EDITORIALS

New Horizons in Staging for Non–Small-Cell Lung Cancer

Didier Lardinois

JCO Apr 20 2006: 1785–1787. First published on Mar 27 2006; 10.1200/JCO.2005.04.7480. [Full Text] [PDF]

Sentinel Node Micrometastases and Non-Sentinel Nodes in Breast Cancer: How Much Do We Need to Know?

Harry D. Bear

JCO Apr 20 2006: 1788–1790. First published on Mar 27 2006; 10.1200/JCO.2005.05.5301. [Full Text] [PDF]

Have We Found the Ultimate Risk Factor for Breast Cancer?

Victor G. Vogel and Emanuela Taioli

JCO Apr 20 2006: 1791–1794. First published on Mar 27 2006; 10.1200/JCO.2005.05.4122. [Full Text] [PDF]

Cancer in the Elderly Population: The Protection Racket

Derek Raghavan and Theodore Suh

JCO Apr 20 2006: 1795–1796. First published on Mar 27 2006; 10.1200/JCO.2005.05.4502. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Estrogen Receptor Testing of Breast Cancer in Current Clinical Practice: What's the Question?

Stuart J. Schnitt

JCO Apr 20 2006: 1797–1799. First published on Mar 27 2006; 10.1200/JCO.2005.05.0666. [Full Text] [PDF]

ORIGINAL REPORTS
Lung Cancer
	Traditional Versus Up-Front [18F] Fluorodeoxyglucose–Positron Emission Tomography Staging of Non–Small-Cell Lung Cancer: A Dutch Cooperative Randomized Study
	Gerarda J.M. Herder, Henk Kramer, Otto S. Hoekstra, Egbert F. Smit, Jan Pruim, Harm van Tinteren, Emile F. Comans, Paul Verboom, Carin A. Uyl-de Groot, Alle Welling, Marinus A. Paul, Maarten Boers, Pieter E. Postmus, Gerrit J. Teule, and Harry J.M. Groen
	JCO Apr 20 2006: 1800–1806. First published on Mar 27 2006; 10.1200/JCO.2005.02.4695. [Abstract] [Full Text] [PDF]
	Gefitinib Therapy in Advanced Bronchioloalveolar Carcinoma: Southwest Oncology Group Study S0126
	Howard L. West, Wilbur A. Franklin, Jason McCoy, Paul H. Gumerlock, Ralph Vance, Derick H.M. Lau, Kari Chansky, John J. Crowley, and David R. Gandara
	JCO Apr 20 2006: 1807–1813. [Abstract] [Full Text] [PDF]

Breast Cancer
	Micrometastases in Sentinel Lymph Node in a Multicentric Study: Predictive Factors of Nonsentinel Lymph Node Involvement—Groupe Des Chirurgiens De La Federation Des Centres De Lutte Contre Le Cancer
	Gilles Houvenaeghel, Claude Nos, Hervé Mignotte, Jean Marc Classe, Sylvie Giard, Philippe Rouanet, Frédérique Penault Lorca, Jocelyne Jacquemier, and Valérie Jeanne Bardou
	JCO Apr 20 2006: 1814–1822. First published on Mar 27 2006; 10.1200/JCO.2005.03.3225. [Abstract] [Full Text] [PDF]
	Endogenous Steroid Hormone Concentrations and Risk of Breast Cancer: Does the Association Vary by a Woman's Predicted Breast Cancer Risk?
	A. Heather Eliassen, Stacey A. Missmer, Shelley S. Tworoger, and Susan E. Hankinson
	JCO Apr 20 2006: 1823–1830. First published on Mar 27 2006; 10.1200/JCO.2005.03.7432. [Abstract] [Full Text] [PDF]
	Docetaxel, Cisplatin, and Trastuzumab As Primary Systemic Therapy for Human Epidermal Growth Factor Receptor 2–Positive Locally Advanced Breast Cancer
	Judith Hurley, Philomena Doliny, Isildinha Reis, Orlando Silva, Carmen Gomez-Fernandez, Pedro Velez, Giovanni Pauletti, Jodeen E. Powell, Mark D. Pegram, and Dennis J. Slamon
	JCO Apr 20 2006: 1831–1838. First published on Mar 20 2006; 10.1200/JCO.2005.02.8886. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Gene Expression Signature Predicting Pathologic Complete Response With Gemcitabine, Epirubicin, and Docetaxel in Primary Breast Cancer
	Olaf Thuerigen, Andreas Schneeweiss, Grischa Toedt, Patrick Warnat, Meinhard Hahn, Heidi Kramer, Benedikt Brors, Christian Rudlowski, Axel Benner, Florian Schuetz, Bjoern Tews, Roland Eils, Hans-Peter Sinn, Christof Sohn, and Peter Lichter
	JCO Apr 20 2006: 1839–1845. [Abstract] [Full Text] [PDF] [Supplementary Data]

