EDITORIALS

Insulin–Insulin-Like Growth Factor Axis and Colon Cancer

Srikala S. Sridhar and Pamela J. Goodwin

JCO Jan 10 2009: 165–167. First published on Dec 8 2008; 10.1200/JCO.2008.19.8937. [Full Text] [PDF]

Time to Shift the Focus of the War: It Is Not All About the Enemy

John L. Marshall

JCO Jan 10 2009: 168–169. First published on Dec 8 2008; 10.1200/JCO.2008.20.0683. [Full Text] [PDF]

Palliative Care and Oncology: Growing Better Together

Ira Byock

JCO Jan 10 2009: 170–171. First published on Dec 8 2008; 10.1200/JCO.2008.20.2671. [Full Text] [PDF]

The Drama of the Gifted Disease

William G. Woods and Michael P. LaQuaglia

JCO Jan 10 2009: 172–173. First published on Dec 1 2008; 10.1200/JCO.2008.19.2153. [Full Text] [PDF]

COMMENTS AND CONTROVERSIES

Cautionary Note Regarding the Use of CIs Obtained From Kaplan-Meier Survival Curves

Rickey E. Carter and Peng Huang

JCO Jan 10 2009: 174–175. First published on Dec 1 2008; 10.1200/JCO.2008.18.8011. [Full Text] [PDF]

ORIGINAL REPORTS
Gastrointestinal Cancer
	Insulin, the Insulin-Like Growth Factor Axis, and Mortality in Patients With Nonmetastatic Colorectal Cancer
	Brian M. Wolpin, Jeffrey A. Meyerhardt, Andrew T. Chan, Kimmie Ng, Jennifer A. Chan, Kana Wu, Michael N. Pollak, Edward L. Giovannucci, and Charles S. Fuchs
	JCO Jan 10 2009: 176–185. First published on Dec 8 2008; 10.1200/JCO.2008.17.9945. [Abstract] [Full Text] [PDF]
	Tumor-Infiltrating FOXP3+ T Regulatory Cells Show Strong Prognostic Significance in Colorectal Cancer
	Paul Salama, Michael Phillips, Fabienne Grieu, Melinda Morris, Nik Zeps, David Joseph, Cameron Platell, and Barry Iacopetta
	JCO Jan 10 2009: 186–192. First published on Dec 8 2008; 10.1200/JCO.2008.18.7229. [Abstract] [Full Text] [PDF]
	Oral mTOR Inhibitor Everolimus in Patients With Gemcitabine-Refractory Metastatic Pancreatic Cancer
	Brian M. Wolpin, Aram F. Hezel, Thomas Abrams, Lawrence S. Blaszkowsky, Jeffrey A. Meyerhardt, Jennifer A. Chan, Peter C. Enzinger, Brittany Allen, Jeffrey W. Clark, David P. Ryan, and Charles S. Fuchs
	JCO Jan 10 2009: 193–198. First published on Dec 1 2008; 10.1200/JCO.2008.18.9514. [Abstract] [Full Text] [PDF]
	Addition of Bevacizumab to Fluorouracil-Based First-Line Treatment of Metastatic Colorectal Cancer: Pooled Analysis of Cohorts of Older Patients From Two Randomized Clinical Trials
	Fairooz F. Kabbinavar, Herbert I. Hurwitz, Jing Yi, Somnath Sarkar, and Oliver Rosen
	JCO Jan 10 2009: 199–205. First published on Dec 8 2008; 10.1200/JCO.2008.17.7931. [Abstract] [Full Text] [PDF]

Palliative and Supportive Care
	Phase II Study of an Outpatient Palliative Care Intervention in Patients With Metastatic Cancer
	Matthew Follwell, Debika Burman, Lisa W. Le, Kristina Wakimoto, Dori Seccareccia, John Bryson, Gary Rodin, and Camilla Zimmermann
	JCO Jan 10 2009: 206–213. First published on Dec 8 2008; 10.1200/JCO.2008.17.7568. [Abstract] [Full Text] [PDF]

