February 8, 2010

BREAST CANCER

Neratinib, an Irreversible ErbB Receptor Tyrosine Kinase Inhibitor, in Patients With Advanced ErbB2-Positive Breast Cancer

Harold J. Burstein, Yan Sun, Luc Y. Dirix, Zefei Jiang, Robert Paridaens, Antoinette R. Tan, Ahmad Awada, Anantbhushan Ranade, Shunchang Jiao, Gary Schwartz, Richat Abbas, Christine Powell, Kathleen Turnbull, Jennifer Vermette, Charles Zacharchuk, and Rajendra Badwe
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.8707 [Abstract] [PDF]  

BREAST CANCER

Effects of Tamoxifen and Exemestane on Cognitive Functioning of Postmenopausal Patients With Breast Cancer: Results From the Neuropsychological Side Study of the Tamoxifen and Exemestane Adjuvant Multinational Trial

Christina M. Schilder, Caroline Seynaeve, Louk V. Beex, Willem Boogerd, Sabine C. Linn, Chad M. Gundy, Hilde M. Huizenga, Johan W. Nortier, Cornelis J. van de Velde, Frits S. van Dam, and Sanne B. Schagen
JCO published online February 8, 2010, DOI:10.1200/JCO.2008.21.3553 [Abstract] [PDF]  

CANCER RELATED COMPLICATIONS

Role of Cancer Treatment in Long-Term Overall and Cardiovascular Mortality After Childhood Cancer

Markhaba Tukenova, Catherine Guibout, Odile Oberlin, Françoise Doyon, Abdeddahir Mousannif, Nadia Haddy, Sylvie Guérin, Hélène Pacquement, Albertine Aouba, Mike Hawkins, Dave Winter, Jean Bourhis, Dimitri Lefkopoulos, Ibrahima Diallo, and Florent de Vathaire
JCO published online February 8, 2010, DOI:10.1200/JCO.2008.20.2267 [Abstract] [PDF]  

COMMENTS AND CONTROVERSIES

Consistency in Insurance Coverage for Iatrogenic Conditions Resulting From Cancer Treatment Including Fertility Preservation

Lisa Campo-Engelstein
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.6883 [Abstract] [PDF]  

EDITORIALS

Cardiotoxicity After Childhood Cancer: Beginning With the End in Mind

Steven E. Lipshultz and M. Jacob Adams
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.26.5751 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Facilitating Informed Decisions Regarding Microsatellite Instability Testing Among High-Risk Individuals Diagnosed With Colorectal Cancer

Sharon L. Manne, Neal J. Meropol, David S. Weinberg, Hetal Vig, Zohra Ali-Khan Catts, Cheri Manning, Eric Ross, Kristen Shannon, and Daniel C. Chung
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.0399 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Cellular Histone Modification Patterns Predict Prognosis and Treatment Response in Resectable Pancreatic Adenocarcinoma: Results From RTOG 9704

Ananya Manuyakorn, Rebecca Paulus, James Farrell, Nicole A. Dawson, Sheila Tze, Gardenia Cheung-Lau, Oscar Joe Hines, Howard Reber, David B. Seligson, Steve Horvath, Siavash K. Kurdistani, Chandhan Guha, and David W. Dawson
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.24.5639 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Skin Toxicity Evaluation Protocol With Panitumumab (STEPP), a Phase II, Open-Label, Randomized Trial Evaluating the Impact of a Pre-Emptive Skin Treatment Regimen on Skin Toxicities and Quality of Life in Patients With Metastatic Colorectal Cancer

Mario E. Lacouture, Edith P. Mitchell, Bilal Piperdi, Madhavan V. Pillai, Heather Shearer, Nicholas Iannotti, Feng Xu, and Mohamed Yassine
JCO published online February 8, 2010, DOI:10.1200/JCO.2008.21.7828 [Abstract] [PDF]  

GENITOURINARY CANCER

Phase II Study of Sunitinib in Patients With Metastatic Urothelial Cancer

David J. Gallagher, Matthew I. Milowsky, Scott R. Gerst, Nicole Ishill, Jamie Riches, Ashley Regazzi, Mary G. Boyle, Alisa Trout, Anne-Marie Flaherty, and Dean F. Bajorin
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.3922 [Abstract] [PDF]  

HEAD AND NECK CANCER

Sentinel Lymph Node Biopsy Accurately Stages the Regional Lymph Nodes for T1-T2 Oral Squamous Cell Carcinomas: Results of a Prospective Multi-Institutional Trial

Francisco J. Civantos, Robert P. Zitsch, David E. Schuller, Amit Agrawal, Russell B. Smith, Richard Nason, Guy Petruzelli, Christine G. Gourin, Richard J. Wong, Robert L. Ferris, Adel El Naggar, John A. Ridge, Randal C. Paniello, Kouros Owzar, Linda McCall, Douglas B. Chepeha, Wendell G. Yarbrough, and Jeffrey N. Myers
JCO published online February 8, 2010, DOI:10.1200/JCO.2008.20.8777 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Sustained Molecular Response With Interferon Alfa Maintenance After Induction Therapy With Imatinib Plus Interferon Alfa in Patients With Chronic Myeloid Leukemia

Andreas Burchert, Martin C. Müller, Philippe Kostrewa, Philipp Erben, Tilman Bostel, Simone Liebler, Rüdiger Hehlmann, Andreas Neubauer, and Andreas Hochhaus
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.5075 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Cost Effectiveness of Positron Emission Tomography in Patients With Hodgkin's Lymphoma in Unconfirmed Complete Remission or Partial Remission After First-Line Therapy

Juliano J. Cerci, Evelinda Trindade, Luís F. Pracchia, Felipe A. Pitella, Camila C.G. Linardi, José Soares Jr, Dominique Delbeke, Leigh-Ann Topfer, Valeria Buccheri, and José C. Meneghetti
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.4367 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Phase II Trial of Weekly Bortezomib in Combination With Rituximab in Relapsed or Relapsed and Refractory Waldenström Macroglobulinemia

