Journal of Clinical Oncology Early Release Articles

Journal of Clinical Oncology publishes all articles on JCO.org in advance of print publication. The new policy provides subscribers with the latest clinical research several weeks before it appears in print. All articles have been reviewed, copyedited, and typeset, and appear in the final form in which they will appear in the print journal. Once an article appears in print, it will be removed from the Early Release page and grouped with the other contents of the issue in which it appears. All articles below are citable by using the Digital Object Identifier (DOI), a unique number given to every article, and the posting date.

Next posting date: November 9, 2009

Last updated November 9, 2009 [View by date]

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ASCO SPECIAL ARTICLES
ART OF ONCOLOGY
BIOLOGY OF NEOPLASIA
BREAST CANCER
CANCER RELATED COMPLICATIONS
CLINICAL TRIALS
COMMENTS AND CONTROVERSIES
CORRESPONDENCE
DIAGNOSIS IN ONCOLOGY
ECONOMIC ANALYSIS
EDITORIALS
EPIDEMIOLOGY
GASTROINTESTINAL CANCER
GENITOURINARY CANCER
GYNECOLOGIC CANCER
HEAD AND NECK CANCER
HEALTH SERVICES AND OUTCOMES
HEMATOLOGIC MALIGNANCIES
MELANOMA
NEUROONCOLOGY
PALLIATIVE AND SUPPORTIVE CARE
PEDIATRIC ONCOLOGY
PHASE I AND CLINICAL PHARMACOLOGY
REVIEW ARTICLES
SPECIAL ARTICLES
THORACIC ONCOLOGY
TREATMENT-RELATED COMPLICATIONS

To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

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ASCO SPECIAL ARTICLES

Clinical Cancer Advances 2009: Major Research Advances in Cancer Treatment, Prevention, and Screening—A Report From the American Society of Clinical Oncology

Nicholas J. Petrelli, Eric P. Winer, Julie Brahmer, Sarita Dubey, Sonali Smith, Charles Thomas, Linda T. Vahdat, Jennifer Obel, Nicholas Vogelzang, Maurie Markman, John W. Sweetenham, David Pfister, Mark G. Kris, Lynn M. Schuchter, Raymond Sawaya, Derek Raghavan, Patricia A. Ganz, and Barnett Kramer
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.26.6171 [Abstract] [PDF]  

American Society of Clinical Oncology 2009 Clinical Evidence Review on Radiofrequency Ablation of Hepatic Metastases From Colorectal Cancer

Sandra L. Wong, Pamela B. Mangu, Michael A. Choti, Todd S. Crocenzi, Gerald D. Dodd III, Gary S. Dorfman, Cathy Eng, Yuman Fong, Andrew F. Giusti, David Lu, Thomas A. Marsland, Rob Michelson, Graeme J. Poston, Deborah Schrag, Jerome Seidenfeld, and Al B. Benson III
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.4450 [Abstract] [PDF]  

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ART OF ONCOLOGY

The Hardest Job in Medicine

Richard C. Frank
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1371 [Abstract] [PDF]  

The Homecoming

Navneet S. Majhail
JCO published online August 24, 2009, DOI:10.1200/JCO.2009.24.4681 [Abstract] [PDF]  

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BIOLOGY OF NEOPLASIA

MicroRNAs in Cancer: Small Molecules With a Huge Impact

Marilena V. Iorio and Carlo M. Croce
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.0317 [Abstract] [PDF]  

Personalized Cancer Therapy With Selective Kinase Inhibitors: An Emerging Paradigm in Medical Oncology

Ultan McDermott and Jeff Settleman
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.9054 [Abstract] [PDF]  

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BREAST CANCER

Neoadjuvant Chemotherapy Shows Similar Response in Patients With Inflammatory or Locally Advanced Breast Cancer When Compared With Operable Breast Cancer: A Secondary Analysis of the GeparTrio Trial Data

Serban Dan Costa, Sibylle Loibl, Manfred Kaufmann, Dirk-Michael Zahm, Jörn Hilfrich, Jens Huober, Holger Eidtmann, Andreas du Bois, Jens-Uwe Blohmer, Beyhan Ataseven, Erich Weiss, Hans Tesch, Bernd Gerber, Klaus H. Baumann, Christoph Thomssen, Georg Peter Breitbach, Shaip Ibishi, Christian Jackisch, Keyur Mehta, and Gunter von Minckwitz
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.5101 [Abstract] [PDF]  

Cyclophosphamide, Epirubicin, and Fluorouracil Versus Dose-Dense Epirubicin and Cyclophosphamide Followed by Paclitaxel Versus Doxorubicin and Cyclophosphamide Followed by Paclitaxel in Node-Positive or High-Risk Node-Negative Breast Cancer

Margot Burnell, Mark N. Levine, Judith-Anne W. Chapman, Vivien Bramwell, Karen Gelmon, Barbara Walley, Ted Vandenberg, Haji Chalchal, Kathy S. Albain, Edith A. Perez, Hope Rugo, Kathleen Pritchard, Patti O'Brien, and Lois E. Shepherd
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.1077 [Abstract] [PDF]  

Conjugated Equine Estrogen Influence on Mammographic Density in Postmenopausal Women in a Substudy of the Women's Health Initiative Randomized Trial

Anne McTiernan, Rowan T. Chlebowski, Christopher Martin, Jennifer David Peck, Aaron Aragaki, Etta D. Pisano, C. Y. Wang, Karen C. Johnson, JoAnn E. Manson, Robert B. Wallace, Mara Z. Vitolins, and Gerardo Heiss
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.21.7166 [Abstract] [PDF]  

Dose-Dense Adjuvant Doxorubicin and Cyclophosphamide Is Not Associated With Frequent Short-Term Changes in Left Ventricular Ejection Fraction

Patrick G. Morris, Maura Dickler, Heather L. McArthur, Tiffany Traina, Steven Sugarman, Nancy Lin, Beverly Moy, Steven Come, Laura Godfrey, Benjamin Nulsen, Carol Chen, Richard Steingart, Hope Rugo, Larry Norton, Eric Winer, Clifford A. Hudis, and Chau T. Dang
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.2952 [Abstract] [PDF]  

Y-Box–Binding Protein YB-1 Identifies High-Risk Patients With Primary Breast Cancer Benefiting From Rapidly Cycled Tandem High-Dose Adjuvant Chemotherapy

Oleg Gluz, Karin Mengele, Manfred Schmitt, Ronald Kates, Raihana Diallo-Danebrock, Frauke Neff, Hans-Dieter Royer, Niels Eckstein, Svjetlana Mohrmann, Evelyn Ting, Marion Kiechle, Christopher Poremba, Ulrike Nitz, and Nadia Harbeck
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.19.6261 [Abstract] [PDF]  

Multimodality Screening of High-Risk Women: A Prospective Cohort Study

Susan P. Weinstein, A. Russell Localio, Emily F. Conant, Mark Rosen, Kathleen M. Thomas, and Mitchell D. Schnall
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4277 [Abstract] [PDF]  

High Risk of Recurrence for Patients With Breast Cancer Who Have Human Epidermal Growth Factor Receptor 2–Positive, Node-Negative Tumors 1 cm or Smaller

Ana M. Gonzalez-Angulo, Jennifer K. Litton, Kristine R. Broglio, Funda Meric-Bernstam, Ronjay Rakkhit, Fatima Cardoso, Florentia Peintinger, Emer O. Hanrahan, Aysegul Sahin, Merih Guray, Denis Larsimont, Francesco Feoli, Heidi Stranzl, Thomas A. Buchholz, Vicente Valero, Richard Theriault, Martine Piccart-Gebhart, Peter M. Ravdin, Donald A. Berry, and Gabriel N. Hortobagyi
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.2025 [Abstract] [PDF]  

Advanced Breast Cancer and Breast Cancer Mortality in Randomized Controlled Trials on Mammography Screening

Philippe Autier, Clarisse Héry, Jari Haukka, Mathieu Boniol, and Graham Byrnes
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.7041 [Abstract] [PDF]  

Clinical Relevance of HER2 Overexpression/Amplification in Patients With Small Tumor Size and Node-Negative Breast Cancer

Giuseppe Curigliano, Giuseppe Viale, Vincenzo Bagnardi, Luca Fumagalli, Marzia Locatelli, Nicole Rotmensz, Raffaella Ghisini, Marco Colleoni, Elisabetta Munzone, Paolo Veronesi, Stefano Zurrida, Franco Nolè, and Aron Goldhirsch
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.0962 [Abstract] [PDF]  

Fluorouracil, Epirubicin, and Cyclophosphamide With Either Docetaxel or Vinorelbine, With or Without Trastuzumab, As Adjuvant Treatments of Breast Cancer: Final Results of the FinHer Trial

Heikki Joensuu, Petri Bono, Vesa Kataja, Tuomo Alanko, Riitta Kokko, Raija Asola, Tapio Utriainen, Taina Turpeenniemi-Hujanen, Sirkku Jyrkkiö, Kari Möykkynen, Leena Helle, Seija Ingalsuo, Marjo Pajunen, Mauri Huusko, Tapio Salminen, Päivi Auvinen, Hannu Leinonen, Mika Leinonen, Jorma Isola, and Pirkko-Liisa Kellokumpu-Lehtinen
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.4577 [Abstract] [PDF]  

One-Year Outcomes of a Behavioral Therapy Intervention Trial on Sleep Quality and Cancer-Related Fatigue

