IN MEMORIAM

Martin D. Abeloff, MD

Nancy E. Davidson

JCO Apr 1 2008: 1573–1574. [Full Text] [PDF]

CELEBRATING 25 YEARS OF JCO

Commentary

Breaking the Cure Barrier 25 Years Later

James F. Holland

JCO Apr 1 2008: 1575. [Full Text] [PDF] [From JCO 1983]

EDITORIALS

Dose Selection in Phase I Studies: Why We Should Always Go for the Top

Stefan Sleijfer and Erik Wiemer

JCO Apr 1 2008: 1576–1578. First published on Mar 10 2008; 10.1200/JCO.2007.15.5192. [Full Text] [PDF]

Should Intravenous Iron Be the Standard of Care in Oncology?

Michael Auerbach

JCO Apr 1 2008: 1579–1581. [Full Text] [PDF]

Determinants of RASistance to Anti–Epidermal Growth Factor Receptor Agents

José Baselga and Neal Rosen

JCO Apr 1 2008: 1582–1584. First published on Mar 3 2008; 10.1200/JCO.2007.15.3700. [Full Text] [PDF]

Optimal Schedule of Paclitaxel: Weekly Is Better

Ana M. Gonzalez-Angulo and Gabriel N. Hortobagyi

JCO Apr 1 2008: 1585–1587. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Patients With Advanced Solid Tumors
	Anne O'Donnell, Sandrine Faivre, Howard A. Burris, III, Daniel Rea, Vassiliki Papadimitrakopoulou, Nicholas Shand, Heidi A. Lane, Katharine Hazell, Ulrike Zoellner, John M. Kovarik, Cathryn Brock, Suzanne Jones, Eric Raymond, and Ian Judson
	JCO Apr 1 2008: 1588–1595. First published on Mar 10 2008; 10.1200/JCO.2007.14.0988. [Abstract] [Full Text] [PDF]
	Identifying Optimal Biologic Doses of Everolimus (RAD001) in Patients With Cancer Based on the Modeling of Preclinical and Clinical Pharmacokinetic and Pharmacodynamic Data
	Chiaki Tanaka, Terence O’Reilly, John M. Kovarik, Nicholas Shand, Katharine Hazell, Ian Judson, Eric Raymond, Sabine Zumstein-Mecker, Christine Stephan, Anne Boulay, Marc Hattenberger, George Thomas, and Heidi A. Lane
	JCO Apr 1 2008: 1596–1602. First published on Mar 10 2008; 10.1200/JCO.2007.14.1127. [Abstract] [Full Text] [PDF]
	Dose- and Schedule-Dependent Inhibition of the Mammalian Target of Rapamycin Pathway With Everolimus: A Phase I Tumor Pharmacodynamic Study in Patients With Advanced Solid Tumors
	Josep Tabernero, Federico Rojo, Emiliano Calvo, Howard Burris, Ian Judson, Katharine Hazell, Erika Martinelli, Santiago Ramon y Cajal, Suzanne Jones, Laura Vidal, Nicholas Shand, Teresa Macarulla, Francisco Javier Ramos, Sasa Dimitrijevic, Ulrike Zoellner, Pui Tang, Michael Stumm, Heidi A. Lane, David Lebwohl, and José Baselga
	JCO Apr 1 2008: 1603–1610. First published on Mar 10 2008; 10.1200/JCO.2007.14.5482. [Abstract] [Full Text] [PDF]

Supportive Care and Quality of Life
	Randomized, Multicenter, Controlled Trial Comparing the Efficacy and Safety of Darbepoetin Alfa Administered Every 3 Weeks With or Without Intravenous Iron in Patients With Chemotherapy-Induced Anemia
	Laurent Bastit, An Vandebroek, Sevilay Altintas, Bernd Gaede, Tamás Pintér, Tamas S. Suto, Tony W. Mossman, Kay E. Smith, and Johan F. Vansteenkiste
	JCO Apr 1 2008: 1611–1618. [Abstract] [Full Text] [PDF]
	Randomized Trial of Intravenous Iron Supplementation in Patients With Chemotherapy-Related Anemia Without Iron Deficiency Treated With Darbepoetin Alfa
	Paolo Pedrazzoli, Antonio Farris, Salvatore Del Prete, Filomena Del Gaizo, Daris Ferrari, Clara Bianchessi, Giuseppe Colucci, Alberto Desogus, Teresa Gamucci, Alessandro Pappalardo, Giuseppe Fornarini, Paola Pozzi, Alessandra Fabi, Roberto Labianca, Francesco Di Costanzo, Simona Secondino, Enrico Crucitta, Federica Apolloni, Antonio Del Santo, and Salvatore Siena
	JCO Apr 1 2008: 1619–1625. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Wild-Type KRAS Is Required for Panitumumab Efficacy in Patients With Metastatic Colorectal Cancer
	Rafael G. Amado, Michael Wolf, Marc Peeters, Eric Van Cutsem, Salvatore Siena, Daniel J. Freeman, Todd Juan, Robert Sikorski, Sid Suggs, Robert Radinsky, Scott D. Patterson, and David D. Chang
	JCO Apr 1 2008: 1626–1634. First published on Mar 3 2008; 10.1200/JCO.2007.14.7116. [Abstract] [Full Text] [PDF] [Hungarian PDF] [Chinese PDF]
	Complete Pathologic Response After Preoperative Chemotherapy for Colorectal Liver Metastases: Myth or Reality?
	René Adam, Dennis A. Wicherts, Robbert J. de Haas, Thomas Aloia, Francis Lévi, Bernard Paule, Catherine Guettier, Francis Kunstlinger, Valérie Delvart, Daniel Azoulay, and Denis Castaing
	JCO Apr 1 2008: 1635–1641. [Abstract] [Full Text] [PDF]

