EDITORIALS

Epidermal Growth Factor Receptor Inhibitors in Colorectal Cancer: It's Time to Get Back on Target

Neal J. Meropol

JCO Mar 20 2005: 1791–1793. First published on Jan 27 2005; 10.1200/JCO.2005.10.951. [Full Text] [PDF]

Randomized Phase II Trials: What Does Randomization Gain?

H. Samuel Wieand

JCO Mar 20 2005: 1794–1795. First published on Feb 7 2005; 10.1200/JCO.2005.10.956. [Full Text] [PDF]

Indifferently Pursued or Unowned Drugs: Who Should Lead Where Companies Do Not Tread?

Edward A. Sausville

JCO Mar 20 2005: 1796–1798. First published on Feb 7 2005; 10.1200/JCO.2005.10.963. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

An Increasingly Common Challenge: Management of the Complete Responder With Multi-Focal Metastatic Colorectal Cancer

Deborah Schrag, Martin Weiser, Mark Schattner, Jinru Shia, and Tim Akhurst

JCO Mar 20 2005: 1799–1802. [Full Text] [PDF]

ORIGINAL REPORTS
Gastrointestinal Cancer
	Cetuximab Shows Activity in Colorectal Cancer Patients With Tumors That Do Not Express the Epidermal Growth Factor Receptor by Immunohistochemistry
	Ki Young Chung, Jinru Shia, Nancy E. Kemeny, Manish Shah, Gary K. Schwartz, Archie Tse, Audrey Hamilton, Dorothy Pan, Deborah Schrag, Lawrence Schwartz, David S. Klimstra, Daniel Fridman, David P. Kelsen, and Leonard B. Saltz
	JCO Mar 20 2005: 1803–1810. First published on Jan 27 2005; 10.1200/JCO.2005.08.037. [Abstract] [Full Text] [PDF]
	Expression of the Caudal-Type Homeodomain Transcription Factors CDX 1/2 and Outcome in Carcinomas of the Ampulla of Vater
	Donna E. Hansel, Anirban Maitra, John W. Lin, Michael Goggins, Pedram Argani, Charles J. Yeo, Steven Piantadosi, Steven D. Leach, and Andrew V. Biankin
	JCO Mar 20 2005: 1811–1818. [Abstract] [Full Text] [PDF]
	Phase III Southwest Oncology Group 9415/Intergroup 0153 Randomized Trial of Fluorouracil, Leucovorin, and Levamisole Versus Fluorouracil Continuous Infusion and Levamisole for Adjuvant Treatment of Stage III and High-Risk Stage II Colon Cancer
	Elizabeth A. Poplin, Jacqueline K. Benedetti, Norman C. Estes, Daniel G. Haller, Robert J. Mayer, Richard M. Goldberg, Geoffrey R. Weiss, Saul E. Rivkin, and John S. Macdonald
	JCO Mar 20 2005: 1819–1825. [Abstract] [Full Text] [PDF]
	Effectiveness of Gene Expression Profiling for Response Prediction of Rectal Adenocarcinomas to Preoperative Chemoradiotherapy
	B. Michael Ghadimi, Marian Grade, Michael J. Difilippantonio, Sudhir Varma, Richard Simon, Cristina Montagna, Laszlo Füzesi, Claus Langer, Heinz Becker, Torsten Liersch, and Thomas Ried
	JCO Mar 20 2005: 1826–1838. [Abstract] [Full Text] [PDF]
	Phase II Study of Radiotherapy Employing Proton Beam for Hepatocellular Carcinoma
	Mitsuhiko Kawashima, Junji Furuse, Teiji Nishio, Masaru Konishi, Hiroshi Ishii, Taira Kinoshita, Michitaka Nagase, Keiji Nihei, and Takashi Ogino
	JCO Mar 20 2005: 1839–1846. [Abstract] [Full Text] [PDF]
	Impact of Short-Term Preoperative Radiotherapy on Health-Related Quality of Life and Sexual Functioning in Primary Rectal Cancer: Report of a Multicenter Randomized Trial
	Corrie A.M. Marijnen, Cornelis J.H. van de Velde, Hein Putter, Mandy van den Brink, Cornelis P. Maas, Hendrik Martijn, Harm J. Rutten, Theo Wiggers, Elma Klein Kranenbarg, Jan-Willem H. Leer, and Anne M. Stiggelbout
	JCO Mar 20 2005: 1847–1858. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	Randomized Trial of Two Intravenous Schedules of the Topoisomerase I Inhibitor Liposomal Lurtotecan in Women With Relapsed Epithelial Ovarian Cancer: A Trial of the National Cancer Institute of Canada Clinical Trials Group
	Graham G. Dark, A. Hilary Calvert, Robert Grimshaw, Christopher Poole, Ken Swenerton, Stan Kaye, Robert Coleman, Gordon Jayson, Tien Le, Susan Ellard, Marc Trudeau, Paul Vasey, Marta Hamilton, Terri Cameron, Emma Barrett, Wendy Walsh, Lynn McIntosh, and Elizabeth A. Eisenhauer
	JCO Mar 20 2005: 1859–1866. First published on Feb 7 2005; 10.1200/JCO.2005.02.028. [Abstract] [Full Text] [PDF]
	Trabectedin for Women With Ovarian Carcinoma After Treatment With Platinum and Taxanes Fails
	Cristiana Sessa, Filippo De Braud, Antonella Perotti, Jean Bauer, Giuseppe Curigliano, Cristina Noberasco, Flavia Zanaboni, Luca Gianni, Silvia Marsoni, José Jimeno, Maurizio D'Incalci, Elisa Dall’ó, and Nicoletta Colombo
	JCO Mar 20 2005: 1867–1874. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Phase I Trial of the Cyclin-Dependent Kinase Inhibitor and Protein Kinase C Inhibitor 7-Hydroxystaurosporine in Combination With Fluorouracil in Patients With Advanced Solid Tumors
	Jeremy Kortmansky, Manish A. Shah, Andreas Kaubisch, Amanda Weyerbacher, Sandy Yi, William Tong, Rebecca Sowers, Mithat Gonen, Eileen O'Reilly, Nancy Kemeny, David I. Ilson, Leonard B. Saltz, Robert G. Maki, David P. Kelsen, and Gary K. Schwartz
	JCO Mar 20 2005: 1875–1884. First published on Feb 7 2005; 10.1200/JCO.2005.03.116. [Abstract] [Full Text] [PDF]
	Phase I and Pharmacologic Study of 17-(Allylamino)-17-Demethoxygeldanamycin in Adult Patients With Solid Tumors
	Jean L. Grem, Geraldine Morrison, Xiao-Du Guo, Elizabeth Agnew, Chris H. Takimoto, Rebecca Thomas, Eva Szabo, Louise Grochow, Frank Grollman, J. Michael Hamilton, Len Neckers, and Richard H. Wilson
	JCO Mar 20 2005: 1885–1893. [Abstract] [Full Text] [PDF]

