Journal of Clinical Oncology Early Release Articles

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Journal of Clinical Oncology Early Release Articles

Journal of Clinical Oncology publishes all articles on JCO.org in advance of print publication. The new policy provides subscribers with the latest clinical research several weeks before it appears in print. All articles have been reviewed, copyedited, and typeset, and appear in the final form in which they will appear in the print journal. Once an article appears in print, it will be removed from the Early Release page and grouped with the other contents of the issue in which it appears. All articles below are citable by using the Digital Object Identifier (DOI), a unique number given to every article, and the posting date.

Next posting date: March 22, 2010

Last updated March 15, 2010 [View by date]

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To see an article, click its [PDF] link. To review many abstracts, check the boxes to the left of the titles you want, and click the 'Get All Checked Abstract(s)' button. To see one abstract at a time, click its [Abstract] link.

AIDS-RELATED CANCER

HIV As a Risk Factor for Lung Cancer in Women: Data From the Women's Interagency HIV Study: Alexandra M. Levine, Eric C. Seaberg, Nancy A. Hessol, Susan Preston-Martin, Sylvia Silver, Mardge H. Cohen, Kathryn Anastos, Howard Minkoff, Jan Orenstein, Geraldina Dominguez, and D. Heather Watts
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.6149 [Abstract] [PDF]

ART OF ONCOLOGY

Our Version of Normal: William A. Wood
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.27.3201 [Abstract] [PDF]

Art Informs Medicine: Celia Engel Bandman
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.27.2708 [Abstract] [PDF]

Hope and Noncurative Chemotherapies: Which Affects the Other?: Serge Daneault, Dominique Dion, Claude Sicotte, Louise Yelle, Suzanne Mongeau, Véronique Lussier, Manon Coulombe, and Pierre Paillé
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.8425 [Abstract] [PDF]

Life's Lessons Lost...and Learned: Reena George
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.0413 [Abstract] [PDF]

BIOLOGY OF NEOPLASIA

Translating Gene Expression into Clinical Care: Sarcomas As a Paradigm: Torsten O. Nielsen and Robert B. West
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.1917 [Abstract] [PDF]

BREAST CANCER

Predictors of Tumor Progression During Neoadjuvant Chemotherapy in Breast Cancer: Abigail S. Caudle, Ana M. Gonzalez-Angulo, Kelly K. Hunt, Ping Liu, Lajos Pusztai, W. Fraser Symmans, Henry M. Kuerer, Elizabeth A. Mittendorf, Gabriel N. Hortobagyi, and Funda Meric-Bernstam
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.3286 [Abstract] [PDF]

Identification of Subtypes in Human Epidermal Growth Factor Receptor 2–Positive Breast Cancer Reveals a Gene Signature Prognostic of Outcome: Johan Staaf, Markus Ringnér, Johan Vallon-Christersson, Göran Jönsson, Pär-Ola Bendahl, Karolina Holm, Adalgeir Arason, Haukur Gunnarsson, Cecilia Hegardt, Bjarni A. Agnarsson, Lena Luts, Dorthe Grabau, Mårten Fernö, Per-Olof Malmström, Oskar Th. Johannsson, Niklas Loman, Rosa B. Barkardottir, and Åke Borg
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.22.8775 [Abstract] [PDF] [Data Supplements]

Prediction of Risk of Distant Recurrence Using the 21-Gene Recurrence Score in Node-Negative and Node-Positive Postmenopausal Patients With Breast Cancer Treated With Anastrozole or Tamoxifen: A TransATAC Study: Mitch Dowsett, Jack Cuzick, Christopher Wale, John Forbes, Elizabeth A. Mallon, Janine Salter, Emma Quinn, Anita Dunbier, Michael Baum, Aman Buzdar, Anthony Howell, Roberto Bugarini, Frederick L. Baehner, and Steven Shak
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.24.4798 [Abstract] [PDF]

Comparable Survival Between pN0 Breast Cancer Patients Undergoing Sentinel Node Biopsy and Extensive Axillary Dissection: A Report From the Korean Breast Cancer Society: Hyeong-Gon Moon, Wonshik Han, and Dong-Young Noh
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.9226 [Abstract] [PDF]

Breast Cancer Subtypes and the Risk of Local and Regional Relapse: K. David Voduc, Maggie C.U. Cheang, Scott Tyldesley, Karen Gelmon, Torsten O. Nielsen, and Hagen Kennecke
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.9284 [Abstract] [PDF]

Prospective Multicenter Cohort Study to Refine Management Recommendations for Women at Elevated Familial Risk of Breast Cancer: The EVA Trial: Christiane Kuhl, Stefanie Weigel, Simone Schrading, Birke Arand, Heribert Bieling, Roy König, Bernd Tombach, Claudia Leutner, Andrea Rieber-Brambs, Dennis Nordhoff, Walter Heindel, Maximilian Reiser, and Hans H. Schild
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.23.0839 [Abstract] [PDF]

First-Line Trastuzumab Plus Epirubicin and Cyclophosphamide Therapy in Patients With Human Epidermal Growth Factor Receptor 2–Positive Metastatic Breast Cancer: Cardiac Safety and Efficacy Data From the Herceptin, Cyclophosphamide, and Epirubicin (HERCULES) Trial: Michael Untch, Michael Muscholl, Sergei Tjulandin, Walter Jonat, Hans-Gerd Meerpohl, Mikhail Lichinitser, Alexey G. Manikhas, Alexandra Coumbos, Rolf Kreienberg, Andreas du Bois, Nadia Harbeck, Christian Jackisch, Volkmar Müller, Matthias Pauschinger, Christoph Thomssen, Michaela Lehle, Olivier Catalani, and Hans-Joachim Lück
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.21.9709 [Abstract] [PDF]

Alberta Physical Activity and Breast Cancer Prevention Trial: Sex Hormone Changes in a Year-Long Exercise Intervention Among Postmenopausal Women: Christine M. Friedenreich, Christy G. Woolcott, Anne McTiernan, Rachel Ballard-Barbash, Rollin F. Brant, Frank Z. Stanczyk, Tim Terry, Norman F. Boyd, Martin J. Yaffe, Melinda L. Irwin, Charlotte A. Jones, Yutaka Yasui, Kristin L. Campbell, Margaret L. McNeely, Kristina H. Karvinen, Qinggang Wang, and Kerry S. Courneya
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.24.9557 [Abstract] [PDF]

Aspirin Intake and Survival After Breast Cancer: Michelle D. Holmes, Wendy Y. Chen, Lisa Li, Ellen Hertzmark, Donna Spiegelman, and Susan E. Hankinson
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.22.7918 [Abstract] [PDF]

