EDITORIALS

Genes in the Service of Therapeutic Index: Progress for Virus-Directed Enzyme Prodrug Therapy

Edward A. Sausville

JCO May 1 2004: 1535–1537. First published on Mar 29 2004; 10.1200/JCO.2004.02.921. [Full Text] [PDF]

Of What Value Genomics in Colorectal Cancer? Opportunities and Challenges

Patrick G. Johnston

JCO May 1 2004: 1538–1539. First published on Mar 29 2004; 10.1200/JCO.2004.02.945. [Full Text] [PDF]

Nothing Ventured, Nothing Gained: Treatment of Glioblastoma Multiforme in the Elderly

Edward G. Shaw

JCO May 1 2004: 1540–1541. First published on Mar 29 2004; 10.1200/JCO.2004.01.989. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

The Ethics of Early Stopping Rules: Who Is Protecting Whom?

Stephen A. Cannistra

JCO May 1 2004: 1542–1545. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	Virus-Directed Enzyme Prodrug Therapy: Intratumoral Administration of a Replication-Deficient Adenovirus Encoding Nitroreductase to Patients With Resectable Liver Cancer
	Daniel H. Palmer, Vivien Mautner, Darius Mirza, Simon Oliff, Winald Gerritsen, Joost R.M. van der Sijp, Stefan Hubscher, Gary Reynolds, Sarah Bonney, Ratna Rajaratnam, Diana Hull, Mark Horne, John Ellis, Andrew Mountain, Simon Hill, Peter A. Harris, Peter F. Searle, Lawrence S. Young, Nicholas D. James, and David J. Kerr
	JCO May 1 2004: 1546–1552. First published on Mar 29 2004; 10.1200/JCO.2004.10.005. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacokinetic Study of the Ribonucleotide Reductase Inhibitor, 3-Aminopyridine-2-Carboxaldehyde Thiosemicarbazone, Administered by 96-Hour Intravenous Continuous Infusion
	Scott Wadler, Della Makower, Caroline Clairmont, Paula Lambert, Karen Fehn, and Mario Sznol
	JCO May 1 2004: 1553–1563. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Gene Expression Profiles and Molecular Markers To Predict Recurrence of Dukes' B Colon Cancer
	Yixin Wang, Tim Jatkoe, Yi Zhang, Matthew G. Mutch, Dmitri Talantov, John Jiang, Howard L. McLeod, and David Atkins
	JCO May 1 2004: 1564–1571. First published on Mar 29 2004; 10.1200/JCO.2004.08.186. [Abstract] [Full Text] [PDF]
	Prognostic Value of Proliferation, Apoptosis, Defective DNA Mismatch Repair, and p53 Overexpression in Patients With Resected Dukes' B2 or C Colon Cancer: A North Central Cancer Treatment Group Study
	Megan M. Garrity, Lawrence J. Burgart, Michelle R. Mahoney, Harold E. Windschitl, Muhammad Salim, Martin Wiesenfeld, James E. Krook, John C. Michalak, Richard M. Goldberg, Michael J. O'Connell, Alfred F. Furth, Daniel J. Sargent, Linda M. Murphy, Eunice Hill, Darren L. Riehle, Cecelia H. Meyers, and Thomas E. Witzig
	JCO May 1 2004: 1572–1582. [Abstract] [Full Text] [PDF]

Radiation Oncology
	Abbreviated Course of Radiation Therapy in Older Patients With Glioblastoma Multiforme: A Prospective Randomized Clinical Trial
	W. Roa, P.M.A. Brasher, G. Bauman, M. Anthes, E. Bruera, A. Chan, B. Fisher, D. Fulton, S. Gulavita, C. Hao, S. Husain, A. Murtha, K. Petruk, D. Stewart, P. Tai, R. Urtasun, J.G. Cairncross, and P. Forsyth
	JCO May 1 2004: 1583–1588. First published on Mar 29 2004; 10.1200/JCO.2004.06.082. [Abstract] [Full Text] [PDF]

