IN MEMORIAM

Sam Wieand, PhD

Daniel G. Haller, Michael J. O'Connell, Daniel Sargent, Joseph P. Costantino, and Norman Wolmark

JCO Oct 1 2006: 4523–4525. [Full Text] [PDF]

EDITORIALS

Changing Face of Small-Cell Lung Cancer: Real and Artifact

David S. Ettinger and Joseph Aisner

JCO Oct 1 2006: 4526–4527. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Intraperitoneal Chemotherapy in Ovarian Cancer Remains Experimental

Martin Gore, Andreas du Bois, and Ignace Vergote

JCO Oct 1 2006: 4528–4530. [Full Text] [PDF]

Intraperitoneal Therapy for Ovarian Cancer: A Treatment Ready for Prime Time

Deborah K. Armstrong and Mark F. Brady

JCO Oct 1 2006: 4531–4533. [Full Text] [PDF]

Uridine Diphosphate Glucuronosyltransferase (UGT) 1A1 and Irinotecan: Practical Pharmacogenomics Arrives in Cancer Therapy

Peter J. O'Dwyer and Robert B. Catalano

JCO Oct 1 2006: 4534–4538. [Full Text] [PDF]

ORIGINAL REPORTS
Lung Cancer
	Changing Epidemiology of Small-Cell Lung Cancer in the United States Over the Last 30 Years: Analysis of the Surveillance, Epidemiologic, and End Results Database
	Ramaswamy Govindan, Nathan Page, Daniel Morgensztern, William Read, Ryan Tierney, Anna Vlahiotis, Edward L. Spitznagel, and Jay Piccirillo
	JCO Oct 1 2006: 4539–4544. [Abstract] [Full Text] [PDF]

Clinical Trials
	Invisible Barriers to Clinical Trials: The Impact of Structural, Infrastructural, and Procedural Barriers to Opening Oncology Clinical Trials
	David M. Dilts and Alan B. Sandler
	JCO Oct 1 2006: 4545–4552. [Abstract] [Full Text] [PDF]
	Processes to Activate Phase III Clinical Trials in a Cooperative Oncology Group: The Case of Cancer and Leukemia Group B
	David M. Dilts, Alan B. Sandler, Matthew Baker, Steven K. Cheng, Stephen L. George, Kathleen S. Karas, Stephen McGuire, Gourija S. Menon, Jason Reusch, Debbie Sawyer, Maren Scoggins, Amy Wu, Kai Zhou, and Richard L. Schilsky
	JCO Oct 1 2006: 4553–4557. [Abstract] [Full Text] [PDF]

Clinical Pharmacology
	Clinical and Pharmacologic Study of the Farnesyltransferase Inhibitor Tipifarnib in Cancer Patients With Normal or Mildly or Moderately Impaired Hepatic Function
	Wandena S. Siegel-Lakhai, Mirjam Crul, Peter De Porre, Steven Zhang, Ilsung Chang, Henk Boot, Jos H. Beijnen, and Jan H.M. Schellens
	JCO Oct 1 2006: 4558–4564. [Abstract] [Full Text] [PDF]

Melanoma
	Prognostic Significance of Nuclear Receptor Coactivator-3 Overexpression in Primary Cutaneous Melanoma
	Javier Rangel, Sima Torabian, Ladan Shaikh, Mehdi Nosrati, Frederick L. Baehner, Chris Haqq, Stanley P.L. Leong, James R. Miller, III, Richard W. Sagebiel, and Mohammed Kashani-Sabet
	JCO Oct 1 2006: 4565–4569. [Abstract] [Full Text] [PDF]