Association Between the 21-Gene Recurrence Score Assay and Risk of Locoregional Recurrence in Node-Negative, Estrogen Receptor–Positive Breast Cancer: Results From NSABP B-14 and NSABP B-20: Eleftherios P. Mamounas, Gong Tang, Bernard Fisher, Soonmyung Paik, Steven Shak, Joseph P. Costantino, Drew Watson, Charles E. Geyer Jr, D. Lawrence Wickerham, and Norman Wolmark
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.23.7610 [Abstract] [PDF]

Prospective Multicenter Study of the Impact of the 21-Gene Recurrence Score Assay on Medical Oncologist and Patient Adjuvant Breast Cancer Treatment Selection: Shelly S. Lo, Patricia B. Mumby, John Norton, Karen Rychlik, Jeffrey Smerage, Joseph Kash, Helen K. Chew, Ellen R. Gaynor, Daniel F. Hayes, Andrew Epstein, and Kathy S. Albain
JCO published online January 11, 2010, DOI:10.1200/JCO.2008.20.2119 [Abstract] [PDF]

CLINICAL PRACTICE

Review of Adherence-Related Issues in Adolescents and Young Adults With Cancer: Phyllis Butow, Susan Palmer, Ahna Pai, Belinda Goodenough, Tim Luckett, and Madeleine King
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.22.2802 [Abstract] [PDF]

COMMENTS AND CONTROVERSIES

Neutrophil Count in African-Americans: Lowering the Target Cutoff to Initiate or Resume Chemotherapy?: Matthew M. Hsieh, John F. Tisdale, Griffin P. Rodgers, Neal S. Young, Edward L. Trimble, and Richard F. Little
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.3881 [Abstract] [PDF]

CORRESPONDENCE

Reply to M.H. Tan et al: Hyeong-Gon Moon, Wonshik Han, and Dong-Young Noh
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.27.0991 [Abstract] [PDF]

Association Between Being Underweight and Outcomes in Breast Cancer: Alternative Explanations: Min-Han Tan, Nicholas Qijie Leo, En Yun Loy, Wei-Yen Lim, and Kee Seng Chia
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.27.0363 [Abstract] [PDF]

Bevacizumab and Recurrent Malignant Gliomas: A European Perspective: Wolfgang Wick, Michael Weller, Martin van den Bent, and Roger Stupp
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.26.9027 [Abstract] [PDF] [Publisher's Note]

Reply to T. Grenader et al: Joseph A. Sparano
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.9514 [Abstract] [PDF]

What Is the Right Way to Administer Pegylated Liposomal Doxorubicin in Breast Cancer Therapy?: Tal Grenader and Alberto Gabizon
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.8052 [Abstract] [PDF]

Reply to P. Laneuville et al: Carlo Gambacorti-Passerini, Rocco Piazza, Pietro Perini, Roberta Rostagno, and Sara Redaelli
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.5371 [Abstract] [PDF]

Reply to M.L. Lanthier et al: Charles L. Bennett and Jonathan R. Nebeker
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.5330 [Abstract] [PDF]

Comparative In Vitro Cellular Data Alone Are Insufficient to Predict Clinical Responses and Guide the Choice of BCR-ABL Inhibitor for Treating Imatinib-Resistant Chronic Myeloid Leukemia: Pierre Laneuville, Clifford DiLea, Ophelia Q.P. Yin, Richard C. Woodman, Jürgen Mestan, and Paul W. Manley
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.4945 [Abstract] [PDF]

Accelerated Approval and Oncology Drug Development Timelines: Michael L. Lanthier, Rajeshwari Sridhara, John R. Johnson, Ann Farrell, Patricia Keegan, Robert Justice, and Richard Pazdur
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.2121 [Abstract] [PDF]

Reply to P. Mathew: Emmanuel S. Antonarakis, Angelo M. De Marzo, Theodore L. DeWeese, and Michael A. Carducci
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.27.1346 [Abstract] [PDF]

The Inflammatory Pathogenesis of Prostate Cancer and Celecoxib: Paul Mathew
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.27.1098 [Abstract] [PDF]

Reply to U. De Giorgi et al: Wen Wee Ma
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.8391 [Abstract] [PDF]

[¹⁸F]Fluorodeoxyglucose Positron Emission Tomography for Outcome Prediction of Mammalian Target of Rapamycin Inhibitor Therapy: Ugo De Giorgi and Dino Amadori
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.6866 [Abstract] [PDF]

Reply to C. Cremolini et al: Bart Jacobs, Wendy De Roock, Hubert Piessevaux, Bart Biesmans, Jef De Schutter, Bart Claes, and Sabine Tejpar
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.6809 [Abstract] [PDF]

Predictors of Benefit in Colorectal Cancer Treated With Cetuximab: Are We Getting "Lost in TranslationAL"?: Chiara Cremolini, Fotios Loupakis, Annamaria Ruzzo, Giuseppe Perrone, Eliana Rulli, Bruno Vincenzi, Giuseppe Tonini, Francesco Graziano, Andrea Onetti Muda, and Alfredo Falcone
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.6148 [Abstract] [PDF]

Reply to I. Abraham: Athanassios Kyrgidis, Evgenia Verrou, Kyriaki Kitikidou, Charalampos G. Andreadis, Irini Katodritou, and Konstantinos Vahtsevanos
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.27.1809 [Abstract] [PDF]

Reply to G. Sonpavde et al: Joaquim Bellmunt and Yacine Salhi
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.27.1338 [Abstract] [PDF]

Intravenous Bisphosphonate Treatment and Osteonecrosis of the Jaw in Patients With Cancer: Wide CIs, Yule-Simpson and King Kong Effects, and No Therapeutic Outcomes: Ivo Abraham
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.27.1270 [Abstract] [PDF]

Suggestions for Regulatory Agency Approval of Second-Line Systemic Therapy for Metastatic Transitional Cell Carcinoma: Guru Sonpavde, Jonathan E. Rosenberg, Noah M. Hahn, Matthew D. Galsky, Rick Bangs, Cora N. Sternberg, and Nicholas J. Vogelzang
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.27.1114 [Abstract] [PDF]

Reply to J. Livneh et al: Kristen McNiff
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.27.1015 [Abstract] [PDF]

Addressing Safety Issues of Health Care Personnel, Family Members, and the Environment: Jessica Livneh, Kent Waddington, and Jair Bar
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.9704 [Abstract] [PDF]

Reply to W. Wick et al: Henry S. Friedman, Michael D. Prados, Patrick Y. Wen, Tom Mikkelsen, David Schiff, Lauren E. Abrey, W. K. Alfred Yung, Nina Paleologos, Martin K. Nicholas, Randy Jensen, James Vredenburgh, Jane Huang, Maoxia Zheng, and Timothy Cloughesy
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.9472 [Abstract] [PDF]

