Other Issues:		[Index by Author]
Contents:	Volume 28, Issue 5 February 10, 2010

	EDITORIALS
	ORIGINAL REPORTS
	Breast Cancer
	Clinical Practice
	Thoracic Oncology
	Head and Neck Cancer
	Aids-Related Cancer
	Phase I and Clinical Pharmacology
	Epidemiology
	Hematologic Malignancies
	Sarcomas
	Melanoma
	Gastrointestinal Cancer
	Pediatric Oncology
	REVIEW ARTICLE
	ASCO SPECIAL ARTICLE
	DIAGNOSIS IN ONCOLOGY
	CORRESPONDENCE

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                                      EDITORIALS

Breast Conservation Treatment With Radiation: An Ongoing Success Story Lawrence J. Solin JCO Feb 2010: 709–711. First published on Jan 4 2010; 10.1200/JCO.2009.26.1164. [Full Text] [PDF]

Is Seeing Believing? Michael D. Brundage JCO Feb 2010: 711–713. First published on Jan 11 2010; 10.1200/JCO.2009.25.0720. [Full Text] [PDF]

INTERESTing Biomarker to Select IDEAL Patients for Epidermal Growth Factor Receptor Tyrosine Kinase Inhibitors: Yes, for EGFR Mutation Analysis, Others, I PASS Ramaswamy Govindan JCO Feb 2010: 713–715. First published on Dec 28 2009; 10.1200/JCO.2009.25.1637. [Full Text] [PDF]

Functional p53 Status As a Biomarker for Chemotherapy Response in Oral-Cavity Cancer Edmund A. Mroz and James W. Rocco JCO Feb 2010: 715–717. First published on Jan 4 2010; 10.1200/JCO.2009.26.3475. [Full Text] [PDF]

                                      ORIGINAL REPORTS
Breast Cancer

Validation of a Web-Based Predictive Nomogram for Ipsilateral Breast Tumor Recurrence After Breast Conserving Therapy Mona Sanghani, Pauline T. Truong, Rita Abi Raad, Andrzej Niemierko, Mary Lesperance, Ivo A. Olivotto, David E. Wazer, and Alphonse G. Taghian JCO Feb 2010: 718–722. First published on Jan 4 2010; 10.1200/JCO.2009.22.6662. [Abstract] [Full Text] [PDF]

Phase I/II Trial of Metronomic Chemotherapy With Daily Dalteparin and Cyclophosphamide, Twice-Weekly Methotrexate, and Daily Prednisone As Therapy for Metastatic Breast Cancer Using Vascular Endothelial Growth Factor and Soluble Vascular Endothelial Growth Factor Receptor Levels As Markers of Response Nan Soon Wong, Robert A. Buckman, Mark Clemons, Shailendra Verma, Susan Dent, Maureen E. Trudeau, Kathie Roche, John Ebos, Robert Kerbel, Gerrit E. DeBoer, Donald J.A. Sutherland, Urban Emmenegger, Joyce Slingerland, Sandra Gardner, and Kathleen I. Pritchard JCO Feb 2010: 723–730. First published on Dec 21 2009; 10.1200/JCO.2009.24.0143. [Abstract] [Full Text] [PDF]

Role of Axillary Clearance After a Tumor-Positive Sentinel Node in the Administration of Adjuvant Therapy in Early Breast Cancer Marieke E. Straver, Philip Meijnen, Geertjan van Tienhoven, Cornelis J.H. van de Velde, Robert E. Mansel, Jan Bogaerts, Gaston Demonty, Nicole Duez, Luigi Cataliotti, Jean Klinkenbijl, Helen A. Westenberg, Huub van der Mijle, Coen Hurkmans, and Emiel J.T. Rutgers JCO Feb 2010: 731–737. First published on Dec 28 2009; 10.1200/JCO.2008.21.7554. [Abstract] [Full Text] [PDF]

Clinical Practice

Communicating the Results of Randomized Clinical Trials: Do Patients Understand Multidimensional Patient-Reported Outcomes? Angus G.K. McNair, Sara T. Brookes, Christopher R. Davis, Miltiadis Argyropoulos, and Jane M. Blazeby JCO Feb 2010: 738–743. First published on Jan 11 2010; 10.1200/JCO.2009.23.9111. [Abstract] [Full Text] [PDF]