Ann M. Berger, Brett R. Kuhn, Lynne A. Farr, Susanna G. Von Essen, Julie Chamberlain, James C. Lynch, and Sangeeta Agrawal
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.20.8306 [Abstract] [PDF] [Data Supplement]  

Prognostic and Predictive Value of HER2 Extracellular Domain in Metastatic Breast Cancer Treated With Lapatinib and Paclitaxel in a Randomized Phase III Study

Richard S. Finn, Robert Gagnon, Angelo Di Leo, Michael F. Press, Michael Arbushites, and Maria Koehler
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.1763 [Abstract] [PDF] [HTML Page - index.htslp] [Publisher's Note]  

Phase II Multicenter Trial of Anthracycline Rechallenge With Pegylated Liposomal Doxorubicin Plus Cyclophosphamide for First-Line Therapy of Metastatic Breast Cancer Previously Treated With Adjuvant Anthracyclines

Maureen E. Trudeau, Mark J. Clemons, Louise Provencher, Lawrence Panasci, Louise Yelle, Daniel Rayson, Jean Latreille, Ted Vandenberg, Rakesh Goel, Labib Zibdawi, Yasmin Rahim, and Jean-Francois Pouliot
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7504 [Abstract] [PDF]  

Contralateral Breast Cancer Risk in BRCA1 and BRCA2 Mutation Carriers

Monika K. Graeser, Christoph Engel, Kerstin Rhiem, Dorothea Gadzicki, Ulrich Bick, Karin Kast, Ursula G. Froster, Bettina Schlehe, Astrid Bechthold, Norbert Arnold, Sabine Preisler-Adams, Carolin Nestle-Kraemling, Mohammad Zaino, Markus Loeffler, Marion Kiechle, Alfons Meindl, Dominic Varga, and Rita K. Schmutzler
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.9430 [Abstract] [PDF]  

Feasibility Trial of Letrozole in Combination With Bevacizumab in Patients With Metastatic Breast Cancer

Tiffany A. Traina, Hope S. Rugo, James F. Caravelli, Sujata Patil, Benjamin Yeh, Michele E. Melisko, John W. Park, Stephanie Geneus, Matthew Paulson, Jill Grothusen, Andrew D. Seidman, Monica Fornier, Diana Lake, Chau Dang, Mark Robson, Maria Theodoulou, Carlos D. Flombaum, Larry Norton, Clifford A. Hudis, and Maura N. Dickler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8784 [Abstract] [PDF]  

Extensive Nodal Disease May Impair Axillary Reverse Mapping in Patients With Breast Cancer

Riccardo Ponzone, Nicoletta Tomasi Cont, Furio Maggiorotto, Elisa Cassina, Paola Mininanni, Nicoletta Biglia, and Piero Sismondi
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.1846 [Abstract] [PDF]  

Prospective Multicenter Comparison of Models to Predict Four or More Involved Axillary Lymph Nodes in Patients With Breast Cancer With One to Three Metastatic Sentinel Lymph Nodes

Gabrielle Werkoff, Eric Lambaudie, Eric Fondrinier, Jean Levêque, Fréderic Marchal, Michele Uzan, Emmanuel Barranger, François Guillemin, Emile Darai, Serge Uzan, Gilles Houvenaeghel, Roman Rouzier, and Charles Coutant
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.21.9139 [Abstract] [PDF]  

Timed Sequential Treatment With Cyclophosphamide, Doxorubicin, and an Allogeneic Granulocyte-Macrophage Colony-Stimulating Factor–Secreting Breast Tumor Vaccine: A Chemotherapy Dose-Ranging Factorial Study of Safety and Immune Activation

Leisha A. Emens, Justin M. Asquith, James M. Leatherman, Barry J. Kobrin, Silvia Petrik, Marina Laiko, Joy Levi, Maithili M. Daphtary, Barbara Biedrzycki, Antonio C. Wolff, Vered Stearns, Mary L. Disis, Xiaobu Ye, Steven Piantadosi, John H. Fetting, Nancy E. Davidson, and Elizabeth M. Jaffee
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.3494 [Abstract] [PDF]  

Underweight and Breast Cancer Recurrence and Death: A Report From the Korean Breast Cancer Society

Hyeong-Gon Moon, Wonshik Han, and Dong-Young Noh
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.4436 [Abstract] [PDF]  

Novel Breast Tissue Feature Strongly Associated With Risk of Breast Cancer

Kevin P. McKian, Carol A. Reynolds, Daniel W. Visscher, Aziza Nassar, Derek C. Radisky, Robert A. Vierkant, Amy C. Degnim, Judy C. Boughey, Karthik Ghosh, Stephanie S. Anderson, Douglas Minot, Jill L. Caudill, Celine M. Vachon, Marlene H. Frost, V. Shane Pankratz, and Lynn C. Hartmann
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.5079 [Abstract] [PDF]  

Lapatinib Combined With Letrozole Versus Letrozole and Placebo As First-Line Therapy for Postmenopausal Hormone Receptor–Positive Metastatic Breast Cancer

Stephen Johnston, John Pippen Jr, Xavier Pivot, Mikhail Lichinitser, Saeed Sadeghi, Veronique Dieras, Henry Leonidas Gomez, Gilles Romieu, Alexey Manikhas, M. John Kennedy, Michael F. Press, Julie Maltzman, Allison Florance, Lisa O'Rourke, Cristina Oliva, Steven Stein, and Mark Pegram
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.3734 [Abstract] [PDF]  

Trastuzumab Plus Anastrozole Versus Anastrozole Alone for the Treatment of Postmenopausal Women With Human Epidermal Growth Factor Receptor 2–Positive, Hormone Receptor–Positive Metastatic Breast Cancer: Results From the Randomized Phase III TAnDEM Study

Bella Kaufman, John R. Mackey, Michael R. Clemens, Poonamalle P. Bapsy, Ashok Vaid, Andrew Wardley, Sergei Tjulandin, Michaela Jahn, Michaela Lehle, Andrea Feyereislova, Cédric Révil, and Alison Jones
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.20.6847 [Abstract] [PDF]  

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CANCER RELATED COMPLICATIONS

Aortic Stiffness Increases Upon Receipt of Anthracycline Chemotherapy

Narumol Chaosuwannakit, Ralph D'Agostino Jr, Craig A. Hamilton, Kimberly S. Lane, William O. Ntim, Julia Lawrence, Susan A. Melin, Leslie R. Ellis, Frank M. Torti, William C. Little, and W. Gregory Hundley
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.8527 [Abstract] [PDF]  

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CLINICAL TRIALS

Role of Sensitivity Analyses in Assessing Progression-Free Survival in Late-Stage Oncology Trials

Suman Bhattacharya, Gwen Fyfe, Robert J. Gray, and Daniel J. Sargent
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4329 [Abstract] [PDF]  

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COMMENTS AND CONTROVERSIES

To Treat Pelvic Nodes or Not: Could the Greater Testicular Scatter Dose From Whole Pelvic Fields Confound Results of Prostate Cancer Trials?

Christopher R. King and Daniel S. Kapp
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.3808 [Abstract] [PDF]  

Bladder Cancer: Narrowing the Gap Between Evidence and Practice

Maha H.A. Hussain, David P. Wood, Dean F. Bajorin, Bernard H. Bochner, Robert Dreicer, Donald L. Lamm, Michael A. O'Donnell, Arlene O. Siefker-Radtke, Dan Theodorescu, and Colin P. Dinney
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.6901 [Abstract] [PDF]  

Toward Efficient Trials in Colorectal Cancer: The ARCAD Clinical Trials Program

Aimery de Gramont, Daniel G. Haller, Daniel J. Sargent, Josep Tabernero, Alastair Matheson, and Richard L. Schilsky
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2544 [Abstract] [PDF]  

Incremental Advance or Seismic Shift? The Need to Raise the Bar of Efficacy for Drug Approval

Alberto Sobrero and Paolo Bruzzi
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.4162 [Abstract] [PDF]  

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CORRESPONDENCE

Reply to C. Kollmannsberger et al

Hua-yin Yu and Christopher S. Saigal
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.8632 [Abstract] [PDF]  

Clinical Claims From Claims-Based Data

Craig R. Nichols and Christian Kollmannsberger
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.8319 [Abstract] [PDF]  

Reply to M. Chao et al

Heidi Nelson, Daniel Sargent, and Vassiliki Tsikitis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.6669 [Abstract] [PDF]  

Caution Is Required Before Recommending Routine Carcinoembryonic Antigen and Imaging Follow-Up for Patients With Early-Stage Colon Cancer

Michael Chao and Peter Gibbs
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.6156 [Abstract] [PDF]  

Reply to D.L. Raunig

Lori E. Dodd, Edward L. Korn, Boris Freidlin, Lawrence Rubinstein, Janet Dancey, C. Carl Jaffe, and Margaret Mooney
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.4342 [Abstract] [PDF]  

Are Onsite Image Evaluations the Solution or Are We Trading One Problem for Another?

