Other Issues:		[Index by Author]
Contents:	Volume 27, Issue 33 November 20, 2009

	EDITORIALS
	ORIGINAL REPORTS
	Gastrointestinal Cancer
	Breast Cancer
	Palliative and Supportive Care
	Epidemiology
	Hematologic Malignancies
	Gynecologic Cancer
	Health Services and Outcomes
	Melanoma
	Thoracic Oncology
	Genitourinary Cancer
	REVIEW ARTICLE
	BIOLOGY OF NEOPLASIA
	SPECIAL ARTICLE
	DIAGNOSIS IN ONCOLOGY
	CORRESPONDENCE

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                                      EDITORIALS

Changing the Paradigm in Conducting Randomized Clinical Studies in Advanced Pancreatic Cancer: An Opportunity for Better Clinical Development Josep Tabernero and Teresa Macarulla JCO Nov 2009: 5487–5491. First published on Oct 26 2009; 10.1200/JCO.2009.23.3098. [Full Text] [PDF]

How to Treat Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Amplified Breast Cancer Javier Cortes and José Baselga JCO Nov 2009: 5492–5494. First published on Sep 28 2009; 10.1200/JCO.2009.23.8089. [Full Text] [PDF]

Axillary Reverse Mapping to Prevent Lymphedema After Breast Cancer Surgery: Defining the Limits of the Concept Seema A. Khan JCO Nov 2009: 5494–5496. First published on Oct 13 2009; 10.1200/JCO.2009.24.3311. [Full Text] [PDF]

What's Race Got to Do With It? Ramona Rhodes and Joan M. Teno JCO Nov 2009: 5496–5498. First published on Oct 5 2009; 10.1200/JCO.2009.24.2206. [Full Text] [PDF]

                                      ORIGINAL REPORTS
Gastrointestinal Cancer

Dose Finding and Early Efficacy Study of Gemcitabine Plus Capecitabine in Combination With Bevacizumab Plus Erlotinib in Advanced Pancreatic Cancer Naureen Starling, David Watkins, David Cunningham, Janet Thomas, Janine Webb, Gina Brown, Karen Thomas, Jacqui Oates, and Ian Chau JCO Nov 2009: 5499–5505. First published on Oct 26 2009; 10.1200/JCO.2008.21.5384. [Abstract] [Full Text] [PDF]

Randomized Phase II Study of Gemcitabine Administered at a Fixed Dose Rate or in Combination With Cisplatin, Docetaxel, or Irinotecan in Patients With Metastatic Pancreatic Cancer: CALGB 89904 Matthew H. Kulke, Margaret A. Tempero, Donna Niedzwiecki, Donna R. Hollis, Hedy L. Kindler, Michael Cusnir, Peter C. Enzinger, Stefan M. Gorsch, Richard M. Goldberg, and Robert J. Mayer JCO Nov 2009: 5506–5512. First published on Oct 26 2009; 10.1200/JCO.2009.22.1309. [Abstract] [Full Text] [PDF]

Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer David Cunningham, Ian Chau, Deborah D. Stocken, Juan W. Valle, David Smith, William Steward, Peter G. Harper, Janet Dunn, Catrin Tudur-Smith, Julia West, Stephen Falk, Adrian Crellin, Fawzi Adab, Joyce Thompson, Pauline Leonard, Joe Ostrowski, Martin Eatock, Werner Scheithauer, Richard Herrmann, and John P. Neoptolemos JCO Nov 2009: 5513–5518. First published on Oct 26 2009; 10.1200/JCO.2009.24.2446. [Abstract] [Full Text] [PDF]

Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial Michael S. Braun, Susan D. Richman, Lindsay Thompson, Catherine L. Daly, Angela M. Meade, Julian W. Adlard, James M. Allan, Mahesh K.B. Parmar, Philip Quirke, and Matthew T. Seymour JCO Nov 2009: 5519–5528. First published on Oct 26 2009; 10.1200/JCO.2008.21.6283. [Abstract] [Full Text] [PDF]

Breast Cancer

Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2–Positive, Hormone Receptor–Positive Metastatic Breast Cancer: Results From the Randomized Phase III TAnDEM Study Bella Kaufman, John R. Mackey, Michael R. Clemens, Poonamalle P. Bapsy, Ashok Vaid, Andrew Wardley, Sergei Tjulandin, Michaela Jahn, Michaela Lehle, Andrea Feyereislova, Cédric Révil, and Alison Jones JCO Nov 2009: 5529–5537. First published on Sep 28 2009; 10.1200/JCO.2008.20.6847. [Abstract] [Full Text] [PDF]

Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor–Positive Metastatic Breast Cancer Stephen Johnston, John Pippen, Jr, Xavier Pivot, Mikhail Lichinitser, Saeed Sadeghi, Veronique Dieras, Henry Leonidas Gomez, Gilles Romieu, Alexey Manikhas, M. John Kennedy, Michael F. Press, Julie Maltzman, Allison Florance, Lisa O'Rourke, Cristina Oliva, Steven Stein, and Mark Pegram JCO Nov 2009: 5538–5546. First published on Sep 28 2009; 10.1200/JCO.2009.23.3734. [Abstract] [Full Text] [PDF]

Extensive Nodal Disease May Impair Axillary Reverse Mapping in Patients With Breast Cancer Riccardo Ponzone, Nicoletta Tomasi Cont, Furio Maggiorotto, Elisa Cassina, Paola Mininanni, Nicoletta Biglia, and Piero Sismondi JCO Nov 2009: 5547–5551. First published on Oct 13 2009; 10.1200/JCO.2009.22.1846. [Abstract] [Full Text] [PDF]

Prognostic and Predictive Value of HER2 Extracellular Domain in Metastatic Breast Cancer Treated With Lapatinib and Paclitaxel in a Randomized Phase III Study Richard S. Finn, Robert Gagnon, Angelo Di Leo, Michael F. Press, Michael Arbushites, and Maria Koehler JCO Nov 2009: 5552–5558. First published on Oct 26 2009; 10.1200/JCO.2008.21.1763. [Abstract] [Full Text] [PDF] [Publisher's Note]

Palliative and Supportive Care

Racial Differences in Predictors of Intensive End-of-Life Care in Patients With Advanced Cancer Elizabeth Trice Loggers, Paul K. Maciejewski, Elizabeth Paulk, Susan DeSanto-Madeya, Matthew Nilsson, Kasisomayajula Viswanath, Alexi Anne Wright, Tracy A. Balboni, Jennifer Temel, Heather Stieglitz, Susan Block, and Holly G. Prigerson JCO Nov 2009: 5559–5564. First published on Oct 5 2009; 10.1200/JCO.2009.22.4733. [Abstract] [Full Text] [PDF]

Epidemiology

Mobile Phone Use and Risk of Tumors: A Meta-Analysis Seung-Kwon Myung, Woong Ju, Diana D. McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, and Joel M. Moskowitz JCO Nov 2009: 5565–5572. First published on Oct 13 2009; 10.1200/JCO.2008.21.6366. [Abstract] [Full Text] [PDF]

Hematologic Malignancies

Immuno–Fluorescence In Situ Hybridization Index Predicts Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A GELA Study Christiane Copie-Bergman, Philippe Gaulard, Karen Leroy, Josette Briere, Maryse Baia, Jean-Philippe Jais, Gilles A. Salles, Françoise Berger, Corinne Haioun, Herve Tilly, Jean-François Emile, Alison H. Banham, Nicolas Mounier, Christian Gisselbrecht, Pierre Feugier, Bertrand Coiffier, and Thierry J. Molina JCO Nov 2009: 5573–5579. First published on Sep 28 2009; 10.1200/JCO.2009.22.7058. [Abstract] [Full Text] [PDF]

Age-Specific Differences in Oncogenic Pathway Dysregulation and Anthracycline Sensitivity in Patients With Acute Myeloid Leukemia Arati V. Rao, Peter J.M. Valk, Klaus H. Metzeler, Chaitanya R. Acharya, Sascha A. Tuchman, Marvaretta M. Stevenson, David A. Rizzieri, Ruud Delwel, Christian Buske, Stefan K. Bohlander, Anil Potti, and Bob Löwenberg JCO Nov 2009: 5580–5586. First published on Oct 26 2009; 10.1200/JCO.2009.22.2547. [Abstract] [Full Text] [PDF]

Dynamic Model for Predicting Death Within 12 Months in Patients With Primary or Post–Polycythemia Vera/Essential Thrombocythemia Myelofibrosis Constantine S. Tam, Hagop Kantarjian, Jorge Cortes, Alice Lynn, Sherry Pierce, Lingsha Zhou, Michael J. Keating, Deborah A. Thomas, and Srdan Verstovsek JCO Nov 2009: 5587–5593. First published on Sep 28 2009; 10.1200/JCO.2009.22.8833. [Abstract] [Full Text] [PDF]

Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma: Japan Clinical Oncology Group Study JCOG0211 Motoko Yamaguchi, Kensei Tobinai, Masahiko Oguchi, Naoki Ishizuka, Yukio Kobayashi, Yasushi Isobe, Kenichi Ishizawa, Nobuo Maseki, Kuniaki Itoh, Noriko Usui, Izumi Wasada, Tomohiro Kinoshita, Koichi Ohshima, Yoshihiro Matsuno, Takashi Terauchi, Shigeru Nawano, Satoshi Ishikura, Yoshikazu Kagami, Tomomitsu Hotta, and Kazuo Oshimi JCO Nov 2009: 5594–5600. First published on Oct 5 2009; 10.1200/JCO.2009.23.8295. [Abstract] [Full Text] [PDF]

Gynecologic Cancer

Cediranib, an Oral Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Is an Active Drug in Recurrent Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer Ursula A. Matulonis, Suzanne Berlin, Percy Ivy, Karin Tyburski, Carolyn Krasner, Corrine Zarwan, Anna Berkenblit, Susana Campos, Neil Horowitz, Stephen A. Cannistra, Hang Lee, Julie Lee, Maria Roche, Margaret Hill, Christin Whalen, Laura Sullivan, Chau Tran, Benjamin D. Humphreys, and Richard T. Penson JCO Nov 2009: 5601–5606. First published on Oct 13 2009; 10.1200/JCO.2009.23.2777. [Abstract] [Full Text] [PDF]

Health Services and Outcomes

Evidence-Based Approach to the Introduction of Positron Emission Tomography in Ontario, Canada William K. Evans, Andreas Laupacis, Karen Y. Gulenchyn, Les Levin, and Mark Levine JCO Nov 2009: 5607–5613. First published on Oct 26 2009; 10.1200/JCO.2009.22.1614. [Abstract] [Full Text] [PDF]

Melanoma

Targeted High-Resolution Ultrasound Is Not an Effective Substitute for Sentinel Lymph Node Biopsy in Patients With Primary Cutaneous Melanoma Amira Sanki, Roger F. Uren, Marc Moncrieff, Kayla L. Tran, Richard A. Scolyer, Hui-Yi Lin, and John F. Thompson JCO Nov 2009: 5614–5619. First published on Sep 28 2009; 10.1200/JCO.2008.21.4882. [Abstract] [Full Text] [PDF]

Thoracic Oncology

Genetic Abnormalities of the EGFR Pathway in African American Patients With Non–Small-Cell Lung Cancer Rom S. Leidner, Pingfu Fu, Bradley Clifford, Ayad Hamdan, Cheng Jin, Rosana Eisenberg, Titus J. Boggon, Margaret Skokan, Wilbur A. Franklin, Federico Cappuzzo, Fred R. Hirsch, Marileila Varella-Garcia, and Balazs Halmos JCO Nov 2009: 5620–5626. First published on Sep 28 2009; 10.1200/JCO.2009.23.1431. [Abstract] [Full Text] [PDF]

Genitourinary Cancer

Prospective Study of Prostate Tumor Angiogenesis and Cancer-Specific Mortality in the Health Professionals Follow-Up Study Lorelei A. Mucci, Anna Powolny, Edward Giovannucci, Zhiming Liao, Stacey A. Kenfield, Rulong Shen, Meir J. Stampfer, and Steven K. Clinton JCO Nov 2009: 5627–5633. First published on Oct 26 2009; 10.1200/JCO.2008.20.8876. [Abstract] [Full Text] [PDF]

Randomized Phase II/III Trial Assessing Gemcitabine/ Carboplatin and Methotrexate/Carboplatin/Vinblastine in Patients With Advanced Urothelial Cancer "Unfit" for Cisplatin-Based Chemotherapy: Phase II—Results of EORTC Study 30986 Maria De Santis, Joaquim Bellmunt, Graham Mead, J. Martijn Kerst, Michael Leahy, Pablo Maroto, Iwona Skoneczna, Sandrine Marreaud, Ronald de Wit, and Richard Sylvester JCO Nov 2009: 5634–5639. First published on Sep 28 2009; 10.1200/JCO.2008.21.4924. [Abstract] [Full Text] [PDF]

                                      REVIEW ARTICLE

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management Meagan Elizabeth Brennan, Nehmat Houssami, Sarah Lord, Petra Macaskill, Les Irwig, J. Michael Dixon, Ruth M.L. Warren, and Stefano Ciatto JCO Nov 2009: 5640–5649. First published on Oct 5 2009; 10.1200/JCO.2008.21.5756. [Abstract] [Full Text] [PDF]

