CELEBRATING 25 YEARS OF JCO

Commentary

Evolution of Knowledge Related to Breast Cancer Heterogeneity: A 25-Year Retrospective

Bernard Fisher, Carol K. Redmond, and Edwin R. Fisher

JCO May 1 2008: 2068–2071. [Full Text] [PDF] [From JCO 1983]

EDITORIALS

Should Intensity-Modulated Radiation Therapy Be the Standard of Care in the Conservatively Managed Breast Cancer Patient?

Bruce G. Haffty, Thomas A. Buchholz, and Beryl McCormick

JCO May 1 2008: 2072–2074. First published on Feb 19 2008; 10.1200/JCO.2007.15.9442. [Full Text] [PDF]

One to Three Versus Four or More Positive Nodes and Postmastectomy Radiotherapy: Time to End the Debate

Lawrence B. Marks, Jing Zeng, and Leonard R. Prosnitz

JCO May 1 2008: 2075–2077. [Full Text] [PDF]

Will We Ever Be Ready for Blood Level–Guided Therapy?

Christine M. Walko and Howard L. McLeod

JCO May 1 2008: 2078–2079. [Full Text] [PDF]

Predicting Fluorouracil Toxicity: Can We Finally Do It?

Hany H. Ezzeldin and Robert B. Diasio

JCO May 1 2008: 2080–2082. First published on Feb 25 2008; 10.1200/JCO.2007.15.5481. [Full Text] [PDF]

Practice-Based Evidence of the Beneficial Impact of Positron Emission Tomography in Clinical Oncology

Steven M. Larson

JCO May 1 2008: 2083–2084. First published on Mar 24 2008; 10.1200/JCO.2007.15.6935. [Full Text] [PDF]

ORIGINAL REPORTS
Breast Cancer
	A Multicenter Randomized Trial of Breast Intensity-Modulated Radiation Therapy to Reduce Acute Radiation Dermatitis
	Jean-Philippe Pignol, Ivo Olivotto, Eileen Rakovitch, Sandra Gardner, Katharina Sixel, Wayne Beckham, Thi Trinh Thuc Vu, Pauline Truong, Ida Ackerman, and Lawrence Paszat
	JCO May 1 2008: 2085–2092. First published on Feb 19 2008; 10.1200/JCO.2007.15.2488. [Abstract] [Full Text] [PDF]
	Nomogram for the Prediction of Having Four or More Involved Nodes for Sentinel Lymph Node–Positive Breast Cancer
	Angela Katz, Barbara L. Smith, Mehra Golshan, Andrzej Niemierko, Wendy Kobayashi, Rita Abi Raad, Alexandra Kelada, Levi Rizk, Julia S. Wong, Jennifer R. Bellon, Michele Gadd, Michelle Specht, and Alphonse G. Taghian
	JCO May 1 2008: 2093–2098. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer
	Individual Fluorouracil Dose Adjustment Based on Pharmacokinetic Follow-Up Compared With Conventional Dosage: Results of a Multicenter Randomized Trial of Patients With Metastatic Colorectal Cancer
	Erick Gamelin, Remy Delva, Jacques Jacob, Yacine Merrouche, Jean Luc Raoul, Denis Pezet, Etienne Dorval, Gilles Piot, Alain Morel, and Michele Boisdron-Celle
	JCO May 1 2008: 2099–2105. [Abstract] [Full Text] [PDF]
	Prognostic Implications of the Distribution of Lymph Node Metastases in Rectal Cancer After Neoadjuvant Chemoradiotherapy
	Tobias Leibold, Jinru Shia, Leyo Ruo, Bruce D. Minsky, Timothy Akhurst, Marc J. Gollub, Michelle S. Ginsberg, Steven Larson, Elyn Riedel, W. Douglas Wong, and José G. Guillem
	JCO May 1 2008: 2106–2111. First published on Mar 24 2008; 10.1200/JCO.2007.12.7704. [Abstract] [Full Text] [PDF]
	Prediction Model for Estimating the Survival Benefit of Adjuvant Radiotherapy for Gallbladder Cancer
	Samuel J. Wang, C. David Fuller, Jong-Sung Kim, Dean F. Sittig, Charles R. Thomas, Jr, and Peter M. Ravdin
	JCO May 1 2008: 2112–2117. First published on Mar 31 2008; 10.1200/JCO.2007.14.7934. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Potential Regional Differences for the Tolerability Profiles of Fluoropyrimidines
	Daniel G. Haller, Jim Cassidy, Stephen J. Clarke, David Cunningham, Eric Van Cutsem, Paulo M. Hoff, Mace L. Rothenberg, Leonard B. Saltz, Hans-Joachim Schmoll, Carmen Allegra, Joseph R. Bertino, Jean-Yves Douillard, Bengt G. Gustavsson, Gerard Milano, Michael O'Connell, Youcef Rustum, Josep Tabernero, Frank Gilberg, Florin Sirzén, and Chris Twelves
	JCO May 1 2008: 2118–2123. [Abstract] [Full Text] [PDF]
	Treatment With the Radiolabeled Somatostatin Analog [177Lu-DOTA0,Tyr3]Octreotate: Toxicity, Efficacy, and Survival
	Dik J. Kwekkeboom, Wouter W. de Herder, Boen L. Kam, Casper H. van Eijck, Martijn van Essen, Peter P. Kooij, Richard A. Feelders, Maarten O. van Aken, and Eric P. Krenning
	JCO May 1 2008: 2124–2130. [Abstract] [Full Text] [PDF]

