and Treatment of Cancer Lymphoma Group Phase II Trial 20962
	Philip M.P. Poortmans, Hanneke C. Kluin-Nelemans, Hanny Haaxma-Reiche, Mars Van’t Veer, Mads Hansen, Pierre Soubeyran, Martin Taphoorn, José Thomas, Martin Van den Bent, Martin Fickers, Gustaaf Van Imhoff, Cynthia Rozewicz, Ivana Teodorovic, and Martine van Glabbeke
	JCO Dec 15 2003: 4483–4488. First published on Nov 3 2003; 10.1200/JCO.2003.03.108. [Abstract] [Full Text] [PDF]
	Primary Central Nervous System Lymphoma: Results of a Pilot and Phase II Study of Systemic and Intraventricular Chemotherapy With Deferred Radiotherapy
	Hendrik Pels, Ingo G.H. Schmidt-Wolf, Axel Glasmacher, Holger Schulz, Andreas Engert, Volker Diehl, Anton Zellner, Gabriele Schackert, Heinz Reichmann, Frank Kroschinsky, Marlies Vogt-Schaden, Gerlinde Egerer, Udo Bode, Carlo Schaller, Martina Deckert, Rolf Fimmers, Christoph Helmstaedter, Aslihan Atasoy, Thomas Klockgether, and Uwe Schlegel
	JCO Dec 15 2003: 4489–4495. First published on Nov 3 2003; 10.1200/JCO.2003.04.056. [Abstract] [Full Text] [PDF]
	6-Thioguanine, Cytarabine, and Daunorubicin (TAD) and High-Dose Cytarabine and Mitoxantrone (HAM) for Induction, TAD for Consolidation, and Either Prolonged Maintenance by Reduced Monthly TAD or TAD-HAM-TAD and One Course of Intensive Consolidation by Sequential HAM in Adult Patients at All Ages With De Novo Acute Myeloid Leukemia (AML): A Randomized Trial of the German AML Cooperative Group
	Thomas Büchner, Wolfgang Hiddemann, Wolfgang E. Berdel, Bernhard Wörmann, Claudia Schoch, Christa Fonatsch, Helmut Löffler, Torsten Haferlach, Wolf-Dieter Ludwig, Georg Maschmeyer, Peter Staib, Carlo Aul, Andreas Grüneisen, Eva Lengfelder, Norbert Frickhofen, Wolfgang Kern, Hubert L. Serve, Rolf M. Mesters, Maria Cristina Sauerland, and Achim Heinecke
	JCO Dec 15 2003: 4496–4504. [Abstract] [Full Text] [PDF]
	TP53, BRCA1, and BRCA2 Tumor Suppressor Genes Are Not Commonly Mutated in Survivors of Hodgkin’s Disease With Second Primary Neoplasms
	Kim E. Nichols, John A. Heath, Debra Friedman, Jaclyn A. Biegel, Arupa Ganguly, Peter Mauch, and Lisa Diller
	JCO Dec 15 2003: 4505–4509. [Abstract] [Full Text] [PDF]