Breast Cancer
	Randomized Phase III Trial of Weekly Compared With Every-3-Weeks Paclitaxel for Metastatic Breast Cancer, With Trastuzumab for all HER-2 Overexpressors and Random Assignment to Trastuzumab or Not in HER-2 Nonoverexpressors: Final Results of Cancer and Leukemia Group B Protocol 9840
	Andrew D. Seidman, Donald Berry, Constance Cirrincione, Lyndsay Harris, Hyman Muss, P. Kelly Marcom, Grandella Gipson, Harold Burstein, Diana Lake, Charles L. Shapiro, Peter Ungaro, Larry Norton, Eric Winer, and Clifford Hudis
	JCO Apr 1 2008: 1642–1649. [Abstract] [Full Text] [PDF] [Chinese PDF]
	Phase III Randomized Placebo-Controlled Trial of Two Doses of Megestrol Acetate as Treatment for Menopausal Symptoms in Women With Breast Cancer: Southwest Oncology Group Study 9626
	J. Wendall Goodwin, Stephanie J. Green, Carol M. Moinpour, James D. Bearden, III, Jeffrey K. Giguere, Caroline S. Jiang, Scott M. Lippman, Silvana Martino, and Kathy S. Albain
	JCO Apr 1 2008: 1650–1656. [Abstract] [Full Text] [PDF]
	Clinical Classification of BRCA1 and BRCA2 DNA Sequence Variants: The Value of Cytokeratin Profiles and Evolutionary Analysis—A Report From the kConFab Investigators
	Amanda B. Spurdle, Sunil R. Lakhani, Sue Healey, Suzanne Parry, Leonard M. Da Silva, Ross Brinkworth, John L. Hopper, Melissa A. Brown, Davit Babikyan, Georgia Chenevix-Trench, Sean V. Tavtigian, and David E. Goldgar
	JCO Apr 1 2008: 1657–1663. [Abstract] [Full Text] [PDF]
	Double-Blind, Randomized Placebo Controlled Trial of Fulvestrant Compared With Exemestane After Prior Nonsteroidal Aromatase Inhibitor Therapy in Postmenopausal Women With Hormone Receptor–Positive, Advanced Breast Cancer: Results From EFECT
	Stephen Chia, William Gradishar, Louis Mauriac, Jose Bines, Frederic Amant, Miriam Federico, Luis Fein, Gilles Romieu, Aman Buzdar, John F.R. Robertson, Adam Brufsky, Kurt Possinger, Pamela Rennie, Francisco Sapunar, Elizabeth Lowe, and Martine Piccart
	JCO Apr 1 2008: 1664–1670. First published on Mar 3 2008; 10.1200/JCO.2007.13.5822. [Abstract] [Full Text] [PDF]
	Letrozole Suppresses Plasma Estradiol and Estrone Sulphate More Completely Than Anastrozole in Postmenopausal Women With Breast Cancer
	J. Michael Dixon, Lorna Renshaw, Oliver Young, Juliette Murray, E. Jane Macaskill, Mary McHugh, Elizabeth Folkerd, David A. Cameron, Roger P. A'Hern, and Mitch Dowsett
	JCO Apr 1 2008: 1671–1676. [Abstract] [Full Text] [PDF]
	Plasma Isoflavone Level and Subsequent Risk of Breast Cancer Among Japanese Women: A Nested Case-Control Study From the Japan Public Health Center-Based Prospective Study Group
	Motoki Iwasaki, Manami Inoue, Tetsuya Otani, Shizuka Sasazuki, Norie Kurahashi, Tsutomu Miura, Seiichiro Yamamoto, and Shoichiro Tsugane
	JCO Apr 1 2008: 1677–1683. First published on Mar 3 2008; 10.1200/JCO.2007.13.9964. [Abstract] [Full Text] [PDF]
	Economic Evaluation Alongside a Clinical Trial of Psycho-Educational Interventions to Improve Adjustment to Survivorship Among Patients With Breast Cancer
	Jeanne S. Mandelblatt, Jennifer Cullen, William F. Lawrence, Annette L. Stanton, Bin Yi, Lorna Kwan, and Patricia A. Ganz
	JCO Apr 1 2008: 1684–1690. [Abstract] [Full Text] [PDF]
	Randomized Phase II Adjuvant Trial of Dose-Dense Docetaxel Before or After Doxorubicin Plus Cyclophosphamide in Axillary Node-Positive Breast Cancer
	Shannon Puhalla, Ewa Mrozek, Donn Young, Susan Ottman, Anne McVey, Kari Kendra, Nancy J. Merriman, Mark Knapp, Taral Patel, Mark E. Thompson, James F. Maher, Timothy D. Moore, and Charles L. Shapiro
	JCO Apr 1 2008: 1691–1697. First published on Mar 3 2008; 10.1200/JCO.2007.14.3941. [Abstract] [Full Text] [PDF] [Hungarian PDF]