Phase I and Clinical Pharmacology
	Prospective Evaluation of the Relationship of Patient Age and Paclitaxel Clinical Pharmacology: Cancer and Leukemia Group B (CALGB 9762)
	Stuart M. Lichtman, Donna Hollis, Antonius A. Miller, Gary L. Rosner, Chris A. Rhoades, Eric P. Lester, Frederick Millard, John Byrd, Stephen A. Cullinan, D. Marc Rosen, Robert A. Parise, Mark J. Ratain, and Merrill J. Egorin
	JCO Apr 20 2006: 1846–1851. First published on Mar 27 2006; 10.1200/JCO.2005.03.9289. [Abstract] [Full Text] [PDF]
	Assessment of Tumor Necrosis Factor Alpha Blockade As an Intervention to Improve Tolerability of Dose-Intensive Chemotherapy in Cancer Patients
	J. Paul Monk, Gary Phillips, Ross Waite, John Kuhn, Larry J. Schaaf, Gregory A. Otterson, Denis Guttridge, Chris Rhoades, Manisha Shah, Tamara Criswell, Michael A. Caligiuri, and Miguel A. Villalona-Calero
	JCO Apr 20 2006: 1852–1859. [Abstract] [Full Text] [PDF]

Clinical Trials
	Factors Associated With Participation in Breast Cancer Treatment Clinical Trials
	Nancy E. Avis, Kevin W. Smith, Carol L. Link, Gabriel N. Hortobagyi, and Edgardo Rivera
	JCO Apr 20 2006: 1860–1867. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Immediate or Deferred Androgen Deprivation for Patients With Prostate Cancer Not Suitable for Local Treatment With Curative Intent: European Organisation for Research and Treatment of Cancer (EORTC) Trial 30891
	Urs E. Studer, Peter Whelan, Walter Albrecht, Jacques Casselman, Theo de Reijke, Dieter Hauri, Wolfgang Loidl, Santiago Isorna, Subramanian K. Sundaram, Muriel Debois, and Laurence Collette
	JCO Apr 20 2006: 1868–1876. [Abstract] [Full Text] [PDF] [Russian PDF]