Lung Cancer
	Randomized Phase III Trial of Pemetrexed Versus Docetaxel in Patients With Non–Small-Cell Lung Cancer Previously Treated With Chemotherapy
	Nasser Hanna, Frances A. Shepherd, Frank V. Fossella, Jose R. Pereira, Filippo De Marinis, Joachim von Pawel, Ulrich Gatzemeier, Thomas Chang Yao Tsao, Miklos Pless, Thomas Muller, Hong-Liang Lim, Christopher Desch, Klara Szondy, Radj Gervais, Shaharyar, Christian Manegold, Sofia Paul, Paolo Paoletti, Lawrence Einhorn, and Paul A. Bunn, Jr.
	JCO May 1 2004: 1589–1597. [Abstract] [Full Text] [PDF]

Neurooncology
	First-Line Chemotherapy With Cisplatin Plus Fractionated Temozolomide in Recurrent Glioblastoma Multiforme: A Phase II Study of the Gruppo Italiano Cooperativo di Neuro-Oncologia
	Alba A. Brandes, Umberto Basso, Michele Reni, Francesca Vastola, Alicia Tosoni, Giovanna Cavallo, Luciano Scopece, Andres J. Ferreri, Maria G. Panucci, Silvio Monfardini, and Mario Ermani
	JCO May 1 2004: 1598–1604. [Abstract] [Full Text] [PDF]