Thoracic Oncology
	Phase III Trial of Pemetrexed Plus Best Supportive Care Compared With Best Supportive Care in Previously Treated Patients With Advanced Malignant Pleural Mesothelioma
	Jacek Jassem, Rodryg Ramlau, Armando Santoro, Wolfgang Schuette, Assad Chemaissani, Shengyan Hong, Johannes Blatter, Susumu Adachi, Axel Hanauske, and Christian Manegold
	JCO Apr 1 2008: 1698–1704. [Abstract] [Full Text] [PDF] [Chinese PDF]

Genitourinary Cancer
	Concordance of Survival in Family Members With Prostate Cancer
	Kari Hemminki, Jianguang Ji, Asta Försti, Jan Sundquist, and Per Lenner
	JCO Apr 1 2008: 1705–1709. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Retrospective Study of Childhood Ganglioneuroma
	Bruno De Bernardi, Claudio Gambini, Riccardo Haupt, Claudio Granata, Antonino Rizzo, Massimo Conte, Gian Paolo Tonini, Maurizio Bianchi, Maria Giuliano, Roberto Luksch, Arcangelo Prete, Elisabetta Viscardi, Alberto Garaventa, Angela Rita Sementa, Paolo Bruzzi, and Paola Angelini
	JCO Apr 1 2008: 1710–1716. [Abstract] [Full Text] [PDF]
	Easing of Suffering in Children With Cancer at the End of Life: Is Care Changing?
	Joanne Wolfe, Jim F. Hammel, Kelly E. Edwards, Janet Duncan, Michael Comeau, Joanna Breyer, Sarah A. Aldridge, Holcombe E. Grier, Charles Berde, Veronica Dussel, and Jane C. Weeks
	JCO Apr 1 2008: 1717–1723. [Abstract] [Full Text] [PDF]

Clinical Practice
	Physician-Identified Factors Affecting Patient Participation in Reaching Treatment Decisions
	Heather L. Shepherd, Martin H.N. Tattersall, and Phyllis N. Butow
	JCO Apr 1 2008: 1724–1731. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Phase I Study of Bevacizumab Added to Fluorouracil- and Hydroxyurea-Based Concomitant Chemoradiotherapy for Poor-Prognosis Head and Neck Cancer
	Tanguy Y. Seiwert, Daniel J. Haraf, Ezra E.W. Cohen, Kerstin Stenson, Mary Ellyn Witt, Allison Dekker, Masha Kocherginsky, Ralph R. Weichselbaum, Helen X. Chen, and Everett E. Vokes
	JCO Apr 1 2008: 1732–1741. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	Structure and Clinical Relevance of the Epidermal Growth Factor Receptor in Human Cancer
	Amit Kumar, Edward T. Petri, Balazs Halmos, and Titus J. Boggon
	JCO Apr 1 2008: 1742–1751. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Widespread Metastases After Resection of Noninvasive Thymoma

Eric O. Gamboa, Vishal Sawhney, Reynerio S. Lanoy, Nairmeen A. Haller, Angela T. Powell, and Sandra V. Hazra

JCO Apr 1 2008: 1752–1755. [Full Text] [PDF]