Micrometastases and Isolated Tumor Cells in Breast Cancer Are Indeed Associated With Poorer Outcome: Paul J. van Diest, Maaike de Boer, Carolien H.M. van Deurzen, and Vivianne C.G. Tjan-Heijnen
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.7575 [Abstract] [PDF]

Reply to L.C. Panasci and D.S.-W. Tan et al: Bente Holm, Anders Mellemgaard, Torsten Skov, and Birgit Guldhammer Skov
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.6833 [Abstract] [PDF]

Different Impact of Excision Repair Cross-Complementing Group 1 on Survival: Lawrence C. Panasci
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.6619 [Abstract] [PDF]

Truth About ERCC1 in Lung Cancer: Daniel S.-W. Tan, Quan-Sing Ng, Iain B.-H. Tan, Soon-Thye Lim, and Wan-Teck Lim
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.6270 [Abstract] [PDF]

Reply to M.A. Rosen et al: Shauna L. Hillman and Daniel J. Sargent
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.3426 [Abstract] [PDF]

Reply to S.L. Gomez et al: Matthew P. Goetz, Tanya L. Hoskin, Judy C. Boughey, and Amy C. Degnim
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.2972 [Abstract] [PDF]

Reply to D.E. Gyorki et al and P.J. van Diest et al: Armando E. Giuliano, Nora M. Hansen, Baiba J. Grube, Xing Ye, Roderick R. Turner, R. J. Brenner, and Myung-Shin Sim
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.2964 [Abstract] [PDF]

Optimal Lesion Number for Evaluation of Tumor Response in Response Evaluation Criteria in Solid Tumors: Mark A. Rosen and Daniel Sullivan
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.2642 [Abstract] [PDF]

Significance of Sentinel Lymph Node Micrometastases in Patients With Breast Cancer: David E. Gyorki and Michael A. Henderson
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.1420 [Abstract] [PDF]

Increasing Mastectomy Rates for Early-Stage Breast Cancer? Population-Based Trends From California: Scarlett Lin Gomez, Daphne Lichtensztajn, Allison W. Kurian, Melinda L. Telli, Ellen T. Chang, Theresa H.M. Keegan, Sally L. Glaser, and Christina A. Clarke
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.1032 [Abstract] [PDF]

Reply to M. Isik et al: Heikki Joensuu, Petri Bono, and Pirkko-Liisa Kellokumpu-Lehtinen
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.3243 [Abstract] [PDF]

Two Important Determinants May Play a Role in the Success of the FinHer Trial: Metin Isik, Omer Dizdar, and Kadri Altundag
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.27.2740 [Abstract] [PDF]

DIAGNOSIS IN ONCOLOGY

Retroperitoneal Diffuse Large B-Cell Lymphoma Presenting As Pseudoachalasia: Danielle M. Pastor, Ashley D. Eggers, Joseph J. Drabick, Thomas P. Loughran, Michael G. Bayerl, and Timothy R. Shope
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.8715 [Abstract] [PDF]

Mixed Response in Interim Positron Emission Tomography/Computed Tomography Leads to Detection of a Gastrointestinal Stromal Tumor in a Patient With Mediastinal Diffuse Large B-Cell Lymphoma: Cord Rehmsmeier, Torsten Kessler, Steffen Koschmieder, Matthias Ross, Matthias Weckesser, Johannes Wessling, Gabriele Koehler, and Wolfgang E. Berdel
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.8848 [Abstract] [PDF]

Diffuse Osteosclerosis Complicating Hairy Cell Leukemia: Rock Leung, David Lopes, Clarence Lam, Kit-Fai Wong, Annie W.C. Kung, and Yok-Lam Kwong
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.7601 [Abstract] [PDF]

Isolated Loss of Hormonal Receptors in Leptomeningeal Metastasis From Estrogen Receptor– and Progesterone Receptor–Positive Lobular Breast Cancer: Jai Grewal, Huadong Zhou, Rachel Factor, and Santosh Kesari
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.3518 [Abstract] [PDF]

Disseminated Tumor Embolism From Breast Cancer Leading to Multiorgan Failure: Daphne T. Tsoi, Corwyn Rowsell, Caitlin McGregor, Catherine M. Kelly, Sunil Verma, and Kathleen I. Pritchard
JCO published online February 1, 2010, DOI:10.1200/JCO.2009.25.1009 [Abstract] [PDF]

Systemic Fibrinolysis Caused by Tissue Plasminogen Activator–Producing Metastatic Breast Cancer: Harris V.K. Naina, Mrinal M. Patnaik, Uzma A. Ali, Dong Chen, and Aneel A. Ashrani
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.2502 [Abstract] [PDF]

Hodgkin's Lymphoma Arising in a Patient With Hypersensitivity to Mosquito Bites: A Case Report: Silvia Park, Sunha Bahng, Eun Kyoung Kim, Sung Bum Park, Young Kyung Sung, Suk Jin Kim, Won Seog Kim, and Young Hyeh Ko
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.0357 [Abstract] [PDF]

Panhypopituitarism Secondary to Hypothalamic Involvement in a Woman With Diffuse Large B-Cell Lymphoma: Theresa W. Chan and Paul Hoskins
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.24.9060 [Abstract] [PDF]

Pulmonary Calciphylaxis and Metastatic Calcification With Acute Respiratory Failure in Multiple Myeloma: Claudia Crippa, Samantha Ferrari, Monica Drera, Regina Tardanico, Marco Ungari, Fabio Facchetti, Giovanni Cancarini, and Giuseppe Rossi
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.25.1587 [Abstract] [PDF]

Superior Vena Cava Syndrome: A Presentation of Anaplastic Thyroid Carcinoma: Hema Padmanabhan
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.24.8740 [Abstract] [PDF]

Burkitt's Lymphoma in Early Pregnancy: Cary Peterson, Darrell R. Lester Jr, and Warren Sanger
JCO published online January 4, 2010, DOI:10.1200/JCO.2009.24.6355 [Abstract] [PDF]

Isolated Relapse of Acute Lymphoblastic Leukemia in the Epididymis: A Rare Sanctuary Site: Andrew E. Bourne, Robert O. Wayment, Thomas H. Tarter, and Patrick Hemmer
JCO published online December 14, 2009, DOI:10.1200/JCO.2009.23.8014 [Abstract] [PDF]