Genetic Testing for Cancer
	Clinical Characteristics of Pheochromocytoma Patients With Germline Mutations in SDHD
	Hilde Dannenberg, Francien H. van Nederveen, Mustaffa Abbou, Albert A. Verhofstad, Paul Komminoth, Ronald R. de Krijger, and Winand N.M. Dinjens
	JCO Mar 20 2005: 1894–1901. [Abstract] [Full Text] [PDF]
	Psychological Impact of Genetic Testing for Hereditary Nonpolyposis Colorectal Cancer
	Ellen R. Gritz, Susan K. Peterson, Sally W. Vernon, Salma K. Marani, Walter F. Baile, Beatty G. Watts, Christopher I. Amos, Marsha L. Frazier, and Patrick M. Lynch
	JCO Mar 20 2005: 1902–1910. [Abstract] [Full Text] [PDF]

Prevention
	Implications of the Prostate Cancer Prevention Trial: A Decision Analysis Model of Survival Outcomes
	Yair Lotan, Jeffrey A. Cadeddu, J. Jack Lee, Claus G. Roehrborn, and Scott M. Lippman
	JCO Mar 20 2005: 1911–1920. [Abstract] [Full Text] [PDF]

Lung Cancer
	EGR1 Predicts PTEN and Survival in Patients With Non–Small-Cell Lung Cancer
	Bernadette Ferraro, Gerold Bepler, Swati Sharma, Alan Cantor, and Eric B. Haura
	JCO Mar 20 2005: 1921–1926. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Risk Markers of Oral Cancer in Clinically Normal Mucosa As an Aid in Smoking Cessation Counseling
	Jon Sudbø, Roy Samuelsson, Björn Risberg, Stig Heistein, Christian Nyhus, Margaretha Samuelsson, Ruth Puntervold, Eva Sigstad, Ben Davidson, Albrecht Reith, and Åsmund Berner
	JCO Mar 20 2005: 1927–1933. [Abstract] [Full Text] [PDF] [Investigating Committee Report]

Breast Cancer
	Sequencing of Chemotherapy and Radiation Therapy in Early-Stage Breast Cancer: Updated Results of a Prospective Randomized Trial
	Jennifer R. Bellon, Steven E. Come, Rebecca S. Gelman, I. Craig Henderson, Lawrence N. Shulman, Barbara J. Silver, Jay R. Harris, and Abram Recht
	JCO Mar 20 2005: 1934–1940. [Abstract] [Full Text] [PDF]
	Evolving Treatment Strategies for Inflammatory Breast Cancer: A Population-Based Survival Analysis
	Miguel Panades, Ivo A. Olivotto, Caroline H. Speers, Tamara Shenkier, Theodora A. Olivotto, Lorna Weir, Sharon J. Allan, and Pauline T. Truong
	JCO Mar 20 2005: 1941–1950. [Abstract] [Full Text] [PDF]
	Paclitaxel Decreases the Interstitial Fluid Pressure and Improves Oxygenation in Breast Cancers in Patients Treated With Neoadjuvant Chemotherapy: Clinical Implications
	Alphonse G. Taghian, Rita Abi-Raad, Sherif I. Assaad, Adrian Casty, Marek Ancukiewicz, Eren Yeh, Peryhan Molokhia, Khaled Attia, Timothy Sullivan, Irene Kuter, Yves Boucher, and Simon N. Powell
	JCO Mar 20 2005: 1951–1961. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Pattern of Prostate-Specific Antigen (PSA) Failure Dictates the Probability of a Positive Bone Scan in Patients With an Increasing PSA After Radical Prostatectomy