David L. Raunig
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.3716 [Abstract] [PDF]  

Reply to S.J. Faivre et al

Andrew X. Zhu, Dushyant V. Sahani, Dan G. Duda, and Rakesh K. Jain
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.1173 [Abstract] [PDF]  

Sunitinib in Hepatocellular Carcinoma: Redefining Appropriate Dosing, Schedule, and Activity End Points

Sandrine Faivre, Mohamed Bouattour, Chantal Dreyer, and Eric Raymond
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.0670 [Abstract] [PDF]  

Reply to A. Sánchez-Muñoz et al

Filippo Montemurro, Lucia Del Mastro, and Massimo Aglietta
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4326 [Abstract] [PDF]  

Reply to Aragon-Ching

Shabbir M.H. Alibhai
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4300 [Abstract] [PDF]  

Reply to T. Grenader et al

Sao Jiralerspong and Ana M. Gonzalez-Angulo
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4292 [Abstract] [PDF]  

Reply to K. Satharasinghe et al

Brian H. Kushner, Kim Kramer, Shakeel Modak, and Nai-Kong V. Cheung
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4144 [Abstract] [PDF]  

Metformin As an Addition to Conventional Chemotherapy in Breast Cancer

Tal Grenader, Anthony Goldberg, and Linda Shavit
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4110 [Abstract] [PDF]  

Cardiovascular Disease With Androgen Deprivation: The (forgotten) Role of Testosterone

Jeanny B. Aragon-Ching
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.4078 [Abstract] [PDF]  

Aromatase Inhibitors As Adjuvant Therapy for Breast Cancer: Overall Survival Versus Disease-Free Survival As a Primary End Point in Clinical Practice

Alfonso Sánchez-Muñoz, Nuria Ribelles, Antonia Márquez, Elisabeth Pérez-Ruiz, and Emilio Alba
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3914 [Abstract] [PDF]  

Reply to A. Sasse et al

Yu Yang Soon, Martin R. Stockler, Lisa M. Askie, and Michael J. Boyer
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.3757 [Abstract] [PDF]  

Duration of Chemotherapy for Metastatic Non–Small-Cell Lung Cancer: More May Be Not Better

Andre D. Sasse, Joao P. Lima, Emma C. Sasse, and Lucas V. Santos
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.1918 [Abstract] [PDF]  

Reply to N. Magné et al

Michele Y. Halyard, Thomas M. Pisansky, Amylou C. Dueck, Vera J. Suman, Lori J. Pierce, Lawrence J. Solin, Lawrence B. Marks, Nancy Davidson, Silvana Martino, Peter Kaufman, Leila Kutteh, Shaker Dakhil, and Edith A. Perez
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.7767 [Abstract] [PDF]  

Impact on Cardiac Toxicity With Trastuzumab and Radiotherapy: The Question Is Still Ongoing

Nicolas Magné, Lionel Védrine, and Cyrus Chargari
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.6918 [Abstract] [PDF]  

Reply to J. Dalmau

Sebastian Rauer and Hendrik Veelken
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.6009 [Abstract] [PDF]  

Reply to S. Williams et al

Luis Souhami, Kyounghwa Bae, and Howard Sandler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5217 [Abstract] [PDF]  

Recognizing Paraneoplastic Limbic Encephalitis

Josep Dalmau
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4822 [Abstract] [PDF]  

Androgen Deprivation Therapy and Prostate Cancer Duration

Scott G. Williams, Tom Pickles, and Mark K. Buyyounouski
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.4137 [Abstract] [PDF]  

False-Positive MIBG Scans With Normal Computed Tomography Imaging In Patients With High-Risk Neuroblastoma

Keshan Satharasinghe, Toby N. Trahair, Draga Barbaric, Tracey A. O'Brien, Susan J. Russell, Richard J. Cohn, Glenn M. Marshall, and David S. Ziegler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.0036 [Abstract] [PDF]  

Critical Review of the Determination Process by the Japanese Reviewing Authority in Approving the Additional Efficacy of Fludarabine Phosphate

Hiroto Narimatsu, Giichiro Oiso, Shunsuke Ono, and Masahiro Kami
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.9020 [Abstract] [PDF]  

Reply to R. Memmott et al

Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.4284 [Abstract] [PDF]  

LKB1 and Mammalian Target of Rapamycin As Predictive Factors for the Anticancer Efficacy of Metformin

Regan M. Memmott and Phillip A. Dennis
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.3963 [Abstract] [PDF]  

Reply to G. Ferretti et al

Heinz Ludwig and Alex Fleishman
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.0860 [Abstract] [PDF]  

Call for Clarity in the Reporting of Benefit Associated With Anticancer Therapies

Christopher M. Booth, Pavlo Ohorodnyk, and Elizabeth A. Eisenhauer
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.8542 [Abstract] [PDF]  

Reply to L.H. Jensen et al and S. Jahn et al

Heather Hampel, Wendy Frankel, and Albert de la Chapelle
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.7015 [Abstract] [PDF]  

Molecular Screening for Lynch Syndrome: From Bench to Bedside

Lars Henrik Jensen, Jan Lindebjerg, Steen Kølvraa, and Dorthe G. Crüger
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6744 [Abstract] [PDF]  

Darbepoetin Alfa and History of Thromboembolic Events

Gianluigi Ferretti, Alessandra Felici, and Francesco Cognetti
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6454 [Abstract] [PDF]  

Reply to A. Vazquez-Martin et al

Pamela J. Goodwin, Jennifer A. Ligibel, and Vuk Stambolic
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.6033 [Abstract] [PDF]  

If Mammalian Target of Metformin Indirectly Is Mammalian Target of Rapamycin, Then the Insulin-Like Growth Factor-1 Receptor Axis Will Audit the Efficacy of Metformin in Cancer Clinical Trials

Alejandro Vazquez-Martin, Cristina Oliveras-Ferraros, Sonia Del Barco, Begoña Martin-Castillo, and Javier A. Menendez
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.5456 [Abstract] [PDF]  

Reply to J. Thiele et al

Peter J. Campbell, David Bareford, Wendy N. Erber, Bridget S. Wilkins, Penny A. Wright, Georgina Buck, Keith Wheatley, Claire N. Harrison, and Anthony R. Green
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.5233 [Abstract] [PDF]  

Bone Marrow Fibrosis and Diagnosis of Essential Thrombocythemia

Juergen Thiele, Hans Michael Kvasnicka, James W. Vardiman, Attilio Orazi, Vito Franco, Heinz Gisslinger, Gunnar Birgegard, Martin Griesshammer, and Ayalew Tefferi
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.3485 [Abstract] [PDF]  

Reply to F. Puglisi

Stephen Chan
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.9798 [Abstract] [PDF]  

What Does Similarity Mean in Clinical Trials?

Fabio Puglisi
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.9467 [Abstract] [PDF]  

Reply to Lin et al

Luis Souhami, Kyounghwa Bae, and Howard M. Sandler
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.2221 [Abstract] [PDF]  

Selection Bias Clouds Apparent Benefit of Longer Hormone Duration

Kevin Lin, Steve P. Lee, and Michael L. Steinberg
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0969 [Abstract] [PDF]  

Reply to S. Nagai et al

David Grimwade, Jelena V. Jovanovic, Robert K. Hills, Ellen Solomon, Francesco Lo-Coco, Keith Wheatley, and Alan K. Burnett
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0522 [Abstract] [PDF]  

Revisiting the Concept of Phenotypically Distinct Malignant Pancreatic Stem-Cell Subsets Based on Limiting Dilution Transplantation Assays

Thierry Bonnefoix and Mary Callanan
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.25.0282 [Abstract] [PDF]  

How Should We Prevent Hematologic Relapse of Acute Promyelocytic Leukemia?

Sumimasa Nagai, Tsuyoshi Takahashi, and Mineo Kurokawa
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.9995 [Abstract] [PDF]  

Reply to P. Prassopoulos et al

Shauna L. Hillman and Daniel J. Sargent
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.6736 [Abstract] [PDF]  

Metastatic Disease Response to Treatment: How Many Lesions to Measure?

Panos Prassopoulos and Michael Mantatzis
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.4004 [Abstract] [PDF]  

Reply to V. Arena et al

Stefano Zurrida, Giuseppe Viale, and Umberto Veronesi
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.3253 [Abstract] [PDF]  

Breast Cancer Classification: The Dialogue Is Open

Vincenzo Arena, Ilaria Pennacchia, Giovanni Monego, Arnaldo Carbone, and Arnaldo Capelli
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.24.2461 [Abstract] [PDF]  

Biased Hormonal Therapy Duration Analysis Makes Results Uninterpretable

Catherine M. Tangen, Bryan H. Goldman, Gregory P. Swanson, and Ian M. Thompson
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.6000 [Abstract] [PDF]  

Reply to L. Collette et al and C.M. Tangen et al

Luis Souhami, Kyounghwa Bae, and Howard Sandler
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.5341 [Abstract] [PDF]  

Selection Bias Is Not a Good Reason for Advising More Than 5 Years of Adjuvant Hormonal Therapy for All Patients With Locally Advanced Prostate Cancer Treated With Radiotherapy

Laurence Collette and Urs E. Studer
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.3601 [Abstract] [PDF]  

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DIAGNOSIS IN ONCOLOGY

Esophageal Carcinoma in a 16-Year-Old Girl 8 Years After Gastrotomy

Onkar Singh, Shilpi Gupta, Praveen Baghel, Sapna Shukla, Dharamdas Paramhans, and Raj K. Mathur
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.3238 [Abstract] [PDF]  

Acute Myeloid Leukemia With Myeloid Sarcoma and Eosinophilia: Prolonged Remission and Molecular Response to Imatinib