DIAGNOSTICS

Early Detection of Superficial Squamous Cell Carcinoma in the Head and Neck Region and Esophagus by Narrow Band Imaging: A Multicenter Randomized Controlled Trial: Manabu Muto, Keiko Minashi, Tomonori Yano, Yutaka Saito, Ichiro Oda, Satoru Nonaka, Tai Omori, Hitoshi Sugiura, Kenichi Goda, Mitsuru Kaise, Haruhiro Inoue, Hideki Ishikawa, Atsushi Ochiai, Tadakazu Shimoda, Hidenobu Watanabe, Hisao Tajiri, and Daizo Saito
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.4680 [Abstract] [PDF]

EDITORIAL

If Histology Matters...: Thomas E. Stinchcombe, Juneko E. Grilley-Olson, and Mark A. Socinski
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.27.1247 [Abstract] [PDF]

EDITORIALS

HER2 Signatures in Breast Cancer: Ready to Go to Print?: Pieter J.A. Eichhorn and José Baselga
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.26.7146 [Abstract] [PDF]

Molecular Predictors of Locoregional Recurrence in Breast Cancer: Ready for Prime Time?: Bruce G. Haffty and Thomas A. Buchholz
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.27.1080 [Abstract] [PDF]

Improving Local Control in Rectal Cancer: Radiation Sensitizers or Radiation Dose?: Joel E. Tepper and Andrew Z. Wang
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.9787 [Abstract] [PDF]

Critical Need for International Consensus on Ototoxicity Assessment Criteria: Edward A. Neuwelt and Penelope Brock
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.7872 [Abstract] [PDF]

Early Diagnosis of Hereditary Breast Cancer by Magnetic Resonance Imaging: What Is Realistic?: Jan G.M. Klijn
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.3467 [Abstract] [PDF]

Lifestyle and Breast Cancer Risk: The Way Forward?: Rowan T. Chlebowski
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.26.7898 [Abstract] [PDF]

Castration-Resistant Prostate Cancer—Hormone Therapy Redux: Anthony W. Tolcher and Josh Cooper
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.3781 [Abstract] [PDF]

Defining the Clinical Utility of Gene Expression Assays in Breast Cancer: The Intersection of Science and Art in Clinical Decision Making: Joseph A. Sparano and Lawrence J. Solin
JCO published online January 11, 2010, DOI:10.1200/JCO.2009.25.2882 [Abstract] [PDF]

EPIDEMIOLOGY

Functional Promoter -1271G>C Variant of HSPB1 Predicts Lung Cancer Risk and Survival: Huan Guo, Yun Bai, Ping Xu, Zhibin Hu, Li Liu, Fang Wang, Guangfu Jin, Feng Wang, Qifei Deng, Yixiao Tu, Maohui Feng, Daru Lu, Hongbing Shen, and Tangchun Wu
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.24.4954 [Abstract] [PDF]

GASTROINTESTINAL CANCER

Multicenter Phase II Study of Everolimus in Patients With Previously Treated Metastatic Gastric Cancer: Toshihiko Doi, Kei Muro, Narikazu Boku, Yasuhide Yamada, Tomohiro Nishina, Hiroya Takiuchi, Yoshito Komatsu, Yasuo Hamamoto, Nobutsugu Ohno, Yoshie Fujita, Matthew Robson, and Atsushi Ohtsu
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.26.2923 [Abstract] [PDF]

Randomized Phase III Trial of Gemcitabine Plus Cisplatin Compared With Single-Agent Gemcitabine As First-Line Treatment of Patients With Advanced Pancreatic Cancer: The GIP-1 Study: Giuseppe Colucci, Roberto Labianca, Francesco Di Costanzo, Vittorio Gebbia, Giacomo Cartenì, Bruno Massidda, Elisa Dapretto, Luigi Manzione, Elena Piazza, Mirella Sannicolò, Marco Ciaparrone, Luigi Cavanna, Francesco Giuliani, Evaristo Maiello, Antonio Testa, Paolo Pederzoli, Massimo Falconi, Ciro Gallo, Massimo Di Maio, and Francesco Perrone
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.4433 [Abstract] [PDF]

Pancreatic Proteolytic Enzyme Therapy Compared With Gemcitabine-Based Chemotherapy for the Treatment of Pancreatic Cancer: John A. Chabot, Wei-Yann Tsai, Robert L. Fine, Chunxia Chen, Carolyn K. Kumah, Karen A. Antman, and Victor R. Grann
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.22.8429 [Abstract] [PDF] [Publisher's Note]

Clinical Scoring System to Predict Hepatocellular Carcinoma in Chronic Hepatitis B Carriers: Vincent Wai-Sun Wong, Stephen Lam Chan, Frankie Mo, Tung-Ching Chan, Herbert Ho-Fung Loong, Grace Lai-Hung Wong, Yanni Yan-Ni Lui, Anthony Tak-Cheung Chan, Joseph Jao-Yiu Sung, Winnie Yeo, Henry Lik-Yuen Chan, and Tony Shu-Kam Mok
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.2675 [Abstract] [PDF]

Comparison of Two Neoadjuvant Chemoradiotherapy Regimens for Locally Advanced Rectal Cancer: Results of the Phase III Trial ACCORD 12/0405-Prodige 2: Jean-Pierre Gérard, David Azria, Sophie Gourgou-Bourgade, Isabelle Martel-Laffay, Christophe Hennequin, Pierre-Luc Etienne, Véronique Vendrely, Eric François, Guy de La Roche, Olivier Bouché, Xavier Mirabel, Bernard Denis, Laurent Mineur, Jean-François Berdah, Marc André Mahé, Yves Bécouarn, Olivier Dupuis, Gérard Lledo, Christine Montoto-Grillot, and Thierry Conroy
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.8376 [Abstract] [PDF]

Prognostic Value of Changes in Health-Related Quality of Life Scores During Curative Treatment for Esophagogastric Cancer: Therese Djärv, Chris Metcalfe, Kerry N.L. Avery, Pernilla Lagergren, and Jane M. Blazeby
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.23.5143 [Abstract] [PDF]

⁹⁰Y-Edotreotide for Metastatic Carcinoid Refractory to Octreotide: David L. Bushnell Jr, Thomas M. O'Dorisio, M. Sue O'Dorisio, Yusuf Menda, Rodney J. Hicks, Eric Van Cutsem, Jean-Louis Baulieu, Francoise Borson-Chazot, Lowell Anthony, Al B. Benson, Kjell Oberg, Ashley B. Grossman, Mary Connolly, Hakim Bouterfa, Yong Li, Katherine A. Kacena, Norman LaFrance, and Stanislas A. Pauwels
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.22.8585 [Abstract] [PDF]