Surgical Oncology
	Dermoscopy Improves Accuracy of Primary Care Physicians to Triage Lesions Suggestive of Skin Cancer
	Giuseppe Argenziano, Susana Puig, Iris Zalaudek, Francesco Sera, Rosamaria Corona, Mercè Alsina, Filomena Barbato, Cristina Carrera, Gerardo Ferrara, Antonio Guilabert, Daniela Massi, Juan A. Moreno-Romero, Carlos Muñoz-Santos, Gianluca Petrillo, Sonia Segura, H. Peter Soyer, Renato Zanchini, and Josep Malvehy
	JCO Apr 20 2006: 1877–1882. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Pharmacogenetic Profiling and Clinical Outcome of Patients With Advanced Gastric Cancer Treated With Palliative Chemotherapy
	Annamaria Ruzzo, Francesco Graziano, Kazuyuki Kawakami, Go Watanabe, Daniele Santini, Vincenzo Catalano, Renato Bisonni, Emanuele Canestrari, Rita Ficarelli, Ettore Tito Menichetti, Davide Mari, Enrica Testa, Rosarita Silva, Bruno Vincenzi, Paolo Giordani, Stefano Cascinu, Lucio Giustini, Giuseppe Tonini, and Mauro Magnani
	JCO Apr 20 2006: 1883–1891. [Abstract] [Full Text] [PDF] [Polish PDF]
	Phase II Study of Capecitabine, Oxaliplatin, and Erlotinib in Previously Treated Patients With Metastastic Colorectal Cancer
	Jeffrey A. Meyerhardt, Andrew X. Zhu, Peter C. Enzinger, David P. Ryan, Jeffrey W. Clark, Matthew H. Kulke, Craig C. Earle, Michele Vincitore, Ann Michelini, Susan Sheehan, and Charles S. Fuchs
	JCO Apr 20 2006: 1892–1897. [Abstract] [Full Text] [PDF]
	Phase II Study of Gemcitabine and Oxaliplatin in Combination With Bevacizumab in Patients With Advanced Hepatocellular Carcinoma
	Andrew X. Zhu, Lawrence S. Blaszkowsky, David P. Ryan, Jeffrey W. Clark, Alona Muzikansky, Kerry Horgan, Susan Sheehan, Kelly E. Hale, Peter C. Enzinger, Pankaj Bhargava, and Keith Stuart
	JCO Apr 20 2006: 1898–1903. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Sensorineural Hearing Loss After Radiotherapy and Chemoradiotherapy: A Single, Blinded, Randomized Study
	Wong Kein Low, Song Tar Toh, Joseph Wee, Stephanie M.C. Fook-Chong, and De Yun Wang
	JCO Apr 20 2006: 1904–1909. [Abstract] [Full Text] [PDF]

Tumor Biology
	Chemokine Receptor CCR6 Expression Level and Liver Metastases in Colorectal Cancer
	Pirus Ghadjar, Sarah Ellen Coupland, Il-Kang Na, Michel Noutsias, Anne Letsch, Andrea Stroux, Sandra Bauer, Heinz J. Buhr, Eckhard Thiel, Carmen Scheibenbogen, and Ulrich Keilholz
	JCO Apr 20 2006: 1910–1916. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Phase II Study of Clofarabine in Pediatric Patients With Refractory or Relapsed Acute Lymphoblastic Leukemia
	Sima Jeha, Paul S. Gaynon, Bassem I. Razzouk, Janet Franklin, Richard Kadota, Violet Shen, Lori Luchtman-Jones, Michael Rytting, Lisa R. Bomgaars, Susan Rheingold, Kim Ritchey, Edythe Albano, Robert J. Arceci, Stewart Goldman, Timothy Griffin, Arnold Altman, Bruce Gordon, Laurel Steinherz, Steven Weitman, and Peter Steinherz
	JCO Apr 20 2006: 1917–1923. [Abstract] [Full Text] [PDF]
	Genomics Identifies Medulloblastoma Subgroups That Are Enriched for Specific Genetic Alterations
	Margaret C. Thompson, Christine Fuller, Twala L. Hogg, James Dalton, David Finkelstein, Ching C. Lau, Murali Chintagumpala, Adekunle Adesina, David M. Ashley, Stewart J. Kellie, Michael D. Taylor, Tom Curran, Amar Gajjar, and Richard J. Gilbertson
	JCO Apr 20 2006: 1924–1931. First published on Mar 27 2006; 10.1200/JCO.2005.04.4974. [Abstract] [Full Text] [PDF] [Supplementary Data]

REVIEW ARTICLE
	Educating Undergraduate Medical Students About Oncology: A Literature Review
	Judith Gaffan, Jane Dacre, and Alison Jones
	JCO Apr 20 2006: 1932–1939. [Abstract] [Full Text] [PDF] [Supplementary Data]

SPECIAL ARTICLE
	Recommendations From an International Expert Panel on the Use of Neoadjuvant (Primary) Systemic Treatment of Operable Breast Cancer: An Update
	Manfred Kaufmann, Gabriel N. Hortobagyi, Aron Goldhirsch, Suzy Scholl, Andreas Makris, Pinuccia Valagussa, Jens-Uwe Blohmer, Wolfgang Eiermann, Raimund Jackesz, Walter Jonat, Annette Lebeau, Sibylle Loibl, William Miller, Sigfried Seeber, Vladimir Semiglazov, Roy Smith, Rainer Souchon, Vered Stearns, Michael Untch, and Gunter von Minckwitz
	JCO Apr 20 2006: 1940–1949. [Abstract] [Full Text] [PDF] [Russian PDF]