Breast Cancer
	Comparison of Fulvestrant Versus Tamoxifen for the Treatment of Advanced Breast Cancer in Postmenopausal Women Previously Untreated With Endocrine Therapy: A Multinational, Double-Blind, Randomized Trial
	Anthony Howell, John F.R. Robertson, Paul Abram, Mikhail R. Lichinitser, Richard Elledge, Emilio Bajetta, Toru Watanabe, Charles Morris, Alan Webster, Isaiah Dimery, and C. Kent Osborne
	JCO May 1 2004: 1605–1613. [Abstract] [Full Text] [PDF]
	Clinical Relevance of Different Sequencing of Doxorubicin and Cyclophosphamide, Methotrexate, and Fluorouracil in Operable Breast Cancer
	Gianni Bonadonna, Milvia Zambetti, Angela Moliterni, Luca Gianni, and Pinuccia Valagussa
	JCO May 1 2004: 1614–1620. [Abstract] [Full Text] [PDF]
	Phase II Trial of Trastuzumab Followed by Weekly Paclitaxel/Carboplatin As First-Line Treatment for Patients With Metastatic Breast Cancer
	Howard Burris, III, Denise Yardley, Suzanne Jones, Gerry Houston, Catherine Broome, Dana Thompson, F. Anthony Greco, Melissa White, and John Hainsworth
	JCO May 1 2004: 1621–1629. [Abstract] [Full Text] [PDF]
	Ten-Year Outcomes in a Population-Based Cohort of Node-Negative, Lymphatic, and Vascular Invasion–Negative Early Breast Cancers Without Adjuvant Systemic Therapies
	Stephen K. Chia, Caroline H. Speers, Cicely J. Bryce, Malcolm M. Hayes, and Ivo A. Olivotto
	JCO May 1 2004: 1630–1637. [Abstract] [Full Text] [PDF]
	Incidence of BRCA1 and BRCA2 Mutations in Young Korean Breast Cancer Patients
	Doo Ho Choi, Min Hyuk Lee, Allen E. Bale, Darryl Carter, and Bruce G. Haffty
	JCO May 1 2004: 1638–1645. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Use of the Humanized Anti-Epidermal Growth Factor Receptor Monoclonal Antibody h-R3 in Combination With Radiotherapy in the Treatment of Locally Advanced Head and Neck Cancer Patients
	Tania Crombet, Marta Osorio, Teresa Cruz, Carlos Roca, Ramón del Castillo, Rosa Mon, Normando Iznaga-Escobar, René Figueredo, James Koropatnick, Enrique Renginfo, Eduardo Fernández, Daniel Alvárez, Olga Torres, Mayra Ramos, Idrissa Leonard, Rolando Pérez, and Agustín Lage
	JCO May 1 2004: 1646–1654. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Association of Preoperative Plasma Levels of Vascular Endothelial Growth Factor and Soluble Vascular Cell Adhesion Molecule-1 With Lymph Node Status and Biochemical Progression After Radical Prostatectomy
	Shahrokh F. Shariat, Veronica A. Anwuri, Dolores J. Lamb, Nina V. Shah, Thomas M. Wheeler, and Kevin M. Slawin
	JCO May 1 2004: 1655–1663. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Influence of Biologic Markers on the Outcome of Hodgkin's Lymphoma: A Study by the Spanish Hodgkin’s Lymphoma Study Group
	Carlos Montalbán, Juan F. García, Víctor Abraira, Leocricia González-Camacho, Manuel M. Morente, Jose L. Bello, Eulogio Conde, Miguel A. Cruz, Ramón García-Sanz, José García-Laraña, Carlos Grande, Marta Llanos, Rafael Martínez, Eduardo Flores, Miguel Méndez, Concepción Ponderós, Concepción Rayón, Pedro Sánchez-Godoy, Javier Zamora, and Miguel A. Piris
	JCO May 1 2004: 1664–1673. [Abstract] [Full Text] [PDF]
	Benefit and Timing of Second Transplantations in Multiple Myeloma: Clinical Findings and Methodological Limitations in a European Group for Blood and Marrow Transplantation Registry Study
	C. Morris, S. Iacobelli, R. Brand, B. Bjorkstrand, M. Drake, D. Niederwieser, and G. Gahrton
	JCO May 1 2004: 1674–1681. First published on Mar 22 2004; 10.1200/JCO.2004.06.144. [Abstract] [Full Text] [PDF]
	Survivin Expression Predicts Poorer Prognosis in Anaplastic Large-Cell Lymphoma
	Ellen J. Schlette, L. Jeffrey Medeiros, Andre Goy, Raymond Lai, and George Z. Rassidakis
	JCO May 1 2004: 1682–1688. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Localized Pelvic Neuroblastoma: Excellent Survival and Low Morbidity With Tailored Therapy—The 10-Year Experience of the French Society of Pediatric Oncology
	Marc-David Leclair, Olivier Hartmann, Yves Heloury, Laurent Fourcade, Anne Laprie, Françoise Mechinaud, Caroline Munzer, and Herve Rubie
	JCO May 1 2004: 1689–1695. [Abstract] [Full Text] [PDF]
	Increasing Mixed Chimerism Is an Important Prognostic Factor for Unfavorable Outcome in Children With Acute Lymphoblastic Leukemia After Allogeneic Stem-Cell Transplantation: Possible Role For Pre-Emptive Immunotherapy?
	Peter Bader, Hermann Kreyenberg, Walter Hoelle, Gregor Dueckers, Rupert Handgretinger, Peter Lang, Bernhard Kremens, Dagmar Dilloo, Karl-Walter Sykora, Martin Schrappe, Charlotte Niemeyer, Arend von Stackelberg, Bernd Gruhn, Günter Henze, Johann Greil, Dietrich Niethammer, Klaus Dietz, James F. Beck, and Thomas Klingebiel
	JCO May 1 2004: 1696–1705. [Abstract] [Full Text] [PDF]

Sarcomas
	Laboratory and Clinical Evidence of Synergistic Cytotoxicity of Sequential Treament With Gemcitabine Followed by Docetaxel in the Treatment of Sarcoma
	Kirsten M. Leu, Leo J. Ostruszka, Donna Shewach, Mark Zalupski, Vernon Sondak, J. Sybil Biermann, Julia Shin-Jung Lee, Carol Couwlier, Krisinda Palazzolo, and Laurence H. Baker
	JCO May 1 2004: 1706–1712. [Abstract] [Full Text] [PDF]