Cross-Sectional Study of Imatinib Plasma Trough Levels in Patients With Advanced Gastrointestinal Stromal Tumors: Impact of Gastrointestinal Resection on Exposure to Imatinib: Changhoon Yoo, Min-Hee Ryu, Byung Woog Kang, Shin-Kyo Yoon, Baek-Yeol Ryoo, Heung-Moon Chang, Jae-Lyun Lee, Mo Youl Beck, Tae Won Kim, and Yoon-Koo Kang
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.26.5785 [Abstract] [PDF]

Multicenter Phase III Comparison of Cisplatin/S-1 With Cisplatin/Infusional Fluorouracil in Advanced Gastric or Gastroesophageal Adenocarcinoma Study: The FLAGS Trial: Jaffer A. Ajani, Wuilbert Rodriguez, Gyorgy Bodoky, Vladimir Moiseyenko, Mikhail Lichinitser, Vera Gorbunova, Ihor Vynnychenko, August Garin, Istvan Lang, and Silvia Falcon
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.4706 [Abstract] [PDF]

GENITOURINARY CANCER

Prognostic Factors in Patients With Advanced Transitional Cell Carcinoma of the Urothelial Tract Experiencing Treatment Failure With Platinum-Containing Regimens: Joaquim Bellmunt, Toni K. Choueiri, Ronan Fougeray, Fabio A.B. Schutz, Yacine Salhi, Eric Winquist, Stéphane Culine, Hans von der Maase, David J. Vaughn, and Jonathan E. Rosenberg
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.4599 [Abstract] [PDF]

TI-CE High-Dose Chemotherapy for Patients With Previously Treated Germ Cell Tumors: Results and Prognostic Factor Analysis: Darren R. Feldman, Joel Sheinfeld, Dean F. Bajorin, Patricia Fischer, Stefan Turkula, Nicole Ishill, Sujata Patil, Manjit Bains, Lilian M. Reich, George J. Bosl, and Robert J. Motzer
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.1561 [Abstract] [PDF]

Risk Factors for Prostate Cancer Detection After a Negative Biopsy: A Novel Multivariable Longitudinal Approach: Peter H. Gann, Angela Fought, Ryan Deaton, William J. Catalona, and Edward Vonesh
JCO published online February 22, 2010, DOI:10.1200/JCO.2008.20.3422 [Abstract] [PDF]

Phase II Multicenter Study of Abiraterone Acetate Plus Prednisone Therapy in Patients With Docetaxel-Treated Castration-Resistant Prostate Cancer: Daniel C. Danila, Michael J. Morris, Johann S. de Bono, Charles J. Ryan, Samuel R. Denmeade, Matthew R. Smith, Mary-Ellen Taplin, Glenn J. Bubley, Thian Kheoh, Christopher Haqq, Arturo Molina, Aseem Anand, Michael Koscuiszka, Steve M. Larson, Lawrence H. Schwartz, Martin Fleisher, and Howard I. Scher
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.9259 [Abstract] [PDF]

Neoadjuvant Clinical Trial With Sorafenib for Patients With Stage II or Higher Renal Cell Carcinoma: C. Lance Cowey, Chirag Amin, Raj S. Pruthi, Eric M. Wallen, Matthew E. Nielsen, Gayle Grigson, Cathy Watkins, Keith V. Nance, Jeffrey Crane, Mark Jalkut, Dominic T. Moore, William Y. Kim, Paul A. Godley, Young E. Whang, Julia R. Fielding, and W. Kimryn Rathmell
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.24.7759 [Abstract] [PDF]

Significant and Sustained Antitumor Activity in Post-Docetaxel, Castration-Resistant Prostate Cancer With the CYP17 Inhibitor Abiraterone Acetate: Alison H.M. Reid, Gerhardt Attard, Daniel C. Danila, Nikhil Babu Oommen, David Olmos, Peter C. Fong, L. Rhoda Molife, Joanne Hunt, Christina Messiou, Christopher Parker, David Dearnaley, Joost F. Swennenhuis, Leon W.M.M. Terstappen, Gloria Lee, Thian Kheoh, Arturo Molina, Charles J. Ryan, Eric Small, Howard I. Scher, and Johann S. de Bono
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.24.6819 [Abstract] [PDF]

Phase I Clinical Trial of the CYP17 Inhibitor Abiraterone Acetate Demonstrating Clinical Activity in Patients With Castration-Resistant Prostate Cancer Who Received Prior Ketoconazole Therapy: Charles J. Ryan, Matthew R. Smith, Lawrence Fong, Jonathan E. Rosenberg, Philip Kantoff, Florence Raynaud, Vanessa Martins, Gloria Lee, Thian Kheoh, Jennifer Kim, Arturo Molina, and Eric J. Small
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.24.1281 [Abstract] [PDF]

Metastasis After Radical Prostatectomy or External Beam Radiotherapy for Patients With Clinically Localized Prostate Cancer: A Comparison of Clinical Cohorts Adjusted for Case Mix: Michael J. Zelefsky, James A. Eastham, Angel M. Cronin, Zvi Fuks, Zhigang Zhang, Yoshiya Yamada, Andrew Vickers, and Peter T. Scardino
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.22.2265 [Abstract] [PDF]

GYNECOLOGIC CANCER

Potential Role of Lymphadenectomy in Advanced Ovarian Cancer: A Combined Exploratory Analysis of Three Prospectively Randomized Phase III Multicenter Trials: Andreas du Bois, Alexander Reuss, Philipp Harter, Eric Pujade-Lauraine, Isabelle Ray-Coquard, and Jacobus Pfisterer
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.3617 [Abstract] [PDF]

Outcomes of Fertility-Sparing Surgery for Stage I Epithelial Ovarian Cancer: A Proposal for Patient Selection: Toyomi Satoh, Masayuki Hatae, Yoh Watanabe, Nobuo Yaegashi, Osamu Ishiko, Shoji Kodama, Satoshi Yamaguchi, Kazunori Ochiai, Masashi Takano, Harushige Yokota, Yosuke Kawakami, Sadako Nishimura, Daiki Ogishima, Shunsuke Nakagawa, Hiroaki Kobayashi, Tanri Shiozawa, Toru Nakanishi, Toshiharu Kamura, Ikuo Konishi, and Hiroyuki Yoshikawa
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.8617 [Abstract] [PDF]

HEALTH SERVICES AND OUTCOMES

Employment Among Survivors of Lung Cancer and Colorectal Cancer: Craig C. Earle, Yves Chretien, Carl Morris, John Z. Ayanian, Nancy L. Keating, Linnea A. Polgreen, Robert Wallace, Patricia A. Ganz, and Jane C. Weeks
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.7411 [Abstract] [PDF]