Phase I and Clinical Pharmacology
	Role of Genetic and Nongenetic Factors for Fluorouracil Treatment-Related Severe Toxicity: A Prospective Clinical Trial by the German 5-FU Toxicity Study Group
	Matthias Schwab, Ulrich M. Zanger, Claudia Marx, Elke Schaeffeler, Kathrin Klein, Jürgen Dippon, Reinhold Kerb, Julia Blievernicht, Joachim Fischer, Ute Hofmann, Carsten Bokemeyer, and Michel Eichelbaum
	JCO May 1 2008: 2131–2138. First published on Feb 25 2008; 10.1200/JCO.2006.10.4182. [Abstract] [Full Text] [PDF] [Publisher's Note]
	Phase I Pharmacokinetic and Pharmacodynamic Study of the Oral, Small-Molecule Mitogen-Activated Protein Kinase Kinase 1/2 Inhibitor AZD6244 (ARRY-142886) in Patients With Advanced Cancers
	Alex A. Adjei, Roger B. Cohen, Wilbur Franklin, Clive Morris, David Wilson, Julian R. Molina, Lorelei J. Hanson, Lia Gore, Laura Chow, Stephen Leong, Lara Maloney, Gilad Gordon, Heidi Simmons, Allison Marlow, Kevin Litwiler, Suzy Brown, Gregory Poch, Katie Kane, Jerry Haney, and S. Gail Eckhardt
	JCO May 1 2008: 2139–2146. First published on Apr 7 2008; 10.1200/JCO.2007.14.4956. [Abstract] [Full Text] [PDF]
	Phase I Trial of the Prostate-Specific Membrane Antigen–Directed Immunoconjugate MLN2704 in Patients With Progressive Metastatic Castration-Resistant Prostate Cancer
	Matthew D. Galsky, Mario Eisenberger, Sandra Moore-Cooper, W. Kevin Kelly, Susan F. Slovin, Anthony DeLaCruz, Yih Lee, Iain J. Webb, and Howard I. Scher
	JCO May 1 2008: 2147–2154. First published on Mar 24 2008; 10.1200/JCO.2007.15.0532. [Abstract] [Full Text] [PDF]

Diagnostics
	Impact of Positron Emission Tomography/Computed Tomography and Positron Emission Tomography (PET) Alone on Expected Management of Patients With Cancer: Initial Results From the National Oncologic PET Registry
	Bruce E. Hillner, Barry A. Siegel, Dawei Liu, Anthony F. Shields, Ilana F. Gareen, Lucy Hanna, Sharon Hartson Stine, and R. Edward Coleman
	JCO May 1 2008: 2155–2161. First published on Mar 24 2008; 10.1200/JCO.2007.14.5631. [Abstract] [Full Text] [PDF]