Pain Management
	Randomized Clinical Trial of the Effectiveness of a Self-Care Intervention to Improve Cancer Pain Management
	Christine Miaskowski, Marylin Dodd, Claudia West, Karen Schumacher, Steven M. Paul, Debu Tripathy, and Peter Koo
	JCO May 1 2004: 1713–1720. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Cancer Patient Preferences for Communication of Prognosis in the Metastatic Setting
	Rebecca G. Hagerty, Phyllis N. Butow, Peter A. Ellis, Elizabeth A. Lobb, Susan Pendlebury, Natasha Leighl, David Goldstein, Sing Kai Lo, and Martin H.N. Tattersall
	JCO May 1 2004: 1721–1730. [Abstract] [Full Text] [PDF]
	Acupuncture for Postchemotherapy Fatigue: A Phase II Study
	Andrew J. Vickers, David J. Straus, Bertha Fearon, and Barrie R. Cassileth
	JCO May 1 2004: 1731–1735. [Abstract] [Full Text] [PDF]
	Individuals With an Increased Risk of Colorectal Cancer: Perceived Benefits and Psychological Aspects of Surveillance by Means of Regular Colonoscopies
	A. Liljegren, G. Lindgren, Y. Brandberg, S. Rotstein, B. Nilsson, T. Hatschek, E. Jaramillo, and A. Lindblom
	JCO May 1 2004: 1736–1742. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	The Expanding Role of Systemic Therapy in Head and Neck Cancer
	Ezra E.W. Cohen, Mark W. Lingen, and Everett E. Vokes
	JCO May 1 2004: 1743–1752. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Germ Cell Tumors: CASE 1. Intraocular Metastases From Testicular Cancer

Hikaru Nakajima, Masayuki Oki, Shuji Matsukura, Masato Nakamura, Masatoshi Tokunaga, and Kiyoshi Ando

JCO May 1 2004: 1753–1755. [Full Text] [PDF]

Germ Cell Tumors: CASE 2. Unusual Course of Pure Testicular Seminoma

Dany Gholam, Jean-Pierre Lotz, David Atallah, and Christine Theodore

JCO May 1 2004: 1755–1756. [Full Text] [PDF]

Germ Cell Tumors: CASE 3. Primary Yolk Sac Tumor of the Liver

Nabil Toumi, Marie-Thérèse Chaumette-Plankaert, Daniel Cherqui, Thierry de Revel, Pierre Duvillard, and Christine Theodore

JCO May 1 2004: 1756–1758. [Full Text] [PDF]

ART OF ONCOLOGY

Treatment Decision Aids in Advanced Cancer: When the Goal Is Not Cure and the Answer Is Not Clear

Natasha B. Leighl, Phyllis N. Butow, and Martin H.N. Tattersall

JCO May 1 2004: 1759–1762. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Operate on My Stomach Cancer? Oh, No—Not You, or Not Yet!

Jaffer A. Ajani

JCO May 1 2004: 1763–1764. [Full Text] [PDF]

In Reply:

Murray F. Brennan

JCO May 1 2004: 1764–1765. [Full Text] [PDF]

The Field of Radiation Therapy May Effect Health-Related Quality of Life in Patients With Operable Breast Cancer

Muzaffer Altundag, Kadri Altundag, Mustafa Cengiz, and Ozden Altundag

JCO May 1 2004: 1765. [Full Text] [PDF]

In Reply:

Yvonne Brandberg, Elisabet Lidbrink, Helena Michelson, Nils Wilking, Jonas Bergh, Tom Wiklund, and Bjørn Erikstein

JCO May 1 2004: 1765-a–1766. [Full Text] [PDF]

Is Docetaxel Now an Essential Component of Neoadjuvant Breast Chemotherapy?

Nasir Shahab and Syed Haider

JCO May 1 2004: 1766. [Full Text] [PDF]

In Reply:

Harry D. Bear

JCO May 1 2004: 1766-a–1767. [Full Text] [PDF]

Use of Gabapentin in the Prevention of Taxane-Induced Arthralgias and Myalgias

Vu H. Nguyen and H. Jeffrey Lawrence

JCO May 1 2004: 1767–1769. [Full Text] [PDF]

Time to Stop Progesterone Receptor Testing in Breast Cancer Management

Ivo A. Olivotto, Pauline T. Truong, Caroline H. Speers, Vanessa Bernstein, Sharon J. Allan, Seamus J. Kelly, and Mary L. Lesperance

JCO May 1 2004: 1769–1770. [Full Text] [PDF]

Erratum

ERRATUM

JCO May 1 2004: 1771. [Full Text] [PDF]

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