HEMATOLOGIC MALIGNANCIES

Relapse and Late Mortality in 5-Year Survivors of Myeloablative Allogeneic Hematopoietic Cell Transplantation for Chronic Myeloid Leukemia in First Chronic Phase: John M. Goldman, Navneet S. Majhail, John P. Klein, Zhiwei Wang, Kathleen A. Sobocinski, Mukta Arora, Mary M. Horowitz, and J. Douglas Rizzo
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.26.7757 [Abstract] [PDF]

Risk-Adapted Dose-Dense Immunochemotherapy Determined by Interim FDG-PET in Advanced-Stage Diffuse Large B-Cell Lymphoma: Craig H. Moskowitz, Heiko Schöder, Julie Teruya-Feldstein, Camelia Sima, Alexia Iasonos, Carol S. Portlock, David Straus, Ariela Noy, Maria L. Palomba, Owen A. O'Connor, Steven Horwitz, Sarah A. Weaver, Jessica L. Meikle, Daniel A. Filippa, James F. Caravelli, Paul A. Hamlin, and Andrew D. Zelenetz
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.26.5942 [Abstract] [PDF]

Phase III Placebo-Controlled Trial of Denileukin Diftitox for Patients With Cutaneous T-Cell Lymphoma: H. Miles Prince, Madeleine Duvic, Ann Martin, Wolfram Sterry, Chalid Assaf, Yijun Sun, David Straus, Mark Acosta, and Andres Negro-Vilar
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.26.2386 [Abstract] [PDF]

Comparison of Cladribine Plus Cyclophosphamide With Fludarabine Plus Cyclophosphamide As First-Line Therapy for Chronic Lymphocytic Leukemia: A Phase III Randomized Study by the Polish Adult Leukemia Group (PALG-CLL3 Study): Tadeusz Robak, Krzysztof Jamroziak, Joanna Gora-Tybor, Beata Stella-Holowiecka, Lech Konopka, Bernadetta Ceglarek, Krzysztof Warzocha, Ilona Seferynska, Jaros $l$ aw Piszcz, Malgorzata Calbecka, Aleksandra Kostyra, Jadwiga Dwilewicz-Trojaczek, Anna Dmoszyñska, Krystyna Zawilska, Andrzej Hellmann, Andrzej Zdunczyk, Stanislaw Potoczek, Magdalena Piotrowska, Krzysztof Lewandowski, and Jerzy Z. Blonski
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.25.9630 [Abstract] [PDF]

Phase I/II Study of Combination Therapy With Sorafenib, Idarubicin, and Cytarabine in Younger Patients With Acute Myeloid Leukemia: Farhad Ravandi, Jorge E. Cortes, Daniel Jones, Stefan Faderl, Guillermo Garcia-Manero, Marina Y. Konopleva, Susan O'Brien, Zeev Estrov, Gautam Borthakur, Deborah Thomas, Sherry R. Pierce, Mark Brandt, Anna Byrd, B. Nebiyou Bekele, Keith Pratz, Rajyalakshmi Luthra, Mark Levis, Michael Andreeff, and Hagop M. Kantarjian
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.25.4888 [Abstract] [PDF]

Effect of Age on Outcome of Reduced-Intensity Hematopoietic Cell Transplantation for Older Patients With Acute Myeloid Leukemia in First Complete Remission or With Myelodysplastic Syndrome: Brian L. McClune, Daniel J. Weisdorf, Tanya L. Pedersen, Gisela Tunes da Silva, Martin S. Tallman, Jorge Sierra, John DiPersio, Armand Keating, Robert P. Gale, Biju George, Vikas Gupta, Theresa Hahn, Luis Isola, Madan Jagasia, Hillard Lazarus, David Marks, Richard Maziarz, Edmund K. Waller, Chris Bredeson, and Sergio Giralt
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.25.4821 [Abstract] [PDF]

Rituximab Plus Fludarabine and Cyclophosphamide Prolongs Progression-Free Survival Compared With Fludarabine and Cyclophosphamide Alone in Previously Treated Chronic Lymphocytic Leukemia: Tadeusz Robak, Anna Dmoszynska, Philippe Solal-Céligny, Krzysztof Warzocha, Javier Loscertales, John Catalano, Boris V. Afanasiev, Loree Larratt, Christian H. Geisler, Marco Montillo, Ilya Zyuzgin, Peter S. Ganly, Caroline Dartigeas, András Rosta, Jörg Maurer, Myriam Mendila, M. Wayne Saville, Nancy Valente, Michael K. Wenger, and Sergey I. Moiseev
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.26.4556 [Abstract] [PDF]

Ofatumumab As Single-Agent CD20 Immunotherapy in Fludarabine-Refractory Chronic Lymphocytic Leukemia: William G. Wierda, Thomas J. Kipps, Ji $r$ í Mayer, Stephan Stilgenbauer, Cathy D. Williams, Andrzej Hellmann, Tadeusz Robak, Richard R. Furman, Peter Hillmen, Marek Trneny, Martin J.S. Dyer, Swami Padmanabhan, Magdalena Piotrowska, Tomas Kozak, Geoffrey Chan, Randy Davis, Nedjad Losic, Joris Wilms, Charlotte A. Russell, and Anders Österborg
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.3187 [Abstract] [PDF]

Gene Expression Profiling Uncovers Molecular Classifiers for the Recognition of Anaplastic Large-Cell Lymphoma Within Peripheral T-Cell Neoplasms: Roberto Piva, Luca Agnelli, Elisa Pellegrino, Katia Todoerti, Valentina Grosso, Ilaria Tamagno, Alessandro Fornari, Barbara Martinoglio, Enzo Medico, Alberto Zamò, Fabio Facchetti, Maurilio Ponzoni, Eva Geissinger, Andreas Rosenwald, Hans Konrad Müller-Hermelink, Christiane De Wolf-Peeters, Pier Paolo Piccaluga, Stefano Pileri, Antonino Neri, and Giorgio Inghirami
JCO published online March 1, 2010, DOI:10.1200/JCO.2008.20.9759 [Abstract] [PDF] [Data Supplement] [Publisher's Note]

Prognostic Significance of Focal Lesions in Whole-Body Magnetic Resonance Imaging in Patients With Asymptomatic Multiple Myeloma: Jens Hillengass, Kerstin Fechtner, Marc-André Weber, Tobias Bäuerle, Sofia Ayyaz, Christiane Heiss, Thomas Hielscher, Thomas M. Moehler, Gerlinde Egerer, Kai Neben, Anthony D. Ho, Hans-Ulrich Kauczor, Stefan Delorme, and Hartmut Goldschmidt
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.5356 [Abstract] [PDF]