Dana Védy, Dominique Muehlematter, Thierry Rausch, Michèle Stalder, Martine Jotterand, and Olivier Spertini
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.6976 [Abstract] [PDF]  

Lymphangioleiomyomatosis: Cause of a Malignant Chylous Pleural Effusion

Izabela Malinowska-Kolodziej, Geraldine Finlay, Gregory Campbell, Maria L. Garcia-Moliner, Barbara Weinstein, Cheryl A. Doughty, Wei Qin, Catherine Butterfield, Sarah Short, Kuniaki Seyama, and David J. Kwiatkowski
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.3890 [Abstract] [PDF]  

Bilateral Occipital Lobe Invasion in Chronic Lymphocytic Leukemia

Tsunayuki Kakimoto, Tomonori Nakazato, Ryuichiro Hayashi, Hiroyuki Hayashi, Norihide Hayashi, Taijiro Ishiyama, Hiroyuki Asada, and Akaru Ishida
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8436 [Abstract] [PDF]  

Sorafenib-Induced Bilateral Osteonecrosis of Femoral Heads

Marielle Guillet, Thomas Walter, Jean-Yves Scoazec, Thierry Vial, Catherine Lombard-Bohas, and Jérôme Dumortier
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.4252 [Abstract] [PDF]  

Hodgkin's Lymphoma of the Breast

Christopher J. Hoimes, Megan K. Selbst, Nelofar Q. Shafi, Michal G. Rose, and Manuel F. Rosado
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1613 [Abstract] [PDF]  

Solitary Extramedullary Plasmacytoma of the Vocal Cord in an Adolescent

Issai Vanan, Arlene Redner, Mark Atlas, Lorraine Marin, Prajoy Kadkade, Jela Bandovic, and Elaine S. Jaffe
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7461 [Abstract] [PDF]  

Bisphosphonate-Related Osteonecrosis of the Jaw and Left Thumb

Raffaele Longo, Maria Angela Castellana, and Giampietro Gasparini
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.4468 [Abstract] [PDF]  

Tracheal Glomangioma in a Patient With Asthma and Chest Pain

Kathryn L. Parker, Michael D. Zervos, Jessica S. Donington, Pratibha S. Shukla, and Costas S. Bizekis
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.7942 [Abstract] [PDF]  

Incidental Detection of Acute Lymphoblastic Leukemia on [¹⁸F]Fluorodeoxyglucose Positron Emission Tomography

Daisuke Ennishi, Yoshinobu Maeda, Masami Niiya, Katsuji Shinagawa, and Mitsune Tanimoto
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.7769 [Abstract] [PDF]  

Paraneoplastic Acrokeratosis (Bazex Syndrome) in Lung Cancer

Antonio Crucitti, Claudio Feliciani, Ugo Grossi, Antonio La Greca, Venanzio Porziella, Piero Giustacchini, Maria Teresa Congedo, Pietrangelo Fronterré, and Pierluigi Maria Granone
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6852 [Abstract] [PDF]  

Spontaneous Remission in a Patient With t(4;14) Translocation Multiple Myeloma

Noemi Puig, Suzanne Trudel, Jonathan J. Keats, Zhi Hua Li, Esteban Braggio, Gregory J. Ahmann, Seda Zeng, Rafael Fonseca, and Vishal Kukreti
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.0392 [Abstract] [PDF] [Data Supplement]  

Recognition of a New Chemotherapeutic Vesicant: Trabectedin (Ecteinascidin-743) Extravasation With Skin and Soft Tissue Damage

Todd A. Theman, Tristan L. Hartzell, Indranil Sinha, Kathleen Polson, Jeffrey Morgan, George D. Demetri, Dennis P. Orgill, and Suzanne George
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.6473 [Abstract] [PDF]  

Geographic Distribution of Lapatinib-Induced Skin Rash: Sparing of Abdominal Skin Persists in the Transverse Rectus Abdominis Myocutaneous Flap

Nancy U. Lin, Elizabeth Kasparian, Daniel E. Morganstern, and Clair Beard
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7868 [Abstract] [PDF]  

Rapid Clinical Deterioration and Leukemoid Reaction After Treatment of Urothelial Carcinoma of the Bladder: Possible Effect of Granulocyte Colony-Stimulating Factor

Francisco A. Perez, Corinne L. Fligner, and Evan Y. Yu
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.4931 [Abstract] [PDF]  

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ECONOMIC ANALYSIS

Costs and Benefits of the National Cancer Institute Central Institutional Review Board

Todd H. Wagner, Christine Murray, Jacquelyn Goldberg, Jeanne M. Adler, and Jeffrey Abrams
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2470 [Abstract] [PDF]  

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EDITORIALS

Long-Term Cardiac Safety of Dose-Dense Anthracycline Therapy Cannot Be Predicted From Early Ejection Fraction Data

Michael S. Ewer and Steven M. Ewer
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.5091 [Abstract] [PDF]  

Balancing Efficacy and Safety in the Treatment of Adolescents With Hodgkin's Lymphoma

Monika L. Metzger and Melissa M. Hudson
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.25.3765 [Abstract] [PDF]  

Anaplastic Gliomas

Lisa M. DeAngelis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.5985 [Abstract] [PDF]  

The Forest and the Trees: Pathways and Proteins As Colorectal Cancer Biomarkers

Monica M. Bertagnolli
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.8013 [Abstract] [PDF]  

Recognition and Treatment of Sleep Disturbances in Cancer

Sonia Ancoli-Israel
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5993 [Abstract] [PDF]  

Refining Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer: T Stands for Trastuzumab, Tumor Size, and Treatment Strategy

Harold J. Burstein and Eric P. Winer
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.2222 [Abstract] [PDF]  

Contralateral Breast Cancer in BRCA1/BRCA2 Mutation Carriers: The Story of the Other Side

Judy E. Garber and Mehra Golshan
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.25.1652 [Abstract] [PDF]  

Changing the Paradigm in Conducting Randomized Clinical Studies in Advanced Pancreatic Cancer: An Opportunity for Better Clinical Development

Josep Tabernero and Teresa Macarulla
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.3098 [Abstract] [PDF]  

Predicting the Risk of Axillary Nodal Metastases and Their Use in Selecting Breast Surgery Options

Lisa K. Jacobs, Charles M. Balch, and Seng-jaw Soong
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.24.4525 [Abstract] [PDF]  

Axillary Reverse Mapping to Prevent Lymphedema After Breast Cancer Surgery: Defining the Limits of the Concept

Seema A. Khan
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.24.3311 [Abstract] [PDF]  

What's Race Got to Do With It?

Ramona Rhodes and Joan M. Teno
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.24.2206 [Abstract] [PDF]  

Stop and Go: Yes or No?

Howard S. Hochster
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.24.5209 [Abstract] [PDF]  

Relapse/Refractory Myeloma Patient: Potential Treatment Guidelines

Jesús F. San Miguel
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.24.3683 [Abstract] [PDF]  

How to Treat Hormone Receptor–Positive, Human Epidermal Growth Factor Receptor 2–Amplified Breast Cancer

Javier Cortes and José Baselga
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.8089 [Abstract] [PDF]  

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EPIDEMIOLOGY

Mobile Phone Use and Risk of Tumors: A Meta-Analysis

Seung-Kwon Myung, Woong Ju, Diana D. McDonnell, Yeon Ji Lee, Gene Kazinets, Chih-Tao Cheng, and Joel M. Moskowitz
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.6366 [Abstract] [PDF]  

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GASTROINTESTINAL CANCER

Nodal Staging Score: A Tool to Assess Adequate Staging of Node-Negative Colon Cancer

Mithat Gönen, Deborah Schrag, and Martin R. Weiser
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7958 [Abstract] [PDF]  

Unique Localization of Circulating Tumor Cells in Patients With Hepatic Metastases

Long R. Jiao, Christos Apostolopoulos, Jimmy Jacob, Richard Szydlo, Natalia Johnson, Nicole Tsim, Nagy A. Habib, R. Charles Coombes, and Justin Stebbing
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.5837 [Abstract] [PDF]  

KRAS and BRAF Mutations in Advanced Colorectal Cancer Are Associated With Poor Prognosis but Do Not Preclude Benefit From Oxaliplatin or Irinotecan: Results From the MRC FOCUS Trial

Susan D. Richman, Matthew T. Seymour, Philip Chambers, Faye Elliott, Catherine L. Daly, Angela M. Meade, Graham Taylor, Jennifer H. Barrett, and Philip Quirke
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.4295 [Abstract] [PDF]  

Analysis of PTEN, BRAF, and EGFR Status in Determining Benefit From Cetuximab Therapy in Wild-Type KRAS Metastatic Colon Cancer

Pierre Laurent-Puig, Anne Cayre, Gilles Manceau, Emmanuel Buc, Jean-Baptiste Bachet, Thierry Lecomte, Philippe Rougier, Astrid Lievre, Bruno Landi, Valérie Boige, Michel Ducreux, Marc Ychou, Fréderic Bibeau, Olivier Bouché, Julia Reid, Steven Stone, and Frédérique Penault-Llorca
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.6796 [Abstract] [PDF]  

Phase III Randomized Comparison of Gemcitabine Versus Gemcitabine Plus Capecitabine in Patients With Advanced Pancreatic Cancer