Breast Cancer
	Quality of Life in Goserelin-Treated Versus Cyclophosphamide + Methotrexate + Fluorouracil–Treated Premenopausal and Perimenopausal Patients With Node-Positive, Early Breast Cancer: The Zoladex Early Breast Cancer Research Association Trialists Group
	H. de Haes, M. Olschewski, M. Kaufmann, M. Schumacher, W. Jonat, and W. Sauerbrei
	JCO Dec 15 2003: 4510–4516. First published on Nov 10 2003; 10.1200/JCO.2003.11.064. [Abstract] [Full Text] [PDF]
	Adjuvant Endocrine Therapy Compared With No Systemic Therapy for Elderly Women With Early Breast Cancer: 21-Year Results of International Breast Cancer Study Group Trial IV
	Diana Crivellari, Karen Price, Richard D. Gelber, Monica Castiglione-Gertsch, Carl-Magnus Rudenstam, Jurij Lindtner, Martin F. Fey, Hans-Jörg Senn, Alan S. Coates, John Collins, and Aron Goldhirsch
	JCO Dec 15 2003: 4517–4523. [Abstract] [Full Text] [PDF]
	Incidence and Predictors of Low Dose-Intensity in Adjuvant Breast Cancer Chemotherapy: A Nationwide Study of Community Practices
	Gary H. Lyman, David C. Dale, and Jeffrey Crawford
	JCO Dec 15 2003: 4524–4531. [Abstract] [Full Text] [PDF]
	Consultation With a Medical Oncologist Before Surgery and Type of Surgery Among Elderly Women With Early-Stage Breast Cancer
	Nancy L. Keating, Mary Beth Landrum, John Z. Ayanian, Eric P. Winer, and Edward Guadagnoli
	JCO Dec 15 2003: 4532–4539. [Abstract] [Full Text] [PDF]
	Is Surgery Necessary After Complete Clinical Remission Following Neoadjuvant Chemotherapy for Early Breast Cancer?
	A. Ring, A. Webb, S. Ashley, W.H. Allum, S. Ebbs, G. Gui, N.P. Sacks, G. Walsh, and I.E. Smith
	JCO Dec 15 2003: 4540–4545. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	An Attenuated Adenovirus, ONYX-015, As Mouthwash Therapy for Premalignant Oral Dysplasia
	Charles M. Rudin, Ezra E.W. Cohen, Vassiliki A. Papadimitrakopoulou, Sol Silverman, Jr, Wendy Recant, Adel K. El-Naggar, Kirsten Stenson, Scott M. Lippman, Waun Ki Hong, and Everett E. Vokes
	JCO Dec 15 2003: 4546–4552. First published on Nov 3 2003; 10.1200/JCO.2003.03.544. [Abstract] [Full Text] [PDF]

Lung Cancer
	Radiotherapy Patterns of Care Study in Lung Carcinoma
	B. Movsas, J. Moughan, R. Komaki, H. Choy, R. Byhardt, C. Langer, M. Goldberg, M. Graham, D. Ettinger, D. Johnstone, R. Abrams, R. Munden, G. Starkschall, and J. Owen
	JCO Dec 15 2003: 4553–4559. First published on Nov 3 2003; 10.1200/JCO.2003.04.018. [Abstract] [Full Text] [PDF]
	Analysis of Factors Associated With Outcome in Patients With Malignant Peritoneal Mesothelioma Undergoing Surgical Debulking and Intraperitoneal Chemotherapy
	Andrew L. Feldman, Steven K. Libutti, James F. Pingpank, David L. Bartlett, Tatiana H. Beresnev, Sharon M. Mavroukakis, Seth M. Steinberg, David J. Liewehr, David E. Kleiner, and H. Richard Alexander
	JCO Dec 15 2003: 4560–4567. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Pretreatment Nomogram That Predicts 5-Year Probability of Metastasis Following Three-Dimensional Conformal Radiation Therapy for Localized Prostate Cancer
	Michael W. Kattan, Michael J. Zelefsky, Patrick A. Kupelian, Daniel Cho, Peter T. Scardino, Zvi Fuks, and Steven A. Leibel
	JCO Dec 15 2003: 4568–4571. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Progression-Free Survival in Children With Optic Pathway Tumors: Dependence on Age and the Quality of the Response to Chemotherapy—Results of the First French Prospective Study for the French Society of Pediatric Oncology
	Véronique Laithier, Jacques Grill, Marie-Cécile Le Deley, Marie-Madeleine Ruchoux, Dominique Couanet, François Doz, Fabienne Pichon, Hervé Rubie, Didier Frappaz, Jean-Paul Vannier, Annie Babin-Boilletot, Eric Sariban, Pascal Chastagner, Michel Zerah, Marie-Anne Raquin, Olivier Hartmann, and Chantal Kalifa
	JCO Dec 15 2003: 4572–4578. [Abstract] [Full Text] [PDF]
	Characteristics and Outcomes of Children With the Wilms Tumor-Aniridia Syndrome: A Report From the National Wilms Tumor Study Group
	Norman E. Breslow, Robin Norris, Patricia A. Norkool, Tammy Kang, J. Bruce Beckwith, Elizabeth J. Perlman, Michael L. Ritchey, Daniel M. Green, and Kim E. Nichols
	JCO Dec 15 2003: 4579–4585. [Abstract] [Full Text] [PDF]

