CELEBRATING 25 YEARS OF JCO

Commentary

Retinol, Vitamins, and Cancer Prevention: 25 Years of Learning and Relearning

Gary E. Goodman, David S. Alberts, and Frank L. Meyskens

JCO Dec 1 2008: 5495–5496. First published on Nov 3 2008; 10.1200/JCO.2008.19.0884. [Full Text] [PDF] [From JCO 1983]

EDITORIALS

Targeting Polo-Like Kinase: Learning Too Little Too Late?

David Olmos, Charles Swanton, and Johann de Bono

JCO Dec 1 2008: 5497–5499. First published on Oct 27 2008; 10.1200/JCO.2008.18.6585. [Full Text] [PDF]

Reirradiation and Concurrent Chemotherapy After Salvage Surgery: Pay Now or Pay Later

Stuart J. Wong and Sharon Spencer

JCO Dec 1 2008: 5500–5501. First published on Oct 20 2008; 10.1200/JCO.2008.19.0868. [Full Text] [PDF]

Clinical Relevance of "Late" in the Management of Late Relapse After Treatment for a Germ Cell Tumor

Guy C. Toner

JCO Dec 1 2008: 5502–5503. First published on Oct 20 2008; 10.1200/JCO.2008.18.7120. [Full Text] [PDF]

ORIGINAL REPORTS
Phase I and Clinical Pharmacology
	Phase I Study of ON 01910.Na, a Novel Modulator of the Polo-Like Kinase 1 Pathway, in Adult Patients With Solid Tumors
	Antonio Jimeno, Jing Li, Wells A. Messersmith, Daniel Laheru, Michelle A. Rudek, Manoj Maniar, Manuel Hidalgo, Sharyn D. Baker, and Ross C. Donehower
	JCO Dec 1 2008: 5504–5510. First published on Oct 27 2008; 10.1200/JCO.2008.17.9788. [Abstract] [Full Text] [PDF]
	Phase I Dose Escalation and Pharmacokinetic Study of BI 2536, a Novel Polo-Like Kinase 1 Inhibitor, in Patients With Advanced Solid Tumors
	Klaus Mross, Annette Frost, Simone Steinbild, Susanne Hedbom, Jochen Rentschler, Rolf Kaiser, Nicolas Rouyrre, Dirk Trommeshauser, Cornelia E. Hoesl, and Gerd Munzert
	JCO Dec 1 2008: 5511–5517. First published on Oct 27 2008; 10.1200/JCO.2008.16.1547. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Randomized Trial of Postoperative Reirradiation Combined With Chemotherapy After Salvage Surgery Compared With Salvage Surgery Alone in Head and Neck Carcinoma
	François Janot, Dominique de Raucourt, Ellen Benhamou, Christophe Ferron, Gilles Dolivet, René-Jean Bensadoun, Marc Hamoir, Bernard Géry, Morbize Julieron, Marine Castaing, Etienne Bardet, Vincent Grégoire, and Jean Bourhis
	JCO Dec 1 2008: 5518–5523. First published on Oct 20 2008; 10.1200/JCO.2007.15.0102. [Abstract] [Full Text] [PDF] [Italian PDF] [French PDF]

Genitourinary Cancer
	Clinical Outcome and Predictors of Survival in Late Relapse of Germ Cell Tumor
	David S. Sharp, Brett S. Carver, Scott E. Eggener, G. Varuni Kondagunta, Robert J. Motzer, George J. Bosl, and Joel Sheinfeld
	JCO Dec 1 2008: 5524–5529. First published on Oct 20 2008; 10.1200/JCO.2007.15.7453. [Abstract] [Full Text] [PDF]

Gynecologic Cancer
	"BRCAness" Syndrome in Ovarian Cancer: A Case-Control Study Describing the Clinical Features and Outcome of Patients With Epithelial Ovarian Cancer Associated With BRCA1 and BRCA2 Mutations
	David S.P. Tan, Christian Rothermundt, Karen Thomas, Elizabeth Bancroft, Rosalind Eeles, Susan Shanley, Audrey Ardern-Jones, Andrew Norman, Stanley B. Kaye, and Martin E. Gore
	JCO Dec 1 2008: 5530–5536. First published on Oct 27 2008; 10.1200/JCO.2008.16.1703. [Abstract] [Full Text] [PDF]