David Cunningham, Ian Chau, Deborah D. Stocken, Juan W. Valle, David Smith, William Steward, Peter G. Harper, Janet Dunn, Catrin Tudur-Smith, Julia West, Stephen Falk, Adrian Crellin, Fawzi Adab, Joyce Thompson, Pauline Leonard, Joe Ostrowski, Martin Eatock, Werner Scheithauer, Richard Herrmann, and John P. Neoptolemos
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.24.2446 [Abstract] [PDF]  

Randomized Phase II Study of Gemcitabine Administered at a Fixed Dose Rate or in Combination With Cisplatin, Docetaxel, or Irinotecan in Patients With Metastatic Pancreatic Cancer: CALGB 89904

Matthew H. Kulke, Margaret A. Tempero, Donna Niedzwiecki, Donna R. Hollis, Hedy L. Kindler, Michael Cusnir, Peter C. Enzinger, Stefan M. Gorsch, Richard M. Goldberg, and Robert J. Mayer
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.1309 [Abstract] [PDF]  

Association of Molecular Markers With Toxicity Outcomes in a Randomized Trial of Chemotherapy for Advanced Colorectal Cancer: The FOCUS Trial

Michael S. Braun, Susan D. Richman, Lindsay Thompson, Catherine L. Daly, Angela M. Meade, Julian W. Adlard, James M. Allan, Mahesh K.B. Parmar, Philip Quirke, and Matthew T. Seymour
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.21.6283 [Abstract] [PDF]  

Dose Finding and Early Efficacy Study of Gemcitabine Plus Capecitabine in Combination With Bevacizumab Plus Erlotinib in Advanced Pancreatic Cancer

Naureen Starling, David Watkins, David Cunningham, Janet Thomas, Janine Webb, Gina Brown, Karen Thomas, Jacqui Oates, and Ian Chau
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.21.5384 [Abstract] [PDF]  

In Situ Cytotoxic and Memory T Cells Predict Outcome in Patients With Early-Stage Colorectal Cancer

Franck Pagès, Amos Kirilovsky, Bernhard Mlecnik, Martin Asslaber, Marie Tosolini, Gabriela Bindea, Christine Lagorce, Philippe Wind, Florence Marliot, Patrick Bruneval, Kurt Zatloukal, Zlatko Trajanoski, Anne Berger, Wolf-Herman Fridman, and Jérôme Galon
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.6147 [Abstract] [PDF]  

Practical Application of a Calculator for Conditional Survival in Colon Cancer

George J. Chang, Chung-Yuan Hu, Cathy Eng, John M. Skibber, and Miguel A. Rodriguez-Bigas
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.1860 [Abstract] [PDF]  

Alpha-Fetoprotein Response After Locoregional Therapy for Hepatocellular Carcinoma: Oncologic Marker of Radiologic Response, Progression, and Survival

Ahsun Riaz, Robert K. Ryu, Laura M. Kulik, Mary F. Mulcahy, Robert J. Lewandowski, Jeet Minocha, Saad M. Ibrahim, Kent T. Sato, Talia Baker, Frank H. Miller, Steven Newman, Reed Omary, Michael Abecassis, Al B. Benson III, and Riad Salem
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.1282 [Abstract] [PDF]  

Can Chemotherapy Be Discontinued in Unresectable Metastatic Colorectal Cancer? The GERCOR OPTIMOX2 Study

Benoist Chibaudel, Frédérique Maindrault-Goebel, Gérard Lledo, Laurent Mineur, Thierry André, Mostepha Bennamoun, May Mabro, Pascal Artru, Elisabeth Carola, Michel Flesch, Olivier Dupuis, Philippe Colin, Annette K. Larsen, Pauline Afchain, Christophe Tournigand, Christophe Louvet, and Aimery de Gramont
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.4344 [Abstract] [PDF]  

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer

John A. Chabot, Wei-Yann Tsai, Robert L. Fine, Chunxia Chen, Carolyn K. Kumah, Karen A. Antman, and Victor R. Grann
JCO published online August 17, 2009, DOI:10.1200/JCO.2009.22.8429 [Abstract] [PDF]  

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GENITOURINARY CANCER

Phase II Study of Erlotinib in Patients With Locally Advanced or Metastatic Papillary Histology Renal Cell Cancer: SWOG S0317

Michael S. Gordon, Michael Hussey, Raymond B. Nagle, Primo N. Lara Jr, Philip C. Mack, Janice Dutcher, Wolfram Samlowski, Joseph I. Clark, David I. Quinn, Chong-Xian Pan, and David Crawford
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.18.8821 [Abstract] [PDF]  

Evaluating the Combined Effect of Comorbidity and Prostate-Specific Antigen Kinetics on the Risk of Death in Men After Prostate-Specific Antigen Recurrence

Jennifer Y. Wo, Ming-Hui Chen, Paul L. Nguyen, Andrew A. Renshaw, Marian J. Loffredo, Philip W. Kantoff, and Anthony V. D'Amico
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.6067 [Abstract] [PDF]  

Prospective Study of Prostate Tumor Angiogenesis and Cancer-Specific Mortality in the Health Professionals Follow-Up Study

Lorelei A. Mucci, Anna Powolny, Edward Giovannucci, Zhiming Liao, Stacey A. Kenfield, Rulong Shen, Meir J. Stampfer, and Steven K. Clinton
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.20.8876 [Abstract] [PDF]  

Health-Related Quality of Life in Long-Term Survivors of Testicular Cancer

Philip Blach Rossen, Anette Fischer Pedersen, Robert Zachariae, and Hans von der Maase
JCO published online October 26, 2009, DOI:10.1200/JCO.2008.19.6931 [Abstract] [PDF]  

Randomized Phase III Trial on Gemcitabine Versus Mytomicin in Recurrent Superficial Bladder Cancer: Evaluation of Efficacy and Tolerance

Raffaele Addeo, Michele Caraglia, Sergio Bellini, Alberto Abbruzzese, Bruno Vincenzi, Liliana Montella, Antonio Miragliuolo, Rosario Guarrasi, Michele Lanna, Gregorio Cennamo, Vincenzo Faiola, and Salvatore Del Prete
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.20.8199 [Abstract] [PDF]  

Prognostic Factors for Overall Survival in Patients With Metastatic Renal Cell Carcinoma Treated With Vascular Endothelial Growth Factor–Targeted Agents: Results From a Large, Multicenter Study

Daniel Y.C. Heng, Wanling Xie, Meredith M. Regan, Mark A. Warren, Ali Reza Golshayan, Chakshu Sahi, Bernhard J. Eigl, J. Dean Ruether, Tina Cheng, Scott North, Peter Venner, Jennifer J. Knox, Kim N. Chi, Christian Kollmannsberger, David F. McDermott, William K. Oh, Michael B. Atkins, Ronald M. Bukowski, Brian I. Rini, and Toni K. Choueiri
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.4809 [Abstract] [PDF]  

Randomized Phase II/III Trial Assessing Gemcitabine/Carboplatin and Methotrexate/Carboplatin/Vinblastine in Patients With Advanced Urothelial Cancer "Unfit" for Cisplatin-Based Chemotherapy: Phase II—Results of EORTC Study 30986

Maria De Santis, Joaquim Bellmunt, Graham Mead, J. Martijn Kerst, Michael Leahy, Pablo Maroto, Iwona Skoneczna, Sandrine Marreaud, Ronald de Wit, and Richard Sylvester
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.21.4924 [Abstract] [PDF]  

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GYNECOLOGIC CANCER

Clinical Activity of Gemcitabine Plus Pertuzumab in Platinum-Resistant Ovarian Cancer, Fallopian Tube Cancer, or Primary Peritoneal Cancer

Sharmila Makhija, Lukas C. Amler, Dana Glenn, Frederick R. Ueland, Michael A. Gold, Don S. Dizon, Virginia Paton, Chin-Yu Lin, Thomas Januario, Kimmie Ng, Andreas Strauss, Stephen Kelsey, Mark X. Sliwkowski, and Ursula Matulonis
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.3354 [Abstract] [PDF]  

Cancer During Pregnancy: An Analysis of 215 Patients Emphasizing the Obstetrical and the Neonatal Outcomes

Kristel Van Calsteren, Liesbeth Heyns, Frank De Smet, Liesbet Van Eycken, Mina Mhallem Gziri, Willemijn Van Gemert, Michael Halaska, Ignace Vergote, Nelleke Ottevanger, and Frédéric Amant
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.2801 [Abstract] [PDF]  

Preventing Future Cancers by Testing Women With Ovarian Cancer for BRCA Mutations

Janice S. Kwon, Molly S. Daniels, Charlotte C. Sun, and Karen H. Lu
JCO published online October 19, 2009, DOI:10.1200/JCO.2008.21.4684 [Abstract] [PDF]  

Cediranib, an Oral Inhibitor of Vascular Endothelial Growth Factor Receptor Kinases, Is an Active Drug in Recurrent Epithelial Ovarian, Fallopian Tube, and Peritoneal Cancer

Ursula A. Matulonis, Suzanne Berlin, Percy Ivy, Karin Tyburski, Carolyn Krasner, Corrine Zarwan, Anna Berkenblit, Susana Campos, Neil Horowitz, Stephen A. Cannistra, Hang Lee, Julie Lee, Maria Roche, Margaret Hill, Christin Whalen, Laura Sullivan, Chau Tran, Benjamin D. Humphreys, and Richard T. Penson
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.2777 [Abstract] [PDF]  

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HEAD AND NECK CANCER

Comparative Prognostic Value of HPV16 E6 mRNA Compared With In Situ Hybridization for Human Oropharyngeal Squamous Carcinoma