Thoracic Oncology

Molecular Predictors of Outcome With Gefitinib and Docetaxel in Previously Treated Non–Small-Cell Lung Cancer: Data From the Randomized Phase III INTEREST Trial Jean-Yves Douillard, Frances A. Shepherd, Vera Hirsh, Tony Mok, Mark A. Socinski, Radj Gervais, Mei-Lin Liao, Helge Bischoff, Martin Reck, Mark V. Sellers, Claire L. Watkins, Georgina Speake, Alison A. Armour, and Edward S. Kim JCO Feb 2010: 744–752. First published on Dec 28 2009; 10.1200/JCO.2009.24.3030. [Abstract] [Full Text] [PDF]

Randomized Phase III Trial of Platinum-Doublet Chemotherapy Followed by Gefitinib Compared With Continued Platinum-Doublet Chemotherapy in Japanese Patients With Advanced Non–Small-Cell Lung Cancer: Results of a West Japan Thoracic Oncology Group Trial (WJTOG0203) Koji Takeda, Toyoaki Hida, Tosiya Sato, Masahiko Ando, Takashi Seto, Miyako Satouchi, Yukito Ichinose, Nobuyuki Katakami, Nobuyuki Yamamoto, Shinzoh Kudoh, Jiichiro Sasaki, Kaoru Matsui, Koichi Takayama, Tatsuhiko Kashii, Yasuo Iwamoto, Toshiyuki Sawa, Isamu Okamoto, Takayasu Kurata, Kazuhiko Nakagawa, and Masahiro Fukuoka JCO Feb 2010: 753–760. First published on Dec 28 2009; 10.1200/JCO.2009.23.3445. [Abstract] [Full Text] [PDF]

Head and Neck Cancer

TP53 Mutations and Pathologic Complete Response to Neoadjuvant Cisplatin and Fluorouracil Chemotherapy in Resected Oral Cavity Squamous Cell Carcinoma Federica Perrone, Paolo Bossi, Barbara Cortelazzi, Laura Locati, Pasquale Quattrone, Marco A. Pierotti, Silvana Pilotti, and Lisa Licitra JCO Feb 2010: 761–766. First published on Jan 4 2010; 10.1200/JCO.2009.22.4170. [Abstract] [Full Text] [PDF]

Vandetanib for the Treatment of Patients With Locally Advanced or Metastatic Hereditary Medullary Thyroid Cancer Samuel A. Wells, Jr, Jessica E. Gosnell, Robert F. Gagel, Jeffrey Moley, David Pfister, Julie A. Sosa, Michael Skinner, Annetta Krebs, James Vasselli, and Martin Schlumberger JCO Feb 2010: 767–772. First published on Jan 11 2010; 10.1200/JCO.2009.23.6604. [Abstract] [Full Text] [PDF]

Aids-Related Cancer

Circulating Serum Free Light Chains As Predictive Markers of AIDS-Related Lymphoma Ola Landgren, James J. Goedert, Charles S. Rabkin, Wyndham H. Wilson, Kieron Dunleavy, Robert A. Kyle, Jerry A. Katzmann, S. Vincent Rajkumar, and Eric A. Engels JCO Feb 2010: 773–779. First published on Jan 4 2010; 10.1200/JCO.2009.25.1322. [Abstract] [Full Text] [PDF] [Publisher's Note]

Phase I and Clinical Pharmacology

Phase I Pharmacologic and Biologic Study of Ramucirumab (IMC-1121B), a Fully Human Immunoglobulin G1 Monoclonal Antibody Targeting the Vascular Endothelial Growth Factor Receptor-2 Jennifer L. Spratlin, Roger B. Cohen, Matthew Eadens, Lia Gore, D. Ross Camidge, Sami Diab, Stephen Leong, Cindy O'Bryant, Laura Q.M. Chow, Natalie J. Serkova, Neal J. Meropol, Nancy L. Lewis, E. Gabriela Chiorean, Floyd Fox, Hagop Youssoufian, Eric K. Rowinsky, and S. Gail Eckhardt JCO Feb 2010: 780–787. First published on Jan 4 2010; 10.1200/JCO.2009.23.7537. [Abstract] [Full Text] [PDF]

Epidemiology

Absolute Risk of Endometrial Carcinoma During 20-Year Follow-Up Among Women With Endometrial Hyperplasia James V. Lacey, Jr, Mark E. Sherman, Brenda B. Rush, Brigitte M. Ronnett, Olga B. Ioffe, Máire A. Duggan, Andrew G. Glass, Douglas A. Richesson, Nilanjan Chatterjee, and Bryan Langholz JCO Feb 2010: 788–792. First published on Jan 11 2010; 10.1200/JCO.2009.24.1315. [Abstract] [Full Text] [PDF]