	Zohar A Dotan, Fernando J. Bianco, Jr, Farhang Rabbani, James A. Eastham, Paul Fearn, Howard I. Scher, Kevin W. Kelly, Hui-Ni Chen, Heiko Schöder, Hedvig Hricak, Peter T. Scardino, and Michael W. Kattan
	JCO Mar 20 2005: 1962–1968. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Prognostic Index for Adult Patients With Acute Myeloid Leukemia in First Relapse
	Dimitri A. Breems, Wim L.J. Van Putten, Peter C. Huijgens, Gert J. Ossenkoppele, Gregor E.G. Verhoef, Leo F. Verdonck, Edo Vellenga, Georgine E. De Greef, Emanuel Jacky, Johannes Van der Lelie, Marc A. Boogaerts, and Bob Löwenberg
	JCO Mar 20 2005: 1969–1978. First published on Jan 4 2005; 10.1200/JCO.2005.06.027. [Abstract] [Full Text] [PDF]
	Clinical Activity of Rituximab in Gastric Marginal Zone Non-Hodgkin's Lymphoma Resistant to or Not Eligible for Anti–Helicobacter Pylori Therapy
	Giovanni Martinelli, Daniele Laszlo, Andrés J.M. Ferreri, Giancarlo Pruneri, Maurilio Ponzoni, Annarita Conconi, Cristiano Crosta, Ennio Pedrinis, Francesco Bertoni, Liliana Calabrese, and Emanuele Zucca
	JCO Mar 20 2005: 1979–1983. First published on Jan 24 2005; 10.1200/JCO.2005.08.128. [Abstract] [Full Text] [PDF]
	Immunochemotherapy With Rituximab and Cyclophosphamide, Doxorubicin, Vincristine, and Prednisone Significantly Improves Response and Time to Treatment Failure, But Not Long-Term Outcome in Patients With Previously Untreated Mantle Cell Lymphoma: Results of a Prospective Randomized Trial of the German Low Grade Lymphoma Study Group (GLSG)
	Georg Lenz, Martin Dreyling, Eva Hoster, Bernhard Wörmann, Ulrich Dührsen, Bernd Metzner, Hartmut Eimermacher, Andreas Neubauer, Hannes Wandt, Hjalmar Steinhauer, Sonja Martin, Else Heidemann, Ali Aldaoud, Reza Parwaresch, Joerg Hasford, Michael Unterhalt, and Wolfgang Hiddemann
	JCO Mar 20 2005: 1984–1992. First published on Jan 24 2005; 10.1200/JCO.2005.08.133. [Abstract] [Full Text] [PDF]
	Graft-Versus-Tumor Effects After Allogeneic Hematopoietic Cell Transplantation With Nonmyeloablative Conditioning
	Frédéric Baron, Michael B. Maris, Brenda M. Sandmaier, Barry E. Storer, Mohamed Sorror, Razvan Diaconescu, Ann E. Woolfrey, Thomas R. Chauncey, Mary E.D. Flowers, Marco Mielcarek, David G. Maloney, and Rainer Storb
	JCO Mar 20 2005: 1993–2003. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Osteosarcoma: A Randomized, Prospective Trial of the Addition of Ifosfamide and/or Muramyl Tripeptide to Cisplatin, Doxorubicin, and High-Dose Methotrexate
	Paul A. Meyers, Cindy L. Schwartz, Mark Krailo, Eugenie S. Kleinerman, Donna Betcher, Mark L. Bernstein, Ernest Conrad, William Ferguson, Mark Gebhardt, Allen M. Goorin, Michael B. Harris, John Healey, Andrew Huvos, Michael Link, Joseph Montebello, Helen Nadel, Michael Nieder, Judith Sato, Gene Siegal, Michael Weiner, Robert Wells, Lester Wold, Richard Womer, and Holcombe Grier
	JCO Mar 20 2005: 2004–2011. [Abstract] [Full Text] [PDF] [Publisher's Note]