Wei Shi, Hisayuki Kato, Bayardo Perez-Ordonez, Melania Pintilie, Shaohui Huang, Angela Hui, Brian O'Sullivan, John Waldron, Bernard Cummings, John Kim, Jolie Ringash, Laura A. Dawson, Patrick Gullane, Lillian Siu, Maura Gillison, and Fei-Fei Liu
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.1670 [Abstract] [PDF]  

Effect of Epoetin Alfa on Survival and Cancer Treatment–Related Anemia and Fatigue in Patients Receiving Radical Radiotherapy With Curative Intent for Head and Neck Cancer

Peter J. Hoskin, Martin Robinson, Nicholas Slevin, David Morgan, Kevin Harrington, and Christopher Gaffney
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.3693 [Abstract] [PDF]  

Reporting of Time-to-Event End Points and Tracking of Failures in Randomized Trials of Radiotherapy With or Without Any Concomitant Anticancer Agent for Locally Advanced Head and Neck Cancer

Christophe Le Tourneau, Stefan Michiels, Hui K. Gan, and Lillian L. Siu
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.3685 [Abstract] [PDF]  

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HEALTH SERVICES AND OUTCOMES

Evidence-Based Approach to the Introduction of Positron Emission Tomography in Ontario, Canada

William K. Evans, Andreas Laupacis, Karen Y. Gulenchyn, Les Levin, and Mark Levine
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.1614 [Abstract] [PDF]  

Physician Referral for Fertility Preservation in Oncology Patients: A National Study of Practice Behaviors

Gwendolyn P. Quinn, Susan T. Vadaparampil, Ji-Hyun Lee, Paul B. Jacobsen, Gerold Bepler, Johnathan Lancaster, David L. Keefe, and Terrance L. Albrecht
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.0250 [Abstract] [PDF] [Data Supplement]  

To Tell or Not to Tell: The Community Wants to Know About Expensive Anticancer Drugs As a Potential Treatment Option

Linda Mileshkin, Penelope E. Schofield, Michael Jefford, Emilia Agalianos, Michele Levine, Alan Herschtal, Julian Savulescu, Jacqui Ann Thomson, and John R. Zalcberg
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7793 [Abstract] [PDF] [Data Supplement]  

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HEMATOLOGIC MALIGNANCIES

Mutations of E3 Ubiquitin Ligase Cbl Family Members Constitute a Novel Common Pathogenic Lesion in Myeloid Malignancies

Hideki Makishima, Heather Cazzolli, Hadrian Szpurka, Andrew Dunbar, Ramon Tiu, Jungwon Huh, Hideki Muramatsu, Christine O'Keefe, Eric Hsi, Ronald L. Paquette, Seiji Kojima, Alan F. List, Mikkael A. Sekeres, Michael A. McDevitt, and Jaroslaw P. Maciejewski
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7503 [Abstract] [PDF]  

Survival Effect of Venous Thromboembolism in Patients With Multiple Myeloma Treated With Lenalidomide and High-Dose Dexamethasone

Maurizio Zangari, Guido Tricot, Latha Polavaram, Fenghuang Zhan, Ashlie Finlayson, Robert Knight, Tommy Fu, Donna Weber, Meletios A. Dimopoulos, Ruben Niesvizky, and Louis Fink
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.0169 [Abstract] [PDF]  

Hodgkin's Lymphoma in Adolescents Treated With Adult Protocols: A Report From the German Hodgkin Study Group

Dennis A. Eichenauer, Henning Bredenfeld, Heinz Haverkamp, Horst Müller, Jeremy Franklin, Michael Fuchs, Peter Borchmann, Hans-Konrad Müller-Hermelink, Hans T. Eich, Rolf-Peter Müller, Volker Diehl, and Andreas Engert
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.2655 [Abstract] [PDF]  

Multicenter, Phase I, Dose-Escalation Trial of Lenalidomide Plus Bortezomib for Relapsed and Relapsed/Refractory Multiple Myeloma

Paul G. Richardson, Edie Weller, Sundar Jagannath, David E. Avigan, Melissa Alsina, Robert L. Schlossman, Amitabha Mazumder, Nikhil C. Munshi, Irene M. Ghobrial, Deborah Doss, Diane L. Warren, Laura E. Lunde, Mary McKenney, Carol Delaney, Constantine S. Mitsiades, Teru Hideshima, William Dalton, Robert Knight, Dixie-Lee Esseltine, and Kenneth C. Anderson
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.2679 [Abstract] [PDF]  

Phase II Trial of Concurrent Radiation and Weekly Cisplatin Followed by VIPD Chemotherapy in Newly Diagnosed, Stage IE to IIE, Nasal, Extranodal NK/T-Cell Lymphoma: Consortium for Improving Survival of Lymphoma Study

Seok Jin Kim, Kihyun Kim, Byung Soo Kim, Chul Yong Kim, Cheolwon Suh, Jooryung Huh, Sang-Wook Lee, Jin Seok Kim, Jaeho Cho, Gyeong-Won Lee, Ki Mun Kang, Hyeon Seok Eom, Hong Ryull Pyo, Yong Chan Ahn, Young Hyeh Ko, and Won Seog Kim
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.8592 [Abstract] [PDF]  

Do Male Lymphoma Survivors Have Impaired Sexual Function?

Cecilie E. Kiserud, Leslie R. Schover, Alv A. Dahl, Alexander Fosså, Trine Bjøro, Jon Håvard Loge, Harald Holte, Ying Yuan, and Sophie D. Fosså
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.2280 [Abstract] [PDF]  

Quantitative PCR Analysis for Bcl-2/IgH in a Phase III Study of Yttrium-90 Ibritumomab Tiuxetan As Consolidation of First Remission in Patients With Follicular Lymphoma

Lindsey Goff, Karin Summers, Sameena Iqbal, Jens Kuhlmann, Michael Kunz, Tom Louton, Anton Hagenbeek, Franck Morschhauser, Barbara Putz, Andrew Lister, and Ama Rohatiner
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.6258 [Abstract] [PDF]  

Age-Specific Differences in Oncogenic Pathway Dysregulation and Anthracycline Sensitivity in Patients With Acute Myeloid Leukemia

Arati V. Rao, Peter J.M. Valk, Klaus H. Metzeler, Chaitanya R. Acharya, Sascha A. Tuchman, Marvaretta M. Stevenson, David A. Rizzieri, Ruud Delwel, Christian Buske, Stefan K. Bohlander, Anil Potti, and Bob Löwenberg
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.2547 [Abstract] [PDF]  

VMP (Bortezomib, Melphalan, and Prednisone) Is Active and Well Tolerated in Newly Diagnosed Patients With Multiple Myeloma With Moderately Impaired Renal Function, and Results in Reversal of Renal Impairment: Cohort Analysis of the Phase III VISTA Study

Meletios A. Dimopoulos, Paul G. Richardson, Rudolf Schlag, Nuriet K. Khuageva, Ofer Shpilberg, Efstathios Kastritis, Martin Kropff, Maria T. Petrucci, Michel Delforge, Julia Alexeeva, Rik Schots, Tamás Masszi, Maria-Victoria Mateos, William Deraedt, Kevin Liu, Andrew Cakana, Helgi van de Velde, and Jesús F. San Miguel
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.22.2232 [Abstract] [PDF]  

Phase II Study of Flavopiridol in Relapsed Chronic Lymphocytic Leukemia Demonstrating High Response Rates in Genetically High-Risk Disease

Thomas S. Lin, Amy S. Ruppert, Amy J. Johnson, Beth Fischer, Nyla A. Heerema, Leslie A. Andritsos, Kristie A. Blum, Joseph M. Flynn, Jeffrey A. Jones, Weihong Hu, Mollie E. Moran, Sarah M. Mitchell, Lisa L. Smith, Amy J. Wagner, Chelsey A. Raymond, Larry J. Schaaf, Mitch A. Phelps, Miguel A. Villalona-Calero, Michael R. Grever, and John C. Byrd
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.6944 [Abstract] [PDF]  

Achievement of at Least Very Good Partial Response Is a Simple and Robust Prognostic Factor in Patients With Multiple Myeloma Treated With High-Dose Therapy: Long-Term Analysis of the IFM 99-02 and 99-04 Trials

Jean-Luc Harousseau, Herve Avet-Loiseau, Michel Attal, Catherine Charbonnel, Frederic Garban, Cyrille Hulin, Mauricette Michallet, Thierry Facon, Laurent Garderet, Gerald Marit, Nicolas Ketterer, Thierry Lamy, Laurent Voillat, Francois Guilhot, Chantal Doyen, Claire Mathiot, and Philippe Moreau
JCO published online October 13, 2009, DOI:10.1200/JCO.2008.21.1060 [Abstract] [PDF]  

Phase I/II Study of Concurrent Chemoradiotherapy for Localized Nasal Natural Killer/T-Cell Lymphoma: Japan Clinical Oncology Group Study JCOG0211

Motoko Yamaguchi, Kensei Tobinai, Masahiko Oguchi, Naoki Ishizuka, Yukio Kobayashi, Yasushi Isobe, Kenichi Ishizawa, Nobuo Maseki, Kuniaki Itoh, Noriko Usui, Izumi Wasada, Tomohiro Kinoshita, Koichi Ohshima, Yoshihiro Matsuno, Takashi Terauchi, Shigeru Nawano, Satoshi Ishikura, Yoshikazu Kagami, Tomomitsu Hotta, and Kazuo Oshimi
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.8295 [Abstract] [PDF]  

