EDITORIALS

Integrin Inhibitors Reaching the Clinic

Roger Stupp and Curzio Ruegg

JCO May 1 2007: 1637–1638. [Full Text] [PDF]

Targeted Therapy Trials: Approval Strategies, Target Validation, or Helping Patients?

Paulo M. Hoff and Lee M. Ellis

JCO May 1 2007: 1639–1641. [Full Text] [PDF]

Adjuvant Chemotherapy for High-Risk Operable Breast Cancer

Aman U. Buzdar

JCO May 1 2007: 1642–1644. First published on Apr 2 2007; 10.1200/JCO.2006.09.9796. [Full Text] [PDF]

"Will I Suffer?"

Ann M. O'Mara

JCO May 1 2007: 1645–1646. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Combinations of Tumor and Treatment Parameters Are More Discriminative for Prognosis Than the Present TNM System in Rectal Cancer

Iris D. Nagtegaal, Marleen J.E.M. Gosens, Corrie A.M. Marijnen, Harm J. Rutten, Cornelis J.H. van de Velde, and J. Han J.M. van Krieken

JCO May 1 2007: 1647–1650. [Full Text] [PDF]

ORIGINAL REPORTS
Neurooncology
	Phase I and Correlative Biology Study of Cilengitide in Patients With Recurrent Malignant Glioma
	L. Burt Nabors, Tom Mikkelsen, Steven S. Rosenfeld, Fred Hochberg, Narasimha S. Akella, Joy D. Fisher, Gretchen A. Cloud, Yu Zhang, Kathryn Carson, Sabine M. Wittemer, A. Dimitrios Colevas, and Stuart A. Grossman
	JCO May 1 2007: 1651–1657. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Open-Label Phase III Trial of Panitumumab Plus Best Supportive Care Compared With Best Supportive Care Alone in Patients With Chemotherapy-Refractory Metastatic Colorectal Cancer
	Eric Van Cutsem, Marc Peeters, Salvatore Siena, Yves Humblet, Alain Hendlisz, Bart Neyns, Jean-Luc Canon, Jean-Luc Van Laethem, Joan Maurel, Gary Richardson, Michael Wolf, and Rafael G. Amado
	JCO May 1 2007: 1658–1664. [Abstract] [Full Text] [PDF] [Chinese PDF]
	Phase II Trial of Infusional Fluorouracil, Leucovorin, Mitomycin, and Dipyridamole in Locally Advanced Unresectable Pancreatic Adenocarcinoma: SWOG S9700
	William H. Isacoff, Jacqueline K. Bendetti, John J. Barstis, Abdul-Rahman Jazieh, John S. Macdonald, and Philip A. Philip
	JCO May 1 2007: 1665–1669. [Abstract] [Full Text] [PDF]
	Phase III Trial of Infusional Fluorouracil, Leucovorin, Oxaliplatin, and Irinotecan (FOLFOXIRI) Compared With Infusional Fluorouracil, Leucovorin, and Irinotecan (FOLFIRI) As First-Line Treatment for Metastatic Colorectal Cancer: The Gruppo Oncologico Nord Ovest
	Alfredo Falcone, Sergio Ricci, Isa Brunetti, Elisabetta Pfanner, Giacomo Allegrini, Cecilia Barbara, Lucio Crinò, Giovanni Benedetti, Walter Evangelista, Laura Fanchini, Enrico Cortesi, Vincenzo Picone, Stefano Vitello, Silvana Chiara, Cristina Granetto, Gianfranco Porcile, Luisa Fioretto, Cinzia Orlandini, Michele Andreuccetti, and Gianluca Masi
	JCO May 1 2007: 1670–1676. [Abstract] [Full Text] [PDF] [Chinese PDF]

Breast Cancer
	Intensive Dose-Dense Compared With High-Dose Adjuvant Chemotherapy for High-Risk Operable Breast Cancer: Southwest Oncology Group/Intergroup Study 9623
	Halle C.F. Moore, Stephanie J. Green, Julie R. Gralow, Scott I. Bearman, Danika Lew, William E. Barlow, Clifford Hudis, Antonio C. Wolff, James N. Ingle, Helen K. Chew, Anthony D. Elias, Robert B. Livingston, and Silvana Martino
	JCO May 1 2007: 1677–1682. First published on Apr 2 2007; 10.1200/JCO.2006.08.9383. [Abstract] [Full Text] [PDF] [Chinese PDF]
	Breast Cancer Mortality Trends in the United States According to Estrogen Receptor Status and Age at Diagnosis
	Ismail Jatoi, Bingshu E. Chen, William F. Anderson, and Philip S. Rosenberg
	JCO May 1 2007: 1683–1690. First published on Apr 2 2007; 10.1200/JCO.2006.09.2106. [Abstract] [Full Text] [PDF]