Irene M. Ghobrial, Fangxin Hong, Swaminathan Padmanabhan, Ashraf Badros, Meghan Rourke, Renee Leduc, Stacey Chuma, Janet Kunsman, Diane Warren, Brianna Harris, Amy Sam, Kenneth C. Anderson, Paul G. Richardson, Steven P. Treon, Edie Weller, and Jeffrey Matous
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.3237 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Phase II Trial of the Oral Mammalian Target of Rapamycin Inhibitor Everolimus in Relapsed or Refractory Waldenström Macroglobulinemia

Irene M. Ghobrial, Morie Gertz, Betsy LaPlant, John Camoriano, Suzanne Hayman, Martha Lacy, Stacey Chuma, Brianna Harris, Renee Leduc, Meghan Rourke, Stephen M. Ansell, Daniel DeAngelo, Angela Dispenzieri, Leif Bergsagel, Craig Reeder, Kenneth C. Anderson, Paul G. Richardson, Steven P. Treon, and Thomas E. Witzig
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.24.0994 [Abstract] [PDF]  

NEUROONCOLOGY

Universal Poor Survival in Children With Medulloblastoma Harboring Somatic TP53 Mutations

Uri Tabori, Berivan Baskin, Mary Shago, Noa Alon, Michael D. Taylor, Peter N. Ray, Eric Bouffet, David Malkin, and Cynthia Hawkins
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.23.5952 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Whole-Genome Profiling of Pediatric Diffuse Intrinsic Pontine Gliomas Highlights Platelet-Derived Growth Factor Receptor and Poly (ADP-ribose) Polymerase As Potential Therapeutic Targets

Maryam Zarghooni, Ute Bartels, Eric Lee, Pawel Buczkowicz, Andrew Morrison, Annie Huang, Eric Bouffet, and Cynthia Hawkins
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.5463 [Abstract] [PDF] [Data Supplements]  

PEDIATRIC ONCOLOGY

Phase II, Randomized, Open-Label Study of Pegfilgrastim-Supported VDC/IE Chemotherapy in Pediatric Sarcoma Patients

Sheri L. Spunt, Helen Irving, Jami Frost, Leonard Sender, Matthew Guo, Bing-Bing Yang, Lyndah Dreiling, and Victor M. Santana
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.24.8872 [Abstract] [PDF]  

THORACIC ONCOLOGY

Phase I/II Study of the Src Inhibitor Dasatinib in Combination With Erlotinib in Advanced Non–Small-Cell Lung Cancer

Eric B. Haura, Tawee Tanvetyanon, Alberto Chiappori, Charles Williams, George Simon, Scott Antonia, Jhanelle Gray, Sharon Litschauer, Leticia Tetteh, Anthony Neuger, Lanxi Song, Bhupendra Rawal, Michael J. Schell, and Gerold Bepler
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.25.4029 [Abstract] [PDF] [Data Supplement]  

THORACIC ONCOLOGY

Mature Results of an Individualized Radiation Dose Prescription Study Based on Normal Tissue Constraints in Stages I to III Non–Small-Cell Lung Cancer

Angela van Baardwijk, Stofferinus Wanders, Liesbeth Boersma, Jacques Borger, Michel Öllers, Anne-Marie C. Dingemans, Gerben Bootsma, Wiel Geraedts, Cordula Pitz, Ragnar Lunde, Philippe Lambin, and Dirk De Ruysscher
JCO published online February 8, 2010, DOI:10.1200/JCO.2009.24.7221 [Abstract] [PDF]  

February 1, 2010

ART OF ONCOLOGY

Life's Lessons Lost...and Learned

Reena George
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.0413 [Abstract] [PDF]  

BREAST CANCER

Significant Effect of Polymorphisms in CYP2D6 and ABCC2 on Clinical Outcomes of Adjuvant Tamoxifen Therapy for Breast Cancer Patients

Kazuma Kiyotani, Taisei Mushiroda, Chiyo K. Imamura, Naoya Hosono, Tatsuhiko Tsunoda, Michiaki Kubo, Yusuke Tanigawara, David A. Flockhart, Zeruesenay Desta, Todd C. Skaar, Fuminori Aki, Koichi Hirata, Yuichi Takatsuka, Minoru Okazaki, Shozo Ohsumi, Takashi Yamakawa, Mitsunori Sasa, Yusuke Nakamura, and Hitoshi Zembutsu
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.7246 [Abstract] [PDF]  

BREAST CANCER

Phase II Trial of Pertuzumab and Trastuzumab in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer That Progressed During Prior Trastuzumab Therapy

José Baselga, Karen A. Gelmon, Shailendra Verma, Andrew Wardley, PierFranco Conte, David Miles, Giulia Bianchi, Javier Cortes, Virginia A. McNally, Graham A. Ross, Pierre Fumoleau, and Luca Gianni
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.2024 [Abstract] [PDF]  

BREAST CANCER

Open-Label, Phase II, Multicenter, Randomized Study of the Efficacy and Safety of Two Dose Levels of Pertuzumab, a Human Epidermal Growth Factor Receptor 2 Dimerization Inhibitor, in Patients With Human Epidermal Growth Factor Receptor 2–Negative Metastatic Breast Cancer

Luca Gianni, Anna Lladó, Giulia Bianchi, Javier Cortes, Pirkko-Liisa Kellokumpu-Lehtinen, David A. Cameron, David Miles, Stefania Salvagni, Andrew Wardley, Jean-Charles Goeminne, Veronica Hersberger, and José Baselga
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.1661 [Abstract] [PDF]  

BREAST CANCER

Relationship Between Plasma Estradiol Levels and Estrogen-Responsive Gene Expression in Estrogen Receptor–Positive Breast Cancer in Postmenopausal Women

Anita K. Dunbier, Helen Anderson, Zara Ghazoui, Elizabeth J. Folkerd, Roger A'Hern, Robert J. Crowder, Jeremy Hoog, Ian E. Smith, Peter Osin, Ashutosh Nerurkar, Joel S. Parker, Charles M. Perou, Matthew J. Ellis, and Mitch Dowsett
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.23.9616 [Abstract] [PDF]  

BREAST CANCER

Randomized Study of Lapatinib Alone or in Combination With Trastuzumab in Women With ErbB2-Positive, Trastuzumab-Refractory Metastatic Breast Cancer