Palliative Care
	Attitudes of Patients With Incurable Cancer Toward Medical Treatment in the Last Phase of Life
	Elsbeth Voogt, Agnes van der Heide, Judith A.C. Rietjens, Anna F. van Leeuwen, Adriaan P. Visser, Carin C.D. van der Rijt, and Paul J. van der Maas
	JCO Mar 20 2005: 2012–2019. [Abstract] [Full Text] [PDF]

REVIEW ARTICLES
	Clinical Trial Designs for Predictive Marker Validation in Cancer Treatment Trials
	Daniel J. Sargent, Barbara A. Conley, Carmen Allegra, and Laurence Collette
	JCO Mar 20 2005: 2020–2027. [Abstract] [Full Text] [PDF]
	Systematic Review of the Diagnosis and Management of Malignant Extradural Spinal Cord Compression: The Cancer Care Ontario Practice Guidelines Initiative‘s Neuro-Oncology Disease Site Group
	D. Andrew Loblaw, James Perry, Alexandra Chambers, and Normand J. Laperriere
	JCO Mar 20 2005: 2028–2037. [Abstract] [Full Text] [PDF]
	Neoadjuvant Chemotherapy Before Liver Resection for Patients With Unresectable Liver Metastases From Colorectal Carcinoma
	Gregory D. Leonard, Baruch Brenner, and Nancy E. Kemeny
	JCO Mar 20 2005: 2038–2048. [Abstract] [Full Text] [PDF]

ASCO SPECIAL ARTICLE

ACCO: ASCO Core Curriculum Outline

Hyman B. Muss, Jamie Von Roenn, Lloyd Earl Damon, Lisa Marie Deangelis, Lawrence E. Flaherty, Paul M. Harari, Karen Kelly, Michael P. Kosty, Matthew J. Loscalzo, Robert Mennel, Beverly S. Mitchell, Joanne E. Mortimer, Franco Muggia, Edith A. Perez, Peter W.T. Pisters, Leonard Saltz, Lidia Schapira, and Joseph Sparano

JCO Mar 20 2005: 2049–2077. First published on Feb 22 2005; 10.1200/JCO.2005.99.008. [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	Role of Transforming Growth Factor Beta in Human Cancer
	Rebecca L. Elliott and Gerard C. Blobe
	JCO Mar 20 2005: 2078–2093. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Unusual Sites of Malignancies: CASE 1. Small-Cell Carcinoma of the Hypopharynx