Breast Cancer
	Sensitivity to Input Variability of the Adjuvant! Online Breast Cancer Prognostic Model
	Elissa M. Ozanne, Dejana Braithwaite, Karen Sepucha, Dan Moore, Laura Esserman, and Jeffrey Belkora
	JCO Jan 10 2009: 214–219. First published on Dec 1 2008; 10.1200/JCO.2008.17.3914. [Abstract] [Full Text] [PDF]
	Triple Receptor–Negative Breast Cancer: The Effect of Race on Response to Primary Systemic Treatment and Survival Outcomes
	Shaheenah Dawood, Kristine Broglio, Shu-Wan Kau, Marjorie C. Green, Sharon H. Giordano, Funda Meric-Bernstam, Thomas A. Buchholz, Constance Albarracin, Wei T. Yang, Bryan T.J. Hennessy, Gabriel N. Hortobagyi, and Ana Maria Gonzalez-Angulo
	JCO Jan 10 2009: 220–226. First published on Dec 1 2008; 10.1200/JCO.2008.17.9952. [Abstract] [Full Text] [PDF]
	Phosphorylated ER, HIF-1, and MAPK Signaling As Predictors of Primary Endocrine Treatment Response and Resistance in Patients With Breast Cancer
	Daniele Generali, Francesca M. Buffa, Alfredo Berruti, Maria P. Brizzi, Leticia Campo, Simone Bonardi, Alessandra Bersiga, Giovanni Allevi, Manuela Milani, Sergio Aguggini, Mauro Papotti, Luigi Dogliotti, Alberto Bottini, Adrian L. Harris, and Stephen B. Fox
	JCO Jan 10 2009: 227–234. First published on Dec 8 2008; 10.1200/JCO.2007.13.7083. [Abstract] [Full Text] [PDF]

Genitourinary Cancer
	Metastatic Sarcomatoid Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Therapy
	Ali Reza Golshayan, Saby George, Daniel Y. Heng, Paul Elson, Laura S. Wood, Tarek M. Mekhail, Jorge A. Garcia, Hakan Aydin, Ming Zhou, Ronald M. Bukowski, and Brian I. Rini
	JCO Jan 10 2009: 235–241. First published on Dec 8 2008; 10.1200/JCO.2008.18.0000. [Abstract] [Full Text] [PDF]

Head and Neck Cancer
	Randomized Phase II Trial of Concurrent Cisplatin-Radiotherapy With or Without Neoadjuvant Docetaxel and Cisplatin in Advanced Nasopharyngeal Carcinoma
	Edwin P. Hui, Brigette B. Ma, Sing F. Leung, Ann D. King, Frankie Mo, Michael K. Kam, Brian K. Yu, Samuel K. Chiu, Wing H. Kwan, Rosalie Ho, Iris Chan, Anil T. Ahuja, Benny C. Zee, and Anthony T. Chan
	JCO Jan 10 2009: 242–249. First published on Dec 8 2008; 10.1200/JCO.2008.18.1545. [Abstract] [Full Text] [PDF]