Kimberly L. Blackwell, Harold J. Burstein, Anna Maria Storniolo, Hope Rugo, George Sledge, Maria Koehler, Catherine Ellis, Michelle Casey, Svetislava Vukelja, Joachim Bischoff, Jose Baselga, and Joyce O'Shaughnessy
JCO published online February 1, 2010, DOI:10.1200/JCO.2008.21.4437 [Abstract] [PDF]  

CORRESPONDENCE

Reply to M. Isik et al

Heikki Joensuu, Petri Bono, and Pirkko-Liisa Kellokumpu-Lehtinen
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.3243 [Abstract] [PDF]  

CORRESPONDENCE

Two Important Determinants May Play a Role in the Success of the FinHer Trial

Metin Isik, Omer Dizdar, and Kadri Altundag
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.2740 [Abstract] [PDF]  

CORRESPONDENCE

Reply to T. Watanabe et al

Shuji Ogino, Jeffrey A. Meyerhardt, and Charles S. Fuchs
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.1007 [Abstract] [PDF]  

CORRESPONDENCE

Prognostic Significance of 18q Loss of Heterzygosity in Microsatellite-Stable Colorectal Cancer

Toshiaki Watanabe, Takashi Kobunai, Yoko Yamamoto, Tsuyoshi Konishi, Hideaki Yano, Hisae Iinuma, Tamuro Hayama, Keijiro Nozawa, Soichiro Ishihara, and Keiji Matsuda
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.0256 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Isolated Loss of Hormonal Receptors in Leptomeningeal Metastasis From Estrogen Receptor– and Progesterone Receptor–Positive Lobular Breast Cancer

Jai Grewal, Huadong Zhou, Rachel Factor, and Santosh Kesari
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.3518 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Disseminated Tumor Embolism From Breast Cancer Leading to Multiorgan Failure

Daphne T. Tsoi, Corwyn Rowsell, Caitlin McGregor, Catherine M. Kelly, Sunil Verma, and Kathleen I. Pritchard
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.1009 [Abstract] [PDF]  

EDITORIALS

Evidence and Practice Regarding the Role for CYP2D6 Inhibition in Decisions About Tamoxifen Therapy

Timothy L. Lash and Carol L. Rosenberg
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.26.7906 [Abstract] [PDF]  

EDITORIALS

Seduced by Dose?

W. Robert Lee
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.26.5579 [Abstract] [PDF]  

EDITORIALS

Enzastaurin in the Treatment of Recurrent Glioblastoma: A Promise That Did Not Materialize

Evanthia Galanis and Jan C. Buckner
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.26.1149 [Abstract] [PDF]  

EDITORIALS

Whither HER2-Related Therapeutics?

Pradip De and Brian Leyland-Jones
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.8624 [Abstract] [PDF]  

EDITORIALS

Optimizing the Delivery of Targeted Research: An Opportunity for Comparative Effectiveness Research

Kathleen I. Pritchard
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.2205 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Decision Model of Segmental Compared With Total Abdominal Colectomy for Colon Cancer in Hereditary Nonpolyposis Colorectal Cancer

Takafumi Maeda, Rebecca R. Cannom, Robert W. Beart Jr, and David A. Etzioni
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.9812 [Abstract] [PDF]  

GENITOURINARY CANCER

Time Trends and Local Variation in Primary Treatment of Localized Prostate Cancer

Matthew R. Cooperberg, Jeanette M. Broering, and Peter R. Carroll
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.26.0133 [Abstract] [PDF]  

GENITOURINARY CANCER

Randomized Trial Comparing Conventional-Dose With High-Dose Conformal Radiation Therapy in Early-Stage Adenocarcinoma of the Prostate: Long-Term Results From Proton Radiation Oncology Group/American College of Radiology 95-09

Anthony L. Zietman, Kyounghwa Bae, Jerry D. Slater, William U. Shipley, Jason A. Efstathiou, John J. Coen, David A. Bush, Margie Lunt, Daphna Y. Spiegel, Rafi Skowronski, B. Rodney Jabola, and Carl J. Rossi
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.8475 [Abstract] [PDF]  

GENITOURINARY CANCER

Finasteride to Prevent Prostate Cancer: Should All Men or Only a High-Risk Subgroup Be Treated?

Andrew J. Vickers, Caroline J. Savage, and Hans Lilja
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.23.5572 [Abstract] [PDF]  

GYNECOLOGIC CANCER

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Sharmila Makhija, Lukas C. Amler, Dana Glenn, Frederick R. Ueland, Michael A. Gold, Don S. Dizon, Virginia Paton, Chin-Yu Lin, Thomas Januario, Kimmie Ng, Andreas Strauss, Stephen Kelsey, Mark X. Sliwkowski, and Ursula Matulonis
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.22.3354 [Abstract] [PDF]  

HEAD AND NECK CANCER

Positron Emission Tomography With [¹⁸F]Fluorodeoxyglucose Improves Staging and Patient Management in Patients With Head and Neck Squamous Cell Carcinoma: A Multicenter Prospective Study

Max Lonneux, Marc Hamoir, Hervé Reychler, Philippe Maingon, Christian Duvillard, Gilles Calais, Boumédiène Bridji, Laurence Digue, Michel Toubeau, and Vincent Grégoire
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.6298 [Abstract] [PDF]  

HISTORY OF ONCOLOGY

Ephraim McDowell, the First Ovariotomy, and the Birth of Abdominal Surgery

Leora Horn and David H. Johnson
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.7261 [Abstract] [PDF]  

MELANOMA

Cytokine Working Group Study of Lymphodepleting Chemotherapy, Interleukin-2, and Granulocyte-Macrophage Colony-Stimulating Factor in Patients With Metastatic Melanoma: Clinical Outcomes and Peripheral-Blood Cell Recovery

Krishna S. Gunturu, Kenneth R. Meehan, Todd A. Mackenzie, Todd S. Crocenzi, David McDermott, Edward J. Usherwood, Kim A. Margolin, Nancy A. Crosby, Michael B. Atkins, Mary Jo Turk, Cory Ahonen, Shinichiro Fuse, Joseph I. Clark, Jan L. Fisher, Randolph J. Noelle, and Marc S. Ernstoff
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.8153 [Abstract] [PDF]  