Dynamic Model for Predicting Death Within 12 Months in Patients With Primary or Post–Polycythemia Vera/Essential Thrombocythemia Myelofibrosis

Constantine S. Tam, Hagop Kantarjian, Jorge Cortes, Alice Lynn, Sherry Pierce, Lingsha Zhou, Michael J. Keating, Deborah A. Thomas, and Srdan Verstovsek
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.8833 [Abstract] [PDF]  

Immuno–Fluorescence In Situ Hybridization Index Predicts Survival in Patients With Diffuse Large B-Cell Lymphoma Treated With R-CHOP: A GELA Study

Christiane Copie-Bergman, Philippe Gaulard, Karen Leroy, Josette Briere, Maryse Baia, Jean-Philippe Jais, Gilles A. Salles, Françoise Berger, Corinne Haioun, Herve Tilly, Jean-François Emile, Alison H. Banham, Nicolas Mounier, Christian Gisselbrecht, Pierre Feugier, Bertrand Coiffier, and Thierry J. Molina
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.7058 [Abstract] [PDF]  

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MELANOMA

Analysis of Factors Influencing Outcome in Patients With In-Transit Malignant Melanoma Undergoing Isolated Limb Perfusion Using Modern Treatment Parameters

H. Richard Alexander Jr, Douglas L. Fraker, David L. Bartlett, Steven K. Libutti, Seth M. Steinberg, Perry Soriano, and Tatiana Beresnev
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.7511 [Abstract] [PDF]  

Phase II Clinical Trial of a Granulocyte-Macrophage Colony-Stimulating Factor–Encoding, Second-Generation Oncolytic Herpesvirus in Patients With Unresectable Metastatic Melanoma

Neil N. Senzer, Howard L. Kaufman, Thomas Amatruda, Mike Nemunaitis, Tony Reid, Gregory Daniels, Rene Gonzalez, John Glaspy, Eric Whitman, Kevin Harrington, Howard Goldsweig, Tracey Marshall, Colin Love, Robert Coffin, and John J. Nemunaitis
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.24.3675 [Abstract] [PDF]  

Melanoma Prognostic Model Using Tissue Microarrays and Genetic Algorithms

Bonnie E. Gould Rothberg, Aaron J. Berger, Annette M. Molinaro, Antonio Subtil, Michael O. Krauthammer, Robert L. Camp, William R. Bradley, Stephan Ariyan, Harriet M. Kluger, and David L. Rimm
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.8239 [Abstract] [PDF]  

Targeted High-Resolution Ultrasound Is Not an Effective Substitute for Sentinel Lymph Node Biopsy in Patients With Primary Cutaneous Melanoma

Amira Sanki, Roger F. Uren, Marc Moncrieff, Kayla L. Tran, Richard A. Scolyer, Hui-Yi Lin, and John F. Thompson
JCO published online September 28, 2009, DOI:10.1200/JCO.2008.21.4882 [Abstract] [PDF]  

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NEUROONCOLOGY

MGMT Promoter Methylation Is Prognostic but Not Predictive for Outcome to Adjuvant PCV Chemotherapy in Anaplastic Oligodendroglial Tumors: A Report From EORTC Brain Tumor Group Study 26951

Martin J. van den Bent, Hendrikus J. Dubbink, Marc Sanson, Cathleen R. van der Lee-Haarloo, Monika Hegi, Judith W.M. Jeuken, Ahmed Ibdaih, Alba A. Brandes, Martin J.B. Taphoorn, Marc Frenay, Denis Lacombe, Thierry Gorlia, Winand N.M. Dinjens, and Johan M. Kros
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.1034 [Abstract] [PDF]  

NOA-04 Randomized Phase III Trial of Sequential Radiochemotherapy of Anaplastic Glioma With Procarbazine, Lomustine, and Vincristine or Temozolomide

Wolfgang Wick, Christian Hartmann, Corinna Engel, Mandy Stoffels, Jörg Felsberg, Florian Stockhammer, Michael C. Sabel, Susanne Koeppen, Ralf Ketter, Richard Meyermann, Marion Rapp, Christof Meisner, Rolf D. Kortmann, Torsten Pietsch, Otmar D. Wiestler, Ulrike Ernemann, Michael Bamberg, Guido Reifenberger, Andreas von Deimling, and Michael Weller
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.6497 [Abstract] [PDF]  

Molecular Predictors of Progression-Free and Overall Survival in Patients With Newly Diagnosed Glioblastoma: A Prospective Translational Study of the German Glioma Network

Michael Weller, Jörg Felsberg, Christian Hartmann, Hilmar Berger, Joachim P. Steinbach, Johannes Schramm, Manfred Westphal, Gabriele Schackert, Matthias Simon, Jörg C. Tonn, Oliver Heese, Dietmar Krex, Guido Nikkhah, Torsten Pietsch, Otmar Wiestler, Guido Reifenberger, Andreas von Deimling, and Markus Loeffler
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.23.0805 [Abstract] [PDF]  

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PALLIATIVE AND SUPPORTIVE CARE

Phase III, Randomized, Double-Blind, Placebo-Controlled Evaluation of Pregabalin for Alleviating Hot Flashes, N07C1

Charles L. Loprinzi, Rui Qin, Ernie P. Baclueva, Kathleen A. Flynn, Kendrith M. Rowland Jr, David L. Graham, Nancy K. Erwin, Shaker R. Dakhil, Donald J. Jurgens, and Kelli N. Burger
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.5647 [Abstract] [PDF]  

Care for Imminently Dying Cancer Patients: Family Members' Experiences and Recommendations

Takuya Shinjo, Tatsuya Morita, Kei Hirai, Mitsunori Miyashita, Kazuki Sato, Satoru Tsuneto, and Yasuo Shima
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.23.2793 [Abstract] [PDF]  

Patients' Supportive Care Needs Beyond the End of Cancer Treatment: A Prospective, Longitudinal Survey

Jo Armes, Maggie Crowe, Lynne Colbourne, Helen Morgan, Trevor Murrells, Catherine Oakley, Nigel Palmer, Emma Ream, Annie Young, and Alison Richardson
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.5151 [Abstract] [PDF]  

Prognostic Acceptance and the Well-Being of Patients Receiving Palliative Care for Cancer

Genevieve N. Thompson, Harvey M. Chochinov, Keith G. Wilson, Christine J. McPherson, Srini Chary, Fiona M. O'Shea, David R. Kuhl, Robin L. Fainsinger, Pierre R. Gagnon, and Karen A. Macmillan
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.22.9799 [Abstract] [PDF]  

Racial Differences in Predictors of Intensive End-of-Life Care in Advanced Cancer Patients

Elizabeth Trice Loggers, Paul K. Maciejewski, Elizabeth Paulk, Susan DeSanto-Madeya, Matthew Nilsson, Kasisomayajula Viswanath, Alexi Anne Wright, Tracy A. Balboni, Jennifer Temel, Heather Stieglitz, Susan Block, and Holly G. Prigerson
JCO published online October 5, 2009, DOI:10.1200/JCO.2009.22.4733 [Abstract] [PDF]  

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PEDIATRIC ONCOLOGY

Germline Genetic Variation in an Organic Anion Transporter Polypeptide Associated With Methotrexate Pharmacokinetics and Clinical Effects

Lisa R. Treviño, Noriko Shimasaki, Wenjian Yang, John C. Panetta, Cheng Cheng, Deqing Pei, Diana Chan, Alex Sparreboom, Kathleen M. Giacomini, Ching-Hon Pui, William E. Evans, and Mary V. Relling
JCO published online November 9, 2009, DOI:10.1200/JCO.2008.20.4156 [Abstract] [PDF]  

Comparison of Neurocognitive Functioning in Children Previously Randomly Assigned to Intrathecal Methotrexate Compared With Triple Intrathecal Therapy for the Treatment of Childhood Acute Lymphoblastic Leukemia

Nina S. Kadan-Lottick, Pim Brouwers, David Breiger, Thomas Kaleita, James Dziura, Veronika Northrup, Lu Chen, Megan Nicoletti, Bruce Bostrom, Linda Stork, and Joseph P. Neglia
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.23.5408 [Abstract] [PDF]  

Suicide Ideation in Adult Survivors of Childhood Cancer: A Report From the Childhood Cancer Survivor Study

Christopher J. Recklitis, Lisa R. Diller, Xiaochun Li, Julie Najita, Leslie L. Robison, and Lonnie Zeltzer
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.8635 [Abstract] [PDF]  

Outcome of Patients Treated for Relapsed or Refractory Acute Lymphoblastic Leukemia: A Therapeutic Advances in Childhood Leukemia Consortium Study

Richard H. Ko, Lingyun Ji, Phillip Barnette, Bruce Bostrom, Raymond Hutchinson, Elizabeth Raetz, Nita L. Seibel, Clare J. Twist, Elena Eckroth, Richard Sposto, Paul S. Gaynon, and Mignon L. Loh
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.22.2950 [Abstract] [PDF]  

"Trying to Be a Good Parent" As Defined By Interviews With Parents Who Made Phase I, Terminal Care, and Resuscitation Decisions for Their Children