Phase I Study of KW-0761, a Defucosylated Humanized Anti-CCR4 Antibody, in Relapsed Patients With Adult T-Cell Leukemia-Lymphoma and Peripheral T-Cell Lymphoma: Kazuhito Yamamoto, Atae Utsunomiya, Kensei Tobinai, Kunihiro Tsukasaki, Naokuni Uike, Kimiharu Uozumi, Kazunari Yamaguchi, Yasuaki Yamada, Shuichi Hanada, Kazuo Tamura, Shigeo Nakamura, Hiroshi Inagaki, Koichi Ohshima, Hitoshi Kiyoi, Takashi Ishida, Kouji Matsushima, Shiro Akinaga, Michinori Ogura, Masao Tomonaga, and Ryuzo Ueda
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.3575 [Abstract] [PDF]

Survival and Years of Life Lost in Different Age Cohorts of Patients With Multiple Myeloma: Heinz Ludwig, Vanessa Bolejack, John Crowley, Joan Bladé, Jesus San Miguel, Robert A. Kyle, S. Vincent Rajkumar, Kazuyuki Shimizu, Ingemar Turesson, Jan Westin, Pieter Sonneveld, Michele Cavo, Mario Boccadoro, Antonio Palumbo, Patrizia Tosi, Jean-Luc Harousseau, Michel Attal, Bart Barlogie, A. Keith Stewart, and Brian Durie
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.2114 [Abstract] [PDF]

Treatment of Favorable, Limited-Stage Hodgkin's Lymphoma With Chemotherapy Without Consolidation by Radiation Therapy: George P. Canellos, Jeremy S. Abramson, David C. Fisher, and Ann S. LaCasce
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.3260 [Abstract] [PDF]

Effect of Complete Remission and Responses Less Than Complete Remission on Survival in Acute Myeloid Leukemia: A Combined Eastern Cooperative Oncology Group, Southwest Oncology Group, and M.D. Anderson Cancer Center Study: Roland B. Walter, Hagop M. Kantarjian, Xuelin Huang, Sherry A. Pierce, Zhuoxin Sun, Holly M. Gundacker, Farhad Ravandi, Stefan H. Faderl, Martin S. Tallman, Frederick R. Appelbaum, and Elihu H. Estey
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.1066 [Abstract] [PDF]

MELANOMA

Large Randomized Study of Thymosin ${alpha}$ 1, Interferon Alfa, or Both in Combination With Dacarbazine in Patients With Metastatic Melanoma: Michele Maio, Andrzej Mackiewicz, Alessandro Testori, Uwe Trefzer, Virginia Ferraresi, Jacek Jassem, Claus Garbe, Thierry Lesimple, Bernard Guillot, Pere Gascon, Katalin Gilde, Roberto Camerini, and Francesco Cognetti
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.5208 [Abstract] [PDF]

PALLIATIVE AND SUPPORTIVE CARE

Are the Most Distressing Concerns of Patients With Inoperable Lung Cancer Adequately Assessed? A Mixed-Methods Analysis: Carol Tishelman, Malin Lövgren, Eva Broberger, Katarina Hamberg, and Mirjam A.G. Sprangers
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.23.3403 [Abstract] [PDF]

Experiences and Attitudes of Patients With Terminal Cancer and Their Family Caregivers Toward the Disclosure of Terminal Illness: Young Ho Yun, Yong Chol Kwon, Myung Kyung Lee, Woo Jin Lee, Kyung Hae Jung, Young Rok Do, Samyong Kim, Dae Seog Heo, Jong Soo Choi, and Sang Yoon Park
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.22.9658 [Abstract] [PDF]

Role of Palliative Care in Adolescent and Young Adult Oncology: Simon Wein, Shlomit Pery, and Alona Zer
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.22.4543 [Abstract] [PDF]

Meeting Expectations of Patients With Cancer: Relationship Between Patient Satisfaction, Depression, and Coping: Gil Goldzweig, Amichai Meirowitz, Ayala Hubert, Baruch Brenner, Natalio Walach, Shlomit Perry, Ilanit Hasson-Ohayon, and Lea Baider
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.4987 [Abstract] [PDF]

PEDIATRIC ONCOLOGY

Psychological Outcomes and Health Beliefs in Adolescent and Young Adult Survivors of Childhood Cancer and Controls: Anne E. Kazak, Branlyn Werba DeRosa, Lisa A. Schwartz, Wendy Hobbie, Claire Carlson, Richard F. Ittenbach, Jun J. Mao, and Jill P. Ginsberg
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.9564 [Abstract] [PDF]

Predicting Adverse Events in Children With Fever and Chemotherapy-Induced Neutropenia: The Prospective Multicenter SPOG 2003 FN Study: Roland A. Ammann, Nicole Bodmer, Andreas Hirt, Felix K. Niggli, David Nadal, Arne Simon, Hulya Ozsahin, Udo Kontny, Thomas Kühne, Maja Beck Popovic, Annette Ridolfi Lüthy, and Christoph Aebi
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.25.8988 [Abstract] [PDF]

Gene Expression–Based Classification As an Independent Predictor of Clinical Outcome in Juvenile Myelomonocytic Leukemia: Silvia Bresolin, Marco Zecca, Christian Flotho, Luca Trentin, Andrea Zangrando, Laura Sainati, Jan Stary, Barbara de Moerloose, Henrik Hasle, Charlotte M. Niemeyer, Geertruy te Kronnie, Franco Locatelli, and Giuseppe Basso
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.24.4426 [Abstract] [PDF]

Benefits of the Intermittent Use of 6-Mercaptopurine and Methotrexate in Maintenance Treatment for Low-Risk Acute Lymphoblastic Leukemia in Children: Randomized Trial From the Brazilian Childhood Cooperative Group—Protocol ALL-99: Silvia R. Brandalise, Vitória R. Pinheiro, Simone S. Aguiar, Eduardo I. Matsuda, Rosemary Otubo, José A. Yunes, Waldir V. Pereira, Eny G. Carvalho, Lilian M. Cristofani, Marcelo S. Souza, Maria L. Lee, Jane A. Dobbin, Maria S. Pombo-de-Oliveira, Luiz F. Lopes, Katharina N.T. Melnikoff, Algemir L. Brunetto, Luiz G. Tone, Carlos A. Scrideli, Vera L.L. Morais, and Marcos B. Viana
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.25.6115 [Abstract] [PDF]

Psychological Distress in Adult Survivors of Childhood Cancer: The Swiss Childhood Cancer Survivor Study: Gisela Michel, Cornelia E. Rebholz, Nicolas X. von der Weid, Eva Bergstraesser, and Claudia E. Kuehni
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.23.4534 [Abstract] [PDF]