NEUROONCOLOGY

Phase III Study of Enzastaurin Compared With Lomustine in the Treatment of Recurrent Intracranial Glioblastoma

Wolfgang Wick, Vinay K. Puduvalli, Marc C. Chamberlain, Martin J. van den Bent, Antoine F. Carpentier, Lawrence M. Cher, Warren Mason, Michael Weller, Shengyan Hong, Luna Musib, Astra M. Liepa, Donald E. Thornton, and Howard A. Fine
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.23.2595 [Abstract] [PDF]  

PALLIATIVE AND SUPPORTIVE CARE

End-of-Life Discussions, Goal Attainment, and Distress at the End of Life: Predictors and Outcomes of Receipt of Care Consistent With Preferences

Jennifer W. Mack, Jane C. Weeks, Alexi A. Wright, Susan D. Block, and Holly G. Prigerson
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.4672 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Comparison of the Prognostic Value of Assessing Tumor Diameter Versus Tumor Volume at Diagnosis or in Response to Initial Chemotherapy in Rhabdomyosarcoma

Andrea Ferrari, Rosalba Miceli, Cristina Meazza, Michela Casanova, Francesca Favini, Carlo Morosi, Giovanna Trecate, Alfonso Marchianò, Roberto Luksch, Graziella Cefalo, Monica Terenziani, Filippo Spreafico, Daniela Polastri, Marta Podda, Serena Catania, Elisabetta Schiavello, Patrizia Giannatempo, Lorenza Gandola, Maura Massimino, and Luigi Mariani
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.0803 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Second Malignant Neoplasms in Survivors of Pediatric Hodgkin's Lymphoma Treated With Low-Dose Radiation and Chemotherapy

Maureen M. O'Brien, Sarah S. Donaldson, Raymond R. Balise, Alice S. Whittemore, and Michael P. Link
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.8062 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

Temporal Trends in Cause-Specific Late Mortality Among 5-Year Survivors of Childhood Cancer

Gregory T. Armstrong, Zhenyu Pan, Kirsten K. Ness, Deokumar Srivastava, and Leslie L. Robison
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.4608 [Abstract] [PDF] [Data Supplement]  

PEDIATRIC ONCOLOGY

Gene Expression Profiling for Survival Prediction in Pediatric Rhabdomyosarcomas: A Report From the Children's Oncology Group

Elai Davicioni, James R. Anderson, Jonathan D. Buckley, William H. Meyer, and Timothy J. Triche
JCO published online February 1, 2010, DOI:10.1200/JCO.2008.21.1268 [Abstract] [PDF] [Data Supplement]  

PHASE I AND CLINICAL PHARMACOLOGY

Choice of Starting Dose for Molecularly Targeted Agents Evaluated in First-in-Human Phase I Cancer Clinical Trials

Christophe Le Tourneau, Anastasios Stathis, Laura Vidal, Malcolm J. Moore, and Lillian L. Siu
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.9606 [Abstract] [PDF]  

SARCOMAS

Comparison of Two Doses of Imatinib for the Treatment of Unresectable or Metastatic Gastrointestinal Stromal Tumors: A Meta-Analysis of 1,640 Patients

Gastrointestinal Stromal Tumor Meta-Analysis Group (MetaGIST)
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.24.2099 [Abstract] [PDF]  

THORACIC ONCOLOGY

Clinical Course of Advanced Non–Small-Cell Lung Cancer Patients Experiencing Hypertension During Treatment With Bevacizumab in Combination With Carboplatin and Paclitaxel on ECOG 4599

Suzanne E. Dahlberg, Alan B. Sandler, Julie R. Brahmer, Joan H. Schiller, and David H. Johnson
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.4482 [Abstract] [PDF]  

January 25, 2010

BIOLOGY OF NEOPLASIA

Molecular Mechanisms of Resistance to Cetuximab and Panitumumab in Colorectal Cancer

Alberto Bardelli and Salvatore Siena
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.24.6116 [Abstract] [PDF]  

BREAST CANCER

Migraine History and Breast Cancer Risk Among Postmenopausal Women

Christopher I. Li, Robert W. Mathes, Elizabeth C. Bluhm, Bette Caan, Mary F. Cavanagh, Rowan T. Chlebowski, Yvonne Michael, Mary Jo O'Sullivan, Marcia L. Stefanick, and Ross Prentice
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.25.0423 [Abstract] [PDF]  

BREAST CANCER

Randomized, Blinded, Sham-Controlled Trial of Acupuncture for the Management of Aromatase Inhibitor–Associated Joint Symptoms in Women With Early-Stage Breast Cancer

Katherine D. Crew, Jillian L. Capodice, Heather Greenlee, Lois Brafman, Deborah Fuentes, Danielle Awad, Wei Yann Tsai, and Dawn L. Hershman
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.23.4708 [Abstract] [PDF]  

BREAST CANCER

Efficacy of Neoadjuvant Cisplatin in Triple-Negative Breast Cancer

Daniel P. Silver, Andrea L. Richardson, Aron C. Eklund, Zhigang C. Wang, Zoltan Szallasi, Qiyuan Li, Nicolai Juul, Chee-Onn Leong, Diana Calogrias, Ayodele Buraimoh, Aquila Fatima, Rebecca S. Gelman, Paula D. Ryan, Nadine M. Tung, Arcangela De Nicolo, Shridar Ganesan, Alexander Miron, Christian Colin, Dennis C. Sgroi, Leif W. Ellisen, Eric P. Winer, and Judy E. Garber
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.22.4725 [Abstract] [PDF] [Data Supplements]  

CORRESPONDENCE

Reply to T. Smith et al

Joseph A. Sparano
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.27.3029 [Abstract] [PDF]  

CORRESPONDENCE

Comparison of Studies on Mobile Phone Use and Risk of Tumors

Florence Samkange-Zeeb, Joachim Schüz, Brigitte Schlehofer, Gabrielle Berg-Beckhoff, and Maria Blettner
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.9084 [Abstract] [PDF]  