Hematologic Malignancies

Transformation to Aggressive Lymphoma in Nodular Lymphocyte-Predominant Hodgkin's Lymphoma Mubarak Al-Mansour, Joseph M. Connors, Randy D. Gascoyne, Brian Skinnider, and Kerry J. Savage JCO Feb 2010: 793–799. First published on Jan 4 2010; 10.1200/JCO.2009.24.9516. [Abstract] [Full Text] [PDF]

Bortezomib As Induction Before Autologous Transplantation, Followed by Lenalidomide As Consolidation-Maintenance in Untreated Multiple Myeloma Patients Antonio Palumbo, Francesca Gay, Patrizia Falco, Claudia Crippa, Vittorio Montefusco, Francesca Patriarca, Fausto Rossini, Simona Caltagirone, Giulia Benevolo, Norbert Pescosta, Tommasina Guglielmelli, Sara Bringhen, Massimo Offidani, Nicola Giuliani, Maria Teresa Petrucci, Pellegrino Musto, Anna Marina Liberati, Giuseppe Rossi, Paolo Corradini, and Mario Boccadoro JCO Feb 2010: 800–807. First published on Jan 4 2010; 10.1200/JCO.2009.22.7561. [Abstract] [Full Text] [PDF]

Randomized Study of Intensified Anthracycline Doses for Induction and Recombinant Interleukin-2 for Maintenance in Patients With Acute Myeloid Leukemia Age 50 to 70 Years: Results of the ALFA-9801 Study Cecile Pautas, Fatiha Merabet, Xavier Thomas, Emmanuel Raffoux, Claude Gardin, Selim Corm, Jean-Henri Bourhis, Oumedaly Reman, Pascal Turlure, Nathalie Contentin, Thierry de Revel, Philippe Rousselot, Claude Preudhomme, Dominique Bordessoule, Pierre Fenaux, Christine Terré, Mauricette Michallet, Hervé Dombret, Sylvie Chevret, and Sylvie Castaigne JCO Feb 2010: 808–814. First published on Jan 4 2010; 10.1200/JCO.2009.23.2652. [Abstract] [Full Text] [PDF]

Single-Agent Laromustine, A Novel Alkylating Agent, Has Significant Activity in Older Patients With Previously Untreated Poor-Risk Acute Myeloid Leukemia Gary J. Schiller, Susan M. O'Brien, Arnaud Pigneux, Daniel J. DeAngelo, Norbert Vey, Jonathan Kell, Scott Solomon, Robert K. Stuart, Verena Karsten, Ann L. Cahill, Maher X. Albitar, and Francis J. Giles JCO Feb 2010: 815–821. First published on Dec 21 2009; 10.1200/JCO.2009.24.2008. [Abstract] [Full Text] [PDF]

Long-Term Follow-Up of Patients With Newly Diagnosed Follicular Lymphoma in the Prerituximab Era: Effect of Response Quality on Survival—A Study From the Groupe d'Etude des Lymphomes de l'Adulte Emmanuel Bachy, Pauline Brice, Richard Delarue, Nicole Brousse, Corinne Haioun, Steven Le Gouill, Alain Delmer, Dominique Bordessoule, Hervé Tilly, Bernadette Corront, Christian Allard, Charles Foussard, André Bosly, Bertrand Coiffier, Christian Gisselbrecht, Philippe Solal-Celigny, and Gilles Salles JCO Feb 2010: 822–829. First published on Dec 21 2009; 10.1200/JCO.2009.22.7819. [Abstract] [Full Text] [PDF]

Patterns of Improved Survival in Patients With Multiple Myeloma in the Twenty-First Century: A Population-Based Study Ingemar Turesson, Ramon Velez, Sigurdur Y. Kristinsson, and Ola Landgren JCO Feb 2010: 830–834. First published on Dec 28 2009; 10.1200/JCO.2009.25.4177. [Abstract] [Full Text] [PDF]

Sarcomas

Clinical Activity of mTOR Inhibition With Sirolimus in Malignant Perivascular Epithelioid Cell Tumors: Targeting the Pathogenic Activation of mTORC1 in Tumors Andrew J. Wagner, Izabela Malinowska-Kolodziej, Jeffrey A. Morgan, Wei Qin, Christopher D.M. Fletcher, Natalie Vena, Azra H. Ligon, Cristina R. Antonescu, Nikhil H. Ramaiya, George D. Demetri, David J. Kwiatkowski, and Robert G. Maki JCO Feb 2010: 835–840. First published on Jan 4 2010; 10.1200/JCO.2009.25.2981. [Abstract] [Full Text] [PDF]