Palliative Care
	Suffering With Advanced Cancer
	Keith G. Wilson, Harvey Max Chochinov, Christine J. McPherson, Katerine LeMay, Pierre Allard, Srini Chary, Pierre R. Gagnon, Karen Macmillan, Marina De Luca, Fiona O'Shea, David Kuhl, and Robin L. Fainsinger
	JCO May 1 2007: 1691–1697. [Abstract] [Full Text] [PDF]

Lung Cancer
	Induction Chemotherapy Followed by Chemoradiotherapy Compared With Chemoradiotherapy Alone for Regionally Advanced Unresectable Stage III Non–Small-Cell Lung Cancer: Cancer and Leukemia Group B
	Everett E. Vokes, James E. Herndon, II, Michael J. Kelley, M. Giulia Cicchetti, Nithya Ramnath, Harvey Neill, James N. Atkins, Dorothy M. Watson, Wallace Akerley, and Mark R. Green
	JCO May 1 2007: 1698–1704. First published on Apr 2 2007; 10.1200/JCO.2006.07.3569. [Abstract] [Full Text] [PDF] [Polish PDF] [Russian PDF] [Chinese PDF]
	Sex Differences in Lung Cancer Survival: Do Tumors Behave Differently in Elderly Women?
	Juan P. Wisnivesky and Ethan A. Halm
	JCO May 1 2007: 1705–1712. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Randomized Trial of Exercise Therapy in Women Treated for Breast Cancer
	Amanda J. Daley, Helen Crank, John M. Saxton, Nanette Mutrie, Robert Coleman, and Andrea Roalfe
	JCO May 1 2007: 1713–1721. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Health-Related Quality of Life in Younger Patients With Chronic Lymphocytic Leukemia Treated With Fludarabine Plus Cyclophosphamide or Fludarabine Alone for First-Line Therapy: A Study by the German CLL Study Group
	Barbara F. Eichhorst, Raymonde Busch, Tanja Obwandner, Ingrid Kuhn-Hallek, Peter Herschbach, and Michael Hallek
	JCO May 1 2007: 1722–1731. First published on Mar 26 2007; 10.1200/JCO.2006.05.6929. [Abstract] [Full Text] [PDF]
	Plasma Cytokine and Soluble Receptor Signature Predicts Outcome of Patients With Classical Hodgkin's Lymphoma: A Study From the Groupe d'Etude des Lymphomes de l'Adulte
	René-Olivier Casasnovas, Nicolas Mounier, Pauline Brice, Marine Divine, Franck Morschhauser, Jean Gabarre, Jean-Yves Blay, Laurent Voillat, Pierre Lederlin, Aspasia Stamatoullas, Jacques Bienvenu, Michel Guiguet, Liliane Intrator, Monique Grandjean, Josette Brière, Christophe Ferme, and Gilles Salles
	JCO May 1 2007: 1732–1740. First published on Mar 26 2007; 10.1200/JCO.2006.08.1331. [Abstract] [Full Text] [PDF]
	Phase II Study of Enzastaurin, a Protein Kinase C Beta Inhibitor, in Patients With Relapsed or Refractory Diffuse Large B-Cell Lymphoma
	Michael J. Robertson, Brad S. Kahl, Julie M. Vose, Sven de Vos, Mary Laughlin, Patrick J. Flynn, Kendrith Rowland, Jose C. Cruz, Stuart L. Goldberg, Luna Musib, Christelle Darstein, Nathan Enas, Jeffery L. Kutok, Jon C. Aster, Donna Neuberg, Kerry J. Savage, Ann LaCasce, Donald Thornton, Christopher A. Slapak, and Margaret A. Shipp
	JCO May 1 2007: 1741–1746. First published on Mar 26 2007; 10.1200/JCO.2006.09.3146. [Abstract] [Full Text] [PDF]

Unknown Primary Site Cancer
	Phase II Trial of Bevacizumab and Erlotinib in Carcinomas of Unknown Primary Site: The Minnie Pearl Cancer Research Network
	John D. Hainsworth, David R. Spigel, Cindy Farley, Dana S. Thompson, Dianna L. Shipley, and F. Anthony Greco
	JCO May 1 2007: 1747–1752. [Abstract] [Full Text] [PDF] [Spanish PDF]