                                      BIOLOGY OF NEOPLASIA

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology Ultan McDermott and Jeff Settleman JCO Nov 2009: 5650–5659. First published on Oct 26 2009; 10.1200/JCO.2009.22.9054. [Abstract] [Full Text] [PDF]

                                      SPECIAL ARTICLE

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment Philip A. Philip, Margaret Mooney, Deborah Jaffe, Gail Eckhardt, Malcolm Moore, Neal Meropol, Leisha Emens, Eileen O'Reilly, Murray Korc, Lee Ellis, Jacqueline Benedetti, Mace Rothenberg, Christopher Willett, Margaret Tempero, Andrew Lowy, James Abbruzzese, Diane Simeone, Sunil Hingorani, Jordan Berlin, and Joel Tepper JCO Nov 2009: 5660–5669. First published on Oct 26 2009; 10.1200/JCO.2009.21.9022. [Abstract] [Full Text] [PDF]

                                      DIAGNOSIS IN ONCOLOGY

Spontaneous Remission in a Patient With t(4;14) Translocation Multiple Myeloma Noemi Puig, Suzanne Trudel, Jonathan J. Keats, Zhi Hua Li, Esteban Braggio, Gregory J. Ahmann, Seda Zeng, Rafael Fonseca, and Vishal Kukreti JCO Nov 2009: e194–e197. First published on Oct 5 2009; 10.1200/JCO.2009.22.0392. [Full Text] [PDF] [Data Supplement]

Recognition of a New Chemotherapeutic Vesicant: Trabectedin (Ecteinascidin-743) Extravasation With Skin and Soft Tissue Damage Todd A. Theman, Tristan L. Hartzell, Indranil Sinha, Kathleen Polson, Jeffrey Morgan, George D. Demetri, Dennis P. Orgill, and Suzanne George JCO Nov 2009: e198–e200. First published on Oct 5 2009; 10.1200/JCO.2008.21.6473. [Full Text] [PDF]

                                      CORRESPONDENCE

Selection Bias Is Not a Good Reason for Advising More Than 5 Years of Adjuvant Hormonal Therapy for All Patients With Locally Advanced Prostate Cancer Treated With Radiotherapy Laurence Collette and Urs E. Studer JCO Nov 2009: e201–e202. First published on Sep 28 2009; 10.1200/JCO.2009.23.3601. [Full Text] [PDF]

Biased Hormonal Therapy Duration Analysis Makes Results Uninterpretable Catherine M. Tangen, Bryan H. Goldman, Gregory P. Swanson, and Ian M. Thompson JCO Nov 2009: e203. First published on Sep 28 2009; 10.1200/JCO.2009.23.6000. [Full Text] [PDF]

Reply to L. Collette et al and C.M. Tangen et al Luis Souhami, Kyounghwa Bae, and Howard Sandler JCO Nov 2009: e204. First published on Sep 28 2009; 10.1200/JCO.2009.23.5341. [Full Text] [PDF]

What Does Similarity Mean in Clinical Trials? Fabio Puglisi JCO Nov 2009: e205. First published on Oct 26 2009; 10.1200/JCO.2009.23.9467. [Full Text] [PDF]

Reply to F. Puglisi Stephen Chan JCO Nov 2009: e206. First published on Oct 26 2009; 10.1200/JCO.2009.23.9798. [Full Text] [PDF]

If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Sonia Del Barco, Begoña Martin-Castillo, and Javier A. Menendez JCO Nov 2009: e207–e209. First published on Oct 26 2009; 10.1200/JCO.2009.24.5456. [Full Text] [PDF]

Reply to A. Vazquez-Martin et al Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic JCO Nov 2009: e210. First published on Oct 26 2009; 10.1200/JCO.2009.24.6033. [Full Text] [PDF]

Darbepoetin Alfa and History of Thromboembolic Events Gianluigi Ferretti, Alessandra Felici, and Francesco Cognetti JCO Nov 2009: e211. First published on Oct 26 2009; 10.1200/JCO.2009.24.6454. [Full Text] [PDF]

Reply to G. Ferretti et al Heinz Ludwig and Alex Fleishman JCO Nov 2009: e212. First published on Oct 26 2009; 10.1200/JCO.2009.25.0860. [Full Text] [PDF]

Call for Clarity in the Reporting of Benefit Associated With Anticancer Therapies Christopher M. Booth, Pavlo Ohorodnyk, and Elizabeth A. Eisenhauer JCO Nov 2009: e213–e214. First published on Oct 26 2009; 10.1200/JCO.2009.24.8542. [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.