Treatment-Related Complications
	Late Congestive Heart Failure After Hematopoietic Cell Transplantation
	Saro H. Armenian, Can-Lan Sun, Liton Francisco, Julia Steinberger, Seira Kurian, F. Lennie Wong, Jon Sharp, Richard Sposto, Stephen J. Forman, and Smita Bhatia
	JCO Dec 1 2008: 5537–5543. First published on Sep 22 2008; 10.1200/JCO.2008.17.7428. [Abstract] [Full Text] [PDF]

Breast Cancer
	Phase III, Double-Blind, Randomized Study Comparing Lapatinib Plus Paclitaxel With Placebo Plus Paclitaxel As First-Line Treatment for Metastatic Breast Cancer
	Angelo Di Leo, Henry L. Gomez, Zeba Aziz, Zanete Zvirbule, Jose Bines, Michael C. Arbushites, Stephanie F. Guerrera, Maria Koehler, Cristina Oliva, Steven H. Stein, Lisa S. Williams, Judy Dering, Richard S. Finn, and Michael F. Press
	JCO Dec 1 2008: 5544–5552. First published on Oct 27 2008; 10.1200/JCO.2008.16.2578. [Abstract] [Full Text] [PDF] [Hungarian PDF] [French PDF] [German PDF]
	Chemotherapy Use for Hormone Receptor–Positive, Lymph Node–Negative Breast Cancer
	Michael J. Hassett, Melissa E. Hughes, Joyce C. Niland, Stephen B. Edge, Richard L. Theriault, Yu-Ning Wong, John Wilson, W. Bradford Carter, Douglas W. Blayney, and Jane C. Weeks
	JCO Dec 1 2008: 5553–5560. First published on Oct 27 2008; 10.1200/JCO.2008.17.9705. [Abstract] [Full Text] [PDF]
	Roles of Radiotherapy and Chemotherapy in the Development of Contralateral Breast Cancer
	Maartje J. Hooning, Berthe M.P. Aleman, Michael Hauptmann, Margreet H.A. Baaijens, Jan G.M. Klijn, Ruth Noyon, Marilyn Stovall, and Flora E. van Leeuwen
	JCO Dec 1 2008: 5561–5568. First published on Oct 14 2008; 10.1200/JCO.2007.16.0192. [Abstract] [Full Text] [PDF]
	Prognostic and Predictive Value of Centrally Reviewed Ki-67 Labeling Index in Postmenopausal Women With Endocrine-Responsive Breast Cancer: Results From Breast International Group Trial 1-98 Comparing Adjuvant Tamoxifen With Letrozole
	Giuseppe Viale, Anita Giobbie-Hurder, Meredith M. Regan, Alan S. Coates, Mauro G. Mastropasqua, Patrizia Dell'Orto, Eugenio Maiorano, Gaëtan MacGrogan, Stephen G. Braye, Christian Öhlschlegel, Patrick Neven, Zsolt Orosz, Wojciech P. Olszewski, Fiona Knox, Beat Thürlimann, Karen N. Price, Monica Castiglione-Gertsch, Richard D. Gelber, Barry A. Gusterson, and Aron Goldhirsch
	JCO Dec 1 2008: 5569–5575. First published on Nov 3 2008; 10.1200/JCO.2008.17.0829. [Abstract] [Full Text] [PDF] [German PDF]

Epidemiology
	Body-Mass Index and Progression of Hepatitis B: A Population-Based Cohort Study in Men
	Ming-Whei Yu, Wei-Liang Shih, Chih-Lin Lin, Chun-Jen Liu, Jhih-Wei Jian, Keh-Sung Tsai, and Chien-Jen Chen
	JCO Dec 1 2008: 5576–5582. First published on Oct 27 2008; 10.1200/JCO.2008.16.1075. [Abstract] [Full Text] [PDF]

Sarcomas
	Randomized, Phase II Study of the Thrombospondin-1-Mimetic Angiogenesis Inhibitor ABT-510 in Patients With Advanced Soft Tissue Sarcoma
	Laurence H. Baker, Eric K. Rowinsky, David Mendelson, Rod A. Humerickhouse, Raymond A. Knight, Jiang Qian, Robert A. Carr, Gary B. Gordon, and George D. Demetri
	JCO Dec 1 2008: 5583–5588. First published on Nov 3 2008; 10.1200/JCO.2008.17.4706. [Abstract] [Full Text] [PDF]