Anu Gaba, Rowland Mbaoma, Dwayne Breining, Richard V. Smith, Jonathan J. Beitler, and Missak Haigentz, Jr

JCO Mar 20 2005: 2094–2096. [Full Text] [PDF]

Unusual Sites of Malignancies: CASE 2. Central Neurogenic Hyperventilation As a Complication of Richter's Syndrome

Christoph Schmid, Heinz Diem, Karin Herrmann, Raymond Voltz, German Ott, and Michael Hallek

JCO Mar 20 2005: 2096–2098. [Full Text] [PDF]

Unusual Sites of Malignancies: CASE 3. AIDS-Related Kaposi's Sarcoma of the Gastrointestinal Tract

Weei-Yuarn Huang, Liron Pantanowitz, and Bruce J. Dezube

JCO Mar 20 2005: 2098–2099. [Full Text] [PDF]

ART OF ONCOLOGY

Custodianship of Genetic Information: Clinical Challenges and Professional Responsibility

Annette R. Patterson, Linda D. Robinson, Elizabeth Z. Naftalis, Barbara B. Haley, and Gail E. Tomlinson

JCO Mar 20 2005: 2100–2104. [Full Text] [PDF]

SPECIAL DEPARTMENTS

Correspondence

Is There a New Drug Beyond Floxuridine for Intra-Arterial Hepatic Chemotherapy in Liver Metastases From Colorectal Cancer?

G. Fiorentini, S. Rossi, P. Bernardeschi, M. Cantore, and S. Guadagni

JCO Mar 20 2005: 2105. [Full Text] [PDF]

In Reply:

Nancy E. Kemeny

JCO Mar 20 2005: 2106. [Full Text] [PDF]

Improbable Estimate of Lung Cancer Mortality From Screening Trials

Melvyn S. Tockman

JCO Mar 20 2005: 2106-a–2107. [Full Text] [PDF]

In Reply:

Edward F. Patz, Jr, Stephen J. Swensen, and James E. Herndon

JCO Mar 20 2005: 2107–2108. [Full Text] [PDF]

Thymidylate Synthase Expression in Colorectal Cancer: The Never-Ending Story

Bruno Vincenzi, Daniele Santini, and Giuseppe Tonini

JCO Mar 20 2005: 2108. [Full Text] [PDF]

In Reply:

Sanjay Popat, Athena Matakidou, and Richard S. Houlston

JCO Mar 20 2005: 2108-a–2109. [Full Text] [PDF]

Graft Versus T-Cell–Non-Hodgkin's Lymphoma Effect

Andrew Grigg

JCO Mar 20 2005: 2109–2110. [Full Text] [PDF]

In Reply:

Paolo Corradini

JCO Mar 20 2005: 2110–2111. [Full Text] [PDF]

Serotonin and Cancer Anorexia: Myths or Facts?

A. Laviano, F. Rossi Fanelli, and M.M. Meguid

JCO Mar 20 2005: 2111–2112. [Full Text] [PDF]

In Reply:

Mellar P. Davis, Declan Walsh, and Ruth Lagman

JCO Mar 20 2005: 2112. [Full Text] [PDF]

Inhibition of Angiogenesis: Thalidomide or Low-Molecular-Weight Heparin?

Metin Ozkan, Bulent Eser, Ozlem Er, Gamze Gokoz Dogu, and Mustafa Altinbas

JCO Mar 20 2005: 2113. [Full Text] [PDF]

In Reply:

William D. Figg, Avi Retter, Seth M. Steinberg, and William L. Dahut

JCO Mar 20 2005: 2113-a–2114. [Full Text] [PDF]

Survival After Brain Metastases From Breast Cancer in the Trastuzumab Era

David G. Kirsch, Carlos J. Ledezma, Christina S. Mathews, Atul K. Bhan, Marek Ancukiewicz, Fred H. Hochberg, and Jay S. Loeffler

JCO Mar 20 2005: 2114–2116. [Full Text] [PDF]

Trends in Survival of Patients With Metastatic Breast Cancer

Adri C. Voogd, Kitty van Gestel, and Miranda F. Ernst

JCO Mar 20 2005: 2116. [Full Text] [PDF]

In Reply:

F. Andre, S. Delaloge, and M. Spielmann

JCO Mar 20 2005: 2116-a–2117. [Full Text] [PDF]

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