PHASE I AND CLINICAL PHARMACOLOGY

Phase I Pharmacokinetic and Pharmacodynamic Study of 17-dimethylaminoethylamino-17-demethoxygeldanamycin, an Inhibitor of Heat-Shock Protein 90, in Patients With Advanced Solid Tumors: Ramesh K. Ramanathan, Merrill J. Egorin, Charles Erlichman, Scot C. Remick, Suresh S. Ramalingam, Cynthia Naret, Julianne L. Holleran, Cynthia J. TenEyck, S. Percy Ivy, and Chandra P. Belani
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.0415 [Abstract] [PDF]

REVIEW ARTICLES

Practical Grading System for Evaluating Cisplatin Ototoxicity in Children: Kay W. Chang and Nina Chinosornvatana
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.24.4228 [Abstract] [PDF]

Overall Survival and Post-Progression Survival in Advanced Breast Cancer: A Review of Recent Randomized Clinical Trials: Everardo D. Saad, Artur Katz, and Marc Buyse
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.5414 [Abstract] [PDF]

SPECIAL ARTICLES

Updated Response Assessment Criteria for High-Grade Gliomas: Response Assessment in Neuro-Oncology Working Group: Patrick Y. Wen, David R. Macdonald, David A. Reardon, Timothy F. Cloughesy, A. Gregory Sorensen, Evanthia Galanis, John DeGroot, Wolfgang Wick, Mark R. Gilbert, Andrew B. Lassman, Christina Tsien, Tom Mikkelsen, Eric T. Wong, Marc C. Chamberlain, Roger Stupp, Kathleen R. Lamborn, Michael A. Vogelbaum, Martin J. van den Bent, and Susan M. Chang
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.26.3541 [Abstract] [PDF]

The American Society of Clinical Oncology Cancer Foundation Grants Program: A 25-Year Report and a Look Toward the Future: Jennifer C. King, Theodore S. Lawrence, Sharon B. Murphy, Nancy E. Davidson, and Robert J. Mayer
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.27.4621 [Abstract] [PDF]

SARCOMAS

Imatinib Mesylate in Advanced Dermatofibrosarcoma Protuberans: Pooled Analysis of Two Phase II Clinical Trials: Piotr Rutkowski, Martine Van Glabbeke, Cathryn J. Rankin, Wlodzimierz Ruka, Brian P. Rubin, Maria Debiec-Rychter, Alexander Lazar, Hans Gelderblom, Raf Sciot, Dolores Lopez-Terrada, Peter Hohenberger, Allan T. van Oosterom, and Scott M. Schuetze
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.25.7899 [Abstract] [PDF]

STATISTICS IN ONCOLOGY

Comparison of Error Rates in Single-Arm Versus Randomized Phase II Cancer Clinical Trials: Hui Tang, Nathan R. Foster, Axel Grothey, Stephen M. Ansell, Richard M. Goldberg, and Daniel J. Sargent
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.25.5489 [Abstract] [PDF]

THORACIC ONCOLOGY

Surgery With or Without Preoperative Paclitaxel and Carboplatin in Early-Stage Non–Small-Cell Lung Cancer: Southwest Oncology Group Trial S9900, an Intergroup, Randomized, Phase III Trial: Katherine M.W. Pisters, Eric Vallières, John J. Crowley, Wilbur A. Franklin, Paul A. Bunn Jr, Robert J. Ginsberg ${dagger}$ , Joe B. Putnam Jr, Kari Chansky, and David Gandara
JCO published online March 15, 2010, DOI:10.1200/JCO.2009.26.1685 [Abstract] [PDF]

Phase III Study of Carboplatin and Paclitaxel Alone or With Sorafenib in Advanced Non–Small-Cell Lung Cancer: Giorgio Scagliotti, Silvia Novello, Joachim von Pawel, Martin Reck, José Rodrigues Pereira, Michael Thomas, José Elias Abrão Miziara, Beatrix Balint, Filippo De Marinis, Alan Keller, Osvaldo Arén, Maria Csollak, Istvan Albert, Carlos Henrique Barrios, Francesco Grossi, Maciej Krzakowski, Lisa Cupit, Frank Cihon, Sandra DiMatteo, and Nasser Hanna
JCO published online March 8, 2010, DOI:10.1200/JCO.2009.26.1321 [Abstract] [PDF]

Serum MicroRNA Signatures Identified in a Genome-Wide Serum MicroRNA Expression Profiling Predict Survival of Non–Small-Cell Lung Cancer: Zhibin Hu, Xi Chen, Yang Zhao, Tian Tian, Guangfu Jin, Yongqian Shu, Yijiang Chen, Lin Xu, Ke Zen, Chenyu Zhang, and Hongbing Shen
JCO published online March 1, 2010, DOI:10.1200/JCO.2009.24.9342 [Abstract] [PDF]

Thymidylate Synthase But Not Excision Repair Cross-Complementation Group 1 Tumor Expression Predicts Outcome in Patients With Malignant Pleural Mesothelioma Treated With Pemetrexed-Based Chemotherapy: Luisella Righi, Mauro G. Papotti, Paolo Ceppi, Andrea Billè, Elisa Bacillo, Luca Molinaro, Enrico Ruffini, Giorgio V. Scagliotti, and Giovanni Selvaggi
JCO published online February 22, 2010, DOI:10.1200/JCO.2009.25.9275 [Abstract] [PDF]

Lung Cancer and Hormone Replacement Therapy: Association in the Vitamins and Lifestyle Study: Christopher G. Slatore, Jason W. Chien, David H. Au, Jessie A. Satia, and Emily White
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.9739 [Abstract] [PDF]

Phase 1b Study of Dulanermin (recombinant human Apo2L/TRAIL) in Combination With Paclitaxel, Carboplatin, and Bevacizumab in Patients With Advanced Non-Squamous Non–Small-Cell Lung Cancer: Jean-Charles Soria, Egbert Smit, David Khayat, Benjamin Besse, Xinqun Yang, Cheng-Pang Hsu, David Reese, Jeffrey Wiezorek, and Fiona Blackhall
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.25.4847 [Abstract] [PDF]

TRANSLATIONAL ONCOLOGY

Genomic Changes in Chromosomes 10, 16, and X in Malignant Peripheral Nerve Sheath Tumors Identify a High-Risk Patient Group: Helge R. Brekke, Franclim R. Ribeiro, Matthias Kolberg, Trude H. Ågesen, Guro E. Lind, Mette Eknæs, Kirsten S. Hall, Bodil Bjerkehagen, Eva van den Berg, Manuel R. Teixeira, Nils Mandahl, Sigbjørn Smeland, Fredrik Mertens, Rolf I. Skotheim, and Ragnhild A. Lothe
JCO published online February 16, 2010, DOI:10.1200/JCO.2009.24.8989 [Abstract] [PDF]

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