Leukemia and Bone Marrow Transplantation
	Increased Incidence of Transformation and Myelodysplasia/Acute Leukemia in Patients With Waldenström Macroglobulinemia Treated With Nucleoside Analogs
	Xavier Leleu, Jacob Soumerai, Aldo Roccaro, Evdoxia Hatjiharissi, Zachary R. Hunter, Robert Manning, Bryan T. Ciccarelli, Antonio Sacco, Leukothea Ioakimidis, Sophia Adamia, Anne-Sophie Moreau, Christopher J. Patterson, Irene M. Ghobrial, and Steven P. Treon
	JCO Jan 10 2009: 250–255. First published on Dec 8 2008; 10.1200/JCO.2007.15.1530. [Abstract] [Full Text] [PDF]
	Analysis of Risk Factors for Outcomes After Unrelated Cord Blood Transplantation in Adults With Lymphoid Malignancies: A Study by the Eurocord-Netcord and Lymphoma Working Party of the European Group for Blood and Marrow Transplantation
	Celso A. Rodrigues, Guillermo Sanz, Claudio G. Brunstein, Jaime Sanz, John E. Wagner, Marc Renaud, Marcos de Lima, Mitchell S. Cairo, Sabine Fürst, Bernard Rio, Christopher Dalley, Enric Carreras, Jean-Luc Harousseau, Mohamad Mohty, Denis Taveira, Peter Dreger, Anna Sureda, Eliane Gluckman, and Vanderson Rocha
	JCO Jan 10 2009: 256–263. First published on Dec 8 2008; 10.1200/JCO.2007.15.8865. [Abstract] [Full Text] [PDF] [Publisher's Note]

Thoracic Oncology
	Randomized Phase II Study of Pulse Erlotinib Before or After Carboplatin and Paclitaxel in Current or Former Smokers With Advanced Non–Small-Cell Lung Cancer
	Gregory J. Riely, Naiyer A. Rizvi, Mark G. Kris, Daniel T. Milton, David B. Solit, Neal Rosen, Emir Senturk, Christopher G. Azzoli, Julie R. Brahmer, Francis M. Sirotnak, Venkatraman E. Seshan, Margaret Fogle, Michelle Ginsberg, Vincent A. Miller, and Charles M. Rudin
	JCO Jan 10 2009: 264–270. First published on Dec 1 2008; 10.1200/JCO.2008.17.4656. [Abstract] [Full Text] [PDF]
	Thyroid Transcription Factor 1 Is an Independent Prognostic Factor for Patients With Stage I Lung Adenocarcinoma
	Valsamo K. Anagnostou, Konstantinos N. Syrigos, Gerold Bepler, Robert J. Homer, and David L. Rimm
	JCO Jan 10 2009: 271–278. First published on Dec 8 2008; 10.1200/JCO.2008.17.0043. [Abstract] [Full Text] [PDF]

REVIEW ARTICLE
	Ductal Carcinoma in Situ: State of the Science and Roadmap to Advance the Field
	Henry M. Kuerer, Constance T. Albarracin, Wei T. Yang, Robert D. Cardiff, Abenaa M. Brewster, W. Fraser Symmans, Nola M. Hylton, Lavinia P. Middleton, Savitri Krishnamurthy, George H. Perkins, Gildy Babiera, Mary E. Edgerton, Brian J. Czerniecki, Banu K. Arun, and Gabriel N. Hortobagyi
	JCO Jan 10 2009: 279–288. First published on Dec 8 2008; 10.1200/JCO.2008.18.3103. [Abstract] [Full Text] [PDF] [Italian PDF]

SPECIAL ARTICLES
	The International Neuroblastoma Risk Group (INRG) Classification System: An INRG Task Force Report
	Susan L. Cohn, Andrew D.J. Pearson, Wendy B. London, Tom Monclair, Peter F. Ambros, Garrett M. Brodeur, Andreas Faldum, Barbara Hero, Tomoko Iehara, David Machin, Veronique Mosseri, Thorsten Simon, Alberto Garaventa, Victoria Castel, and Katherine K. Matthay
	JCO Jan 10 2009: 289–297. First published on Dec 1 2008; 10.1200/JCO.2008.16.6785. [Abstract] [Full Text] [PDF]
	The International Neuroblastoma Risk Group (INRG) Staging System: An INRG Task Force Report
	Tom Monclair, Garrett M. Brodeur, Peter F. Ambros, Hervé J. Brisse, Giovanni Cecchetto, Keith Holmes, Michio Kaneko, Wendy B. London, Katherine K. Matthay, Jed G. Nuchtern, Dietrich von Schweinitz, Thorsten Simon, Susan L. Cohn, and Andrew D.J. Pearson
	JCO Jan 10 2009: 298–303. First published on Dec 1 2008; 10.1200/JCO.2008.16.6876. [Abstract] [Full Text] [PDF]