Sarcomas
	Topoisomerase-II Is Upregulated in Malignant Peripheral Nerve Sheath Tumors and Associated With Clinical Outcome
	Rolf I. Skotheim, Anne Kallioniemi, Bodil Bjerkhagen, Fredrik Mertens, Helge R. Brekke, Outi Monni, Spyro Mousses, Nils Mandahl, Gunnar Ster, Jahn M. Nesland, Sigbjørn Smeland, Olli-P. Kallioniemi, and Ragnhild A. Lothe
	JCO Dec 15 2003: 4586–4591. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Surgery Plus Chemotherapy Compared With Surgery Alone for Localized Squamous Cell Carcinoma of the Thoracic Esophagus: A Japan Clinical Oncology Group Study—JCOG9204
	Nobutoshi Ando, Toshifumi Iizuka, Hiroko Ide, Kaoru Ishida, Masayuki Shinoda, Tadashi Nishimaki, Wataru Takiyama, Hiroshi Watanabe, Kaichi Isono, Norio Aoyama, Hiroyasu Makuuchi, Otsuo Tanaka, Hideaki Yamana, Shunji Ikeuchi, Toshiyuki Kabuto, Kagami Nagai, Yutaka Shimada, Yoshihide Kinjo, and Haruhiko Fukuda
	JCO Dec 15 2003: 4592–4596. [Abstract] [Full Text] [PDF]
	Interaction of Splenectomy and Perioperative Blood Transfusions on Prognosis of Patients With Proximal Gastric and Gastroesophageal Junction Cancer
	Jürgen Weitz, Michael D’Angelica, Mithat Gonen, David Klimstra, Daniel G. Coit, Murray F. Brennan, and Martin S. Karpeh
	JCO Dec 15 2003: 4597–4603. [Abstract] [Full Text] [PDF]
	Prediction of Response to Preoperative Chemotherapy in Gastric Carcinoma by Metabolic Imaging: Results of a Prospective Trial
	Katja Ott, Ulrich Fink, Karen Becker, Alexander Stahl, Hans-Joachim Dittler, Raymonde Busch, Hubert Stein, Florian Lordick, Thomas Link, Markus Schwaiger, Jörg-Rüdiger Siewert, and Wolfgang A. Weber
	JCO Dec 15 2003: 4604–4610. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Expanded Experience With an Intradermal Skin Test to Predict for the Presence or Absence of Carboplatin Hypersensitivity
	Maurie Markman, Kristine Zanotti, Gertrude Peterson, Barbara Kulp, Kenneth Webster, and Jerome Belinson
	JCO Dec 15 2003: 4611–4614. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Itraconazole Prevents Invasive Fungal Infections in Neutropenic Patients Treated for Hematologic Malignancies: Evidence From a Meta-Analysis of 3,597 Patients
	Axel Glasmacher, Archibald Prentice, Marcus Gorschlüter, Steffen Engelhart, Corinna Hahn, Benjamin Djulbegovic, and Ingo G.H. Schmidt-Wolf
	JCO Dec 15 2003: 4615–4626. [Abstract] [Full Text] [PDF]
	Are Older Cancer Patients Being Referred to Oncologists? A Mail Questionnaire of Ontario Primary Care Practitioners to Evaluate Their Referral Patterns
	Carol A. Townsley, Kendra Naidoo, Gregory R. Pond, Wendy Melnick, Sharon E. Straus, and Lillian L. Siu
	JCO Dec 15 2003: 4627–4635. [Abstract] [Full Text] [PDF]
	Differential Effects of Paroxetine on Fatigue and Depression: A Randomized, Double-Blind Trial From the University of Rochester Cancer Center Community Clinical Oncology Program
	Gary R. Morrow, Jane T. Hickok, Joseph A. Roscoe, Richard F. Raubertas, Paul L.R. Andrews, Patrick J. Flynn, Harry E. Hynes, Tarit K. Banerjee, Jeffrey J. Kirshner, and David K. King
	JCO Dec 15 2003: 4635–4641. [Abstract] [Full Text] [PDF]

SPECIAL ARTICLE
	Revised Recommendations of the International Working Group for Diagnosis, Standardization of Response Criteria, Treatment Outcomes, and Reporting Standards for Therapeutic Trials in Acute Myeloid Leukemia
	Bruce D. Cheson, John M. Bennett, Kenneth J. Kopecky, Thomas Büchner, Cheryl L. Willman, Elihu H. Estey, Charles A. Schiffer, Hartmut Doehner, Martin S. Tallman, T. Andrew Lister, Francesco Lo-Coco, Roel Willemze, Andrea Biondi, Wolfgang Hiddemann, Richard A. Larson, Bob Löwenberg, Miguel A. Sanz, David R. Head, Ryuzo Ohno, and Clara D. Bloomfield
	JCO Dec 15 2003: 4642–4649. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Complications of Therapy and a Diagnostic Dilemma Case: CASE 1. RADIATION MACULOPATHY FOLLOWING TREATMENT OF NASOPHARYNGEAL CARCINOMA