Bone Marrow Transplantation
	Individual Physician Practice Variation in Hematopoietic Cell Transplantation
	Stephanie J. Lee, Steven Joffe, Andrew S. Artz, Richard E. Champlin, Stella M. Davies, Madan Jagasia, Nancy A. Kernan, Fausto R. Loberiza, Jr, Robert J. Soiffer, and Mary Eapen
	JCO May 1 2008: 2162–2170. First published on Mar 31 2008; 10.1200/JCO.2007.15.0169. [Abstract] [Full Text] [PDF]

Hematologic Malignancies
	Multicenter, Randomized, Double-Blind, Placebo-Controlled Study of Thalidomide Plus Dexamethasone Compared With Dexamethasone As Initial Therapy for Newly Diagnosed Multiple Myeloma
	S. Vincent Rajkumar, Laura Rosiñol, Mohamad Hussein, John Catalano, Wieslaw Jedrzejczak, Lela Lucy, Marta Olesnyckyj, Zhinuan Yu, Robert Knight, Jerome B. Zeldis, and Joan Bladé
	JCO May 1 2008: 2171–2177. First published on Mar 24 2008; 10.1200/JCO.2007.14.1853. [Abstract] [Full Text] [PDF]

Melanoma
	Double-Blind Randomized Phase II Study of the Combination of Sorafenib and Dacarbazine in Patients With Advanced Melanoma: A Report From the 11715 Study Group
	David F. McDermott, Jeffrey A. Sosman, Rene Gonzalez, F. Stephen Hodi, Gerald P. Linette, Jon Richards, James W. Jakub, Muralidhar Beeram, Stefano Tarantolo, Sanjiv Agarwala, Gary Frenette, Igor Puzanov, Lee Cranmer, Karl Lewis, John Kirkwood, J. Michael White, Chenghua Xia, Kiran Patel, and Evan Hersh
	JCO May 1 2008: 2178–2185. [Abstract] [Full Text] [PDF]

Pediatric Oncology
	Prospective Analysis of TEL Gene Rearrangements in Childhood Acute Lymphoblastic Leukemia: A Children's Oncology Group Study
	Jeffrey E. Rubnitz, David Wichlan, Meenakshi Devidas, Jonathan Shuster, Stephen B. Linda, Joanne Kurtzberg, Beverly Bell, Stephen P. Hunger, Allen Chauvenet, Ching-Hon Pui, Bruce Camitta, and Jeanette Pullen
	JCO May 1 2008: 2186–2191. [Abstract] [Full Text] [PDF]

Neurooncology
	MGMT Promoter Methylation Status Can Predict the Incidence and Outcome of Pseudoprogression After Concomitant Radiochemotherapy in Newly Diagnosed Glioblastoma Patients
	Alba A. Brandes, Enrico Franceschi, Alicia Tosoni, Valeria Blatt, Annalisa Pession, Giovanni Tallini, Roberta Bertorelle, Stefania Bartolini, Fabio Calbucci, Alvaro Andreoli, Giampiero Frezza, Marco Leonardi, Federica Spagnolli, and Mario Ermani
	JCO May 1 2008: 2192–2197. [Abstract] [Full Text] [PDF]

Prevention
	Cancer Survivors’ Adherence to Lifestyle Behavior Recommendations and Associations With Health-Related Quality of Life: Results From the American Cancer Society's SCS-II
	Christopher M. Blanchard, Kerry S. Courneya, and Kevin Stein
	JCO May 1 2008: 2198–2204. [Abstract] [Full Text] [PDF]

Clinical Trials
	Consistency of Phase III Clinical Trial Abstracts Presented at an Annual Meeting of the American Society of Clinical Oncology Compared With Their Subsequent Full-Text Publications
	Vincent C. Tam and Sebastien J. Hotte
	JCO May 1 2008: 2205–2211. [Abstract] [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Burkitt's Leukemia After Treatment of Primary Mediastinal Nonseminomatous Germ Cell Tumor

Vinod Raina, Kunjahari Medhi, Satyapal Kataria, Rajive Kumar, Anita Chopra, Dipti Kalita, and Pratibha Amare Kadam

JCO May 1 2008: 2212–2214. [Full Text] [PDF]

Invasive Pulmonary Aspergillosis Associated With Marijuana Use in a Man With Colorectal Cancer