DIAGNOSIS IN ONCOLOGY

Large B-Cell Lymphoma Masquerading As Acute Leukemia

Joanna Steere, Alexander Perl, Ewa Tomczak, and Adam Bagg

JCO Apr 20 2006: 1950-a–1951. [Full Text] [PDF]

Acute Lung Injury Associated With Vinorelbine

Tawee Tanvetyanon, Edward R. Garrity, and Kathy S. Albain

JCO Apr 20 2006: 1952–1953. [Full Text] [PDF]

Laryngeal Obstruction and Hoarseness Associated With Rosai-Dorfman Disease

Furha Cossor, Al-Hareth M. Al-Khater, and Donald C. Doll

JCO Apr 20 2006: 1953–1955. [Full Text] [PDF]

Aromatase Inhibitor Withdrawal Response in Metastatic Breast Cancer

Tessa Cigler and Paul E. Goss

JCO Apr 20 2006: 1955–1956. [Full Text] [PDF]

CORRESPONDENCE
	New Issues on Cetuximab Mechanism of Action in Epidermal Growth Factor Receptor–Negative Colorectal Cancer: The Role of Vascular Endothelial Growth Factor
	Bruno Vincenzi, Daniele Santini, and Giuseppe Tonini
	JCO Apr 20 2006: 1957. [Full Text] [PDF]
	In Reply:
	Ki Young Chung and Leonard B. Saltz
	JCO Apr 20 2006: 1957-a–1958. [Full Text] [PDF]
	Childhood Nonrhabdomyosarcoma Soft Tissue Sarcomas Are Not Adult-Type Tumors
	Sheri L. Spunt and Alberto S. Pappo
	JCO Apr 20 2006: 1958–1959. [Full Text] [PDF]
	In Reply:
	Laurence H. Baker
	JCO Apr 20 2006: 1959–1960. [Full Text] [PDF]
	Is It Time to Abandon Microsatellite Instability As a Pre-Screen for Selecting Families for Mutation Testing for Mismatch Repair Genes?
	Gareth D. Evans, Fiona Lalloo, Tony Mak, Doug Speake, and James Hill
	JCO Apr 20 2006: 1960–1962. [Full Text] [PDF]
	In Reply:
	Melissa C. Southey, Mark A. Jenkins, John L. Hopper, Finlay A. Macrae, and Graham G. Giles
	JCO Apr 20 2006: 1962–1963. [Full Text] [PDF]
	Overestimating the Influence of the 1999 WHO Classification of Lung Tumors on Survival in Bronchioloalveloar Carcinoma
	Junji Tsurutani, Marc S. Ballas, and Phillip A. Dennis
	JCO Apr 20 2006: 1963. [Full Text] [PDF]
	In Reply:
	Jason A. Zell, Sai-Hong Ignatius Ou, Argyrios Ziogas, and Hoda Anton-Culver
	JCO Apr 20 2006: 1963-a–1964. [Full Text] [PDF]
	Are We Cautious Enough When We Interpret Results of Randomized But Underpowered Comparisons?
	Marianne Paesmans and Harry Bleiberg
	JCO Apr 20 2006: 1964–1965. [Full Text] [PDF]
	In Utero Exposure to Chemotherapy: Effect on Cardiac and Neurologic Outcome
	Kristel Van Calsteren, Patrick Berteloot, Myriam Hanssens, Ignace Vergote, Frederic Amant, Javier Ganame, Piet Claus, Luc Mertens, Lieven Lagae, Michel Delforge, Robert Paridaens, Lucien Noens, Yves Humblet, Bruno Vandermeersch, and Xavier De Muylder
	JCO Apr 20 2006: e16–17. [Full Text] [PDF]

ERRATA

ERRATUM

JCO Apr 20 2006: 1966. [Full Text] [PDF]

ERRATUM

JCO Apr 20 2006: 1966-a. [Full Text] [PDF]

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