Diagnostics
	Correlation of Computed Tomography and Positron Emission Tomography in Patients With Metastatic Gastrointestinal Stromal Tumor Treated at a Single Institution With Imatinib Mesylate: Proposal of New Computed Tomography Response Criteria
	Haesun Choi, Chuslip Charnsangavej, Silvana C. Faria, Homer A. Macapinlac, Michael A. Burgess, Shreyaskumar R. Patel, Lei L. Chen, Donald A. Podoloff, and Robert S. Benjamin
	JCO May 1 2007: 1753–1759. [Abstract] [Full Text] [PDF]
	We Should Desist Using RECIST, at Least in GIST
	Robert S. Benjamin, Haesun Choi, Homer A. Macapinlac, Michael A. Burgess, Shreyaskumar R. Patel, Lei L. Chen, Donald A. Podoloff, and Chuslip Charnsangavej
	JCO May 1 2007: 1760–1764. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Death in Patients With Recurrent Prostate Cancer After Radical Prostatectomy: Prostate-Specific Antigen Doubling Time Subgroups and Their Associated Contributions to All-Cause Mortality
	Stephen J. Freedland, Elizabeth B. Humphreys, Leslie A. Mangold, Mario Eisenberger, Frederick J. Dorey, Patrick C. Walsh, and Alan W. Partin
	JCO May 1 2007: 1765–1771. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Cytotoxicity of Dimethylacetamide and Pharmacokinetics in Children Receiving Intravenous Busulfan
	Georg Hempel, Doris Oechtering, Claudia Lanvers-Kaminsky, Thomas Klingebiel, Josef Vormoor, Bernd Gruhn, and Joachim Boos
	JCO May 1 2007: 1772–1778. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Phase I Trial of Imexon in Patients With Advanced Malignancy
	Tomislav Dragovich, Michael Gordon, David Mendelson, Lucas Wong, Manuel Modiano, H.-H. Sherry Chow, Betty Samulitis, Steven O'Day, Kathryn Grenier, Evan Hersh, and Robert Dorr
	JCO May 1 2007: 1779–1784. [Abstract] [Full Text] [PDF]

Sarcomas
	Optimizing Treatment of Desmoid Tumors
	Dina Lev, Dhanasekaran Kotilingam, Caimiao Wei, Matthew T. Ballo, Gunar K. Zagars, Peter W.T. Pisters, Alexander A. Lazar, Shreyaskumar R. Patel, Robert S. Benjamin, and Raphael E. Pollock
	JCO May 1 2007: 1785–1791. [Abstract] [Full Text] [PDF] [Russian PDF]

REVIEW ARTICLE
	Pain Management in Hospitalized Cancer Patients: A Systematic Review
	Gabrielle R. Goldberg and R. Sean Morrison
	JCO May 1 2007: 1792–1801. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Presentation of Hodgkin's Lymphoma With Ophelia Syndrome

David Olmos, Antonio Rueda, Jose M. Jurado, and Emilio Alba

JCO May 1 2007: 1802–1803. [Full Text] [PDF]

Vocal Cord Metastasis From Breast Cancer

Rosario Francesco Grasso, Carlo Cosimo Quattrocchi, Sara Piciucchi, Giuseppe Perrone, Fabrizio Salvinelli, Carla Rabitti, and Bruno Beomonte Zobel

JCO May 1 2007: 1803–1805. [Full Text] [PDF]

Hepatocellular Carcinoma Presenting As Radiculopathy

Victor Ka-Siong Kho and Wen-Chih Chen

JCO May 1 2007: 1805–1806. [Full Text] [PDF]

ART OF ONCOLOGY

When Guidelines Are Not Enough

Robert J. Weil

JCO May 1 2007: 1807–1809. [Full Text] [PDF]

Guidelines Are Never Enough: A Commentary on "When Guidelines Are Not Enough"

Gregory P. Kalemkerian

JCO May 1 2007: 1810–1811. [Full Text] [PDF]

CORRESPONDENCE
	Erythropoietin Receptors on Cancer Cells: A Still Open Question
	Fulvio Della Ragione, Valeria Cucciolla, Adriana Borriello, Adriana Oliva, and Silverio Perrotta
	JCO May 1 2007: 1812–1813. [Full Text] [PDF]
	Are Erythropoietin Receptors Expressed in Tumors? Facts and Fiction—More Careful Studies Are Needed
	Neeraj Agarwal, Victor R. Gordeuk, and Josef T. Prchal
	JCO May 1 2007: 1813–1814. [Full Text] [PDF]
	In Reply
	Michael Henke, Dominik Mattern, and Frank Pajonk
	JCO May 1 2007: 1815. [Full Text] [PDF]
	Elementary, My Dear Watson
	Jose A. García-Saénz, Miguel Martín, and Eduardo Díaz-Rubio
	JCO May 1 2007: 1815-a–1816. [Full Text] [PDF]
	Vascular Endothelial Growth Factor Levels in Immunodepleted Plasma of Cancer Patients As a Possible Pharmacodynamic Marker for Bevacizumab Activity
	Fotios Loupakis, Alfredo Falcone, Gianluca Masi, Anna Fioravanti, Robert S. Kerbel, Mario Del Tacca, and Guido Bocci
	JCO May 1 2007: 1816–1818. [Full Text] [PDF]
	Successful Treatment of Leptomeningeal Disease in Colorectal Cancer With a Regimen of Bevacizumab, Temozolomide, and Irinotecan
	Geoffrey Y. Ku, George Krol, and David H. Ilson
	JCO May 1 2007: e14–16. [Full Text] [PDF]

ERRATUM

ERRATUM

JCO May 1 2007: 1819. [Full Text] [PDF]

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