Melanoma

Efficacy of Low-Dose Interferon 2a 18 Versus 60 Months of Treatment in Patients With Primary Melanoma of 1.5 mm Tumor Thickness: Results of a Randomized Phase III DeCOG Trial Axel Hauschild, Michael Weichenthal, Knuth Rass, Ruthild Linse, Carola Berking, Jörg Böttjer, Thomas Vogt, Konstanze Spieth, Thomas Eigentler, Norbert H. Brockmeyer, Annette Stein, Helmut Näher, Dirk Schadendorf, Peter Mohr, Martin Kaatz, Michael Tronnier, Rüdiger Hein, Gerold Schuler, Friederike Egberts, and Claus Garbe JCO Feb 2010: 841–846. First published on Jan 4 2010; 10.1200/JCO.2009.23.1704. [Abstract] [Full Text] [PDF]

Ultrasound Morphology Criteria Predict Metastatic Disease of the Sentinel Nodes in Patients With Melanoma Christiane Voit, Alexander C.J. Van Akkooi, Gregor Schäfer-Hesterberg, Alfred Schoengen, Katharina Kowalczyk, Joachim C. Roewert, Wolfram Sterry, and Alexander M.M. Eggermont JCO Feb 2010: 847–852. First published on Jan 11 2010; 10.1200/JCO.2009.25.7428. [Abstract] [Full Text] [PDF]

Gastrointestinal Cancer

Alternating Systemic and Hepatic Artery Infusion Therapy for Resected Liver Metastases From Colorectal Cancer: A North Central Cancer Treatment Group (NCCTG)/ National Surgical Adjuvant Breast and Bowel Project (NSABP) Phase II Intergroup Trial, N9945/CI-66 Steven R. Alberts, Mark S. Roh, Michelle R. Mahoney, Michael J. O'Connell, David M. Nagorney, Lawrence Wagman, Thomas C. Smyrk, Timothy L. Weiland, Lily Lau Lai, Roderich E. Schwarz, Roy Molina, Todor Dentchev, and John S. Bolton JCO Feb 2010: 853–858. First published on Jan 4 2010; 10.1200/JCO.2009.24.6728. [Abstract] [Full Text] [PDF]

Phase II, Randomized Study of Concomitant Chemoradiotherapy Followed by Surgery and Adjuvant Capecitabine Plus Oxaliplatin (CAPOX) Compared With Induction CAPOX Followed by Concomitant Chemoradiotherapy and Surgery in Magnetic Resonance Imaging–Defined, Locally Advanced Rectal Cancer: Grupo Cáncer de Recto 3 Study Carlos Fernández-Martos, Carles Pericay, Jorge Aparicio, Antonieta Salud, MariaJose Safont, Bertomeu Massuti, Ruth Vera, Pilar Escudero, Joan Maurel, Eugenio Marcuello, Jose Luis Mengual, Eugenio Saigi, Rafael Estevan, Moises Mira, Sonia Polo, Ana Hernandez, Manuel Gallen, Fernando Arias, Javier Serra, and Vicente Alonso JCO Feb 2010: 859–865. First published on Jan 11 2010; 10.1200/JCO.2009.25.8541. [Abstract] [Full Text] [PDF]

Genotype-Driven Phase I Study of Irinotecan Administered in Combination With Fluorouracil/Leucovorin in Patients With Metastatic Colorectal Cancer Giuseppe Toffoli, Erika Cecchin, Giampiero Gasparini, Mario D'Andrea, Giuseppe Azzarello, Umberto Basso, Enrico Mini, Sergio Pessa, Elena De Mattia, Giovanni Lo Re, Angela Buonadonna, Stefania Nobili, Paolo De Paoli, and Federico Innocenti JCO Feb 2010: 866–871. First published on Dec 28 2009; 10.1200/JCO.2009.23.6125. [Abstract] [Full Text] [PDF]

Pediatric Oncology

Does Childhood Cancer Affect Parental Divorce Rates? A Population-Based Study Astri Syse, Jon H. Loge, and Torkild H. Lyngstad JCO Feb 2010: 872–877. First published on Dec 28 2009; 10.1200/JCO.2009.24.0556. [Abstract] [Full Text] [PDF]

Physician Preferences and Knowledge Gaps Regarding the Care of Childhood Cancer Survivors: A Mailed Survey of Pediatric Oncologists Tara O. Henderson, Fay J. Hlubocky, Kristen E. Wroblewski, Lisa Diller, and Christopher K. Daugherty JCO Feb 2010: 878–883. First published on Dec 28 2009; 10.1200/JCO.2009.25.6107. [Abstract] [Full Text] [PDF] [Data Supplement]