CORRESPONDENCE

Reply to K. Filanovsky et al

Patrice Chevallier, Jacques Delaunay, Pascal Turlure, Arnaud Pigneux, Mathilde Hunault, Richard Garand, Thierry Guillaume, Herve Avet-Loiseau, Nathalia Dmytruk, Stephane Girault, Noel Milpied, Norbert Ifrah, Mohamad Mohty, and Jean-Luc Harousseau
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8680 [Abstract] [PDF]  

CORRESPONDENCE

Reply to M.S. Katz et al

Todd H. Wagner, Christine Murray, Jacquelyn Goldberg, Jeanne M. Adler, and Jeffrey Abrams
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8672 [Abstract] [PDF]  

CORRESPONDENCE

Reply to A.M. Araujo et al

Alex A. Adjei
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8664 [Abstract] [PDF]  

CORRESPONDENCE

Reply to A. Stang et al, J.T. Rowley et al, and F. Samkange-Zeeb et al

Seung-Kwon Myung, Woong Ju, Diana D. McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, and Joel M. Moskowitz
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8375 [Abstract] [PDF]  

CORRESPONDENCE

Comment on Pegylated Liposomal Doxorubicin Plus Docetaxel in Metastatic Breast Cancer

Thomas J. Smith and Bruce E. Hillner
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8243 [Abstract] [PDF]  

CORRESPONDENCE

Studies of Mobile Phone Use and Brain Tumor Risk Are Independent of Industry Influence

Jack T. Rowley and Michael J. Milligan
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.8136 [Abstract] [PDF]  

CORRESPONDENCE

Advantage of MIDAM Protocol in Treatment of the Elderly Patients With Refractory and Relapsing Acute Myeloid Leukemia

Kalman Filanovsky, Lev Shvidel, and Mordechai Shtalrid
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.7930 [Abstract] [PDF]  

CORRESPONDENCE

Arbitrary Results of a Meta-Analysis on Cancer Risks Among Mobile Phone Users

Andreas Stang, Andrea Schmidt-Pokrzywniak, and Oliver Kuss
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.7443 [Abstract] [PDF]  

CORRESPONDENCE

Central Institutional Review Board–Facilitated Review Metrics Omit Critical Components

Michael S. Katz and Mary L. Smith
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.7393 [Abstract] [PDF]  

CORRESPONDENCE

Pemetrexed Plus Bevacizumab for Second-Line Therapy of Non–Small-Cell Lung Cancer: The Importance of Patient Selection

Antonio M. Araujo
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.7351 [Abstract] [PDF]  

EDITORIALS

Epidermal Growth Factor Receptor Biomarkers in Non–Small-Cell Lung Cancer: A Riddle, Wrapped in a Mystery, Inside an Enigma

Frances A. Shepherd and Ming-Sound Tsao
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.3996 [Abstract] [PDF]  

EDITORIALS

Developing Immunotherapy As Legitimate Therapy for Patients With Prostate Cancer

Eric J. Small and Lawrence Fong
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.3483 [Abstract] [PDF]  

GASTROINTESTINAL CANCER

Pharmacogenomic and Pharmacoproteomic Studies of Cetuximab in Metastatic Colorectal Cancer: Biomarker Analysis of a Phase I Dose-Escalation Study

Josep Tabernero, Andres Cervantes, Fernando Rivera, Erika Martinelli, Federico Rojo, Anja von Heydebreck, Teresa Macarulla, Edith Rodriguez-Braun, Maria Eugenia Vega-Villegas, Stefanie Senger, Francisco Javier Ramos, Susana Roselló, Ilhan Celik, Christopher Stroh, José Baselga, and Fortunato Ciardiello
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.22.6043 [Abstract] [PDF] [Data Supplement]  

GENITOURINARY CANCER

Impact of Ethnicity on Primary Treatment Choice and Mortality in Men With Prostate Cancer: Data From CaPSURE

Kelvin A. Moses, Alan T. Paciorek, David F. Penson, Peter R. Carroll, and Viraj A. Master
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.26.2469 [Abstract] [PDF]  

GENITOURINARY CANCER

Overall Survival Analysis of a Phase II Randomized Controlled Trial of a Poxviral-Based PSA-Targeted Immunotherapy in Metastatic Castration-Resistant Prostate Cancer

Philip W. Kantoff, Thomas J. Schuetz, Brent A. Blumenstein, L. Michael Glode, David L. Bilhartz, Michael Wyand, Kelledy Manson, Dennis L. Panicali, Reiner Laus, Jeffrey Schlom, William L. Dahut, Philip M. Arlen, James L. Gulley, and Wayne R. Godfrey
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.25.0597 [Abstract] [PDF]  

GENITOURINARY CANCER

Pazopanib in Locally Advanced or Metastatic Renal Cell Carcinoma: Results of a Randomized Phase III Trial

Cora N. Sternberg, Ian D. Davis, Jozef Mardiak, Cezary Szczylik, Eunsik Lee, John Wagstaff, Carlos H. Barrios, Pamela Salman, Oleg A. Gladkov, Alexander Kavina, Juan J. Zarbá, Mei Chen, Lauren McCann, Lini Pandite, Debasish F. Roychowdhury, and Robert E. Hawkins
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.23.9764 [Abstract] [PDF]  

THORACIC ONCOLOGY

Analysis of Potential Predictive Markers of Cetuximab Benefit in BMS099, a Phase III Study of Cetuximab and First-Line Taxane/Carboplatin in Advanced Non–Small-Cell Lung Cancer

Shirin Khambata-Ford, Christopher T. Harbison, Lowell L. Hart, Melissa Awad, Li-An Xu, Christine E. Horak, Shaker Dakhil, Robert C. Hermann, Thomas J. Lynch, and Martin R. Weber
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.25.2890 [Abstract] [PDF] [Data Supplement]  

THORACIC ONCOLOGY

Cetuximab and First-Line Taxane/Carboplatin Chemotherapy in Advanced Non–Small-Cell Lung Cancer: Results of the Randomized Multicenter Phase III Trial BMS099

Thomas J. Lynch, Taral Patel, Luke Dreisbach, Michael McCleod, William J. Heim, Robert C. Hermann, Eugene Paschold, Nicholas O. Iannotti, Shaker Dakhil, Steven Gorton, Virginie Pautret, Martin R. Weber, and Donald Woytowitz
JCO published online January 25, 2010, DOI:10.1200/JCO.2009.21.9618 [Abstract] [PDF]  