P. Cackett, J. Stebbing, and B. Dhillon

JCO Dec 15 2003: 4650–4651. [Full Text] [PDF]

Complications of Therapy and a Diagnostic Dilemma Case: CASE 2. CUTANEOUS TOXICITY INDUCED BY CETUXIMAB

Marcello Monti, Luca L. Mancini, Benvenuto Ferrari, Daoud Rahal, and Armando Santoro

JCO Dec 15 2003: 4651–4653. [Full Text] [PDF]

Complications of Therapy and a Diagnostic Dilemma Case: CASE 3. DIAGNOSTIC DILEMMA: SARCOIDOSIS SIMULATING METASTATIC MALIGNANCY

Paul Haluska, Patrick H. Luetmer, Carrie Y. Inwards, Bekele Afessa, Thomas C. Shives, and James N. Ingle

JCO Dec 15 2003: 4653–4654. [Full Text] [PDF]

SPECIAL DEPARTMENTS

CORRESPONDENCE

Quality of Life After Treatment for Prostate Cancer: No Difference Between Surgery and Radiotherapy?

Dirk Vordermark and Oliver Koelbl

JCO Dec 15 2003: 4655. [Full Text] [PDF]

In Reply:

David F. Penson and Janet L. Stanford

JCO Dec 15 2003: 4655-a–4656. [Full Text] [PDF]

Superiority of Letrozole Over Tamoxifen in the First-Line Treatment of Metastatic Breast Cancer Patients With Normal Serum HER-2/neu Levels: Question of Tamoxifen Resistance

Kadri Altundag and Ozden Altundag

JCO Dec 15 2003: 4656. [Full Text] [PDF]

In Reply:

A. Lipton, K. Leitzel, L. Demers, H.A. Harvey, S.M. Ali, H.A. Chaudri-Ross, P. Wyld, C. Brady, and W. Carney

JCO Dec 15 2003: 4657. [Full Text] [PDF]

Eicosapentaenoic Acid As a Targeted Therapy for Cancer Cachexia

Cristobal Belda-Iniesta, Javier de Castro Carpeno, Juan Angel Fresno Vara, Paloma Cejas Guerrero, Enrique Casado Saenz, Enrique Espinosa Arranz, Andres Redondo Sanchez, Jaime Feliu Battle, and Manuel Gonzalez Baron

JCO Dec 15 2003: 4657-a–4658. [Full Text] [PDF]

In Reply:

Eduardo D. Bruera

JCO Dec 15 2003: 4658. [Full Text] [PDF]

Phase I Trials: Physician and Patient Perceptions

Debasish Roychowdhury

JCO Dec 15 2003: 4658-a–4659. [Full Text] [PDF]

In Reply:

Neal J. Meropol, Kevin P. Weinfurt, and Kevin A. Schulman

JCO Dec 15 2003: 4659–4660. [Full Text] [PDF]

Hereditary Breast Cancer: Shared Communication and Care

Daniel Rayson, Patricia Steele, Kelly Collins, and Tina Babineau

JCO Dec 15 2003: 4660. [Full Text] [PDF]

In Reply:

Henry T. Lynch

JCO Dec 15 2003: 4660-a. [Full Text] [PDF]

Benefits of Locoregional Treatment

Gilbert A. Lawrence and John Crawford

JCO Dec 15 2003: 4660-b–4661. [Full Text] [PDF]

In Reply:

Ajeet Gajra and Stephen Graziano

JCO Dec 15 2003: 4661–4662. [Full Text] [PDF]

Preoperative Therapy Versus Immediate Surgery in Nonmetastatic Osteosarcoma

G. Bacci, S. Ferrari, A. Longhi, C. Forni, P. Ruggieri, A. Briccoli, M. De Paolis, and E. Setola

JCO Dec 15 2003: 4662–4663. [Full Text] [PDF]

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