Pamela S. Hinds, Linda L. Oakes, Judy Hicks, Brent Powell, Deo Kumar Srivastava, Sheri L. Spunt, JoAnn Harper, Justin N. Baker, Nancy K. West, and Wayne L. Furman
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.20.0204 [Abstract] [PDF]  

Survival After Second Primary Neoplasms of the Brain or Spinal Cord in Survivors of Childhood Cancer: Results From the British Childhood Cancer Survivor Study

Aliki J. Taylor, Clare Frobisher, David W. Ellison, Raoul C. Reulen, David L. Winter, Roger E. Taylor, Charles A. Stiller, Emma R. Lancashire, Edward C.G. Tudor, Christina Baggott, Shaun May, and Mike M. Hawkins
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.22.4386 [Abstract] [PDF]  

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PHASE I AND CLINICAL PHARMACOLOGY

Phase I, Pharmacokinetic, and Pharmacodynamic Study of AMG 479, a Fully Human Monoclonal Antibody to Insulin-Like Growth Factor Receptor 1

Anthony W. Tolcher, John Sarantopoulos, Amita Patnaik, Kyriakos Papadopoulos, Chia-Chi Lin, Jordi Rodon, Barbara Murphy, Bruce Roth, Ian McCaffery, Kevin S. Gorski, Brianne Kaiser, Min Zhu, Hongjie Deng, Greg Friberg, and Igor Puzanov
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.6745 [Abstract] [PDF]  

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REVIEW ARTICLES

Chronic Myeloid Leukemia: An Update of Concepts and Management Recommendations of European LeukemiaNet

Michele Baccarani, Jorge Cortes, Fabrizio Pane, Dietger Niederwieser, Giuseppe Saglio, Jane Apperley, Francisco Cervantes, Michael Deininger, Alois Gratwohl, François Guilhot, Andreas Hochhaus, Mary Horowitz, Timothy Hughes, Hagop Kantarjian, Richard Larson, Jerald Radich, Bengt Simonsson, Richard T. Silver, John Goldman, and Rudiger Hehlmann
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.25.0779 [Abstract] [PDF]  

Understanding the Mechanisms Behind Trastuzumab Therapy for Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer

Neil L. Spector and Kimberly L. Blackwell
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.1507 [Abstract] [PDF]  

Application of Screening Principles to the Reconstructed Breast

Jennifer Zakhireh, Barbara Fowble, and Laura J. Esserman
JCO published online November 2, 2009, DOI:10.1200/JCO.2008.21.7588 [Abstract] [PDF]  

Ultimate Fate of Oncology Drugs Approved by the US Food and Drug Administration Without a Randomized Trial

Apostolia-Maria Tsimberidou, Fadi Braiteh, David J. Stewart, and Razelle Kurzrock
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.6018 [Abstract] [PDF]  

Magnetic Resonance Imaging Screening of the Contralateral Breast in Women With Newly Diagnosed Breast Cancer: Systematic Review and Meta-Analysis of Incremental Cancer Detection and Impact on Surgical Management

Meagan Elizabeth Brennan, Nehmat Houssami, Sarah Lord, Petra Macaskill, Les Irwig, J. Michael Dixon, Ruth M.L. Warren, and Stefano Ciatto
JCO published online October 5, 2009, DOI:10.1200/JCO.2008.21.5756 [Abstract] [PDF]  

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SPECIAL ARTICLES

Consensus Report of the National Cancer Institute Clinical Trials Planning Meeting on Pancreas Cancer Treatment

Philip A. Philip, Margaret Mooney, Deborah Jaffe, Gail Eckhardt, Malcolm Moore, Neal Meropol, Leisha Emens, Eileen O'Reilly, Murray Korc, Lee Ellis, Jacqueline Benedetti, Mace Rothenberg, Christopher Willett, Margaret Tempero, Andrew Lowy, James Abbruzzese, Diane Simeone, Sunil Hingorani, Jordan Berlin, and Joel Tepper
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.21.9022 [Abstract] [PDF]  

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THORACIC ONCOLOGY

Tracheoesophageal Fistula Formation in Patients With Lung Cancer Treated With Chemoradiation and Bevacizumab

David R. Spigel, John D. Hainsworth, Denise A. Yardley, Eric Raefsky, Jeffrey Patton, Nancy Peacock, Cindy Farley, Howard A. Burris III, and F. Anthony Greco
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.24.7353 [Abstract] [PDF]  

Phase II Study of Preoperative Gefitinib in Clinical Stage I Non–Small-Cell Lung Cancer

Humberto Lara-Guerra, Thomas K. Waddell, Maria A. Salvarrey, Anthony M. Joshua, Catherine T. Chung, Narinder Paul, Scott Boerner, Akira Sakurada, Olga Ludkovski, Clement Ma, Jeremy Squire, Geoffrey Liu, Frances A. Shepherd, Ming-Sound Tsao, and Natasha B. Leighl
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.22.3370 [Abstract] [PDF]  

Randomized Phase III Trial of Gemcitabine-Based Chemotherapy With In Situ RRM1 and ERCC1 Protein Levels for Response Prediction in Non–Small-Cell Lung Cancer

Craig Reynolds, Coleman Obasaju, Michael J. Schell, Xueli Li, Zhong Zheng, David Boulware, John R. Caton, Linda C. DeMarco, Mark A. O'Rourke, Gail Shaw Wright, Kristi A. Boehm, Lina Asmar, Jane Bromund, Guangbin Peng, Matthew J. Monberg, and Gerold Bepler
JCO published online November 2, 2009, DOI:10.1200/JCO.2009.21.9766 [Abstract] [PDF]  

Phase II Study of Cisplatin Plus Etoposide and Bevacizumab for Previously Untreated, Extensive-Stage Small-Cell Lung Cancer: Eastern Cooperative Oncology Group Study E3501

Leora Horn, Suzanne E. Dahlberg, Alan B. Sandler, Afshin Dowlati, Dennis F. Moore, John R. Murren, and Joan H. Schiller
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7545 [Abstract] [PDF] [Publisher's Note]  

Quality of Life Supersedes the Classic Prognosticators for Long-Term Survival in Locally Advanced Non–Small-Cell Lung Cancer: An Analysis of RTOG 9801

Benjamin Movsas, Jennifer Moughan, Linda Sarna, Corey Langer, Maria Werner-Wasik, Nicos Nicolaou, Ritsuko Komaki, Mitchell Machtay, Todd Wasserman, and Deborah Watkins Bruner
JCO published online October 26, 2009, DOI:10.1200/JCO.2009.23.7420 [Abstract] [PDF]  

Phase II Trial of Pemetrexed Plus Bevacizumab for Second-Line Therapy of Patients With Advanced Non–Small-Cell Lung Cancer: NCCTG and SWOG Study N0426

Alex A. Adjei, Sumithra J. Mandrekar, Grace K. Dy, Julian R. Molina, Araba A. Adjei, David R. Gandara, Katie L. Allen Ziegler, Philip J. Stella, Kendrith M. Rowland Jr, Steven E. Schild, and Ralph G. Zinner
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.23.6406 [Abstract] [PDF]  

Polymorphisms in the CASPASE Genes and Survival in Patients With Early-Stage Non–Small-Cell Lung Cancer

Seung Soo Yoo, Jin Eun Choi, Won-Kee Lee, Yi-Young Choi, Sin Kam, Min Jung Kim, Hyo-Sung Jeon, Eung-Bae Lee, Dong Sun Kim, Myung-Hoon Lee, In-San Kim, Sanghoon Jheon, and Jae Yong Park
JCO published online October 13, 2009, DOI:10.1200/JCO.2009.23.1738 [Abstract] [PDF]  

Genetic Abnormalities of the EGFR Pathway in African American Patients With Non–Small-Cell Lung Cancer

Rom S. Leidner, Pingfu Fu, Bradley Clifford, Ayad Hamdan, Cheng Jin, Rosana Eisenberg, Titus J. Boggon, Margaret Skokan, Wilbur A. Franklin, Federico Cappuzzo, Fred R. Hirsch, Marileila Varella-Garcia, and Balazs Halmos
JCO published online September 28, 2009, DOI:10.1200/JCO.2009.23.1431 [Abstract] [PDF]  

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TREATMENT-RELATED COMPLICATIONS

Effective Strategies for Management of Hypertension After Vascular Endothelial Growth Factor Signaling Inhibition Therapy: Results From a Phase II Randomized, Factorial, Double-Blind Study of Cediranib in Patients With Advanced Solid Tumors

Marlies H.G. Langenberg, Carla M.L. van Herpen, Johann De Bono, Jan H.M. Schellens, Clemens Unger, Klaas Hoekman, Hubert E. Blum, Walter Fiedler, Joachim Drevs, Florence Le Maulf, Anitra Fielding, Jane Robertson, and Emile E. Voest
JCO published online November 9, 2009, DOI:10.1200/JCO.2009.22.2273 [Abstract] [PDF]  

Clinically Driven Diagnostic Antifungal Approach in Neutropenic Patients: A Prospective Feasibility Study

Corrado Girmenia, Alessandra Micozzi, Giuseppe Gentile, Stefania Santilli, Eva Arleo, Luisa Cardarelli, Saveria Capria, Clara Minotti, Claudio Cartoni, Simonetta Brocchieri, Vito Guerrisi, Giovanna Meloni, Robin Foà, and Pietro Martino
JCO published online October 19, 2009, DOI:10.1200/JCO.2009.21.8032 [Abstract] [PDF]  

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