THORACIC ONCOLOGY

Phase II Trial of a Trimodality Regimen for Stage III Non–Small-Cell Lung Cancer Using Chemotherapy As Induction Treatment With Concurrent Hyperfractionated Chemoradiation With Carboplatin and Paclitaxel Followed by Subsequent Resection: A Single-Center Study

Godehard Friedel, Wilfried Budach, Juergen Dippon, Werner Spengler, Susanne Martina Eschmann, Christina Pfannenberg, Fawaz Al-Kamash, Thorsten Walles, Hermann Aebert, Thomas Kyriss, Stefanie Veit, Martin Kimmich, Michael Bamberg, Martin Kohlhaeufl, Volker Steger, and Thomas Hehr
JCO published online January 25, 2010, DOI:10.1200/JCO.2008.21.7810 [Abstract] [PDF]  

January 19, 2010

BIOLOGY OF NEOPLASIA

The PI3K Pathway As Drug Target in Human Cancer

Kevin D. Courtney, Ryan B. Corcoran, and Jeffrey A. Engelman
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.25.3641 [Abstract] [PDF]  

BREAST CANCER

Nodal-Stage Classification in Invasive Lobular Breast Carcinoma: Influence of Different Interpretations of the pTNM Classification

Carolien H.M. van Deurzen, Gabor Cserni, Simonetta Bianchi, Vania Vezzosi, Riccardo Arisio, Jelle Wesseling, Martin Asslaber, Maria P. Foschini, Anna Sapino, Isabella Castellano, Grace Callagy, Daniel Faverly, Maria-Dolores Martin-Martinez, Cecily Quinn, Isabel Amendoeira, Janina Kulka, Angelika Reiner-Concin, Alicia Cordoba, Cornelis A. Seldenrijk, and Paul J. van Diest
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.22.0723 [Abstract] [PDF]  

CORRESPONDENCE

Reply to P.E. Lønning et al

Francesco Perrone, Ciro Gallo, Emanuela Rossi, and Andrea de Matteis
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.26.9506 [Abstract] [PDF]  

CORRESPONDENCE

Reply to S. Kilickap et al

Ahsun Riaz and Riad Salem
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.26.8383 [Abstract] [PDF]  

CORRESPONDENCE

Endocrine Effects of Aromatase Inhibitors

Per E. Lønning and Mitch Dowsett
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.26.8268 [Abstract] [PDF]  

CORRESPONDENCE

Alpha-Fetoprotein Response After Locoregional Therapy for Hepatocellular Carcinoma

Saadettin Kilickap, Cagatay Arslan, Soner Senel, and Hilmi Ataseven
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.26.7070 [Abstract] [PDF]  

EDITORIALS

Natural Killer Cell Consolidation for Acute Myelogenous Leukemia: A Cell Therapy Ready for Prime Time?

Michael R. Verneris and Stephan A. Grupp
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.26.4002 [Abstract] [PDF]  

GENITOURINARY CANCER

Association of Skeletal Muscle Wasting With Treatment With Sorafenib in Patients With Advanced Renal Cell Carcinoma: Results From a Placebo-Controlled Study

Sami Antoun, Laura Birdsell, Michael B. Sawyer, Peter Venner, Bernard Escudier, and Vickie E. Baracos
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.24.9730 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Long-Term Follow-Up of Autotransplantation Trials for Multiple Myeloma: Update of Protocols Conducted by the Intergroupe Francophone du Myelome, Southwest Oncology Group, and University of Arkansas for Medical Sciences

Bart Barlogie, Michel Attal, John Crowley, Frits van Rhee, Jackie Szymonifka, Philippe Moreau, Brian G.M. Durie, and Jean-Luc Harousseau
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.25.6081 [Abstract] [PDF] [Data Supplement]  

HEMATOLOGIC MALIGNANCIES

Single Cycle of Arsenic Trioxide–Based Consolidation Chemotherapy Spares Anthracycline Exposure in the Primary Management of Acute Promyelocytic Leukemia

Steven D. Gore, Ivana Gojo, Mikkael A. Sekeres, Lawrence Morris, Marcel Devetten, Katarzyna Jamieson, Robert L. Redner, Robert Arceci, Ibitayo Owoeye, Tianna Dauses, Esther Schachter-Tokarz, and Robert E. Gallagher
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.25.5158 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Multicenter Analysis of 80 Solid Organ Transplantation Recipients With Post-Transplantation Lymphoproliferative Disease: Outcomes and Prognostic Factors in the Modern Era

Andrew M. Evens, Kevin A. David, Irene Helenowski, Beverly Nelson, Dixon Kaufman, Sheetal M. Kircher, Alla Gimelfarb, Elise Hattersley, Lauren A. Mauro, Borko Jovanovic, Amy Chadburn, Patrick Stiff, Jane N. Winter, Jayesh Mehta, Koen Van Besien, Stephanie Gregory, Leo I. Gordon, Jamile M. Shammo, Scott E. Smith, and Sonali M. Smith
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.25.4961 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Bortezomib With or Without Dexamethasone in Primary Systemic (Light Chain) Amyloidosis

Efstathios Kastritis, Ashutosh D. Wechalekar, Meletios A. Dimopoulos, Giampaolo Merlini, Philip N. Hawkins, Vittorio Perfetti, Julian D. Gillmore, and Giovanni Palladini
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.23.8220 [Abstract] [PDF]  

PEDIATRIC ONCOLOGY

NKAML: A Pilot Study to Determine the Safety and Feasibility of Haploidentical Natural Killer Cell Transplantation in Childhood Acute Myeloid Leukemia

Jeffrey E. Rubnitz, Hiroto Inaba, Raul C. Ribeiro, Stanley Pounds, Barbara Rooney, Teresa Bell, Ching-Hon Pui, and Wing Leung
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.24.4590 [Abstract] [PDF]  

THORACIC ONCOLOGY

Reduction of Elevated Plasma Osteopontin Levels With Resection of Non–Small-Cell Lung Cancer

Justin D. Blasberg, Harvey I. Pass, Chandra M. Goparaju, Raja M. Flores, Suzie Lee, and Jessica S. Donington
JCO published online January 19, 2010, DOI:10.1200/JCO.2009.25.5711 [Abstract] [PDF]  