Colon Cancer 15 Years After Ureterosigmoidostomy

Chris C.W. Chan, Alan Tan, and Huda Salman

JCO Apr 1 2008: 1755–1757. [Full Text] [PDF]

Value of Cytogenetic Analysis in the Treatment of Dermatofibrosarcoma Protuberans

Delphine Kerob, Florence Pedeutour, Christophe Leboeuf, Olivier Verola, Eric de Kerviler, Jean Marie Servant, Farid Sarandi, Guilhem Bousquet, Isabelle Madelaine-Chambrin, Christelle Pruvost, Fabien Calvo, Anne Janin, and Celeste Lebbe

JCO Apr 1 2008: 1757–1759. [Full Text] [PDF]

ART OF ONCOLOGY

The Sentinel

Bruce H. Campbell

JCO Apr 1 2008: 1760–1761. [Full Text] [PDF]

Missed Opportunities: Commentary on "The Sentinel"

Timothy J. Moynihan and Charles F. von Gunten

JCO Apr 1 2008: 1762–1763. [Full Text] [PDF]

CORRESPONDENCE
	Modification of Tamoxifen Response: What Have We Learned?
	Timothy L. Lash, Thomas P. Ahern, Deirdre Cronin-Fenton, Jens Peter Garne, Stephen Hamilton-Dutoit, Marianne Ewertz Kvistgaard, Carol L. Rosenberg, Rebecca A. Silliman, and Henrik Toft Sørensen
	JCO Apr 1 2008: 1764–1765. [Full Text] [PDF]
	In Reply
	Zeruesenay Desta and David A. Flockhart
	JCO Apr 1 2008: 1765–1766. [Full Text] [PDF]
	Ethnic Considerations in Pharmacogenetic Studies
	Ruth A. Branford, Panagiotis Pantelidis, and Joy R. Ross
	JCO Apr 1 2008: 1766–1767. [Full Text] [PDF]
	In Reply
	Sharon Marsh, Jim Paul, Howard L. McLeod, and Robert Brown
	JCO Apr 1 2008: 1767–1768. [Full Text] [PDF]
	In Early-Stage Breast Cancer, the Estrogen Receptor Interacts With Correlation Between Human Epidermal Growth Factor Receptor 2 Status and Age at Diagnosis, Tumor Grade, and Lymph Node Involvement
	Patrick Neven, Olivier Brouckaert, Vanya Van Belle, Isabelle Vanden Bempt, Wouter Hendrickx, Hyonil Cho, Karen Deraedt, Ben Van Calster, Sabine Van Huffel, Philippe Moerman, Frederic Amant, Karin Leunen, Ann Smeets, Hans Wildiers, Robert Paridaens, Ignace Vergote, and Marie-Rose Christiaens
	JCO Apr 1 2008: 1768–1769. [Full Text] [PDF]
	In Reply
	John M.S. Bartlett, Ian O. Ellis, Mitch Dowsett, Elizabeth A. Mallon, David A. Cameron, Stephen Johnston, Emma Hall, Roger A’Hern, Clare Peckitt, Judith M. Bliss, Lindsay Johnson, Peter Barrett-Lee, and Paul Ellis
	JCO Apr 1 2008: 1769–1771. [Full Text] [PDF]
	Prognostic Role of CA-125 Nadir in Stage IV Epithelial Ovarian Cancer
	Aleix Prat, Marta Parera, and Josep Maria Del Campo
	JCO Apr 1 2008: 1771–1772. [Full Text] [PDF]
	In Reply
	William E. Winter, III, G. Larry Maxwell, and Chunqiao Tian
	JCO Apr 1 2008: 1772. [Full Text] [PDF]
	Induction Chemotherapy Before Chemoradiation in Locally Advanced Non–Small-Cell Lung Cancer: Failure After Failure, Again and Again
	Branislav Jeremic and Caro Koning
	JCO Apr 1 2008: e1–e2. [Full Text] [PDF]
	Resolving the Optimal Timing of Radiotherapy After Radical Prostatectomy: The Need for Further Research
	Christopher Parker and Matthew R. Sydes
	JCO Apr 1 2008: e3. [Full Text] [PDF]
	Journal of Clinical Oncology: The Next 25 Years
	Lodovico Balducci
	JCO Apr 1 2008: e4. [Full Text] [PDF]

ERRATA

ERRATUM

JCO Apr 1 2008: 1773. [Full Text] [PDF]

ERRATUM

JCO Apr 1 2008: 1773. [Full Text] [PDF]

ERRATUM

JCO Apr 1 2008: 1773. [Full Text] [PDF]

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