Thoracic Oncology
	EGFR Mutations Predict Survival Benefit From Gefitinib in Patients With Advanced Lung Adenocarcinoma: A Historical Comparison of Patients Treated Before and After Gefitinib Approval in Japan
	Toshimi Takano, Tomoya Fukui, Yuichiro Ohe, Koji Tsuta, Seiichiro Yamamoto, Hiroshi Nokihara, Noboru Yamamoto, Ikuo Sekine, Hideo Kunitoh, Koh Furuta, and Tomohide Tamura
	JCO Dec 1 2008: 5589–5595. First published on Sep 15 2008; 10.1200/JCO.2008.16.7254. [Abstract] [Full Text] [PDF]
	Circulating 25-Hydroxyvitamin D, VDR Polymorphisms, and Survival in Advanced Non–Small-Cell Lung Cancer
	Rebecca Suk Heist, Wei Zhou, Zhaoxi Wang, Geoffrey Liu, Donna Neuberg, Li Su, Kofi Asomaning, Bruce W. Hollis, Thomas J. Lynch, John C. Wain, Edward Giovannucci, and David C. Christiani
	JCO Dec 1 2008: 5596–5602. First published on Oct 20 2008; 10.1200/JCO.2008.18.0406. [Abstract] [Full Text] [PDF]

Neurooncology
	Phase I/II Trial of Erlotinib and Temozolomide With Radiation Therapy in the Treatment of Newly Diagnosed Glioblastoma Multiforme: North Central Cancer Treatment Group Study N0177
	Paul D. Brown, Sunil Krishnan, Jann N. Sarkaria, Wenting Wu, Kurt A. Jaeckle, Joon H. Uhm, Francois J. Geoffroy, Robert Arusell, Gaspar Kitange, Robert B. Jenkins, John W. Kugler, Roscoe F. Morton, Kendrith M. Rowland, Jr, Paul Mischel, William H. Yong, Bernd W. Scheithauer, David Schiff, Caterina Giannini, and Jan C. Buckner
	JCO Dec 1 2008: 5603–5609. First published on Oct 27 2008; 10.1200/JCO.2008.18.0612. [Abstract] [Full Text] [PDF]
	Randomized Phase II Study of Cilengitide, an Integrin-Targeting Arginine-Glycine-Aspartic Acid Peptide, in Recurrent Glioblastoma Multiforme
	David A. Reardon, Karen L. Fink, Tom Mikkelsen, Timothy F. Cloughesy, Alison O'Neill, Scott Plotkin, Michael Glantz, Paula Ravin, Jeffrey J. Raizer, Keith M. Rich, David Schiff, William R. Shapiro, Susan Burdette-Radoux, Edward J. Dropcho, Sabine M. Wittemer, Johannes Nippgen, Martin Picard, and L. Burt Nabors
	JCO Dec 1 2008: 5610–5617. First published on Nov 3 2008; 10.1200/JCO.2008.16.7510. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Nonpharmacologic Strategies for Managing Common Chemotherapy Adverse Effects: A Systematic Review
	Kerryann Lotfi-Jam, Mariko Carey, Michael Jefford, Penelope Schofield, Catherine Charleson, and Sanchia Aranda
	JCO Dec 1 2008: 5618–5629. First published on Nov 3 2008; 10.1200/JCO.2007.15.9053. [Abstract] [Full Text] [PDF]

BIOLOGY OF NEOPLASIA
	A Decade of Tissue Microarrays: Progress in the Discovery and Validation of Cancer Biomarkers
	Robert L. Camp, Veronique Neumeister, and David L. Rimm
	JCO Dec 1 2008: 5630–5637. First published on Oct 20 2008; 10.1200/JCO.2008.17.3567. [Abstract] [Full Text] [PDF] [French PDF]

SPECIAL ARTICLE
	Recommendations for Collection and Handling of Specimens From Group Breast Cancer Clinical Trials
	Brian R. Leyland-Jones, Christine B. Ambrosone, John Bartlett, Matthew J.C. Ellis, Rebecca A. Enos, Adekunle Raji, Michael R. Pins, Jo Anne Zujewski, Stephen M. Hewitt, John F. Forbes, Mark Abramovitz, Sofia Braga, Fatima Cardoso, Nadia Harbeck, Carsten Denkert, and Scott D. Jewell
	JCO Dec 1 2008: 5638–5644. First published on Oct 27 2008; 10.1200/JCO.2007.15.1712. [Abstract] [Full Text] [PDF] [Data Supplement]