January 11, 2010

BREAST CANCER

Prevention of Aromatase Inhibitor–Induced Bone Loss Using Risedronate: The SABRE Trial

Catherine Van Poznak, Rosemary A. Hannon, John R. Mackey, Mario Campone, Justus P. Apffelstaedt, Glen Clack, David Barlow, Andreas Makris, and Richard Eastell
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.24.5902 [Abstract] [PDF]  

BREAST CANCER

Association Between the 21-Gene Recurrence Score Assay and Risk of Locoregional Recurrence in Node-Negative, Estrogen Receptor–Positive Breast Cancer: Results From NSABP B-14 and NSABP B-20

Eleftherios P. Mamounas, Gong Tang, Bernard Fisher, Soonmyung Paik, Steven Shak, Joseph P. Costantino, Drew Watson, Charles E. Geyer Jr, D. Lawrence Wickerham, and Norman Wolmark
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.23.7610 [Abstract] [PDF]  

BREAST CANCER

Prospective Multicenter Study of the Impact of the 21-Gene Recurrence Score Assay on Medical Oncologist and Patient Adjuvant Breast Cancer Treatment Selection

Shelly S. Lo, Patricia B. Mumby, John Norton, Karen Rychlik, Jeffrey Smerage, Joseph Kash, Helen K. Chew, Ellen R. Gaynor, Daniel F. Hayes, Andrew Epstein, and Kathy S. Albain
JCO published online January 11, 2010, DOI:10.1200/JCO.2008.20.2119 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Systemic Fibrinolysis Caused by Tissue Plasminogen Activator–Producing Metastatic Breast Cancer

Harris V.K. Naina, Mrinal M. Patnaik, Uzma A. Ali, Dong Chen, and Aneel A. Ashrani
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.2502 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Hodgkin's Lymphoma Arising in a Patient With Hypersensitivity to Mosquito Bites: A Case Report

Silvia Park, Sunha Bahng, Eun Kyoung Kim, Sung Bum Park, Young Kyung Sung, Suk Jin Kim, Won Seog Kim, and Young Hyeh Ko
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.0357 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Panhypopituitarism Secondary to Hypothalamic Involvement in a Woman With Diffuse Large B-Cell Lymphoma

Theresa W. Chan and Paul Hoskins
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.24.9060 [Abstract] [PDF]  

EDITORIALS

Authorship and Industry Financial Relationships: The Tie That Binds

David H. Johnson and Leora Horn
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.26.9753 [Abstract] [PDF]  

EDITORIALS

Surgery Versus Stereotactic Body Radiation Therapy for Early-Stage Lung Cancer: Who's Down for the Count?

Robert D. Timmerman
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.26.5165 [Abstract] [PDF]  

EDITORIALS

Stereotactic Body Radiation Therapy Versus Wedge Resection for Medically Inoperable Stage I Lung Cancer: Tailored Therapy or One Size Fits All?

Nasser K. Altorki
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.26.5157 [Abstract] [PDF]  

EDITORIALS

Defining the Clinical Utility of Gene Expression Assays in Breast Cancer: The Intersection of Science and Art in Clinical Decision Making

Joseph A. Sparano and Lawrence J. Solin
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.2882 [Abstract] [PDF]  

ETHICS

Relationships Between Authorship Contributions and Authors' Industry Financial Ties Among Oncology Clinical Trials

Susannah L. Rose, Monika K. Krzyzanowska, and Steven Joffe
JCO published online January 11, 2010, DOI:10.1200/JCO.2008.21.6606 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Life Expectancy in Patients Surviving More Than 5 Years After Hematopoietic Cell Transplantation

Paul J. Martin, George W. Counts Jr, Frederick R. Appelbaum, Stephanie J. Lee, Jean E. Sanders, H. Joachim Deeg, Mary E.D. Flowers, Karen L. Syrjala, John A. Hansen, Rainer F. Storb, and Barry E. Storer
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.6693 [Abstract] [PDF]  

THORACIC ONCOLOGY

Outcomes After Stereotactic Lung Radiotherapy or Wedge Resection for Stage I Non–Small-Cell Lung Cancer

Inga S. Grills, Victor S. Mangona, Robert Welsh, Gary Chmielewski, Erika McInerney, Shannon Martin, Jennifer Wloch, Hong Ye, and Larry L. Kestin
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.0928 [Abstract] [PDF]  

January 4, 2010

BREAST CANCER

Exercise, Tea Consumption, and Depression Among Breast Cancer Survivors

Xiaoli Chen, Wei Lu, Ying Zheng, Kai Gu, Zhi Chen, Wei Zheng, and Xiao Ou Shu
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.23.0565 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Pulmonary Calciphylaxis and Metastatic Calcification With Acute Respiratory Failure in Multiple Myeloma

Claudia Crippa, Samantha Ferrari, Monica Drera, Regina Tardanico, Marco Ungari, Fabio Facchetti, Giovanni Cancarini, and Giuseppe Rossi
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.25.1587 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Superior Vena Cava Syndrome: A Presentation of Anaplastic Thyroid Carcinoma

Hema Padmanabhan
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.24.8740 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Burkitt's Lymphoma in Early Pregnancy

Cary Peterson, Darrell R. Lester Jr, and Warren Sanger
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.24.6355 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Hypoxia-Inducible Factor-1 Expression Predicts Superior Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP

Andrew M. Evens, Laurie H. Sehn, Pedro Farinha, Beverly P. Nelson, Adekunle Raji, Yi Lu, Adam Brakman, Vamsi Parimi, Jane N. Winter, Paul T. Schumacker, Randy D. Gascoyne, and Leo I. Gordon
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.24.1893 [Abstract] [PDF]  

December 28, 2009

BREAST CANCER

HER2, TOP2A, and TIMP-1 and Responsiveness to Adjuvant Anthracycline-Containing Chemotherapy in High-Risk Breast Cancer Patients