                                      REVIEW ARTICLE

Investigational Immunotherapeutics for B-Cell Malignancies Alfonso Quintás-Cardama, William Wierda, and Susan O'Brien JCO Feb 2010: 884–892. First published on Jan 4 2010; 10.1200/JCO.2009.22.8254. [Abstract] [Full Text] [PDF]

                                      ASCO SPECIAL ARTICLE

American Society of Clinical Oncology Policy Statement Update: Genetic and Genomic Testing for Cancer Susceptibility Mark E. Robson, Courtney D. Storm, Jeffrey Weitzel, Dana S. Wollins, and Kenneth Offit JCO Feb 2010: 893–901. First published on Jan 11 2010; 10.1200/JCO.2009.27.0660. [Full Text] [PDF]

                                      DIAGNOSIS IN ONCOLOGY

Sirolimus and Temsirolimus for Epithelioid Angiomyolipoma Nicholas Wolff, Wareef Kabbani, Thomas Bradley, Ganesh Raj, Lori Watumull, and James Brugarolas JCO Feb 2010: e65–e68. First published on Jan 4 2010; 10.1200/JCO.2009.26.3061. [Full Text] [PDF]

Epstein-Barr Virus–Positive Diffuse Large B-Cell Lymphoma During Therapy With Alemtuzumab for T-Cell Prolymphocytic Leukemia Aliyah R. Sohani, Judith A. Ferry, Priscilla S. Chang, and Jeremy S. Abramson JCO Feb 2010: e69–e72. First published on Nov 16 2009; 10.1200/JCO.2009.24.4194. [Full Text] [PDF]

Isolated Ovarian Relapse in a 68-Year-Old Woman With Acute Lymphoblastic Leukemia Manish Kumar Singhal, Vamshi Krishnan, Sarika Singh, Rajive Kumar, and Vinod Raina JCO Feb 2010: e73–e74. First published on Nov 23 2009; 10.1200/JCO.2009.24.1398. [Full Text] [PDF]

Epstein-Barr Virus–Associated Diffuse Large B-Cell Lymphoma in an Immunocompetent Woman Olga Pozdnyakova, Paul J. Spieler, John Abraham, Arnold S. Freedman, and Jeffery L. Kutok JCO Feb 2010: e75–e78. First published on Nov 16 2009; 10.1200/JCO.2009.23.1423. [Full Text] [PDF]

                                      CORRESPONDENCE

Selection Bias Clouds Apparent Benefit of Longer Hormone Duration Kevin Lin, Steve P. Lee, and Michael L. Steinberg JCO Feb 2010: e79. First published on Oct 19 2009; 10.1200/JCO.2009.25.0969. [Full Text] [PDF]

Reply to K. Lin et al Luis Souhami, Kyounghwa Bae, and Howard M. Sandler JCO Feb 2010: e80. First published on Oct 19 2009; 10.1200/JCO.2009.25.2221. [Full Text] [PDF]

Metastatic Disease Response to Treatment: How Many Lesions to Measure? Panos Prassopoulos and Michael Mantatzis JCO Feb 2010: e81. First published on Oct 19 2009; 10.1200/JCO.2009.24.4004. [Full Text] [PDF]

Reply to P. Prassopoulos et al Shauna L. Hillman and Daniel J. Sargent JCO Feb 2010: e82. First published on Oct 19 2009; 10.1200/JCO.2009.24.6736. [Full Text] [PDF]

Fluorescent In Situ Hybridization As a Primary Test for HER2 Status in Breast Cancer: Controversies Vincenzo Arena, Ilaria Pennacchia, Giovanni Monego, Arnaldo Carbone, and Arnaldo Capelli JCO Feb 2010: e83–e84. First published on Jan 11 2010; 10.1200/JCO.2009.25.1397. [Full Text] [PDF]

Reply to V. Arena et al Guido Sauter, James A. Lee, Dennis J. Slamon, and Michael F. Press JCO Feb 2010: e85–e88. First published on Jan 11 2010; 10.1200/JCO.2009.25.3930. [Full Text] [PDF]

Revisiting the Concept of Phenotypically Distinct Malignant Pancreatic Stem-Cell Subsets Based on Limiting Dilution Transplantation Assays Thierry Bonnefoix and Mary Callanan JCO Feb 2010: e89–e90. First published on Oct 19 2009; 10.1200/JCO.2009.25.0282. [Full Text] [PDF]

To see an article, click its [Full Text] or [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.