Neurooncology
	Long-Term Follow-Up of High-Dose Methotrexate-Based Therapy With and Without Whole Brain Irradiation for Newly Diagnosed Primary CNS Lymphoma
	Igor T. Gavrilovic, Adília Hormigo, Joachim Yahalom, Lisa M. DeAngelis, and Lauren E. Abrey
	JCO Oct 1 2006: 4570–4574. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Catheter-Related Deep Venous Thrombosis and Other Catheter Complications in Children With Cancer
	Janna M. Journeycake and George R. Buchanan
	JCO Oct 1 2006: 4575–4580. [Abstract] [Full Text] [PDF]

Urologic Oncology
	Do Patients With Localized Prostate Cancer Treatment Really Want More Aggressive Treatment?
	Julia J. van Tol-Geerdink, Peep F.M. Stalmeier, Emile N.J.T. van Lin, Eric C. Schimmel, Henk Huizenga, Wim A.J. van Daal, and Jan-Willem Leer
	JCO Oct 1 2006: 4581–4586. [Abstract] [Full Text] [PDF]

Thoracic Oncology
	Early Response Evaluation in Malignant Pleural Mesothelioma by Positron Emission Tomography With [18F]Fluorodeoxyglucose
	Giovanni L. Ceresoli, Arturo Chiti, Paolo A. Zucali, Marcello Rodari, Romano F. Lutman, Silvia Salamina, Matteo Incarbone, Marco Alloisio, and Armando Santoro
	JCO Oct 1 2006: 4587–4593. [Abstract] [Full Text] [PDF]

Breast Cancer
	Genomic Prediction of Locoregional Recurrence After Mastectomy in Breast Cancer
	Skye H. Cheng, Cheng-Fang Horng, Mike West, Erich Huang, Jennifer Pittman, Mei-Hua Tsou, Holly Dressman, Chii-Ming Chen, Stella Y. Tsai, James J. Jian, Mei-Chin Liu, Joseph R. Nevins, and Andrew T. Huang
	JCO Oct 1 2006: 4594–4602. [Abstract] [Full Text] [PDF]
	Magnetic Resonance Imaging Captures the Biology of Ductal Carcinoma In Situ
	Laura J. Esserman, Anjali S. Kumar, Alex F. Herrera, Jessica Leung, Alfred Au, Yunn-Yi Chen, Dan H. Moore, Daniel F. Chen, Jennifer Hellawell, Dulcy Wolverton, E. Shelley Hwang, and Nola M. Hylton
	JCO Oct 1 2006: 4603–4610. [Abstract] [Full Text] [PDF]
	The HOXB13:IL17BR Expression Index Is a Prognostic Factor in Early-Stage Breast Cancer
	Xiao-Jun Ma, Susan G. Hilsenbeck, Wilson Wang, Li Ding, Dennis C. Sgroi, Richard A. Bender, C. Kent Osborne, D. Craig Allred, and Mark G. Erlander
	JCO Oct 1 2006: 4611–4619. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Preoperative Radiotherapy With or Without Concurrent Fluorouracil and Leucovorin in T3-4 Rectal Cancers: Results of FFCD 9203
	Jean-Pierre Gérard, Thierry Conroy, Franck Bonnetain, Olivier Bouché, Olivier Chapet, Marie-Thérèse Closon-Dejardin, Michel Untereiner, Bernard Leduc, Éric Francois, Jean Maurel, Jean-François Seitz, Bruno Buecher, Rémy Mackiewicz, Michel Ducreux, and Laurent Bedenne
	JCO Oct 1 2006: 4620–4625. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Prognostic Significance of T-Cell or Cytotoxic Molecules Phenotype in Classical Hodgkin’s Lymphoma: A Clinicopathologic Study
	Naoko Asano, Aya Oshiro, Keitaro Matsuo, Yoshitoyo Kagami, Fumihiro Ishida, Ritsuro Suzuki, Tomohiro Kinoshita, Yoshie Shimoyama, Jun-Ichi Tamaru, Tadashi Yoshino, Kunio Kitamura, Hisashi Fukutani, Yasuo Morishima, and Shigeo Nakamura
	JCO Oct 1 2006: 4626–4633. First published on Sep 5 2006; 10.1200/JCO.2006.06.5342. [Abstract] [Full Text] [PDF]
	Prospective Evaluation of Clonal Evolution During Long-Term Follow-Up of Patients With Untreated Early-Stage Chronic Lymphocytic Leukemia
	Tait D. Shanafelt, Thomas E. Witzig, Stephanie R. Fink, Robert B. Jenkins, Sarah F. Paternoster, Stephanie A. Smoley, Kimberly J. Stockero, Danielle M. Nast, Heather C. Flynn, Renee C. Tschumper, Susan Geyer, Clive S. Zent, Tim G. Call, Diane F. Jelinek, Neil E. Kay, and Gordon W. Dewald
	JCO Oct 1 2006: 4634–4641. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	ASCO/SSO Review of Current Role of Risk-Reducing Surgery in Common Hereditary Cancer Syndromes
	José G. Guillem, William C. Wood, Jeffrey F. Moley, Andrew Berchuck, Beth Y. Karlan, David G. Mutch, Robert F. Gagel, Jeffrey Weitzel, Monica Morrow, Barbara L. Weber, Francis Giardiello, Miguel A. Rodriguez-Bigas, James Church, Stephen Gruber, and Kenneth Offit
	JCO Oct 1 2006: 4642–4660. [Abstract] [Full Text] [PDF]