Bent Ejlertsen, Maj-Britt Jensen, Kirsten V. Nielsen, Eva Balslev, Birgitte B. Rasmussen, Gro L. Willemoe, Pernille B. Hertel, Ann S. Knoop, Henning T. Mouridsen, and Nils Brünner
JCO published online December 28, 2009, DOI:10.1200/JCO.2009.24.1166 [Abstract] [PDF] [Data Supplement]  

BREAST CANCER

Randomized Phase II Trial of First-Line Trastuzumab Plus Docetaxel and Capecitabine Compared With Trastuzumab Plus Docetaxel in HER2-Positive Metastatic Breast Cancer

Andrew M. Wardley, Xavier Pivot, Flavia Morales-Vasquez, Luis M. Zetina, Maria de Fátima Dias Gaui, Douglas Otero Reyes, Jacek Jassem, Claire Barton, Peter Button, Veronica Hersberger, and Antonio Antón Torres
JCO published online December 28, 2009, DOI:10.1200/JCO.2008.21.6531 [Abstract] [PDF]  

HEMATOLOGIC MALIGNANCIES

Evaluation of Coronary Artery Disease by Computed Tomography Angiography in Patients Treated for Childhood Hodgkin's Lymphoma

Serhan Küpeli, Tuncay Hazrolan, Ali Varan, Deniz Akata, Dursun Alehan, Mutlu Hayran, Aytekin Besim, and Münevver Büyükpamukçu
JCO published online December 28, 2009, DOI:10.1200/JCO.2009.25.2627 [Abstract] [PDF]  

December 21, 2009

BREAST CANCER

Intensive Loading Dose of Trastuzumab Achieves Higher-Than-Steady–State Serum Concentrations and Is Well Tolerated

Brian Leyland-Jones, Ramon Colomer, Maureen E. Trudeau, Andrew Wardley, Jean Latreille, David Cameron, Ricardo Cubedo, Nedal Al-Sakaff, Andrea Feyereislova, Olivier Catalani, Yumi Fukushima, Michael Brewster, and Javier Cortés
JCO published online December 21, 2009, DOI:10.1200/JCO.2009.23.1910 [Abstract] [PDF]  

CORRESPONDENCE

Breast Cancer Pathology Report: In Response to Zurrida et al

Vincenzo Arena, Ilaria Pennacchia, and Arnaldo Carbone
JCO published online December 21, 2009, DOI:10.1200/JCO.2009.26.9399 [Abstract] [PDF]  

CORRESPONDENCE

Successful Treatment With Meloxicam, a Cyclooxygenase-2 Inhibitor, of Patients With Extra-Abdominal Desmoid Tumors: A Pilot Study

Yoshihiro Nishida, Satoshi Tsukushi, Yoji Shido, Junji Wasa, Naoki Ishiguro, and Yoshihisa Yamada
JCO published online December 21, 2009, DOI:10.1200/JCO.2009.25.5950 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Adenocarcinoma of Colon Presenting As Cushing's Syndrome

Rajesh Sehgal, Wassim Mchayleh, Jodie (Alton) Reider, Ayeesha Cheema, and Ramesh K. Ramanathan
JCO published online December 21, 2009, DOI:10.1200/JCO.2009.24.0085 [Abstract] [PDF]  

December 14, 2009

DIAGNOSIS IN ONCOLOGY

Favorable Response to Erlotinib in a Lung Adenocarcinoma With Both Epidermal Growth Factor Receptor Exon 19 Deletion and K-ras G13D Mutations

Chun-Nin Lee, Hsiang-Yin Chen, and H. Eugene Liu
JCO published online December 14, 2009, DOI:10.1200/JCO.2009.24.0747 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Isolated Relapse of Acute Lymphoblastic Leukemia in the Epididymis: A Rare Sanctuary Site

Andrew E. Bourne, Robert O. Wayment, Thomas H. Tarter, and Patrick Hemmer
JCO published online December 14, 2009, DOI:10.1200/JCO.2009.23.8014 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Merkel Cell Carcinoma in the Peripheral Blood of a Patient With Concomitant Chronic Lymphocytic Leukemia and Multiple Myeloma

Monique A. Hartley, Jianguo Tao, and Rachid Baz
JCO published online December 14, 2009, DOI:10.1200/JCO.2009.23.4153 [Abstract] [PDF]  

November 30, 2009

DIAGNOSIS IN ONCOLOGY

Primary Gonadal Germ Cell Tumor Associated With Acute Leukemia With Common Cytogenetics

Rashmi Menon, Przemyslaw Twardowski, Stephen J. Forman, Qin Huang, Marilyn L. Slovak, and Amrita Krishnan
JCO published online November 30, 2009, DOI:10.1200/JCO.2009.24.4293 [Abstract] [PDF]  

November 23, 2009

DIAGNOSIS IN ONCOLOGY

Diffusion Magnetic Resonance Imaging Detects Pathologically Confirmed, Nonenhancing Tumor Progression in a Patient With Recurrent Glioblastoma Receiving Bevacizumab

Elizabeth R. Gerstner, Matthew P. Frosch, and Tracy T. Batchelor
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.25.0233 [Abstract] [PDF]  

DIAGNOSIS IN ONCOLOGY

Presentation of Extranodal Natural Killer T-Cell Lymphoma, Nasal Type, With Poorly Circumscribed Erythematous Patches

Laura B. Pincus, James L. Zehnder, Isaac M. Neuhaus, Charalambos Andreadis, and Timothy H. McCalmont
JCO published online November 23, 2009, DOI:10.1200/JCO.2009.24.3428 [Abstract] [PDF]  

November 16, 2009

ART OF ONCOLOGY

Cancer and the Family: The Silent Words of Truth

Lea Baider and Antonella Surbone
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.25.1223 [Abstract] [PDF]  

ART OF ONCOLOGY

Healing by Cancer

Michael Silbermann, Amal Dweib Khleif, and Lodovico Balducci
JCO published online November 16, 2009, DOI:10.1200/JCO.2009.24.8161 [Abstract] [PDF]  

August 17, 2009

GASTROINTESTINAL CANCER

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer

John A. Chabot, Wei-Yann Tsai, Robert L. Fine, Chunxia Chen, Carolyn K. Kumah, Karen A. Antman, and Victor R. Grann
JCO published online August 17, 2009, DOI:10.1200/JCO.2009.22.8429 [Abstract] [PDF]  

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