DIAGNOSIS IN ONCOLOGY

Multiple Myeloma Presenting With a Colonic Obstruction and Bony Lesions: A Clinical Dilemma

Anne Herbst, Stephen W. Renner, Q. Scott Ringenberg, Ronnie Fass, and Robert S. Krouse

JCO Dec 1 2008: 5645–5647. First published on Nov 3 2008; 10.1200/JCO.2008.18.6239. [Full Text] [PDF]

Late Relapsing Stage I Nonseminoma

Carmel J. Pezaro, Girish Mallesara, and Guy C. Toner

JCO Dec 1 2008: 5647–5648. First published on Nov 3 2008; 10.1200/JCO.2008.19.3417. [Full Text] [PDF]

Bevacizumab Reverses Cerebral Radiation Necrosis

Eric T. Wong, Mark Huberman, Xing-Qi Lu, and Anand Mahadevan

JCO Dec 1 2008: 5649–5650. First published on Nov 3 2008; 10.1200/JCO.2008.19.1866. [Full Text] [PDF]

CORRESPONDENCE
	Personalized Medicine in Advanced Non–Small-Cell Lung Cancer: Reality or Wishful Thinking?
	Filip Janku and Brian Bird
	JCO Dec 1 2008: 5651. First published on Oct 20 2008; 10.1200/JCO.2008.19.5164. [Full Text] [PDF]
	In Reply
	Giorgio V. Scagliotti and Katherine P. Sugarman
	JCO Dec 1 2008: 5651–5652. First published on Oct 20 2008; 10.1200/JCO.2008.19.5560. [Full Text] [PDF]
	Temsirolimus in Patients With Renal Cancer on Hemodialysis
	Gianluigi Lunardi, Maria Ornella Vannozzi, Andrea Armirotti, Maurizio Nicodemo, Marco Venturini, and Lucia Cavallini
	JCO Dec 1 2008: 5652–5653. First published on Nov 3 2008; 10.1200/JCO.2008.19.3144. [Full Text] [PDF]
	In Reply
	James Brugarolas
	JCO Dec 1 2008: 5653–5654. First published on Nov 3 2008; 10.1200/JCO.2008.19.4670. [Full Text] [PDF]
	Value of Positron Emission Tomography of the Para-Aortic Lymph Nodes in Cervical Carcinoma Stage IB2-IIIB
	Ignace Vergote, Dimitris Tsolakidis, Dieter Mortier, Patrick Neven, Frederic Amant, Felix Mottaghy, and Erik Van Limbergen
	JCO Dec 1 2008: 5654–5655. First published on Nov 3 2008; 10.1200/JCO.2008.19.5883. [Full Text] [PDF]
	In Reply
	Philippe Morice, Enrica Bentivegna, Catherine Uzan, Sebastien Gouy, Martin Schlumberger, Pierre Duvillard, and Christine Haie-Meder
	JCO Dec 1 2008: 5655–5657. First published on Nov 3 2008; 10.1200/JCO.2008.19.7707. [Full Text] [PDF]
	Management of Tumor Lysis Syndrome: Need for Evidence-Based Guidelines
	James H. Feusner, A. Kim Ritchey, Susan L. Cohn, and Amy L. Billett
	JCO Dec 1 2008: 5657–5658. First published on Nov 3 2008; 10.1200/JCO.2008.19.6030. [Full Text] [PDF]
	In Reply
	Bertrand Coiffier, Arnold Altman, Ching-Hon Pui, Anas Younes, and Mitchell S. Cairo
	JCO Dec 1 2008: 5658–5659. First published on Nov 3 2008; 10.1200/JCO.2008.19.7673. [Full Text] [PDF]
	Carcinoembryonic Antigen Monitoring in Metastatic Colorectal Cancer: Words of Caution
	Marwan G. Fakih
	JCO Dec 1 2008: e7. First published on Nov 3 2008; 10.1200/JCO.2008.19.6451. [Full Text] [PDF]
	In Reply
	Isabelle Iwanicki-Caron, Frederic Di Fiore, and Pierre Michel
	JCO Dec 1 2008: e8. First published on Nov 3 2008; 10.1200/JCO.2008.19.7699. [Full Text] [PDF]

ERRATUM

ERRATUM

JCO Dec 1 2008: 5660. [Full Text] [PDF]

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