ART OF ONCOLOGY

The Discussion Group for Mortals

Kathryn Cornett Heekin

JCO Oct 1 2006: 4661–4663. [Full Text] [PDF]

CORRESPONDENCE
	Role of Neoadjuvant Chemotherapy in Rectal Cancer: Interpretation of the EXPERT Study
	Rob Glynne-Jones and David Sebag-Montefiore
	JCO Oct 1 2006: 4664–4665. [Full Text] [PDF]
	In Reply
	Ian Chau, David Cunningham, Diana Tait, and Gina Brown
	JCO Oct 1 2006: 4665–4666. [Full Text] [PDF]
	Raltitrexed and Pemetrexed Studies in Mesothelioma Have Not Shown Improved Quality of Life nor Prolonged Survival Compared With Effective Pleurodesis With Thoracoscopic Talc Poudrage
	Yossef Aelony
	JCO Oct 1 2006: 4667. [Full Text] [PDF]
	In Reply
	Jan P. van Meerbeeck and Andrew Bottomley
	JCO Oct 1 2006: 4667a–4668. [Full Text] [PDF]
	Are Dose-Finding Studies Still Necessary When Targeted Therapy Is Associated With Chemotherapy?
	Alain J. Gelibter, Sara Lonardi, Susanna Di Segni, Andrea Fontana, Fotios Loupakis, Francesco Cognetti, and Roberto Labianca
	JCO Oct 1 2006: 4668–4669. [Full Text] [PDF]
	In Reply
	Jeffrey A. Meyerhardt and Charles S. Fuchs
	JCO Oct 1 2006: 4669. [Full Text] [PDF]
	Problems With the Randomized Discontinuation Design
	Guru Sonpavde, Thomas E. Hutson, Matthew D. Galsky, and William R. Berry
	JCO Oct 1 2006: 4669a–4670. [Full Text] [PDF]
	In Reply
	Mark J. Ratain
	JCO Oct 1 2006: 4670–4671. [Full Text] [PDF]
	Phase I Trials May Not Need to Be Viewed As Extraordinarily Different From Other Clinical Research
	Sunil Sharma
	JCO Oct 1 2006: e47. [Full Text] [PDF]
	Reversible Posterior Leukoencephalopathy Syndrome Induced by RAF Kinase Inhibitor BAY 43-9006
	Rangaswamy Govindarajan, Josna Adusumilli, Donna L. Baxter, Anthony El-Khoueiry, and Sami I. Harik
	JCO Oct 1 2006: e48. [Full Text] [PDF]

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