David W. Cescon, Andrea V. Page, Susan Richardson, Malcolm J. Moore, Scott Boerner, and Wayne L. Gold

JCO May 1 2008: 2214–2215. [Full Text] [PDF] [Publisher's Note]

Intrathoracic Malignant Peripheral Nerve Sheath Tumor in Neurofibromatosis 1

Bo H. Chao, Kimberly A. Stogner-Underwood, Jonathan Kiev, and Thomas J. Smith

JCO May 1 2008: 2216–2218. [Full Text] [PDF]

ART OF ONCOLOGY

Horns of a Dilemma

Thomas A. Samuel and Karthi Subbannan

JCO May 1 2008: 2219–2220. [Full Text] [PDF]

The Physician on the Horns of a Dilemma

Charles L. Loprinzi and Gregory P. Kalemkerian

JCO May 1 2008: 2221–2222. [Full Text] [PDF]

CORRESPONDENCE

Ixabepilone Plus Capecitabine for Metastatic Breast Cancer Progressing After Anthracycline and Taxane Treatment

Eva S. Thomas

JCO May 1 2008: 2223. [Full Text] [PDF]

Randomized Clinical Trials, Clinical Use, and Hope: What Relationship?

Richard A. Rettig, Peter D. Jacobson, Cynthia M. Farquhar, and Wade M. Aubry

JCO May 1 2008: 2223-a–2224. [Full Text] [PDF]

Pharmacoeconomic Benefits of Capecitabine-Based Chemotherapy in Metastatic Colorectal Cancer

Edward Chu and Thomas H. Cartwright

JCO May 1 2008: 2224–2226. [Full Text] [PDF]

To the Editor

Jim Cassidy, Hans-Joachim Schmoll, and Eric Van Cutsem

JCO May 1 2008: 2226–2227. [Full Text] [PDF]

In Reply

Robert J. Mayer

JCO May 1 2008: 2228. [Full Text] [PDF]

KRAS Mutation Signature in Colorectal Tumors Significantly Overlaps With the Cetuximab Response Signature

Aurélien de Reyniès, Valérie Boige, Gérard Milano, Jean Faivre, and Pierre Laurent-Puig

JCO May 1 2008: 2228-a–2230. [Full Text] [PDF]

In Reply

Christopher T. Harbison, David J. Mauro, Edwin A. Clark, and Shirin Khambata-Ford

JCO May 1 2008: 2230–2231. [Full Text] [PDF]

Hepatic Arterial Infusion: The Beginning of the Combination Era

Bernhard C. Pestalozzi, Salvatore Gruttadauria, and Pierre-Alain Clavien

JCO May 1 2008: 2231–2232. [Full Text] [PDF]

In Reply

Simone Mocellin, Pierluigi Pilati, and Donato Nitti

JCO May 1 2008: 2232–2233. [Full Text] [PDF]

Germline PTEN Mutations As a Cause of Early-Onset Endometrial Cancer

Gideon M. Blumenthal and Phillip A. Dennis

JCO May 1 2008: 2234. [Full Text] [PDF]

In Reply

Karen H. Lu, Molly Daniels, and Russell R. Broaddus

JCO May 1 2008: 2234-a. [Full Text] [PDF]

Is There a Definitive Answer to the Question of Involved-Field Radiotherapy for Inoperable Non–Small-Cell Lung Cancer?

Carlos Genesio Bezerra Lima, Jr and Arno Lotar Cordova, Jr

JCO May 1 2008: 2235. [Full Text] [PDF]

In Reply

Kenneth Rosenzweig

JCO May 1 2008: 2235-a–2236. [Full Text] [PDF]

Area Between Curves: What You See Is Not What You Get

Mithat Gonen

JCO May 1 2008: 2236. [Full Text] [PDF]

In Reply

Jaffer A. Ajani

JCO May 1 2008: 2236-a–2237. [Full Text] [PDF]

ERRATA

ERRATUM

JCO May 1 2008: 2238. [Full Text] [PDF]

ERRATUM

JCO May 1 2008: 2238-a. [Full Text] [PDF]

ERRATUM

JCO May 1 2008: 2238-b. [Full Text] [PDF]

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