ART OF ONCOLOGY

The Role of Investigational Therapy in Management of Patients With Advanced Metastatic Malignancy

Emil J Freireich and Razelle Kurzrock

JCO Jan 10 2009: 304–306. First published on Dec 8 2008; 10.1200/JCO.2008.19.6543. [Full Text] [PDF] [Czech PDF]

Phase I Versus Palliative Care: Striking the Right Balance

Lidia Schapira, Timothy J. Moynihan, Charles F. von Gunten, and Thomas J. Smith

JCO Jan 10 2009: 307–308. First published on Dec 8 2008; 10.1200/JCO.2008.20.7803. [Full Text] [PDF]

DIAGNOSIS IN ONCOLOGY

Cutaneous Paraneoplastic Syndrome in a Patient With Adenocarcinoma of Unknown Primary Site Syndrome

Kwang Ho Yoo, Yong Kwan Rho, Ji Young Kim, Kapsok Li, Seong Jun Seo, and Chang Kwun Hong

JCO Jan 10 2009: 309–311. First published on Dec 8 2008; 10.1200/JCO.2008.19.6758. [Full Text] [PDF]

CORRESPONDENCE

Small Molecule Tyrosine Kinase Inhibitor and Depression

Richard Quek, Jeffrey A. Morgan, Suzanne George, James E. Butrynski, Kathleen Polson, Fremonta Meyer, George D. Demetri, and Susan D. Block

JCO Jan 10 2009: 312–313. First published on Dec 8 2008; 10.1200/JCO.2008.19.7236. [Full Text] [PDF]

Chronic Myeloid Leukemia Stem Cells: Now on the Run

John M. Goldman

JCO Jan 10 2009: 313–314. First published on Dec 8 2008; 10.1200/JCO.2008.19.2260. [Full Text] [PDF]

How Should We Prescribe Lapatinib to Our Patients: Once Daily or Twice Daily, and at What Dose?

Mariangela Ciccarese and Vito Lorusso

JCO Jan 10 2009: 314–315. First published on Dec 8 2008; 10.1200/JCO.2008.20.0345. [Full Text] [PDF]

In Reply

Carlos A. Castañeda and Henry L. Gomez

JCO Jan 10 2009: 315–316. First published on Dec 8 2008; 10.1200/JCO.2008.20.0741. [Full Text] [PDF]

In Reply

Patricia M. LoRusso, Howard A. Burris, III, Suzanne F. Jones, Ronald A. Fleming, and Kevin M. Koch

JCO Jan 10 2009: 316–317. First published on Dec 8 2008; 10.1200/JCO.2008.20.0758. [Full Text] [PDF]

Prevention of Hearing Loss in Children Receiving Cisplatin Chemotherapy

David R. Freyer, Lillian Sung, and Gregory H. Reaman

JCO Jan 10 2009: 317–318. First published on Dec 8 2008; 10.1200/JCO.2008.20.1160. [Full Text] [PDF]

In Reply

Maryam Fouladi and Amar Gajjar

JCO Jan 10 2009: 318–319. First published on Dec 8 2008; 10.1200/JCO.2008.20.1632. [Full Text] [PDF]

Activity of Sunitinib in Patients With Advanced Neuroendocrine Tumors

Emilio Bajetta, Valentina Guadalupi, and Giuseppe Procopio

JCO Jan 10 2009: 319–320. First published on Dec 8 2008; 10.1200/JCO.2008.20.3034. [Full Text] [PDF]

In Reply

Matthew H. Kulke and Charles S. Fuchs

JCO Jan 10 2009: 320. First published on Dec 8 2008; 10.1200/JCO.2008.20.3240. [Full Text] [PDF]

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